AU4701799A - Coadministration of ACAT and MMP inhibitors for the treatment of atherosclerotic lesions - Google Patents
Coadministration of ACAT and MMP inhibitors for the treatment of atherosclerotic lesions Download PDFInfo
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- AU4701799A AU4701799A AU47017/99A AU4701799A AU4701799A AU 4701799 A AU4701799 A AU 4701799A AU 47017/99 A AU47017/99 A AU 47017/99A AU 4701799 A AU4701799 A AU 4701799A AU 4701799 A AU4701799 A AU 4701799A
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- Prior art keywords
- acid
- methyl
- phenyl
- biphenyl
- hydroxy
- Prior art date
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- Abandoned
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- 229940124761 MMP inhibitor Drugs 0.000 title claims description 23
- 230000003902 lesion Effects 0.000 title claims description 18
- 230000003143 atherosclerotic effect Effects 0.000 title claims description 11
- -1 carboxyalkyl ketone Chemical class 0.000 claims description 413
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 156
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 144
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 107
- 150000001875 compounds Chemical class 0.000 claims description 105
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- 125000000217 alkyl group Chemical group 0.000 claims description 96
- ZXKINMCYCKHYFR-UHFFFAOYSA-N aminooxidanide Chemical compound [O-]N ZXKINMCYCKHYFR-UHFFFAOYSA-N 0.000 claims description 88
- 229910052739 hydrogen Inorganic materials 0.000 claims description 78
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- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims description 56
- 239000002253 acid Substances 0.000 claims description 55
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims description 53
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 50
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- GONOPSZTUGRENK-UHFFFAOYSA-N benzyl(trichloro)silane Chemical compound Cl[Si](Cl)(Cl)CC1=CC=CC=C1 GONOPSZTUGRENK-UHFFFAOYSA-N 0.000 claims description 45
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- 238000000034 method Methods 0.000 claims description 42
- 125000004080 3-carboxypropanoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C(O[H])=O 0.000 claims description 40
- 235000019454 L-leucine Nutrition 0.000 claims description 39
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 35
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims description 30
- 239000003112 inhibitor Substances 0.000 claims description 29
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- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 25
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- LNOPIUAQISRISI-UHFFFAOYSA-N n'-hydroxy-2-propan-2-ylsulfonylethanimidamide Chemical compound CC(C)S(=O)(=O)CC(N)=NO LNOPIUAQISRISI-UHFFFAOYSA-N 0.000 claims description 19
- WPYMKLBDIGXBTP-UHFFFAOYSA-N Benzoic acid Natural products OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 18
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- 125000001424 substituent group Chemical group 0.000 claims description 11
