AU526160B2 - Milbemycin compounds as anthelmintic agents - Google Patents

Milbemycin compounds as anthelmintic agents

Info

Publication number
AU526160B2
AU526160B2 AU42309/78A AU4230978A AU526160B2 AU 526160 B2 AU526160 B2 AU 526160B2 AU 42309/78 A AU42309/78 A AU 42309/78A AU 4230978 A AU4230978 A AU 4230978A AU 526160 B2 AU526160 B2 AU 526160B2
Authority
AU
Australia
Prior art keywords
anthelmintic agents
milbemycin compounds
milbemycin
compounds
anthelmintic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU42309/78A
Other languages
English (en)
Other versions
AU4230978A (en
Inventor
Potter Irving
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of AU4230978A publication Critical patent/AU4230978A/en
Application granted granted Critical
Publication of AU526160B2 publication Critical patent/AU526160B2/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Fodder In General (AREA)
AU42309/78A 1977-12-19 1978-12-07 Milbemycin compounds as anthelmintic agents Expired AU526160B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
USUS861808 1977-12-19
US05/861,808 US4144352A (en) 1977-12-19 1977-12-19 Milbemycin compounds as anthelmintic agents

Publications (2)

Publication Number Publication Date
AU4230978A AU4230978A (en) 1979-06-28
AU526160B2 true AU526160B2 (en) 1982-12-23

Family

ID=25336823

Family Applications (1)

Application Number Title Priority Date Filing Date
AU42309/78A Expired AU526160B2 (en) 1977-12-19 1978-12-07 Milbemycin compounds as anthelmintic agents

Country Status (7)

Country Link
US (1) US4144352A (https=)
EP (1) EP0002916B1 (https=)
JP (1) JPS5489041A (https=)
AU (1) AU526160B2 (https=)
DE (1) DE2861426D1 (https=)
NZ (1) NZ189103A (https=)
ZA (1) ZA787082B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU599383B2 (en) * 1986-06-07 1990-07-19 Coopers Animal Health Limited Ectoparasiticidal pour-on formulations

