AU5238393A - PEG hydrazone and PEG oxime linkage forming reagents and protein derivatives thereof - Google Patents
PEG hydrazone and PEG oxime linkage forming reagents and protein derivatives thereofInfo
- Publication number
- AU5238393A AU5238393A AU52383/93A AU5238393A AU5238393A AU 5238393 A AU5238393 A AU 5238393A AU 52383/93 A AU52383/93 A AU 52383/93A AU 5238393 A AU5238393 A AU 5238393A AU 5238393 A AU5238393 A AU 5238393A
- Authority
- AU
- Australia
- Prior art keywords
- peg
- hydrazone
- protein derivatives
- forming reagents
- oxime linkage
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/04—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers only
- C08G65/06—Cyclic ethers having no atoms other than carbon and hydrogen outside the ring
- C08G65/16—Cyclic ethers having four or more ring atoms
- C08G65/20—Tetrahydrofuran
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US98773992A | 1992-12-09 | 1992-12-09 | |
US987739 | 1992-12-09 | ||
US4505293A | 1993-04-07 | 1993-04-07 | |
US045052 | 1993-04-07 | ||
US157343 | 1993-11-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
AU5238393A true AU5238393A (en) | 1994-06-23 |
Family
ID=26722325
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU52383/93A Abandoned AU5238393A (en) | 1992-12-09 | 1993-12-09 | PEG hydrazone and PEG oxime linkage forming reagents and protein derivatives thereof |
Country Status (5)
Country | Link |
---|---|
JP (1) | JPH07196925A (en) |
KR (1) | KR100254650B1 (en) |
AU (1) | AU5238393A (en) |
FI (1) | FI935485A (en) |
NO (1) | NO934477L (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8017739B2 (en) | 2004-03-11 | 2011-09-13 | Fresenius Kabi Deutschland Gmbh | Conjugates of hydroxyalkyl starch and a protein |
US8287850B2 (en) | 2004-03-11 | 2012-10-16 | Fresenius Kabi Deutschland Gmbh | Conjugates of hydroxyalkyl starch and a protein, prepared by reductive amination |
US8466277B2 (en) | 2002-03-06 | 2013-06-18 | Fresenius Kabi Deutschland Gmbh | Coupling low-molecular substances to a modified polysaccharide |
US8475765B2 (en) | 2002-09-11 | 2013-07-02 | Fresenius Kabi Deutschland Gmbh | Hydroxyalkyl starch derivatives |
US8916518B2 (en) | 2002-03-06 | 2014-12-23 | Fresenius Kabi Deutschland Gmbh | Coupling proteins to a modified polysaccharide |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6586398B1 (en) * | 2000-04-07 | 2003-07-01 | Amgen, Inc. | Chemically modified novel erythropoietin stimulating protein compositions and methods |
AU2001290312A1 (en) * | 2000-10-16 | 2002-04-29 | Chugai Seiyaku Kabushiki Kaisha | Peg-modified erythropoietin |
US7214660B2 (en) * | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
WO2004099231A2 (en) | 2003-04-09 | 2004-11-18 | Neose Technologies, Inc. | Glycopegylation methods and proteins/peptides produced by the methods |
US7173003B2 (en) | 2001-10-10 | 2007-02-06 | Neose Technologies, Inc. | Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF |
US7247609B2 (en) | 2001-12-18 | 2007-07-24 | Universitat Zurich | Growth factor modified protein matrices for tissue engineering |
JPWO2003064462A1 (en) * | 2002-02-01 | 2005-05-26 | 中外製薬株式会社 | PEG-conjugated PTH or PEG-conjugated PTH derivative |
EP1400533A1 (en) * | 2002-09-11 | 2004-03-24 | Fresenius Kabi Deutschland GmbH | HASylated polypeptides, especially HASylated erythropoietin |
WO2005012484A2 (en) | 2003-07-25 | 2005-02-10 | Neose Technologies, Inc. | Antibody-toxin conjugates |
US20080305992A1 (en) | 2003-11-24 | 2008-12-11 | Neose Technologies, Inc. | Glycopegylated erythropoietin |
US20080300173A1 (en) | 2004-07-13 | 2008-12-04 | Defrees Shawn | Branched Peg Remodeling and Glycosylation of Glucagon-Like Peptides-1 [Glp-1] |
EP1814573B1 (en) | 2004-10-29 | 2016-03-09 | ratiopharm GmbH | Remodeling and glycopegylation of fibroblast growth factor (fgf) |
