AU5671794A - 17-alpha and 17-beta substituted acyl-3-carboxy-3,5-dienes and use in inhibiting 5-alpha-reductase - Google Patents

17-alpha and 17-beta substituted acyl-3-carboxy-3,5-dienes and use in inhibiting 5-alpha-reductase

Info

Publication number
AU5671794A
AU5671794A AU56717/94A AU5671794A AU5671794A AU 5671794 A AU5671794 A AU 5671794A AU 56717/94 A AU56717/94 A AU 56717/94A AU 5671794 A AU5671794 A AU 5671794A AU 5671794 A AU5671794 A AU 5671794A
Authority
AU
Australia
Prior art keywords
substituted
alkyl
cycloalkyl
compound
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU56717/94A
Other languages
English (en)
Inventor
Dennis Alan Holt
Mark Alan Levy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929224213A external-priority patent/GB9224213D0/en
Priority claimed from GB939316954A external-priority patent/GB9316954D0/en
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of AU5671794A publication Critical patent/AU5671794A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0014—Androstane derivatives substituted in position 17 alfa, not substituted in position 17 beta
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0066—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by a carbon atom forming part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU56717/94A 1992-11-18 1993-11-18 17-alpha and 17-beta substituted acyl-3-carboxy-3,5-dienes and use in inhibiting 5-alpha-reductase Abandoned AU5671794A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB929224213A GB9224213D0 (en) 1992-11-18 1992-11-18 Compounds
GB9224213 1992-11-18
GB939316954A GB9316954D0 (en) 1993-08-14 1993-08-14 Compounds
GB9316954 1993-08-14
PCT/US1993/011241 WO1994011386A1 (en) 1992-11-18 1993-11-18 17-alpha and 17-beta substituted acyl-3-carboxy-3,5-dienes and use in inhibiting 5-alpha-reductase

Publications (1)

Publication Number Publication Date
AU5671794A true AU5671794A (en) 1994-06-08

Family

ID=26302003

Family Applications (2)

Application Number Title Priority Date Filing Date
AU56717/94A Abandoned AU5671794A (en) 1992-11-18 1993-11-18 17-alpha and 17-beta substituted acyl-3-carboxy-3,5-dienes and use in inhibiting 5-alpha-reductase
AU56133/94A Abandoned AU5613394A (en) 1992-11-18 1993-11-18 17 substituted acyl-3-carboxy 3,5-diene steroidals as 5-alpha-reductase inhibitors

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU56133/94A Abandoned AU5613394A (en) 1992-11-18 1993-11-18 17 substituted acyl-3-carboxy 3,5-diene steroidals as 5-alpha-reductase inhibitors

Country Status (12)

Country Link
EP (2) EP0673251A1 (https=)
JP (1) JPH08503471A (https=)
CN (2) CN1101914A (https=)
AP (1) AP9300589A0 (https=)
AU (2) AU5671794A (https=)
CA (1) CA2149427A1 (https=)
IL (1) IL107611A0 (https=)
MA (1) MA23036A1 (https=)
MX (1) MX9307203A (https=)
NZ (1) NZ258723A (https=)
SI (1) SI9300601A (https=)
WO (2) WO1994011386A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW369521B (en) * 1993-09-17 1999-09-11 Smithkline Beecham Corp Androstenone derivative
GB9415183D0 (en) * 1994-07-28 1994-09-21 Erba Carlo Spa 3-carboxysteroids with a fluorinated side-chain
GB9415178D0 (en) * 1994-07-28 1994-09-21 Erba Carlo Spa 4-azasteroids with side-chain fluoroketones
AU3826095A (en) * 1994-10-05 1996-05-02 Smithkline Beecham Corporation Process for preparing 17-beta-substituted-androsta-3,5-dien-3-carboxylic acids
US5541322A (en) * 1994-10-14 1996-07-30 Glaxo Wellcome Inc. Synthesis of 6-azaandrostenones
US5543417A (en) * 1994-10-21 1996-08-06 Merck & Co., Inc. Combination method of treating acne using 4-AZA-5α-cholestan-ones and 4-AZA-5α-androstan-ones as selective 5α-reductase inhibitors with anti-bacterial, keratolytic, or anti-inflammatory agents
CN1130363C (zh) 1997-11-12 2003-12-10 三菱化学株式会社 嘌呤衍生物以及含有其作为有效成分的药物
WO2000068231A1 (en) 1999-05-11 2000-11-16 Mitsubishi Chemical Corporation Purine derivative dihydrate, drugs containing the same as the active ingredient and intermediate in the production thereof
FR2817257B1 (fr) 2000-11-30 2009-03-20 Sanofi Synthelabo Cyclohexyl(alkyl)-propanolamines, leur preparation et compositions pharmaceutiques en contenant
GB201102913D0 (en) 2011-02-18 2011-04-06 Univ Birmingham Novel therapeutic

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4910226A (en) * 1987-04-29 1990-03-20 Smithkline Beckman Corporation Steroid 5-alpha-reductase inhibitors
US5041433A (en) * 1987-04-29 1991-08-20 Smithkline Beecham Corporation 11-keto or hydroxy 3,5-diene steroids as inhibitors of steriod 5-α-reductase
US4954446A (en) * 1988-05-25 1990-09-04 Smithkline Beecham Corporation Aromatic steroid 5-α-reductase inhibitors
US5032586A (en) * 1989-08-24 1991-07-16 Smithkline Beecham Corporation 7-keto or hydroxy 3,5-diene steroids as inhibitors of steroid 5-alpha reductase
US5137882A (en) * 1990-06-11 1992-08-11 Holt Dennis A Steroidal 3-acetic acid derivatives as 5-alpha-reductase inhibitors
EP0465123A3 (en) * 1990-06-28 1992-05-06 Merck & Co. Inc. New intermediates in the synthesis of 17beta-acyl-3-carboxy-androsta-3,5-dienes
CA2045866A1 (en) * 1990-06-28 1991-12-29 Gary H. Rasmusson 17-beta-acyl-3-carboxy-androsta-3,5-dienes as testosterone 5 alpha-reductase inhibitors
US5091380A (en) * 1990-06-28 1992-02-25 Merck & Co., Inc. N-monosubstituted adamantyl/norbornanyl 17β-carbamides of 3-carboxy-androst-3,5-dienes as testosterone 5α-reductase inhibitors
US5196411A (en) * 1991-08-16 1993-03-23 Merck & Co., Inc. 17β-acyl-3-carboxy-androsta-3,5-dienes as testosterone 5α-reductase inhibitors

Also Published As

Publication number Publication date
EP0669932A4 (en) 1995-10-25
CN1101914A (zh) 1995-04-26
EP0673251A4 (https=) 1995-10-25
NZ258723A (en) 1996-12-20
JPH08503471A (ja) 1996-04-16
EP0673251A1 (en) 1995-09-27
IL107611A0 (en) 1994-02-27
AU5613394A (en) 1994-06-08
CA2149427A1 (en) 1994-05-26
SI9300601A (en) 1994-06-30
WO1994011386A1 (en) 1994-05-26
MX9307203A (es) 1994-07-29
WO1994011004A1 (en) 1994-05-26
MA23036A1 (fr) 1994-07-01
EP0669932A1 (en) 1995-09-06
AP9300589A0 (en) 1994-01-31
CN1101916A (zh) 1995-04-26

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