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- QDKWLJJOYIFEBS-UHFFFAOYSA-N 1-fluoro-4-$l^{1}-oxidanylbenzene Chemical group [O]C1=CC=C(F)C=C1 QDKWLJJOYIFEBS-UHFFFAOYSA-N 0.000 claims description 10
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- 125000003774 valeryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 8
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- LVUYWXXLGSVQEH-UHFFFAOYSA-N [3-(2-phenylacetyl)-2,6-di(propan-2-yl)phenyl] sulfamate Chemical compound CC(C)C1=C(OS(N)(=O)=O)C(C(C)C)=CC=C1C(=O)CC1=CC=CC=C1 LVUYWXXLGSVQEH-UHFFFAOYSA-N 0.000 claims description 2
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- BKIZTHMHKWZOPD-UHFFFAOYSA-N [3-(3-methyl-2-phenylpentanoyl)-2,6-di(propan-2-yl)phenyl] sulfamate;sodium Chemical compound [Na].C=1C=CC=CC=1C(C(C)CC)C(=O)C1=CC=C(C(C)C)C(OS(N)(=O)=O)=C1C(C)C BKIZTHMHKWZOPD-UHFFFAOYSA-N 0.000 claims description 2
- YKPBDXIXQLCDMW-UHFFFAOYSA-N [3-(3-phenylpropanoyl)-2,6-di(propan-2-yl)phenyl] sulfamate Chemical compound CC(C)C1=C(OS(N)(=O)=O)C(C(C)C)=CC=C1C(=O)CCC1=CC=CC=C1 YKPBDXIXQLCDMW-UHFFFAOYSA-N 0.000 claims description 2
- IEUKVMHUFHMJNZ-UHFFFAOYSA-N [3-(9h-fluorene-9-carbonyl)-2,6-di(propan-2-yl)phenyl] sulfamate Chemical compound CC(C)C1=C(OS(N)(=O)=O)C(C(C)C)=CC=C1C(=O)C1C2=CC=CC=C2C2=CC=CC=C21 IEUKVMHUFHMJNZ-UHFFFAOYSA-N 0.000 claims description 2
- COLDWNCECCAUKF-UHFFFAOYSA-N [3-[2-(1-adamantyl)acetyl]-2,6-di(propan-2-yl)phenyl] sulfamate Chemical compound C12(CC3CC(CC(C1)C3)C2)CC(=O)C=1C(=C(C(=CC=1)C(C)C)OS(N)(=O)=O)C(C)C COLDWNCECCAUKF-UHFFFAOYSA-N 0.000 claims description 2
- VUKGWEPYJTUIFU-UHFFFAOYSA-N [3-[2-(2,5-dimethoxyphenyl)acetyl]-2,6-di(propan-2-yl)phenyl] sulfamate Chemical compound COC1=CC=C(OC)C(CC(=O)C=2C(=C(OS(N)(=O)=O)C(C(C)C)=CC=2)C(C)C)=C1 VUKGWEPYJTUIFU-UHFFFAOYSA-N 0.000 claims description 2
- DXHYZVZSMDLNBQ-UHFFFAOYSA-N [3-decanoyl-2,6-di(propan-2-yl)phenyl] sulfamate Chemical compound CCCCCCCCCC(=O)C1=CC=C(C(C)C)C(OS(N)(=O)=O)=C1C(C)C DXHYZVZSMDLNBQ-UHFFFAOYSA-N 0.000 claims description 2
- SDKIUQCUWFKCBF-UHFFFAOYSA-N [3-dodecanoyl-2,6-di(propan-2-yl)phenyl] sulfamate Chemical compound CCCCCCCCCCCC(=O)C1=CC=C(C(C)C)C(OS(N)(=O)=O)=C1C(C)C SDKIUQCUWFKCBF-UHFFFAOYSA-N 0.000 claims description 2
- 125000005073 adamantyl group Chemical group C12(CC3CC(CC(C1)C3)C2)* 0.000 claims description 2
- ITQTTZVARXURQS-UHFFFAOYSA-N beta-methylpyridine Natural products CC1=CC=CN=C1 ITQTTZVARXURQS-UHFFFAOYSA-N 0.000 claims description 2
- WZHCOOQXZCIUNC-UHFFFAOYSA-N cyclandelate Chemical compound C1C(C)(C)CC(C)CC1OC(=O)C(O)C1=CC=CC=C1 WZHCOOQXZCIUNC-UHFFFAOYSA-N 0.000 claims description 2
- HTFFABIIOAKIBH-UHFFFAOYSA-N diazinane Chemical compound C1CCNNC1 HTFFABIIOAKIBH-UHFFFAOYSA-N 0.000 claims description 2
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- TXKMVPPZCYKFAC-UHFFFAOYSA-N disulfur monoxide Inorganic materials O=S=S TXKMVPPZCYKFAC-UHFFFAOYSA-N 0.000 claims description 2
- LCMBCJFAKQBFGZ-UHFFFAOYSA-N ethyl 3-(1h-indol-3-yl)-2-(octadec-9-enoylamino)propanoate Chemical compound C1=CC=C2C(CC(NC(=O)CCCCCCCC=CCCCCCCCC)C(=O)OCC)=CNC2=C1 LCMBCJFAKQBFGZ-UHFFFAOYSA-N 0.000 claims description 2
