AU602961B2 - Method of inhibiting interleukin-1 release and alleviating interleukin-1 mediated conditions - Google Patents
Method of inhibiting interleukin-1 release and alleviating interleukin-1 mediated conditions Download PDFInfo
- Publication number
- AU602961B2 AU602961B2 AU13160/88A AU1316088A AU602961B2 AU 602961 B2 AU602961 B2 AU 602961B2 AU 13160/88 A AU13160/88 A AU 13160/88A AU 1316088 A AU1316088 A AU 1316088A AU 602961 B2 AU602961 B2 AU 602961B2
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- AU
- Australia
- Prior art keywords
- methyl
- probucol
- compound
- carbon atoms
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
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- 102000000589 Interleukin-1 Human genes 0.000 title claims description 46
- 108010002352 Interleukin-1 Proteins 0.000 title claims description 46
- 238000000034 method Methods 0.000 title claims description 34
- 230000001404 mediated effect Effects 0.000 title claims description 16
- 230000002401 inhibitory effect Effects 0.000 title claims description 8
- 150000001875 compounds Chemical class 0.000 claims description 47
- FYPMFJGVHOHGLL-UHFFFAOYSA-N probucol Chemical compound C=1C(C(C)(C)C)=C(O)C(C(C)(C)C)=CC=1SC(C)(C)SC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 FYPMFJGVHOHGLL-UHFFFAOYSA-N 0.000 claims description 40
- 229960003912 probucol Drugs 0.000 claims description 39
- 125000000217 alkyl group Chemical group 0.000 claims description 19
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 18
- 241001465754 Metazoa Species 0.000 claims description 16
- 125000004432 carbon atom Chemical group C* 0.000 claims description 14
- 206010061218 Inflammation Diseases 0.000 claims description 13
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 13
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 13
- 230000004054 inflammatory process Effects 0.000 claims description 13
- 229910052739 hydrogen Inorganic materials 0.000 claims description 12
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- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 claims description 10
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- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 6
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- APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K31/10—Sulfides; Sulfoxides; Sulfones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2658687A | 1987-03-17 | 1987-03-17 | |
| US026586 | 1987-03-17 | ||
| US15157288A | 1988-02-18 | 1988-02-18 | |
| US151572 | 1988-02-18 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU1316088A AU1316088A (en) | 1988-09-15 |
| AU602961B2 true AU602961B2 (en) | 1990-11-01 |
Family
ID=26701419
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU13160/88A Expired AU602961B2 (en) | 1987-03-17 | 1988-03-16 | Method of inhibiting interleukin-1 release and alleviating interleukin-1 mediated conditions |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0292660B1 (enExample) |
| JP (1) | JP2671129B2 (enExample) |
| KR (1) | KR960005704B1 (enExample) |
| AU (1) | AU602961B2 (enExample) |
| DE (1) | DE3869202D1 (enExample) |
| DK (1) | DK175801B1 (enExample) |
| ES (1) | ES2039489T3 (enExample) |
| GR (1) | GR3004108T3 (enExample) |
| IE (1) | IE60708B1 (enExample) |
| PH (1) | PH23885A (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4959392A (en) * | 1989-07-24 | 1990-09-25 | Merrell Dow Pharmaceuticals Inc. | Method of treating diabetes mellitus |
| AU651873B2 (en) * | 1991-03-18 | 1994-08-04 | Merrell Dow Pharmaceuticals Inc. | Method of inhibiting the progressive development of diabetes mellitus |
| FI951367A7 (fi) * | 1994-03-28 | 1995-09-29 | Japan Energy Corp | Puriinijohdannaiset ja tulehdustautien tukahduttajat (suppressantit) |
| US6852878B2 (en) | 1998-05-14 | 2005-02-08 | Atherogenics, Inc. | Thioketals and thioethers for inhibiting the expression of VCAM-1 |
| AU2006202461B2 (en) * | 1997-05-14 | 2009-12-03 | Atherogenics, Inc. | Compositions and methods for the inhibition of the expression of VCAM-1 |
| EA010183B1 (ru) * | 1997-05-14 | 2008-06-30 | Атеродженикс, Инк. | Сложный моноэфир янтарной кислоты и пробукола для лечения сердечно-сосудистых и воспалительных заболеваний |
| EP1695959A1 (en) * | 1997-05-14 | 2006-08-30 | Atherogenics, Inc. | Compouds and methods for the inhibition of the expression of VCAM-1 |
| US6670398B2 (en) | 1997-05-14 | 2003-12-30 | Atherogenics, Inc. | Compounds and methods for treating transplant rejection |
| EP1019034A2 (en) | 1997-07-01 | 2000-07-19 | Atherogenics, Inc. | Antioxidant enhancement of therapy for hyperproliferative conditions |
| CA2404044A1 (en) | 2000-04-11 | 2001-10-18 | Atherogenics, Inc. | Compounds and methods to increase plasma hdl cholesterol levels and improve hdl functionality |
| EP2139320A4 (en) | 2007-03-26 | 2010-09-08 | Salutria Pharmaceuticals Llc | METHODS AND COMPOSITIONS OF PROBUCOL DERIVATIVES FOR THE TREATMENT OF DIABETES |
| CN108299263B (zh) * | 2018-01-30 | 2020-12-01 | 北京德默高科医药技术有限公司 | 一种普罗布考衍生物及其制备方法与应用 |
-
1988
- 1988-03-15 ES ES198888104086T patent/ES2039489T3/es not_active Expired - Lifetime
- 1988-03-15 EP EP88104086A patent/EP0292660B1/en not_active Expired - Lifetime
- 1988-03-15 DE DE8888104086T patent/DE3869202D1/de not_active Expired - Lifetime
- 1988-03-16 KR KR1019880002733A patent/KR960005704B1/ko not_active Expired - Lifetime
- 1988-03-16 PH PH36644A patent/PH23885A/en unknown
- 1988-03-16 IE IE78688A patent/IE60708B1/en not_active IP Right Cessation
- 1988-03-16 DK DK198801433A patent/DK175801B1/da not_active IP Right Cessation
- 1988-03-16 AU AU13160/88A patent/AU602961B2/en not_active Expired
- 1988-03-17 JP JP63062074A patent/JP2671129B2/ja not_active Expired - Lifetime
-
1992
- 1992-03-19 GR GR920400463T patent/GR3004108T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2039489T3 (es) | 1993-10-01 |
| DK143388D0 (da) | 1988-03-16 |
| EP0292660A2 (en) | 1988-11-30 |
| JPS63258408A (ja) | 1988-10-25 |
| DE3869202D1 (de) | 1992-04-23 |
| EP0292660B1 (en) | 1992-03-18 |
| KR960005704B1 (ko) | 1996-05-01 |
| DK175801B1 (da) | 2005-02-28 |
| PH23885A (en) | 1989-12-18 |
| JP2671129B2 (ja) | 1997-10-29 |
| GR3004108T3 (enExample) | 1993-03-31 |
| IE880786L (en) | 1988-09-17 |
| AU1316088A (en) | 1988-09-15 |
| KR880010766A (ko) | 1988-10-24 |
| DK143388A (da) | 1988-09-18 |
| IE60708B1 (en) | 1994-08-10 |
| EP0292660A3 (en) | 1990-03-28 |
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