NO934477L - PEG hydrazone and PEG oxime-binding reagents and protein derivatives thereof - Google Patents
PEG hydrazone and PEG oxime-binding reagents and protein derivatives thereofInfo
- Publication number
- NO934477L NO934477L NO934477A NO934477A NO934477L NO 934477 L NO934477 L NO 934477L NO 934477 A NO934477 A NO 934477A NO 934477 A NO934477 A NO 934477A NO 934477 L NO934477 L NO 934477L
- Authority
- NO
- Norway
- Prior art keywords
- peg
- water
- polymeric reagents
- soluble polymeric
- hydrazone
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/04—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers only
- C08G65/06—Cyclic ethers having no atoms other than carbon and hydrogen outside the ring
- C08G65/16—Cyclic ethers having four or more ring atoms
- C08G65/20—Tetrahydrofuran
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Polymers & Plastics (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
Abstract
Det blir beskrevet fremgangsmåter og forbindelser for modifisering av polypeptider med PEG eller andre vannoppløsellge organiske polymerer. Nye vannoppløselige polymerreagenser blir fremskaffet. De vannoppløsellge polymerreagensene omfatter hydrazln, hydrazinkarboksylat, semlkarbazld, tiosemikarbazid, karbonsyredlhydrazld, karbazid, tiokarbazid og arylhydrazidderivater så vel som oksylaminderivater av vannoppløsellge organiske polymerer, slik som poly- etylenglykol, polypropylenglykol, polyoksyetylert polyol, heparln, heparlnfragmenter, dekstran, poly- sakkarider, polyaminosyrer og polyvlnylalkohol. Det ble også fremskaffet aktuelle peptider som er derlvatisert ved foreliggende vannoppløselige polymer- reagenser . Det ble også beskrevet sett for modifisering av polypeptider med foreliggende vannoppløselige polymer- reagenser .Methods and compounds for modifying polypeptides with PEG or other water-soluble organic polymers are described. New water-soluble polymeric reagents are provided. The water-soluble polymeric reagents include hydrazine, hydrazine carboxylate, semicarbazide, thiosemicarbazide, carboxylic acid dihydrazide, carbazide, thiocarbazide and arylhydrazide derivatives as well as oxyamine paraffinic acid, polyethylene glycol, polyethylene glycol, and polyvinyl alcohol. Relevant peptides were also obtained which are derivatized by the present water-soluble polymeric reagents. Kits were also described for modifying polypeptides with the present water-soluble polymeric reagents.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US98773992A | 1992-12-09 | 1992-12-09 | |
US4505293A | 1993-04-07 | 1993-04-07 |
Publications (2)
Publication Number | Publication Date |
---|---|
NO934477D0 NO934477D0 (en) | 1993-12-08 |
NO934477L true NO934477L (en) | 1994-06-10 |
Family
ID=26722325
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO934477A NO934477L (en) | 1992-12-09 | 1993-12-08 | PEG hydrazone and PEG oxime-binding reagents and protein derivatives thereof |
Country Status (5)
Country | Link |
---|---|
JP (1) | JPH07196925A (en) |
KR (1) | KR100254650B1 (en) |
AU (1) | AU5238393A (en) |
FI (1) | FI935485A (en) |
NO (1) | NO934477L (en) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6586398B1 (en) * | 2000-04-07 | 2003-07-01 | Amgen, Inc. | Chemically modified novel erythropoietin stimulating protein compositions and methods |
ES2320101T3 (en) * | 2000-10-16 | 2009-05-19 | Chugai Seiyaku Kabushiki Kaisha | CONJUGATED ERYTHROPOYETINE WITH MONO-PEG. |
US7214660B2 (en) * | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
WO2004099231A2 (en) | 2003-04-09 | 2004-11-18 | Neose Technologies, Inc. | Glycopegylation methods and proteins/peptides produced by the methods |
US7173003B2 (en) | 2001-10-10 | 2007-02-06 | Neose Technologies, Inc. | Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF |
US7247609B2 (en) | 2001-12-18 | 2007-07-24 | Universitat Zurich | Growth factor modified protein matrices for tissue engineering |
JPWO2003064462A1 (en) * | 2002-02-01 | 2005-05-26 | 中外製薬株式会社 | PEG-conjugated PTH or PEG-conjugated PTH derivative |