- PSQWWHGMMWFQLX-UHFFFAOYSA-N ethyl 3-[[3,3-dimethyl-1-oxo-1-(pyridin-4-ylamino)butan-2-yl]carbamoyl]-6-(4-phenylphenyl)hexanoate Chemical compound C=1C=NC=CC=1NC(=O)C(C(C)(C)C)NC(=O)C(CC(=O)OCC)CCCC(C=C1)=CC=C1C1=CC=CC=C1 PSQWWHGMMWFQLX-UHFFFAOYSA-N 0.000 claims description 2
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- 150000002460 imidazoles Chemical class 0.000 claims description 2
- YABYZOPDZUVCSZ-UHFFFAOYSA-N methyl 4-[[2-[2-[2-(hydroxyamino)-2-oxoethyl]hexanoylamino]-3,3-dimethylbutanoyl]amino]benzoate Chemical compound CCCCC(CC(=O)NO)C(=O)NC(C(C)(C)C)C(=O)NC1=CC=C(C(=O)OC)C=C1 YABYZOPDZUVCSZ-UHFFFAOYSA-N 0.000 claims description 2
- BLGRCSGSFJERDA-UHFFFAOYSA-N methyl 4-[[2-[[(2e)-2-(hydroxyamino)-2-hydroxyiminoethyl]-(5-phenylpentanoyl)amino]-4-methylpentanoyl]amino]benzoate Chemical compound C1=CC(C(=O)OC)=CC=C1NC(=O)C(CC(C)C)N(CC(NO)=NO)C(=O)CCCCC1=CC=CC=C1 BLGRCSGSFJERDA-UHFFFAOYSA-N 0.000 claims description 2
- PYBCJEOMAMTGDX-UHFFFAOYSA-N methyl 4-[[2-[[4-(hydroxyamino)-4-oxo-2-(2-phenylethyl)butanoyl]amino]-3,3-dimethylbutanoyl]amino]benzoate Chemical compound C1=CC(C(=O)OC)=CC=C1NC(=O)C(C(C)(C)C)NC(=O)C(CC(=O)NO)CCC1=CC=CC=C1 PYBCJEOMAMTGDX-UHFFFAOYSA-N 0.000 claims description 2
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- VENJMEIMLNFYKD-UHFFFAOYSA-N n-hydroxy-n'-(1-hydroxy-4-methylsulfanylbutan-2-yl)-2-[3-(4-phenylphenyl)propyl]propanediamide Chemical compound C1=CC(CCCC(C(=O)NC(CO)CCSC)C(=O)NO)=CC=C1C1=CC=CC=C1 VENJMEIMLNFYKD-UHFFFAOYSA-N 0.000 description 1
- RGUVUPQQFXCJFC-UHFFFAOYSA-N n-hydroxyoctanamide Chemical compound CCCCCCCC(=O)NO RGUVUPQQFXCJFC-UHFFFAOYSA-N 0.000 description 1
- OXMGLNHHGXDIGQ-UHFFFAOYSA-N n-methyldiazinane-1-carboxamide Chemical compound CNC(=O)N1CCCCN1 OXMGLNHHGXDIGQ-UHFFFAOYSA-N 0.000 description 1
- 125000001624 naphthyl group Chemical group 0.000 description 1
- 235000021096 natural sweeteners Nutrition 0.000 description 1
- 238000011587 new zealand white rabbit Methods 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- 238000010606 normalization Methods 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 239000006186 oral dosage form Substances 0.000 description 1
- 229940100688 oral solution Drugs 0.000 description 1
- 201000008482 osteoarthritis Diseases 0.000 description 1
- 125000006503 p-nitrobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1[N+]([O-])=O)C([H])([H])* 0.000 description 1
- 125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 description 1
- 201000002528 pancreatic cancer Diseases 0.000 description 1
- 208000008443 pancreatic carcinoma Diseases 0.000 description 1
- 239000006201 parenteral dosage form Substances 0.000 description 1
- 239000003182 parenteral nutrition solution Substances 0.000 description 1
- 235000020232 peanut Nutrition 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- DPBLXKKOBLCELK-UHFFFAOYSA-N pentan-1-amine Chemical compound CCCCCN DPBLXKKOBLCELK-UHFFFAOYSA-N 0.000 description 1
- MONRWRVYLOHUFA-UHFFFAOYSA-N pentylurea Chemical compound CCCCCNC(N)=O MONRWRVYLOHUFA-UHFFFAOYSA-N 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 125000003884 phenylalkyl group Chemical group 0.000 description 1
- 125000004660 phenylalkylthio group Chemical group 0.000 description 1
- 125000000286 phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 description 1
