AU4855185A - Benzopyrano(4,3-c) pyrazoles and pyrazolo(4,3-c) quinolines - Google Patents

Benzopyrano(4,3-c) pyrazoles and pyrazolo(4,3-c) quinolines

Info

Publication number
AU4855185A
AU4855185A AU48551/85A AU4855185A AU4855185A AU 4855185 A AU4855185 A AU 4855185A AU 48551/85 A AU48551/85 A AU 48551/85A AU 4855185 A AU4855185 A AU 4855185A AU 4855185 A AU4855185 A AU 4855185A
Authority
AU
Australia
Prior art keywords
compound
nmr
chloro
pyrazolo
propionyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU48551/85A
Other languages
English (en)
Inventor
Yousuke Katsura
Takashi Manabe
Youichi Shiokawa
Ikuo Ueda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Pharma Inc
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848427124A external-priority patent/GB8427124D0/en
Priority claimed from GB858513399A external-priority patent/GB8513399D0/en
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of AU4855185A publication Critical patent/AU4855185A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/42—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4
    • C07D311/56—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 without hydrogen atoms in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Quinoline Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cosmetics (AREA)
AU48551/85A 1984-10-26 1985-10-14 Benzopyrano(4,3-c) pyrazoles and pyrazolo(4,3-c) quinolines Abandoned AU4855185A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB848427124A GB8427124D0 (en) 1984-10-26 1984-10-26 Benzene-fused heterocyclic compound
GB8427124 1984-10-26
GB8513399 1985-05-28
GB858513399A GB8513399D0 (en) 1985-05-28 1985-05-28 Heterocyclic compound

Publications (1)

Publication Number Publication Date
AU4855185A true AU4855185A (en) 1986-05-01

Family

ID=26288380

Family Applications (1)

Application Number Title Priority Date Filing Date
AU48551/85A Abandoned AU4855185A (en) 1984-10-26 1985-10-14 Benzopyrano(4,3-c) pyrazoles and pyrazolo(4,3-c) quinolines

Country Status (16)

Country Link
US (2) US4675324A (enExample)
EP (1) EP0180352B1 (enExample)
JP (1) JPH0649702B2 (enExample)
KR (1) KR860003259A (enExample)
CN (1) CN85108618A (enExample)
AT (1) ATE89825T1 (enExample)
AU (1) AU4855185A (enExample)
DE (1) DE3587362T2 (enExample)
DK (1) DK493185A (enExample)
ES (2) ES8702139A1 (enExample)
FI (1) FI853757A7 (enExample)
GR (1) GR852593B (enExample)
HU (1) HUT40124A (enExample)
NO (1) NO854275L (enExample)
PH (1) PH21213A (enExample)
SU (1) SU1375137A3 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU598893B2 (en) * 1987-01-09 1990-07-05 Farmitalia Carlo Erba S.R.L. Heteroaryl 3-oxo-propanenitrile derivatives and process for their preparation
AU609808B2 (en) * 1987-04-09 1991-05-09 E.I. Du Pont De Nemours And Company Insecticidal substituted indazoles
AU630716B2 (en) * 1986-05-02 1992-11-05 Hodogaya Chemical Co., Ltd. Intermediates of 1-acyl-2,3-dihydro-4(1h)-quinolinone-4-oxime derivatives

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2602037B2 (ja) * 1987-10-31 1997-04-23 持田製薬株式会社 １−アシル−２，３−ジヒドロ−４（１ｈ）−キノリノン−４−オキシム誘導体、その製法およびそれらを主成分とする利尿、降圧、抗浮腫および腹水除去用医薬組成物
US5192768A (en) * 1990-09-14 1993-03-09 Kyowa Hakko Kogyo Co., Ltd. Pyrazoloquinoline derivatives
ATE360617T1 (de) 1994-06-15 2007-05-15 Otsuka Pharma Co Ltd Benzoheterocyclische verbindungen verwendbar als vasopressin- oder oxytocin-modulatoren
US5865170A (en) * 1997-07-23 1999-02-02 Moles; Randall C. Customizable mouthpiece for scuba-divers
EP1813616B1 (en) * 2002-11-22 2013-03-27 Active Biotech AB Pyrazoloquinolines with immunomodulating activity
AU2004270161A1 (en) * 2003-08-28 2005-03-17 Nicox S.A. Nitrosated and nitrosylated cardiovascular compounds, compositions and methods of use
EP1855688A4 (en) * 2005-02-24 2011-09-14 Nicox Sa NON-STAINED OXIDE DIURETIC COMPOUNDS, COMPOSITIONS AND USE PROCESSES
CL2007003879A1 (es) 2006-12-29 2008-07-04 Basf Ag Compuestos derivados de aril-carboxamida; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como alzheimer, epilepsia y parkinson.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2009079A1 (enExample) * 1968-05-22 1970-01-30 Sandoz Sa
US3624102A (en) * 1969-05-21 1971-11-30 Warner Lambert Co Substituted benzopyranopyrazoles
EP0022078B1 (de) * 1979-06-21 1984-07-25 Ciba-Geigy Ag Pyrazolochinoline, Verfahren zu ihrer Herstellung, und pharmazeutische Präparate enthaltend diese Verbindungen
US4524146A (en) * 1982-12-08 1985-06-18 Ciba-Geigy Corporation Certain -2-heterocycle substituted pyrazoloquinolines

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU630716B2 (en) * 1986-05-02 1992-11-05 Hodogaya Chemical Co., Ltd. Intermediates of 1-acyl-2,3-dihydro-4(1h)-quinolinone-4-oxime derivatives
AU598893B2 (en) * 1987-01-09 1990-07-05 Farmitalia Carlo Erba S.R.L. Heteroaryl 3-oxo-propanenitrile derivatives and process for their preparation
AU609808B2 (en) * 1987-04-09 1991-05-09 E.I. Du Pont De Nemours And Company Insecticidal substituted indazoles

Also Published As

Publication number Publication date
JPH0649702B2 (ja) 1994-06-29
JPS61112076A (ja) 1986-05-30
SU1375137A3 (ru) 1988-02-15
CN85108618A (zh) 1986-08-27
KR860003259A (ko) 1986-05-21
PH21213A (en) 1987-08-21
US4767780A (en) 1988-08-30
EP0180352A3 (en) 1988-03-30
ES8801266A1 (es) 1987-12-16
DK493185D0 (da) 1985-10-25
DK493185A (da) 1986-04-27
HUT40124A (en) 1986-11-28
ATE89825T1 (de) 1993-06-15
DE3587362T2 (de) 1993-09-09
GR852593B (enExample) 1985-12-24
EP0180352B1 (en) 1993-05-26
ES548205A0 (es) 1986-12-16
ES557041A0 (es) 1987-12-16
NO854275L (no) 1986-04-28
FI853757A0 (fi) 1985-09-30
US4675324A (en) 1987-06-23
FI853757L (fi) 1986-04-27
FI853757A7 (fi) 1986-04-27
DE3587362D1 (de) 1993-07-01
EP0180352A2 (en) 1986-05-07
ES8702139A1 (es) 1986-12-16

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