FI935485A - The PEG-hydrazone and PEG-oxime bonds form reagents and protein derivatives thereof - Google Patents
The PEG-hydrazone and PEG-oxime bonds form reagents and protein derivatives thereof Download PDFInfo
- Publication number
- FI935485A FI935485A FI935485A FI935485A FI935485A FI 935485 A FI935485 A FI 935485A FI 935485 A FI935485 A FI 935485A FI 935485 A FI935485 A FI 935485A FI 935485 A FI935485 A FI 935485A
- Authority
- FI
- Finland
- Prior art keywords
- peg
- hydrazone
- protein derivatives
- bonds form
- oxime bonds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/04—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers only
- C08G65/06—Cyclic ethers having no atoms other than carbon and hydrogen outside the ring
- C08G65/16—Cyclic ethers having four or more ring atoms
- C08G65/20—Tetrahydrofuran
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US98773992A | 1992-12-09 | 1992-12-09 | |
US4505293A | 1993-04-07 | 1993-04-07 |
Publications (2)
Publication Number | Publication Date |
---|---|
FI935485A0 FI935485A0 (en) | 1993-12-08 |
FI935485A true FI935485A (en) | 1994-06-10 |
Family
ID=26722325
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI935485A FI935485A (en) | 1992-12-09 | 1993-12-08 | The PEG-hydrazone and PEG-oxime bonds form reagents and protein derivatives thereof |
Country Status (5)
Country | Link |
---|---|
JP (1) | JPH07196925A (en) |
KR (1) | KR100254650B1 (en) |
AU (1) | AU5238393A (en) |
FI (1) | FI935485A (en) |
NO (1) | NO934477L (en) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6586398B1 (en) * | 2000-04-07 | 2003-07-01 | Amgen, Inc. | Chemically modified novel erythropoietin stimulating protein compositions and methods |
ES2320101T3 (en) * | 2000-10-16 | 2009-05-19 | Chugai Seiyaku Kabushiki Kaisha | CONJUGATED ERYTHROPOYETINE WITH MONO-PEG. |
US7214660B2 (en) | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
WO2004099231A2 (en) | 2003-04-09 | 2004-11-18 | Neose Technologies, Inc. | Glycopegylation methods and proteins/peptides produced by the methods |
US7173003B2 (en) | 2001-10-10 | 2007-02-06 | Neose Technologies, Inc. | Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF |
US7247609B2 (en) | 2001-12-18 | 2007-07-24 | Universitat Zurich | Growth factor modified protein matrices for tissue engineering |
WO2003064462A1 (en) * | 2002-02-01 | 2003-08-07 | Chugai Seiyaku Kabushiki Kaisha | Peg-binding pth or peg-binding pth derivative |
DE10209821A1 (en) | 2002-03-06 | 2003-09-25 | Biotechnologie Ges Mittelhesse | Coupling of proteins to a modified polysaccharide |
DE10209822A1 (en) | 2002-03-06 | 2003-09-25 | Biotechnologie Ges Mittelhesse | Coupling of low molecular weight substances to a modified polysaccharide |
ES2214166T1 (en) * | 2002-09-11 | 2004-09-16 | Fresenius Kabi Deutschland Gmbh | HAS-ILLATED POLYPEPTIDES, ESPECIALLY, HAS-ILADA ERIPTROPOYETINA. |
CN1681844A (en) * | 2002-09-11 | 2005-10-12 | 弗雷泽纽斯卡比德国有限公司 | Hasylated polypeptides, especially hasylated erythropoietin |
US9005625B2 (en) | 2003-07-25 | 2015-04-14 | Novo Nordisk A/S | Antibody toxin conjugates |
WO2005014655A2 (en) * | 2003-08-08 | 2005-02-17 | Fresenius Kabi Deutschland Gmbh | Conjugates of hydroxyalkyl starch and a protein |
US20080305992A1 (en) | 2003-11-24 | 2008-12-11 | Neose Technologies, Inc. | Glycopegylated erythropoietin |
EP2336192A1 (en) | 2004-03-11 | 2011-06-22 | Fresenius Kabi Deutschland GmbH | Conjugates of hydroxyalkyl starch and a protein, prepared by reductive amination |
