AU530015B2 - 2j,24-difluoro-1alpha,25-dihydroxy-cholecalciferol - Google Patents

2j,24-difluoro-1alpha,25-dihydroxy-cholecalciferol

Info

Publication number
AU530015B2
AU530015B2 AU55810/80A AU5581080A AU530015B2 AU 530015 B2 AU530015 B2 AU 530015B2 AU 55810/80 A AU55810/80 A AU 55810/80A AU 5581080 A AU5581080 A AU 5581080A AU 530015 B2 AU530015 B2 AU 530015B2
Authority
AU
Australia
Prior art keywords
difluoro
compound
vitamin
cholecalciferol
dihydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU55810/80A
Other languages
English (en)
Other versions
AU5581080A (en
Inventor
Hector F. Deluca
Nobuo Ikekawa
Yoshiro Kobayashi
Heinrich K. Schnoes
Yoko Tanaka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wisconsin Alumni Research Foundation
Original Assignee
Wisconsin Alumni Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation
Publication of AU5581080A publication Critical patent/AU5581080A/en
Application granted granted Critical
Publication of AU530015B2 publication Critical patent/AU530015B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/48—Halogenated derivatives
    • C07C35/52—Alcohols with a condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/24—All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nutrition Science (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Character Discrimination (AREA)
  • Information Retrieval, Db Structures And Fs Structures Therefor (AREA)
AU55810/80A 1979-03-28 1980-02-22 2j,24-difluoro-1alpha,25-dihydroxy-cholecalciferol Ceased AU530015B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/024,848 US4201881A (en) 1979-03-28 1979-03-28 24,24-Difluoro-1α,25-dihydroxycholecalciferol
US024848 1979-03-28

Publications (2)

Publication Number Publication Date
AU5581080A AU5581080A (en) 1980-10-02
AU530015B2 true AU530015B2 (en) 1983-06-30

Family

ID=21822707

Family Applications (1)

Application Number Title Priority Date Filing Date
AU55810/80A Ceased AU530015B2 (en) 1979-03-28 1980-02-22 2j,24-difluoro-1alpha,25-dihydroxy-cholecalciferol

Country Status (15)

Country Link
US (1) US4201881A (enExample)
JP (2) JPS6342618B2 (enExample)
AU (1) AU530015B2 (enExample)
BE (1) BE882143A (enExample)
CH (1) CH650240A5 (enExample)
DK (1) DK147300C (enExample)
FR (1) FR2452481A1 (enExample)
GB (2) GB2045765B (enExample)
IE (1) IE49753B1 (enExample)
IL (1) IL58526A (enExample)
IT (1) IT1140776B (enExample)
NL (1) NL7920190A (enExample)
NZ (1) NZ191900A (enExample)
SE (1) SE8008339L (enExample)
WO (1) WO1980002028A1 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4284577A (en) * 1979-02-16 1981-08-18 Sachiko Yamada Novel vitamin D3 derivative and process for preparing the same
NZ201702A (en) * 1981-08-28 1985-08-16 Hoffmann La Roche 1 alpha,25-dihydroxy-(24r or 24s)-fluorocholecal-ciferol and intermediates;pharmaceutical compositions
US4456689A (en) * 1982-05-17 1984-06-26 Becton Dickinson And Company Competitive protein binding assay using an organosilane-silica gel separation medium
CA1221031A (en) * 1982-05-17 1987-04-28 Alfred Boris Use of a cholecalciferol derivative
US4428946A (en) * 1982-07-26 1984-01-31 Wisconsin Alumni Research Foundation Method of preventing milk fever in dairy cattle
JPS6253960A (ja) * 1985-05-30 1987-03-09 Taisho Pharmaceut Co Ltd ビタミンｄ↓３の誘導体
EP0245524B1 (en) * 1985-11-21 1991-04-17 Taisho Pharmaceutical Co. Ltd Vitamin d 3 derivative
US4853378A (en) * 1986-10-20 1989-08-01 Sumitomo Chemical Company, Limited Fluorine derivatives of vitamin D3 and process for producing the same
US5366736A (en) * 1989-02-16 1994-11-22 University Of Georgia Research Foundation, Inc. Vitamin D derivative feed compositions and methods of use
WO1990009179A1 (en) * 1989-02-16 1990-08-23 University Of Georgia Research Foundation, Inc. Treatment of tibial dyschondroplasia
US5316770A (en) * 1989-02-16 1994-05-31 University Of Georgia Research Foundation, Inc. Vitamin D derivative feed compositions and methods of use
US5063234A (en) * 1990-05-25 1991-11-05 Eli Lilly And Company Method of inhibiting demineralization of bone
AU2008345082B2 (en) * 2007-12-28 2014-03-06 Wisconsin Alumni Research Foundation (20S)-23,23-difluoro-2-methylene-19-nor-bishomopregnacalciferol-vitamin D analogs
JP5504898B2 (ja) * 2010-01-08 2014-05-28 セントラル硝子株式会社 ジフルオロシクロプロパン化合物の製造方法
GB202016614D0 (en) 2020-10-20 2020-12-02 King S College London Compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3741996A (en) * 1971-12-02 1973-06-26 Wisconsin Alumni Res Found 1{60 -hydroxycholecalciferol
FR2267590B1 (enExample) * 1974-04-10 1977-05-20 Ibm
US3969700A (en) * 1974-04-10 1976-07-13 International Business Machines Corporation Regional context maximum likelihood error correction for OCR, keyboard, and the like
JPS5729745B2 (enExample) * 1974-09-25 1982-06-24
US3993675A (en) * 1975-02-24 1976-11-23 Hoffmann-La Roche Inc. Process for the preparation of 1α,25-dihydroxycholecalciferol
US4069321A (en) * 1975-10-14 1978-01-17 Merck & Co., Inc. Blocked cholecalciferol and dihydrotachysterol 3 derivatives
US4284577A (en) * 1979-02-16 1981-08-18 Sachiko Yamada Novel vitamin D3 derivative and process for preparing the same

Also Published As

Publication number Publication date
NZ191900A (en) 1984-11-09
JPS63179855A (ja) 1988-07-23
US4201881A (en) 1980-05-06
GB2045765A (en) 1980-11-05
DK147300B (da) 1984-06-12
JPS6342618B2 (enExample) 1988-08-24
DK505080A (da) 1980-11-27
FR2452481B1 (enExample) 1984-10-19
GB2067567A (en) 1981-07-30
DK147300C (da) 1984-12-24
AU5581080A (en) 1980-10-02
JPH0146504B2 (enExample) 1989-10-09
GB2045765B (en) 1983-06-15
IT1140776B (it) 1986-10-10
CH650240A5 (de) 1985-07-15
FR2452481A1 (fr) 1980-10-24
WO1980002028A1 (en) 1980-10-02
BE882143A (fr) 1980-07-01
IE49753B1 (en) 1985-12-11
NL7920190A (nl) 1981-01-30
IL58526A0 (en) 1980-01-31
GB2067567B (en) 1983-03-02
JPS56500296A (enExample) 1981-03-12
IE800619L (en) 1980-09-28
SE8008339L (sv) 1980-11-27
IT8020508A0 (it) 1980-03-11
IL58526A (en) 1983-05-15

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