AU544337B2 - Preparation of proline compounds - Google Patents

Preparation of proline compounds

Info

Publication number
AU544337B2
AU544337B2 AU66941/81A AU6694181A AU544337B2 AU 544337 B2 AU544337 B2 AU 544337B2 AU 66941/81 A AU66941/81 A AU 66941/81A AU 6694181 A AU6694181 A AU 6694181A AU 544337 B2 AU544337 B2 AU 544337B2
Authority
AU
Australia
Prior art keywords
preparation
proline compounds
proline
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU66941/81A
Other languages
English (en)
Other versions
AU6694181A (en
Inventor
Roger Crossley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
John Wyeth and Brother Ltd
Original Assignee
John Wyeth and Brother Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by John Wyeth and Brother Ltd filed Critical John Wyeth and Brother Ltd
Publication of AU6694181A publication Critical patent/AU6694181A/en
Application granted granted Critical
Publication of AU544337B2 publication Critical patent/AU544337B2/en
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AU66941/81A 1980-02-26 1981-02-05 Preparation of proline compounds Expired AU544337B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8006414 1980-02-26
GB8006414 1980-02-26

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU39126/85A Division AU566441B2 (en) 1980-02-26 1985-02-25 Proline derivatives

Publications (2)

Publication Number Publication Date
AU6694181A AU6694181A (en) 1981-09-03
AU544337B2 true AU544337B2 (en) 1985-05-23

Family

ID=10511671

Family Applications (2)

Application Number Title Priority Date Filing Date
AU66941/81A Expired AU544337B2 (en) 1980-02-26 1981-02-05 Preparation of proline compounds
AU39126/85A Expired - Fee Related AU566441B2 (en) 1980-02-26 1985-02-25 Proline derivatives

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU39126/85A Expired - Fee Related AU566441B2 (en) 1980-02-26 1985-02-25 Proline derivatives

Country Status (11)

Country Link
US (4) US4349480A (en, 2012)
EP (1) EP0035336B1 (en, 2012)
JP (2) JPS56128755A (en, 2012)
AR (2) AR227663A1 (en, 2012)
AU (2) AU544337B2 (en, 2012)
CA (1) CA1154782A (en, 2012)
DE (1) DE3174292D1 (en, 2012)
GB (1) GB2070005B (en, 2012)
IE (1) IE50839B1 (en, 2012)
PH (3) PH16751A (en, 2012)
ZA (1) ZA81743B (en, 2012)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE50839B1 (en) * 1980-02-26 1986-07-23 Wyeth John & Brother Ltd Novel processes for preparing proline derivatives and analogous compounds
NL180746C (nl) * 1983-11-18 1987-04-16 Matthijs Cornelis Evers Werkwijze ter bereiding van captopril.
JPH0662671B2 (ja) * 1986-01-17 1994-08-17 株式会社大塚製薬工場 プロリン誘導体
HU196368B (en) * 1986-07-04 1988-11-28 Egyt Gyogyszervegyeszeti Gyar Process for production of 1-/3-brom-/25/-methil-prophionil/-pirrolidin-/25/-carbonic acid
US4847384A (en) * 1987-03-12 1989-07-11 Sandoz Pharm. Corp. Process for the preparation of certain nitrogen-containing mono- and bicyclic ace inhibitors, and novel intermediates useful therefor
US5237073A (en) * 1988-08-26 1993-08-17 Sepracor, Inc. Derivatives and precursors of captopril and its analogues
IL91581A (en) * 1988-09-13 1993-07-08 Sepracor Inc Methods for preparing optically active captopril and its analogues
US5166361A (en) * 1988-09-13 1992-11-24 Sepracor, Inc. Methods for preparing captopril and its analogues
US5430145A (en) * 1990-10-18 1995-07-04 Merrell Dow Pharmaceuticals Inc. Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
US5308841A (en) * 1990-12-21 1994-05-03 Merrell Dow Pharmaceuticals Inc. Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
US5457196A (en) * 1991-09-27 1995-10-10 Merrell Dow Pharmaceuticals Inc. 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
US5455242A (en) * 1991-09-27 1995-10-03 Merrell Dow Pharmaceuticals Inc. Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace
DK0534363T3 (da) * 1991-09-27 1997-09-22 Merrell Pharma Inc 2-substituerede indan-2-mercaptoacetylamid-forbindelse med inhiberende virkning på enkephalinase og ACE.
CA2078759C (en) * 1991-09-27 2003-09-16 Alan M. Warshawsky Novel carboxyalkyl derivatives useful as inhibitors of enkephalinase and ace
HU220596B1 (hu) * 1992-02-14 2002-03-28 Merrell Dow Pharmaceuticals Inc. 7-Szubsztituált pirido-benzazepin-karbonsav-származékok, ezeket tartalmazó gyógyszerkészítmények és eljárás előállításukra
EP0640086B1 (en) * 1992-05-15 1999-08-04 Merrell Pharmaceuticals Inc. MERCAPTOACETYLAMIDO PYRIDAZO[ 1,2-a][1,2]DIAZEPINE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE
US5420271A (en) * 1992-08-24 1995-05-30 Merrell Dow Pharmaceuticals, Inc. 2-substituted indane-2-mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
WO1994010193A1 (en) * 1992-10-30 1994-05-11 Merrell Dow Pharmaceuticals Inc. Novel mercaptoacetylamide bicyclic lactam derivatives useful as inhibitors of enkephalinase and ace
ES2145267T3 (es) * 1994-02-14 2000-07-01 Merrell Pharma Inc Nuevos derivados bisulfuro de mercaptoacetilamido de 1,3,4,5-tetrahidro-benzo(c)azepin-3-ona utiles como inhibidores de la encefalinasa y del enzima de conversion de la angiotensina.
AU689192B2 (en) * 1994-02-14 1998-03-26 Merrell Pharmaceuticals Inc. Novel 2-substituted indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace
US5530013A (en) * 1994-02-14 1996-06-25 American Home Products Corporation Venlafaxine in the inducement of cognition enhancement
FI963166L (fi) * 1994-02-14 1996-08-13 Merrell Pharma Inc Uusia merkaptoasetyyliamididisulfidijohdannaisia, jotka ovat käyttökelpoisia enkefalinaasin ja ACE:n inhibiittoreina
PT745081E (pt) * 1994-02-14 2002-04-29 Merrell Pharma Inc Derivados de dissulfureto de inda-2-mercaptoacetilamida uteis como inibidores da encefalinase
US5484783A (en) * 1994-03-24 1996-01-16 Merrell Dow Pharmaceuticals Inc. Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives
AU698320B2 (en) * 1994-03-24 1998-10-29 Merrell Pharmaceuticals Inc. Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic aminoacetylmercapto derivatives
DK0751774T3 (da) * 1994-03-24 2003-12-08 Merrell Pharma Inc Hypocholesterolæmiske mercaptoacetylamiddisulfid-derivater
GB0119305D0 (en) 2001-04-12 2001-10-03 Aventis Pharma Gmbh Mercaptoacetylamide derivatives,a process for their preparation and their use
US7531217B2 (en) * 2004-12-15 2009-05-12 Iowa State University Research Foundation, Inc. Methods for making high-temperature coatings having Pt metal modified γ-Ni +γ′-Ni3Al alloy compositions and a reactive element