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 description 1
- JSPCTNUQYWIIOT-UHFFFAOYSA-N piperidine-1-carboxamide Chemical compound NC(=O)N1CCCCC1 JSPCTNUQYWIIOT-UHFFFAOYSA-N 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- ALDITMKAAPLVJK-UHFFFAOYSA-N prop-1-ene;hydrate Chemical group O.CC=C ALDITMKAAPLVJK-UHFFFAOYSA-N 0.000 description 1
- XUWVIABDWDTJRZ-UHFFFAOYSA-N propan-2-ylazanide Chemical compound CC(C)[NH-] XUWVIABDWDTJRZ-UHFFFAOYSA-N 0.000 description 1
- 125000004307 pyrazin-2-yl group Chemical group [H]C1=C([H])N=C(*)C([H])=N1 0.000 description 1
- 125000004944 pyrazin-3-yl group Chemical group [H]C1=C([H])N=C(*)C([H])=N1 0.000 description 1
- 125000003226 pyrazolyl group Chemical group 0.000 description 1
- 125000002206 pyridazin-3-yl group Chemical group [H]C1=C([H])C([H])=C(*)N=N1 0.000 description 1
- 125000004940 pyridazin-4-yl group Chemical group N1=NC=C(C=C1)* 0.000 description 1
- DMYLUKNFEYWGCH-UHFFFAOYSA-N pyridazine-3-carboxamide Chemical compound NC(=O)C1=CC=CN=N1 DMYLUKNFEYWGCH-UHFFFAOYSA-N 0.000 description 1
- 125000006514 pyridin-2-ylmethyl group Chemical group [H]C1=C([H])C([H])=C([H])C(=N1)C([H])([H])* 0.000 description 1
- HDOUGSFASVGDCS-UHFFFAOYSA-N pyridin-3-ylmethanamine Chemical compound NCC1=CC=CN=C1 HDOUGSFASVGDCS-UHFFFAOYSA-N 0.000 description 1
- TXQWFIVRZNOPCK-UHFFFAOYSA-N pyridin-4-ylmethanamine Chemical compound NCC1=CC=NC=C1 TXQWFIVRZNOPCK-UHFFFAOYSA-N 0.000 description 1
- 125000000714 pyrimidinyl group Chemical group 0.000 description 1
- 239000001044 red dye Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 description 1
- 229960002855 simvastatin Drugs 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- JXKPEJDQGNYQSM-UHFFFAOYSA-M sodium propionate Chemical compound [Na+].CCC([O-])=O JXKPEJDQGNYQSM-UHFFFAOYSA-M 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- MLTPEFJUDCICLN-UHFFFAOYSA-M sodium;n-[2,6-di(propan-2-yl)phenyl]-n-[[2,4,6-tri(propan-2-yl)phenyl]methylsulfonyl]carbamate Chemical compound [Na+].CC(C)C1=CC(C(C)C)=CC(C(C)C)=C1CS(=O)(=O)N(C([O-])=O)C1=C(C(C)C)C=CC=C1C(C)C MLTPEFJUDCICLN-UHFFFAOYSA-M 0.000 description 1
- 239000007909 solid dosage form Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 238000012289 standard assay Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000007916 tablet composition Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- CWXPZXBSDSIRCS-UHFFFAOYSA-N tert-butyl piperazine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCNCC1 CWXPZXBSDSIRCS-UHFFFAOYSA-N 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- BSAWOLABHUFGBJ-UHFFFAOYSA-N thiomorpholin-3-ol Chemical compound OC1CSCCN1 BSAWOLABHUFGBJ-UHFFFAOYSA-N 0.000 description 1
- 125000005505 thiomorpholino group Chemical group 0.000 description 1
- 125000003944 tolyl group Chemical group 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 239000011345 viscous material Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Quinoline Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Pyrane Compounds (AREA)
- Indole Compounds (AREA)
- Furan Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9363998P | 1998-07-21 | 1998-07-21 | |
| US60093639 | 1998-07-21 | ||
