AU581918B2 - Method for preparing 6-chloro-N-methyl-2, 3, 4, 5- tetrahydro-1H-3-benzazepine - Google Patents

Method for preparing 6-chloro-N-methyl-2, 3, 4, 5- tetrahydro-1H-3-benzazepine

Info

Publication number
AU581918B2
AU581918B2 AU46481/85A AU4648185A AU581918B2 AU 581918 B2 AU581918 B2 AU 581918B2 AU 46481/85 A AU46481/85 A AU 46481/85A AU 4648185 A AU4648185 A AU 4648185A AU 581918 B2 AU581918 B2 AU 581918B2
Authority
AU
Australia
Prior art keywords
methyl
chloro
tetrahydro
benzazepine
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU46481/85A
Other languages
English (en)
Other versions
AU4648185A (en
Inventor
Stanley John Borowski
Thomas Anthony Post
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of AU4648185A publication Critical patent/AU4648185A/en
Application granted granted Critical
Publication of AU581918B2 publication Critical patent/AU581918B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
AU46481/85A 1984-09-05 1985-08-21 Method for preparing 6-chloro-N-methyl-2, 3, 4, 5- tetrahydro-1H-3-benzazepine Ceased AU581918B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US647552 1984-09-05
US06/647,552 US4541954A (en) 1984-09-05 1984-09-05 Method for preparing 6-chloro-N-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Publications (2)

Publication Number Publication Date
AU4648185A AU4648185A (en) 1986-03-13
AU581918B2 true AU581918B2 (en) 1989-03-09

Family

ID=24597406

Family Applications (1)

Application Number Title Priority Date Filing Date
AU46481/85A Ceased AU581918B2 (en) 1984-09-05 1985-08-21 Method for preparing 6-chloro-N-methyl-2, 3, 4, 5- tetrahydro-1H-3-benzazepine

Country Status (19)

Country Link
US (1) US4541954A (enExample)
EP (1) EP0174118A3 (enExample)
JP (1) JPS6168469A (enExample)
KR (1) KR860002470A (enExample)
AU (1) AU581918B2 (enExample)
CA (1) CA1244017A (enExample)
DK (1) DK379985A (enExample)
EG (1) EG17149A (enExample)
ES (1) ES8609266A1 (enExample)
FI (1) FI853255L (enExample)
GR (1) GR852041B (enExample)
HU (1) HU194181B (enExample)
IL (1) IL76100A0 (enExample)
NO (1) NO853255L (enExample)
NZ (1) NZ213141A (enExample)
PH (1) PH20796A (enExample)
PT (1) PT81018B (enExample)
ZA (1) ZA856268B (enExample)
ZW (1) ZW13385A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993000811A1 (en) * 1991-07-01 1993-01-21 The General Hospital Corporation Invertebrate phenylethanolamine transporter and the use thereof
EP0570590B1 (en) * 1991-12-06 1997-03-26 Yuasa Corporation Thin battery and monolithic thin battery
US6953787B2 (en) 2002-04-12 2005-10-11 Arena Pharmaceuticals, Inc. 5HT2C receptor modulators
US8367657B2 (en) * 2003-06-17 2013-02-05 Arena Pharmaceuticals, Inc. Processes for preparing 3-benzazepines
CN1805938B (zh) 2003-06-17 2010-06-16 艾尼纳制药公司 用于治疗5ht2c受体相关疾病的苯并氮杂卓衍生物
EP2149562A1 (en) 2004-12-21 2010-02-03 Arena Pharmaceuticals, Inc. method of preparing (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride hemihydrate
NZ589951A (en) * 2004-12-23 2012-11-30 Arena Pharm Inc 5HT2C receptor modulator compositions and methods of use
CA2646044A1 (en) 2006-04-03 2007-10-25 Arena Pharmaceuticals, Inc. Processes for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates related thereto
EP2099743B1 (en) * 2006-12-05 2014-08-27 Arena Pharmaceuticals, Inc. Processes for preparing (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates thereof
US8822727B2 (en) * 2008-03-04 2014-09-02 Arena Pharmaceuticals, Inc. Processes for the preparation of intermediates related to the 5-HT2C agonist (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
WO2010148207A2 (en) 2009-06-18 2010-12-23 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-ht2c receptor agonists
WO2011153206A1 (en) 2010-06-02 2011-12-08 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-ht2c receptor agonists
KR20180118801A (ko) 2010-09-01 2018-10-31 에자이 알앤드디 매니지먼트 가부시키가이샤 체중 관리에 유용한 5-ｈｔ2ｃ 작동제의 변형-방출 투여 형태
JP2013539470A (ja) 2010-09-01 2013-10-24 アリーナ ファーマシューティカルズ， インコーポレイテッド ロルカセリンと光学活性な酸との塩
EA201390335A1 (ru) 2010-09-01 2013-09-30 Арена Фармасьютикалз, Инк. Введение лоркасерина индивидуумам с почечной недостаточностью
KR20130101524A (ko) 2010-09-01 2013-09-13 아레나 파마슈티칼스, 인크. 5-ｈｔ2ｃ 아고니스트의 비-흡습성 염
RU2674670C1 (ru) 2012-10-09 2018-12-12 Арена Фармасьютикалз, Инк. Способ коррекции массы тела