US20080300173A1 (en) | 2004-07-13 | 2008-12-04 | Defrees Shawn | Branched Peg Remodeling and Glycosylation of Glucagon-Like Peptides-1 [Glp-1] |
EP2586456B1 (en) | 2004-10-29 | 2016-01-20 | ratiopharm GmbH | Remodeling and glycopegylation of fibroblast growth factor (FGF) |
SG160437A1 (en) * | 2004-12-22 | 2010-04-29 | Ambrx Inc | Modified human growth hormone |
CA2593682C (en) | 2005-01-10 | 2016-03-22 | Neose Technologies, Inc. | Glycopegylated granulocyte colony stimulating factor |
US20070154992A1 (en) | 2005-04-08 | 2007-07-05 | Neose Technologies, Inc. | Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants |
US20070105755A1 (en) | 2005-10-26 | 2007-05-10 | Neose Technologies, Inc. | One pot desialylation and glycopegylation of therapeutic peptides |
WO2007056191A2 (en) | 2005-11-03 | 2007-05-18 | Neose Technologies, Inc. | Nucleotide sugar purification using membranes |
US20080280818A1 (en) | 2006-07-21 | 2008-11-13 | Neose Technologies, Inc. | Glycosylation of peptides via o-linked glycosylation sequences |
EP2059527B1 (en) * | 2006-09-01 | 2014-12-03 | Novo Nordisk Health Care AG | Modified glycoproteins |
WO2008057683A2 (en) | 2006-10-03 | 2008-05-15 | Novo Nordisk A/S | Methods for the purification of polypeptide conjugates |
BRPI0809670A8 (en) | 2007-04-03 | 2018-12-18 | Biogenerix Ag | methods to increase stem cell production, to increase the number of granulocytes in an individual, to prevent, treat and alleviate myelosuppression that results from cancer therapy, to treat a condition in an individual, to treat neutropenia and thrombocytopenia in a mammal, to expand hematopoietic stem cells in culture, to increase hematopoiesis in an individual, to increase the number of hematopoietic progenitor cells in an individual, and to provide stable bone marrow graft, and, oral dosage form. |
MX2009013259A (en) | 2007-06-12 | 2010-01-25 | Novo Nordisk As | Improved process for the production of nucleotide sugars. |
CA2710798A1 (en) | 2007-12-28 | 2009-07-09 | Kuros Biosurgery Ag | Pdgf fusion proteins incorporated into fibrin foams |
DK2257311T3 (en) | 2008-02-27 | 2014-06-30 | Novo Nordisk As | Conjugated Factor VIII Molecules |
WO2009113578A1 (en) | 2008-03-13 | 2009-09-17 | 味の素株式会社 | Carbonyl compound remover |
JP5418360B2 (en) | 2009-03-27 | 2014-02-19 | 日油株式会社 | Method for producing polyoxyalkylene derivative |
PL2459224T3 (en) | 2009-07-27 | 2017-08-31 | Baxalta GmbH | Blood coagulation protein conjugates |
US8637640B2 (en) * | 2009-07-27 | 2014-01-28 | Baxter International Inc. | Blood coagulation protein conjugates |
SG178051A1 (en) * | 2009-07-27 | 2012-03-29 | Lipoxen Technologies Ltd | Glycopolysialylation of non-blood coagulation proteins |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0576589A4 (en) * | 1991-03-18 | 1994-07-27 | Enzon Inc | Hydrazine containing conjugates of polypeptides and glycopolypeptides with polymers |
-
1993
- 1993-12-08 FI FI935485A patent/FI935485A/en not_active Application Discontinuation
- 1993-12-08 NO NO934477A patent/NO934477L/en unknown
- 1993-12-09 AU AU52383/93A patent/AU5238393A/en not_active Abandoned
- 1993-12-09 JP JP5340709A patent/JPH07196925A/en active Pending
- 1993-12-09 KR KR1019930027329A patent/KR100254650B1/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
NO934477D0 (en) | 1993-12-08 |
FI935485A0 (en) | 1993-12-08 |
AU5238393A (en) | 1994-06-23 |
NO934477L (en) | 1994-06-10 |
KR940014430A (en) | 1994-07-18 |
JPH07196925A (en) | 1995-08-01 |
KR100254650B1 (en) | 2000-05-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD | Application lapsed |