| PCT/US1999/013948 WO2000004892A2 (en) | 1998-07-21 | 1999-06-18 | Coadministration of acat and mmp inhibitors for the treatment of atherosclerotic lesions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU4701799A true AU4701799A (en) | 2000-02-14 |
Family
ID=22239992
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU47017/99A Abandoned AU4701799A (en) | 1998-07-21 | 1999-06-18 | Coadministration of ACAT and MMP inhibitors for the treatment of atherosclerotic lesions |
Country Status (25)
| Country | Link |
|---|---|
| EP (1) | EP1098662A2 (cs) |
| JP (1) | JP2002521328A (cs) |
| KR (1) | KR20010083134A (cs) |
| CN (1) | CN1310629A (cs) |
| AP (1) | AP2001002035A0 (cs) |
| AU (1) | AU4701799A (cs) |
| BG (1) | BG105162A (cs) |
| BR (1) | BR9912296A (cs) |
| CA (1) | CA2335062A1 (cs) |
| CZ (1) | CZ2001126A3 (cs) |
| EA (1) | EA200100153A1 (cs) |
| EE (1) | EE200100046A (cs) |
| HR (1) | HRP20010055A2 (cs) |
| HU (1) | HUP0102880A3 (cs) |
| ID (1) | ID30030A (cs) |
| IL (1) | IL140982A0 (cs) |
| IS (1) | IS5809A (cs) |
| NO (1) | NO20010291D0 (cs) |
| OA (1) | OA11584A (cs) |
| PL (1) | PL346011A1 (cs) |
| SK (1) | SK502001A3 (cs) |
| TR (1) | TR200100205T2 (cs) |
| WO (1) | WO2000004892A2 (cs) |
| YU (1) | YU3501A (cs) |
| ZA (1) | ZA200100294B (cs) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1414848A (zh) * | 1999-11-05 | 2003-04-30 | 沃尼尔·朗伯公司 | Acat抑制剂对斑块破裂的预防 |
| CO5261615A1 (es) | 1999-12-01 | 2003-03-31 | Agouron Pharma | Compuestos, composiciones y metodos para estimular el crecimiento y elongacion de neuronas |
| WO2001044179A1 (en) * | 1999-12-17 | 2001-06-21 | Versicor, Inc. | Novel succinate compounds, compositions and methods of use and preparation |
| CZ2003593A3 (cs) * | 2000-09-01 | 2003-05-14 | Sankyo Company Limited | Farmaceutický přípravek pro léčbu a prevenci xantomu a aterosklerózy |
| GB0100761D0 (en) | 2001-01-11 | 2001-02-21 | Biocompatibles Ltd | Drug delivery from stents |
| DE60321775D1 (de) * | 2002-04-03 | 2008-08-07 | Topotarget Uk Ltd | Carbaminsäurederivate enthaltend eine piperazin verknüpfung als hdac-inhibitoren |
| JP4617449B2 (ja) * | 2002-07-11 | 2011-01-26 | ヴィキュロン ファーマシューティカルズ インコーポレイテッド | 抗菌活性を有するｎ−ヒドロキシアミド誘導体 |
| WO2011092284A1 (en) * | 2010-01-29 | 2011-08-04 | Euroscreen S.A. | Novel amino acid derivatives and their use as gpr43 receptor modulators |
| CN104211695B (zh) * | 2013-06-04 | 2017-04-12 | 中国医学科学院医药生物技术研究所 | 一组胺甲酰基苯磺酰类化合物的用途 |
| US20180000817A1 (en) * | 2015-01-15 | 2018-01-04 | Biocant - Associação De Transferência De Tecnologia | Treatment of hutchinson-gilford progeria syndrome and diseases related to vascular ageing |
| CN106831697B (zh) * | 2017-03-15 | 2019-11-05 | 深圳市康道生物有限公司 | 川榛有效提取成分及其在防治动脉粥样硬化中的应用 |
| WO2025224168A1 (en) | 2024-04-24 | 2025-10-30 | Idorsia Pharmaceuticals Ltd | Aryl sulfone and sulfanone derivatives as orexin receptor modulators |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5366987A (en) * | 1991-08-22 | 1994-11-22 | Warner-Lambert Company | Isoxazolyl-substituted alkyl amide ACAT inhibitors |
| US5491172A (en) * | 1993-05-14 | 1996-02-13 | Warner-Lambert Company | N-acyl sulfamic acid esters (or thioesters), N-acyl sulfonamides, and N-sulfonyl carbamic acid esters (or thioesters) as hypercholesterolemic agents |