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU555672B2 (en) * 1981-11-27 1986-10-02 Smithkline Beckman Corporation 2,3,4,5-tetrahydro-1h-3-benzaepines as alpha2 anta- gonists

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1118688A (en) * 1967-02-17 1968-07-03 Scherico Ltd Novel benzazepines and process for making same
CH481110A (de) * 1967-02-17 1969-11-15 Geigy Ag J R Verfahren zur Herstellung von 1,2,4,5-Tetrahydro-3-azepinen
US4251660A (en) * 1978-08-10 1981-02-17 Smithkline Corporation Method for preparing tetrahydroisoquinolines
US4200754A (en) * 1979-02-02 1980-04-29 Smithkline Corporation Method for preparing 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline
EP0080779B1 (en) * 1981-11-27 1986-07-16 Smithkline Beckman Corporation 3-benzazepines as alpha-2 antagonists
ZA827887B (en) * 1981-11-27 1983-11-30 Smithkline Beckman Corp Pharmaceutical compositions and method of producing alpha2 antagonism

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU555672B2 (en) * 1981-11-27 1986-10-02 Smithkline Beckman Corporation 2,3,4,5-tetrahydro-1h-3-benzaepines as alpha2 anta- gonists

Also Published As

Publication number Publication date
US4541954A (en) 1985-09-17
CA1244017A (en) 1988-11-01
EP0174118A2 (en) 1986-03-12
EP0174118A3 (en) 1986-12-30
FI853255A0 (fi) 1985-08-23
FI853255A7 (fi) 1986-03-06
ZA856268B (en) 1986-07-30
DK379985D0 (da) 1985-08-21
ES8609266A1 (es) 1986-09-01
KR860002470A (ko) 1986-04-26
ZW13385A1 (en) 1985-11-20
PT81018B (en) 1987-06-24
PH20796A (en) 1987-04-14
DK379985A (da) 1986-03-06
HUT38617A (en) 1986-06-30
JPS6168469A (ja) 1986-04-08
ES546285A0 (es) 1986-09-01
FI853255L (fi) 1986-03-06
NZ213141A (en) 1988-07-28
GR852041B (enExample) 1985-12-19
EG17149A (en) 1989-06-30
IL76100A0 (en) 1985-12-31
HU194181B (en) 1988-01-28
PT81018A (en) 1985-09-01
NO853255L (no) 1986-03-06
AU4648185A (en) 1986-03-13

Similar Documents

Publication Publication Date Title
AU5064785A (en) Preparing 5,6-CIS-1alpha-hydroxy vitamin D compounds
AU561182B2 (en) Method for preparing 26,26,26,27,27,27-hexafluoro-1alpha,25- dihydroxycholesterol
AU4648185A (en) Method for preparing 6-chloro-N-methyl-2, 3, 4, 5- tetrahydro-1H-3-benzazepine
AU4063985A (en) 1,24-dihydroxy-22-vitamin d3 and process for preparing same
EP0212161A3 (en) Process for preparing 1,5-diazido-3-nitrazapentane
PT80956A (en) Process for preparing 1,4-dihydropyridines
CS326886A2 (en) Process for preparing 1,3,5-triazintriones
HUT39168A (en) Process for preparing 1,3-oxazolidin-2-one-derivatives
AU4724385A (en) Elektrodanordning for vattenrenare enligt jonisations- principen, foretradesvis for simbassanger
AU2948189A (en) 4-aralkyl-5-substituted-1,2,4-triazole-5-thiols
AU588017B2 (en) Process for preparing 4,4-dialkyl-2-axetidinones
YU18185A (en) Process for preparing new 1,3,2-dioxaborinanes
AU590431B2 (en) A method for the preparation of 2,4-diamino-3-oxy-6- piperidyl-pyrimidine
EP0174375A4 (en) PRODUCTION PROCESS FOR N-ACYLPHENYLALANINE.
DE3569366D1 (en) Process for producing 4,4'-dihydroxydiphenyls
DE3564940D1 (en) Method for preparing 2,2,6,6-tetramethyl-4-oxopiperidine
PT80104A (en) Process for preparing 1,2,4-triazacycloalkadiene derivatives
GR860230B (en) Process for preparing 6-chloro -3-methyl-1h- 2,3,4,5-tetrahydro-3-benzazepine-n-oxide
HUT40796A (en) Process for preparing 1,3-dioxane-ethers
DE3560069D1 (en) Process for preparing 2,6-dichloro-4-nitro-aniline
HUT38906A (en) Process for preparing 1,3-oxyacyl-2-oxindole derivatives
DE3566539D1 (en) Process for preparing 2,2,6,6-tetramethyl-4-oxopiperidine
HUT37934A (en) Process for preparing 1,4-dihydro-pyridina derivatives
BG37292A1 (en) Method for preparing 5- pregnen- 3- beta, 17 alpha- diol- 20- oh- 3- acetate
BG37284A1 (en) Method for preparing trans- 3- amino- 2- hydroxy- 1, 2, 3, 4- hydronaphthalene