MX2007007580A (en) * | 2004-12-22 | 2007-12-11 | Ambrx Inc | Modified human growth hormone. |
CA2593682C (en) | 2005-01-10 | 2016-03-22 | Neose Technologies, Inc. | Glycopegylated granulocyte colony stimulating factor |
US9187546B2 (en) | 2005-04-08 | 2015-11-17 | Novo Nordisk A/S | Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants |
US20070105755A1 (en) | 2005-10-26 | 2007-05-10 | Neose Technologies, Inc. | One pot desialylation and glycopegylation of therapeutic peptides |
WO2007056191A2 (en) | 2005-11-03 | 2007-05-18 | Neose Technologies, Inc. | Nucleotide sugar purification using membranes |
JP2009544327A (en) | 2006-07-21 | 2009-12-17 | ノヴォ ノルディスク アー/エス | Glycosylation of peptides with O-linked glycosylation sequences |
EP2059527B1 (en) * | 2006-09-01 | 2014-12-03 | Novo Nordisk Health Care AG | Modified glycoproteins |
EP2054521A4 (en) | 2006-10-03 | 2012-12-19 | Novo Nordisk As | Methods for the purification of polypeptide conjugates |
KR20150064246A (en) | 2007-04-03 | 2015-06-10 | 바이오제너릭스 게엠베하 | Methods of treatment using glycopegylated g―csf |
ES2551123T3 (en) | 2007-06-12 | 2015-11-16 | Ratiopharm Gmbh | Improved process for the production of nucleotide sugars |
JP2012512812A (en) | 2007-12-28 | 2012-06-07 | クロス・バイオサージェリー・アクチェンゲゼルシャフト | PDGF fusion protein incorporated into fibrin foam |
CN101965200B (en) | 2008-02-27 | 2013-06-19 | 诺沃-诺迪斯克有限公司 | Conjugated factor VIII molecules |
EP2275202A1 (en) | 2008-03-13 | 2011-01-19 | Ajinomoto Co., Inc. | Carbonyl compound remover |
US8067526B2 (en) | 2009-03-27 | 2011-11-29 | Nof Corporation | Method for producing polyoxalkylene derivative |
TWI537006B (en) * | 2009-07-27 | 2016-06-11 | 巴克斯歐塔公司 | Blood coagulation protein conjugates |
NZ597600A (en) * | 2009-07-27 | 2014-05-30 | Lipoxen Technologies Ltd | Glycopolysialylation of non-blood coagulation proteins |
RU2744370C2 (en) * | 2009-07-27 | 2021-03-05 | Баксалта Инкорпорейтед | Blood coagulation protein conjugates |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2101918A1 (en) * | 1991-03-18 | 1992-09-19 | Samuel Zalipsky | Hydrazine containing conjugates of polypeptides and glycopolypeptides with polymers |
-
1993
- 1993-12-08 FI FI935485A patent/FI935485A/en not_active Application Discontinuation
- 1993-12-08 NO NO934477A patent/NO934477L/en unknown
- 1993-12-09 KR KR1019930027329A patent/KR100254650B1/en not_active IP Right Cessation
- 1993-12-09 AU AU52383/93A patent/AU5238393A/en not_active Abandoned
- 1993-12-09 JP JP5340709A patent/JPH07196925A/en active Pending
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8466277B2 (en) | 2002-03-06 | 2013-06-18 | Fresenius Kabi Deutschland Gmbh | Coupling low-molecular substances to a modified polysaccharide |
US8916518B2 (en) | 2002-03-06 | 2014-12-23 | Fresenius Kabi Deutschland Gmbh | Coupling proteins to a modified polysaccharide |
US8475765B2 (en) | 2002-09-11 | 2013-07-02 | Fresenius Kabi Deutschland Gmbh | Hydroxyalkyl starch derivatives |
US8618266B2 (en) | 2002-09-11 | 2013-12-31 | Fresenius Kabi Deutschland Gmbh | Hasylated polypeptides |
US8017739B2 (en) | 2004-03-11 | 2011-09-13 | Fresenius Kabi Deutschland Gmbh | Conjugates of hydroxyalkyl starch and a protein |
US8287850B2 (en) | 2004-03-11 | 2012-10-16 | Fresenius Kabi Deutschland Gmbh | Conjugates of hydroxyalkyl starch and a protein, prepared by reductive amination |
US8840879B2 (en) | 2004-03-11 | 2014-09-23 | Fresenius Kabi Deutschland Gmbh | Conjugates of hydroxyalkyl starch and a protein |
Also Published As
Publication number | Publication date |
---|---|
JPH07196925A (en) | 1995-08-01 |
NO934477D0 (en) | 1993-12-08 |
KR940014430A (en) | 1994-07-18 |
NO934477L (en) | 1994-06-10 |
FI935485A (en) | 1994-06-10 |
KR100254650B1 (en) | 2000-05-01 |
FI935485A0 (en) | 1993-12-08 |
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