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57139012A (en) * 1981-02-23 1982-08-27 Sankyo Co Ltd Anthelmintic composition
NZ201681A (en) * 1981-09-03 1985-11-08 Merck & Co Inc Avermectin derivatives and parasiticidal compositions
US4597969A (en) * 1982-04-05 1986-07-01 Merck Sharp & Dohme Stabilization of unstable drugs or food supplements
NZ210505A (en) * 1983-12-22 1988-06-30 Merck & Co Inc Parasiticidal compositions containing avermectin or milbemycin derivatives
GB8502925D0 (en) * 1985-02-05 1985-03-06 Ici Plc Macrocyclic lactones
US4680419A (en) * 1985-07-22 1987-07-14 The Upjohn Company Spiroketals and process for preparing same
US4814347A (en) * 1985-07-22 1989-03-21 The Upjohn Company Anthelmintic spiroketals and method of use
US4686297A (en) * 1985-07-22 1987-08-11 The Upjohn Company Anthelmintic spiroketals useful for killing parasitic worms
US4820758A (en) * 1985-07-22 1989-04-11 The Upjohn Company Novel [5.5]-spiroketals
US4812582A (en) * 1985-07-22 1989-03-14 The Upjohn Company Process for preparing aldol intermediates
EP0254583B1 (en) * 1986-07-24 1994-09-07 Beecham Group Plc Parasiticidal milbemycin derivatives, a process for their production, and compositions containing the same
EP0325462A3 (en) * 1988-01-22 1989-11-02 Beecham Group Plc Anthelmintic milbemycin derivatives
ES2086022T3 (es) * 1991-07-23 1996-06-16 American Cyanamid Co Composiciones estables para administracion parenteral y su uso.
NZ335166A (en) * 1999-04-14 2001-11-30 Ashmont Holdings Ltd Anthelmintic composition containing triclabendazole in at least one solvent
AU9785698A (en) 1997-10-02 1999-04-27 Microcide Pharmaceuticals, Inc. Fungal efflux pump inhibitors
ES2359973T3 (es) * 1998-03-19 2011-05-30 MERCK SHARP & DOHME CORP. Composiciones poliméricas líquidas para la liberación controlada de sustancias bioactivas.
US7671034B2 (en) 2003-12-19 2010-03-02 Merial Limited Stabilized formulation of ivermectin feed premix with an extended shelf life
US8362086B2 (en) 2005-08-19 2013-01-29 Merial Limited Long acting injectable formulations
EP2465851A1 (en) 2006-07-05 2012-06-20 Aventis Agriculture 1-Aryl-5-alkyl pyrazole derivative compounds, processes of making and methods of using thereof
FR2906466B1 (fr) * 2006-09-28 2008-11-28 Galderma Sa Utilisation de composes de la famille des milbemycines pour le traitement de desordres dermatologiques chez l'homme
CN100467473C (zh) * 2007-01-17 2009-03-11 东北农业大学 用冰城链霉菌制备化合物的方法
RS55271B1 (sr) 2007-05-15 2017-02-28 Merial Sas Ariloazol-2-il cijanoetilamino jedinjenja, postupci dobijanja i postupci njihove primene
WO2009070687A1 (en) 2007-11-26 2009-06-04 Merial Limited Solvent systems for pour-on formulations for combating parasites
AR074024A1 (es) 2008-11-14 2010-12-15 Merial Ltd Compuesto de arilazol-2-il-cianoetilamino enantiomericamente enriquecidos, composicion plaguicida y su uso para prevenir la infeccion parasitaria
MY155497A (en) 2008-11-19 2015-10-30 Merial Inc Compositions comprising an aryl pyrazole and/or a formamidine, methods and use thereof
JP5595412B2 (ja) 2008-12-04 2014-09-24 メリアル リミテッド 二量体アベルメクチン及びミルベマイシン誘導体
CN102712583B (zh) 2009-12-04 2015-04-08 梅里亚有限公司 农药用双-有机硫化合物
RS54772B1 (sr) 2009-12-17 2016-10-31 Merial Sas Antiparazitska jedinjenja dihidroazola i kompozicije koje ih sadrže
BR112012014933B1 (pt) 2009-12-17 2020-10-27 Merial, Inc. composições que compreendem compostos lactonas macrocíclicas e spirodioxepinoindóis
UA108641C2 (uk) 2010-04-02 2015-05-25 Паразитицидна композиція, яка містить чотири активних агенти, та спосіб її застосування
EP2629772B1 (en) 2010-10-20 2016-05-18 Galderma S.A. Ivermectin for use in the treatment of hemorrhoids
US8901090B2 (en) 2010-10-20 2014-12-02 Galderma S.A. Method of treating otitis externa using macrocyclic lactone compound
US8822528B2 (en) 2010-11-16 2014-09-02 Merial Limited Monensin derivatives for the treatment and prevention of protozoal infections
WO2012150543A1 (en) 2011-05-02 2012-11-08 Universite De Geneve Macrocyclic lactones and use thereof
US20120329832A1 (en) 2011-06-27 2012-12-27 Jean Delaveau Novel Insect-Repellent Coumarin Derivatives, Syntheses, and Methods of Use
ES2618813T3 (es) 2011-06-27 2017-06-22 Merial, Inc. Compuestos y composiciones de éter amido-piridílico y uso contra los parásitos
RS58417B1 (sr) 2011-09-12 2019-04-30 Merial Inc Paraziticidne kompozicije koje sadrže izoksazolinsko aktivno sredstvo, postupci i upotrebe povezane sa njima
WO2013044118A2 (en) 2011-09-23 2013-03-28 Merial Limited Indirect modeling of new repellent molecules active against insects, acarids, and other arthropods
AU2012340351B2 (en) 2011-11-17 2017-06-15 Boehringer Ingelheim Animal Health USA Inc. Compositions comprising an aryl pyrazole and a substituted imidazole, methods and uses thereof
BR112014013371B1 (pt) 2011-12-02 2020-04-07 Merial Ltd formulações de moxidectina injetável de ação prolongada e novas formas de cristal de moxidectina
EP3216448B8 (en) 2012-02-06 2019-06-05 Boehringer Ingelheim Animal Health USA Inc. Parasiticidal oral veterinary compositions comprising systemically-acting active agents, methods and uses thereof
JO3626B1 (ar) 2012-02-23 2020-08-27 Merial Inc تركيبات موضعية تحتوي على فيبرونيل و بيرميثرين و طرق استخدامها
BR122015032741B1 (pt) 2012-04-20 2019-11-26 Merial Ltd composições parasiticídicas compreendendo derivados de benzimidazol, métodos e seus usos
NZ723198A (en) 2012-11-20 2018-11-30 Boehringer Ingelheim Animal Health Usa Inc Anthelmintic compounds and compositions and methods of using thereof
EP2950795B1 (en) 2013-01-31 2018-04-25 Merial, Inc. Method for treating and curing leishmaniosis using fexinindazole
US10307405B2 (en) 2013-04-12 2019-06-04 Zoetis Services Llc Stable veterinary combination formulations of macrocyclic lactones and imidazothiazoles
WO2015066277A1 (en) 2013-11-01 2015-05-07 Merial Limited Antiparisitic and pesticidal isoxazoline compounds
EP2886640A1 (en) 2013-12-18 2015-06-24 Riga Technical University Process for isolation of milbemycins A3 and A4
EP3131398B1 (en) 2014-04-17 2019-10-23 Boehringer Ingelheim Animal Health USA Inc. Use of malononitrile compounds for protecting animals from parasites
ES2842592T3 (es) 2014-05-19 2021-07-14 Boehringer Ingelheim Animal Health Usa Inc Compuestos antihelmínticos
EP3157912B1 (en) 2014-06-19 2019-02-20 Merial, Inc. Parasiticidal compositions comprising indole derivatives, methods and uses thereof
US10864193B2 (en) 2014-10-31 2020-12-15 Boehringer Ingelheim Animal Health USA Inc. Parasiticidal compositions comprising fipronil at high concentrations
UY36570A (es) 2015-02-26 2016-10-31 Merial Inc Formulaciones inyectables de acción prolongada que comprenden un agente activo isoxazolina, métodos y usos de las mismas
SG11201708068PA (en) 2015-04-08 2017-10-30 Merial Inc Extended release injectable formulations comprising an isoxazoline active agent, methods and uses thereof
LT3298027T (lt) 2015-05-20 2021-08-10 Boehringer Ingelheim Animal Health USA Inc. Antihelmintiniai depsipeptido junginiai
WO2016191389A2 (en) 2015-05-27 2016-12-01 Merial, Inc. Compositions containing antimicrobial igy antibodies, for treatment and prevention of disorders and diseases caused by oral health compromising (ohc) microorganisms
US11058700B2 (en) 2015-10-28 2021-07-13 City Of Hope Macrocyclic lactones and uses thereof as modulators of purinergic receptors
UY37137A (es) 2016-02-24 2017-09-29 Merial Inc Compuestos antiparasitarios de isoxazolina, formulaciones inyectables de acción prolongada que los comprenden, métodos y usos de los mismos
WO2018039508A1 (en) 2016-08-25 2018-03-01 Merial, Inc. Method for reducing unwanted effects in parasiticidal treatments
WO2018071535A1 (en) 2016-10-14 2018-04-19 Merial, Inc. Pesticidal and parasiticidal vinyl isoxazoline compounds
CA3044038A1 (en) 2016-11-16 2018-05-24 Boehringer Ingelheim Animal Health USA Inc. Anthelmintic depsipeptide compounds
WO2019005700A1 (en) 2017-06-26 2019-01-03 Merial, Inc. DOUBLE-ACTING PARASITICIDE GRANULATE COMPOSITIONS, METHODS AND USES THEREOF
BR112020003217A2 (pt) 2017-08-14 2020-10-06 Boehringer Ingelheim Animal Health USA Inc. compostos pesticidas e parasiticidas de pirazolisoxazolina
WO2019152808A1 (en) 2018-02-01 2019-08-08 Yale University Compositions and methods for inhibition of nuclear-penetrating antibodies
EP3749096A1 (en) 2018-02-08 2020-12-16 Boehringer Ingelheim Animal Health USA Inc. Parasiticidal compositions comprising eprinomectin and praziquantel, methods and uses thereof
AU2019301510B2 (en) 2018-07-09 2024-06-13 Boehringer Ingelheim Pharma Gmbh & Co. Kg Anthelminthic heterocyclic compounds
CN113260419A (zh) 2018-11-20 2021-08-13 勃林格殷格翰动物保健美国公司 吲唑基氰基乙基氨基化合物、其组合物、其制备方法和其使用方法
NZ776819A (en) 2019-01-16 2023-04-28 Boehringer Ingelheim Animal Health Usa Inc Topical compositions comprising a neonicotinoid and a macrocyclic lactone, methods and uses thereof
AU2020231319A1 (en) 2019-03-01 2021-10-21 Boehringer Ingelheim Animal Health USA Inc. Injectable clorsulon compositions, methods and uses thereof
CA3133100A1 (en) 2019-03-19 2020-09-24 Boehringer Ingelheim Animal Health USA Inc. Anthelmintic aza-benzothiophene and aza-benzofuran compounds
BR112022000982A2 (pt) 2019-07-22 2022-03-08 Intervet Int Bv Forma de dosagem veterinária mastigável macia
KR20230028268A (ko) 2020-05-29 2023-02-28 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 구충성 헤테로시클릭 화합물
WO2022140728A1 (en) 2020-12-21 2022-06-30 Boehringer Ingelheim Animam Health Usa Inc. Parasiticidal collar comprising isoxazoline compounds
WO2025257633A1 (en) 2024-06-12 2025-12-18 Boehringer Ingelheim Vetmedica Gmbh Long-acting castor oil-containing injectable formulations and methods of use thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3950360A (en) * 1972-06-08 1976-04-13 Sankyo Company Limited Antibiotic substances

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU599383B2 (en) * 1986-06-07 1990-07-19 Coopers Animal Health Limited Ectoparasiticidal pour-on formulations

Also Published As

Publication number Publication date
US4144352A (en) 1979-03-13
JPS6121453B2 (https=) 1986-05-27
AU4230978A (en) 1979-06-28
EP0002916B1 (en) 1981-12-02
EP0002916A2 (en) 1979-07-11
ZA787082B (en) 1980-08-27
JPS5489041A (en) 1979-07-14
DE2861426D1 (en) 1982-01-28
NZ189103A (en) 1984-10-19
EP0002916A3 (en) 1979-07-25

Similar Documents

Publication Publication Date Title
AU526160B2 (en) Milbemycin compounds as anthelmintic agents
AU527917B2 (en) 2-pemer compounds
AU4220078A (en) Acylanilide derivatives
AU3900678A (en) Tripherylalkene derivatives
AU3938978A (en) Thienothiazine derivatives
AU519570B2 (en) C-076 compounds
AU511062B2 (en) Oxazolinoazetoine compounds
AU4208778A (en) Thiohydantion derivatives
AU3229078A (en) M-trifluoromethylphenylpiperazine derivatives
AU3263178A (en) Ethoxygquin derivatives
AU3319078A (en) Antioestrogenic phenylbut-1-ene derivatives
AU507066B1 (en) 2-Substituted-5-Hydroxy-1h-Imidazole 4-Carbozamide Derivatives
AU512057B2 (en) Meta-sulfonamido-benzamide derivatives
AU514377B2 (en) l-OXADETHIACEPHAM COMPOUNDS
AU516639B2 (en) Structure for drills
AU3285878A (en) Oxadiazolopyrimidine derivatives
AU521453B2 (en) Silicon-oxime compounds
AU3931878A (en) 25-alkylcholesterol derivatives
AU502293B1 (en) 4-amino-oleandomycin derivatives
AU3835678A (en) Pyranochromone derivatives
AU3245878A (en) Phenylacycloakane derivatives
AU520050B2 (en) Adenine derivatives
AU4224178A (en) Tetracyclononane derivatives
AU3598578A (en) Fortimicing derivatives
AU515062B2 (en) Phosphonomethylglycerine compounds