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT986630B (it) * 1972-04-20 1975-01-30 Pierres Holding Sa Procedimento per la lavorazione di precisione di pezzi mediante radiazioni laser e dispositivo per l esecuzione del procedi mento
US4105776A (en) * 1976-06-21 1978-08-08 E. R. Squibb & Sons, Inc. Proline derivatives and related compounds
US4129566A (en) * 1978-02-15 1978-12-12 E. R. Squibb & Sons, Inc. Derivatives of dehydrocyclicimino acids
US4127535A (en) * 1977-06-16 1978-11-28 Coy David Howard Novel dipeptides, intermediates therefor, and compositions and methods employing said dipeptides
US4154935A (en) * 1978-02-21 1979-05-15 E. R. Squibb & Sons, Inc. Halogen substituted mercaptoacylamino acids
CA1109475A (en) * 1978-07-27 1981-09-22 Miguel A. Ondetti Thiopropanoylamino acid derivatives
US4192945A (en) * 1978-12-07 1980-03-11 E. R. Squibb & Sons, Inc. Process for preparing proline and homoproline derivatives
EP0017390A3 (en) * 1979-03-23 1981-06-24 American Home Products Corporation Bicyclic oxo-thiolactones, pharmaceutical compositions containing them, processes for their preparation and compounds useful as intermediates for their preparation
US4303583A (en) * 1979-08-13 1981-12-01 American Home Products Corporation 1H,5H-[1,4]Thiazepino[4,3-a]indole-1,5-diones
US4291040A (en) * 1979-10-22 1981-09-22 E. R. Squibb & Sons, Inc. Mercaptoacyl derivatives of 4-disubstituted prolines and 4-substituted dehydroprolines
GB2065643B (en) * 1979-12-13 1983-08-24 Kanegafuchi Chemical Ind Optically active n-mercaptoalkanoylamino acids
HU184082B (en) * 1979-12-29 1984-06-28 Egyt Gyogyszervegyeszeti Gyar Process for preparing 1-3-/3mercapto-/2s/-methyl-propinyl/-pyrrolidine-/2s/-carboxylic acid
IE50839B1 (en) * 1980-02-26 1986-07-23 Wyeth John & Brother Ltd Novel processes for preparing proline derivatives and analogous compounds
US4454291A (en) * 1981-07-20 1984-06-12 American Home Products Corporation N-(2-Substituted-1-oxoalkyl)-2,3-dihydro-1H-indole-2-carboxylic acid derivatives

Also Published As

Publication number Publication date
CA1154782A (en) 1983-10-04
AU566441B2 (en) 1987-10-22
IE50839B1 (en) 1986-07-23
GB2070005B (en) 1984-12-19
AU3912685A (en) 1985-07-11
US4349480A (en) 1982-09-14
DE3174292D1 (en) 1986-05-15
PH16751A (en) 1984-02-10
JPS62199283U (en, 2012) 1987-12-18
GB2070005A (en) 1981-09-03
EP0035336A3 (en) 1981-11-25
AR227663A1 (es) 1982-11-30
JPS56128755A (en) 1981-10-08
AU6694181A (en) 1981-09-03
US4506082A (en) 1985-03-19
AR231987A1 (es) 1985-04-30
US4578480A (en) 1986-03-25
EP0035336B1 (en) 1986-04-09
EP0035336A2 (en) 1981-09-09
PH17373A (en) 1984-08-06
ZA81743B (en) 1982-09-29
IE810210L (en) 1981-08-26
PH17181A (en) 1984-06-13
US4391752A (en) 1983-07-05

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired