AU551892B2 - Gnrh antagonists - Google Patents
Gnrh antagonistsInfo
- Publication number
- AU551892B2 AU551892B2 AU82838/82A AU8283882A AU551892B2 AU 551892 B2 AU551892 B2 AU 551892B2 AU 82838/82 A AU82838/82 A AU 82838/82A AU 8283882 A AU8283882 A AU 8283882A AU 551892 B2 AU551892 B2 AU 551892B2
- Authority
- AU
- Australia
- Prior art keywords
- phe
- nal
- pro
- gonads
- steroids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 229940121381 gonadotrophin releasing hormone (gnrh) antagonists Drugs 0.000 title 1
- 210000002149 gonad Anatomy 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 150000003431 steroids Chemical class 0.000 abstract 2
- ONIBWKKTOPOVIA-SCSAIBSYSA-N D-Proline Chemical compound OC(=O)[C@H]1CCCN1 ONIBWKKTOPOVIA-SCSAIBSYSA-N 0.000 abstract 1
- 125000001711 D-phenylalanine group Chemical group [H]N([H])[C@@]([H])(C(=O)[*])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000002698 D-tryptophano group Chemical group C(=O)(O)[C@@H](CC1=CNC2=CC=CC=C12)N* 0.000 abstract 1
- 102000006771 Gonadotropins Human genes 0.000 abstract 1
- 108010086677 Gonadotropins Proteins 0.000 abstract 1
- 206010062767 Hypophysitis Diseases 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 235000013601 eggs Nutrition 0.000 abstract 1
- BEBCJVAWIBVWNZ-UHFFFAOYSA-N glycinamide Chemical group NCC(N)=O BEBCJVAWIBVWNZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000002622 gonadotropin Substances 0.000 abstract 1
- 229940094892 gonadotropins Drugs 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000016087 ovulation Effects 0.000 abstract 1
- 210000003635 pituitary gland Anatomy 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/16—Oxytocins; Vasopressins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/13—Luteinizing hormone-releasing hormone; related peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Endocrinology (AREA)
- Analytical Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/256,063 US4409208A (en) | 1980-04-15 | 1981-04-21 | GnRH antagonists |
| US256063 | 1981-04-21 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU8283882A AU8283882A (en) | 1982-10-28 |
| AU551892B2 true AU551892B2 (en) | 1986-05-15 |
Family
ID=22970967
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU82838/82A Ceased AU551892B2 (en) | 1981-04-21 | 1982-04-20 | Gnrh antagonists |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US4409208A (cs) |
| EP (1) | EP0063423B1 (cs) |
| JP (1) | JPS57181047A (cs) |
| KR (1) | KR830010052A (cs) |
| AT (1) | ATE14886T1 (cs) |
| AU (1) | AU551892B2 (cs) |
| CA (1) | CA1241950A (cs) |
| CS (1) | CS228924B2 (cs) |
| DD (1) | DD202694A5 (cs) |
| DE (1) | DE3265349D1 (cs) |
| DK (1) | DK151033C (cs) |
| ES (1) | ES511525A0 (cs) |
| GR (1) | GR75542B (cs) |
| HU (1) | HU186007B (cs) |
| IE (1) | IE52442B1 (cs) |
| IL (1) | IL65371A (cs) |
| NO (1) | NO821274L (cs) |
| NZ (1) | NZ200125A (cs) |
| PH (1) | PH18965A (cs) |
| ZA (1) | ZA822053B (cs) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58162562A (ja) * | 1982-03-05 | 1983-09-27 | シンテツクス・（ユ−・エス・エイ）・インコ−ポレ−テツド | Ｌｈｒｈのノナペプチド及びデカペプチドアナロ−グ |
| IL70888A0 (en) * | 1983-03-10 | 1984-05-31 | Salk Inst For Biological Studi | Gn rh antagonist peptides and pharmaceutical compositions containing them |
| US4547370A (en) * | 1983-11-29 | 1985-10-15 | The Salk Institute For Biological Studies | GnRH Antagonists |
| IL74827A (en) * | 1984-05-21 | 1989-06-30 | Salk Inst For Biological Studi | Peptides active as gnrh antagonists and pharmaceutical compositions containing them |
| DE3634435A1 (de) * | 1986-10-09 | 1988-04-14 | Hoechst Ag | Analoga von gonadoliberin mit verbesserter loeslichkeit, verfahren zu deren herstellung, diese enthaltende mittel und ihre verwendung |
| EP0378533A4 (en) * | 1987-03-10 | 1990-12-05 | Eastern Virginia Medical Authority | Method and kit for contraception with gnrh-antagonist and progestin |
| US5068221A (en) * | 1989-05-09 | 1991-11-26 | Mathias John R | Treatment of motility disorders with a gnrh analog |
| US5434136A (en) * | 1990-12-14 | 1995-07-18 | Mathias; John R. | Treatment of motility disorders with a GNRH analog |
| US5502035A (en) * | 1993-08-06 | 1996-03-26 | Tap Holdings Inc. | N-terminus modified analogs of LHRH |
| US5843901A (en) * | 1995-06-07 | 1998-12-01 | Advanced Research & Technology Institute | LHRH antagonist peptides |
| MY150763A (en) | 2006-10-24 | 2014-02-28 | Repros Therapeutics Inc | Compositions and methods for suppressing endometrial proliferation |
| EP3600373A1 (en) | 2017-03-31 | 2020-02-05 | Institut National de la Santé et de la Recherche Medicale | A gnrh antagonist for use in the treatment of a women affected with polycystic ovary syndrome |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH11571A (en) * | 1973-10-03 | 1978-03-31 | American Home Prod | P-gui-d-phe-trp-ser-tyr-d-ala-leu-arg-pro-gly-nh2,its non-toxic salts and method of use thereof |
| US3933782A (en) * | 1974-11-14 | 1976-01-20 | American Home Products Corporation | (N-Acetyl)-Pro-D-Phe-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-NHEt and intermediates |
| NZ188987A (en) * | 1977-11-30 | 1982-02-23 | Salk Inst For Biological Studi | Peptide analogues of luteinizing hormone releasing factor |
| US4234571A (en) * | 1979-06-11 | 1980-11-18 | Syntex (U.S.A.) Inc. | Nonapeptide and decapeptide derivatives of luteinizing hormone releasing hormone |
| GB2053229B (en) * | 1979-06-13 | 1983-03-02 | Schally Andrew Victor | Lh-rh antagonists |
| US4253997A (en) * | 1979-12-17 | 1981-03-03 | American Home Products Corporation | Anti-ovulatory decapeptides |
| NZ196558A (en) * | 1980-04-15 | 1984-10-19 | Salk Inst For Biological Studi | Lrf antagonists and pharmaceutical compositions |
-
1981
- 1981-04-21 US US06/256,063 patent/US4409208A/en not_active Expired - Fee Related
-
1982
- 1982-03-24 NZ NZ200125A patent/NZ200125A/en unknown
- 1982-03-25 ZA ZA822053A patent/ZA822053B/xx unknown
- 1982-03-26 AT AT82301612T patent/ATE14886T1/de active
- 1982-03-26 EP EP82301612A patent/EP0063423B1/en not_active Expired
- 1982-03-26 DE DE8282301612T patent/DE3265349D1/de not_active Expired
- 1982-03-29 IL IL65371A patent/IL65371A/xx unknown
- 1982-04-06 IE IE819/82A patent/IE52442B1/en unknown
- 1982-04-06 CA CA000400559A patent/CA1241950A/en not_active Expired
- 1982-04-13 GR GR67903A patent/GR75542B/el unknown
- 1982-04-19 DK DK173082A patent/DK151033C/da active IP Right Grant
- 1982-04-20 HU HU821217A patent/HU186007B/hu unknown
- 1982-04-20 AU AU82838/82A patent/AU551892B2/en not_active Ceased
- 1982-04-20 ES ES511525A patent/ES511525A0/es active Granted
- 1982-04-20 CS CS822832A patent/CS228924B2/cs unknown
- 1982-04-20 KR KR1019820001743A patent/KR830010052A/ko not_active Ceased
- 1982-04-20 NO NO821274A patent/NO821274L/no unknown
- 1982-04-20 JP JP57066179A patent/JPS57181047A/ja active Pending
- 1982-04-21 DD DD82239196A patent/DD202694A5/de unknown
- 1982-04-21 PH PH27170A patent/PH18965A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL65371A (en) | 1985-12-31 |
| DK151033B (da) | 1987-10-12 |
| EP0063423A1 (en) | 1982-10-27 |
| IL65371A0 (en) | 1982-05-31 |
| DK151033C (da) | 1988-03-14 |
| KR830010052A (ko) | 1983-12-24 |
| AU8283882A (en) | 1982-10-28 |
| JPS57181047A (en) | 1982-11-08 |
| CS228924B2 (en) | 1984-05-14 |
| PH18965A (en) | 1985-11-26 |
| CA1241950A (en) | 1988-09-13 |
| ES8307720A1 (es) | 1983-07-16 |
| ATE14886T1 (de) | 1985-08-15 |
| ZA822053B (en) | 1983-02-23 |
| DK173082A (da) | 1982-10-22 |
| NO821274L (no) | 1982-10-22 |
| ES511525A0 (es) | 1983-07-16 |
| US4409208A (en) | 1983-10-11 |
| GR75542B (cs) | 1984-07-27 |
| NZ200125A (en) | 1984-10-19 |
| DE3265349D1 (en) | 1985-09-19 |
| DD202694A5 (de) | 1983-09-28 |
| EP0063423B1 (en) | 1985-08-14 |
| HU186007B (en) | 1985-05-28 |
| IE820819L (en) | 1982-10-21 |
| IE52442B1 (en) | 1987-10-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IE831582L (en) | Gnrh antagonists | |
| AU571595B2 (en) | Gnrh antagonists | |
| AU551892B2 (en) | Gnrh antagonists | |
| ES8802234A1 (es) | Un metodo para preparar un peptido o una sal no toxica del mismo | |
| ES8504677A1 (es) | Un procedimiento para obtener un peptido o una sal no toxica del mismo. | |
| ES8207510A1 (es) | Un metodo de preparacion de un peptido inhibidor de la liberacion de gonadotropinas por la glandula pituitaria en mamiferos. |