| HUP9900668A3 (en) * | 1995-08-04 | 2000-08-28 | Warner Lambert Co | Use of sulfamic acid derivatives, n-acyl sulfonamides or sulfonyl carbamates for the manufacture of a medicament for lowering lipoprotein levels |
| NZ332711A (en) * | 1996-05-17 | 2000-06-23 | Warner Lambert Co | Biphenylsulfonylamino carboxylic acid derivatives as matrix metalloproteinase inhibitors |
| CA2256716A1 (en) * | 1996-09-04 | 1998-03-12 | Warner-Lambert Company | Matrix metalloproteinase inhibitors and their therapeutic uses |
-
1999
- 1999-06-18 OA OA1200100022A patent/OA11584A/en unknown
- 1999-06-18 AU AU47017/99A patent/AU4701799A/en not_active Abandoned
- 1999-06-18 HU HU0102880A patent/HUP0102880A3/hu unknown
- 1999-06-18 IL IL14098299A patent/IL140982A0/xx unknown
- 1999-06-18 EA EA200100153A patent/EA200100153A1/ru unknown
- 1999-06-18 EE EEP200100046A patent/EE200100046A/xx unknown
- 1999-06-18 YU YU3501A patent/YU3501A/sh unknown
- 1999-06-18 CZ CZ2001126A patent/CZ2001126A3/cs unknown
- 1999-06-18 HR HR20010055A patent/HRP20010055A2/hr not_active Application Discontinuation
- 1999-06-18 KR KR1020017000930A patent/KR20010083134A/ko not_active Withdrawn
- 1999-06-18 EP EP99930483A patent/EP1098662A2/en not_active Withdrawn
- 1999-06-18 SK SK50-2001A patent/SK502001A3/sk unknown
- 1999-06-18 ID IDW20010333A patent/ID30030A/id unknown
- 1999-06-18 CA CA002335062A patent/CA2335062A1/en not_active Abandoned
- 1999-06-18 PL PL99346011A patent/PL346011A1/xx unknown
- 1999-06-18 CN CN99808958A patent/CN1310629A/zh active Pending
- 1999-06-18 TR TR2001/00205T patent/TR200100205T2/xx unknown
- 1999-06-18 BR BR9912296-0A patent/BR9912296A/pt not_active IP Right Cessation
- 1999-06-18 WO PCT/US1999/013948 patent/WO2000004892A2/en not_active Ceased
- 1999-06-18 JP JP2000560885A patent/JP2002521328A/ja active Pending
- 1999-06-18 AP APAP/P/2001/002035A patent/AP2001002035A0/en unknown
-
2001
- 2001-01-10 ZA ZA200100294A patent/ZA200100294B/en unknown
- 2001-01-12 IS IS5809A patent/IS5809A/is unknown
- 2001-01-17 BG BG105162A patent/BG105162A/xx unknown
- 2001-01-18 NO NO20010291A patent/NO20010291D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| HRP20010055A2 (en) | 2002-04-30 |
| BG105162A (en) | 2001-12-29 |
| OA11584A (en) | 2004-07-20 |
| ID30030A (id) | 2001-11-01 |
| IS5809A (is) | 2001-01-12 |
| BR9912296A (pt) | 2001-04-17 |
| NO20010291L (no) | 2001-01-18 |
| CN1310629A (zh) | 2001-08-29 |
| AP2001002035A0 (en) | 2001-03-31 |
| EA200100153A1 (ru) | 2001-08-27 |
| PL346011A1 (en) | 2002-01-14 |
| SK502001A3 (en) | 2002-06-04 |
| YU3501A (sh) | 2005-06-10 |
| NO20010291D0 (no) | 2001-01-18 |
| TR200100205T2 (tr) | 2001-05-21 |
| EP1098662A2 (en) | 2001-05-16 |
| KR20010083134A (ko) | 2001-08-31 |
| CZ2001126A3 (cs) | 2002-01-16 |
| WO2000004892A2 (en) | 2000-02-03 |
| HUP0102880A3 (en) | 2002-11-28 |
| CA2335062A1 (en) | 2000-02-03 |
| IL140982A0 (en) | 2002-02-10 |
| ZA200100294B (en) | 2002-01-10 |
| HUP0102880A2 (en) | 2002-06-29 |
| EE200100046A (et) | 2002-06-17 |
| WO2000004892A3 (en) | 2000-05-18 |
| JP2002521328A (ja) | 2002-07-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK5 | Application lapsed section 142(2)(e) - patent request and compl. specification not accepted |