DE10209822A1 (en) | 2002-03-06 | 2003-09-25 | Biotechnologie Ges Mittelhesse | Coupling of low molecular weight substances to a modified polysaccharide |
DE10209821A1 (en) | 2002-03-06 | 2003-09-25 | Biotechnologie Ges Mittelhesse | Coupling of proteins to a modified polysaccharide |
DE02020425T1 (en) * | 2002-09-11 | 2004-07-15 | Fresenius Kabi Deutschland Gmbh | Hasylated polypeptides, especially hasylated erythropoietin |
KR101045422B1 (en) | 2002-09-11 | 2011-06-30 | 프레제니우스 카비 도이치란트 게엠베하 | Method of producing hydroxyalkyl starch derivatives |
US9005625B2 (en) | 2003-07-25 | 2015-04-14 | Novo Nordisk A/S | Antibody toxin conjugates |
WO2005014655A2 (en) | 2003-08-08 | 2005-02-17 | Fresenius Kabi Deutschland Gmbh | Conjugates of hydroxyalkyl starch and a protein |
US20080305992A1 (en) | 2003-11-24 | 2008-12-11 | Neose Technologies, Inc. | Glycopegylated erythropoietin |
DE202005021885U1 (en) | 2004-03-11 | 2011-03-03 | Fresenius Kabi Deutschland Gmbh | Hydroxyalkyl starch-protein conjugates prepared by reductive amination |
WO2006010143A2 (en) | 2004-07-13 | 2006-01-26 | Neose Technologies, Inc. | Branched peg remodeling and glycosylation of glucagon-like peptide-1 [glp-1] |
PL2586456T3 (en) | 2004-10-29 | 2016-07-29 | Ratiopharm Gmbh | Remodeling and glycopegylation of fibroblast growth factor (FGF) |
EP2284191A3 (en) * | 2004-12-22 | 2011-07-20 | Ambrx, Inc. | Process for the preparation of hGH |
EP2514757A3 (en) | 2005-01-10 | 2014-03-05 | ratiopharm GmbH | Glycopegylated granulocyte colony stimulating factor |
EP1871795A4 (en) | 2005-04-08 | 2010-03-31 | Biogenerix Ag | Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants |
US20070105755A1 (en) | 2005-10-26 | 2007-05-10 | Neose Technologies, Inc. | One pot desialylation and glycopegylation of therapeutic peptides |
US20090048440A1 (en) | 2005-11-03 | 2009-02-19 | Neose Technologies, Inc. | Nucleotide Sugar Purification Using Membranes |
US9187532B2 (en) | 2006-07-21 | 2015-11-17 | Novo Nordisk A/S | Glycosylation of peptides via O-linked glycosylation sequences |
JP5570809B2 (en) * | 2006-09-01 | 2014-08-13 | ノボ ノルディスク ヘルス ケア アーゲー | Modified protein |
US20100075375A1 (en) | 2006-10-03 | 2010-03-25 | Novo Nordisk A/S | Methods for the purification of polypeptide conjugates |
KR20150064246A (en) | 2007-04-03 | 2015-06-10 | 바이오제너릭스 게엠베하 | Methods of treatment using glycopegylated g―csf |
EP2170919B8 (en) | 2007-06-12 | 2016-01-20 | ratiopharm GmbH | Improved process for the production of nucleotide sugars |
JP2012512812A (en) | 2007-12-28 | 2012-06-07 | クロス・バイオサージェリー・アクチェンゲゼルシャフト | PDGF fusion protein incorporated into fibrin foam |
WO2009108806A1 (en) | 2008-02-27 | 2009-09-03 | Novo Nordisk A/S | Conjugated factor viii molecules |
JPWO2009113578A1 (en) | 2008-03-13 | 2011-07-21 | 味の素株式会社 | Carbonyl compound removal material |
JP5418360B2 (en) | 2009-03-27 | 2014-02-19 | 日油株式会社 | Method for producing polyoxyalkylene derivative |
SG178051A1 (en) * | 2009-07-27 | 2012-03-29 | Lipoxen Technologies Ltd | Glycopolysialylation of non-blood coagulation proteins |
CN104530182A (en) * | 2009-07-27 | 2015-04-22 | 利普森技术有限公司 | Glycopolysialylation of non-blood coagulation proteins |
AU2010281453C1 (en) * | 2009-07-27 | 2019-08-15 | Takeda Pharmaceutical Company Limited | Blood coagulation protein conjugates |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH06506217A (en) * | 1991-03-18 | 1994-07-14 | エンゾン,インコーポレーテッド | Hydrazine-containing conjugates of polypeptides or glycopolypeptides and polymers |
-
1993
- 1993-12-08 NO NO934477A patent/NO934477L/en unknown
- 1993-12-08 FI FI935485A patent/FI935485A/en not_active Application Discontinuation
- 1993-12-09 KR KR1019930027329A patent/KR100254650B1/en not_active IP Right Cessation
- 1993-12-09 JP JP5340709A patent/JPH07196925A/en active Pending
- 1993-12-09 AU AU52383/93A patent/AU5238393A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
KR940014430A (en) | 1994-07-18 |
FI935485A0 (en) | 1993-12-08 |
FI935485A (en) | 1994-06-10 |
KR100254650B1 (en) | 2000-05-01 |
NO934477D0 (en) | 1993-12-08 |
AU5238393A (en) | 1994-06-23 |
JPH07196925A (en) | 1995-08-01 |
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