AU528634B2 - Pyrimido- and imidazo-pyroindole derivatives - Google Patents

Pyrimido- and imidazo-pyroindole derivatives

Info

Publication number
AU528634B2
AU528634B2 AU54630/80A AU5463080A AU528634B2 AU 528634 B2 AU528634 B2 AU 528634B2 AU 54630/80 A AU54630/80 A AU 54630/80A AU 5463080 A AU5463080 A AU 5463080A AU 528634 B2 AU528634 B2 AU 528634B2
Authority
AU
Australia
Prior art keywords
radical
alkyl
formula
pharmaceutically acceptable
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU54630/80A
Other languages
English (en)
Other versions
AU5463080A (en
Inventor
Regis Dupont
Jonathan Frost
Gabor Koletar
Patrick Lardenois
Claude Morel
Henry Najer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo SA filed Critical Synthelabo SA
Publication of AU5463080A publication Critical patent/AU5463080A/en
Application granted granted Critical
Publication of AU528634B2 publication Critical patent/AU528634B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AU54630/80A 1979-04-26 1980-01-15 Pyrimido- and imidazo-pyroindole derivatives Ceased AU528634B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR7910653A FR2455039A1 (fr) 1979-04-26 1979-04-26 Pyrimido et imidazo-pyrido-indole-diones et leur application en therapeutique
FR7910653 1979-04-26

Publications (2)

Publication Number Publication Date
AU5463080A AU5463080A (en) 1980-10-30
AU528634B2 true AU528634B2 (en) 1983-05-05

Family

ID=9224796

Family Applications (1)

Application Number Title Priority Date Filing Date
AU54630/80A Ceased AU528634B2 (en) 1979-04-26 1980-01-15 Pyrimido- and imidazo-pyroindole derivatives

Country Status (15)

Country Link
US (1) US4358451A (enExample)
EP (1) EP0018857B1 (enExample)
JP (1) JPS55145689A (enExample)
AT (1) ATE2253T1 (enExample)
AU (1) AU528634B2 (enExample)
CA (1) CA1129854A (enExample)
DE (1) DE3061648D1 (enExample)
DK (1) DK16980A (enExample)
ES (1) ES487713A1 (enExample)
FR (1) FR2455039A1 (enExample)
GR (1) GR74394B (enExample)
IL (1) IL59128A (enExample)
NO (1) NO794271L (enExample)
PT (1) PT70698A (enExample)
ZA (1) ZA80242B (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3246932A1 (de) * 1982-12-16 1984-06-20 Schering AG, 1000 Berlin und 4709 Bergkamen Substituierte 5h-pyrimido(5,4-b)indole
CA2450073C (en) 2001-07-25 2017-08-29 Biomarin Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
US7595311B2 (en) 2002-05-24 2009-09-29 Exelixis, Inc. Azepinoindole derivatives as pharmaceutical agents
TWI329111B (en) * 2002-05-24 2010-08-21 X Ceptor Therapeutics Inc Azepinoindole and pyridoindole derivatives as pharmaceutical agents
EP2671508B1 (en) 2005-04-28 2020-09-16 Proteus Digital Health, Inc. Pharma-informatics system
FR2901795A1 (fr) * 2006-05-30 2007-12-07 Fourtillan Snc Derives de pyrimidino[1',6'-1,2]pyrido[3,4-b]indoles et leur utilisation en therapeutique
JP2010503710A (ja) 2006-09-18 2010-02-04 ラプトール ファーマシューティカル インコーポレイテッド 受容体関連タンパク質（ｒａｐ）結合体の投与による肝障害の処置
ES2919563T3 (es) 2009-02-20 2022-07-27 Enhanx Biopharm Inc Sistema de administración de medicamentos a base de glutatión
KR20180114970A (ko) 2009-05-06 2018-10-19 라보라토리 스킨 케어, 인크. 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1076114A (en) * 1975-02-10 1980-04-22 Mitsubishi Chemical Industries Limited 1,5-alkylene-3-aryl hydantoin derivatives

Also Published As

Publication number Publication date
ZA80242B (en) 1980-12-31
DE3061648D1 (en) 1983-02-24
IL59128A (en) 1982-07-30
EP0018857B1 (fr) 1983-01-19
EP0018857A1 (fr) 1980-11-12
PT70698A (fr) 1980-02-01
ES487713A1 (es) 1980-06-16
JPS55145689A (en) 1980-11-13
AU5463080A (en) 1980-10-30
DK16980A (da) 1980-10-27
CA1129854A (en) 1982-08-17
ATE2253T1 (de) 1983-02-15
NO794271L (no) 1980-10-28
IL59128A0 (en) 1980-05-30
GR74394B (enExample) 1984-06-28
FR2455039B1 (enExample) 1983-05-13
FR2455039A1 (fr) 1980-11-21
US4358451A (en) 1982-11-09

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