AU4503201A - Resonant optical cavities for high-sensitivity, high-throughput biological sensors and methods - Google Patents

Resonant optical cavities for high-sensitivity, high-throughput biological sensors and methods

Info

Publication number
AU4503201A
AU4503201A AU45032/01A AU4503201A AU4503201A AU 4503201 A AU4503201 A AU 4503201A AU 45032/01 A AU45032/01 A AU 45032/01A AU 4503201 A AU4503201 A AU 4503201A AU 4503201 A AU4503201 A AU 4503201A
Authority
AU
Australia
Prior art keywords
sensitivity
methods
resonant optical
optical cavities
biological sensors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU45032/01A
Other languages
English (en)
Inventor
Steven M. Blair
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Utah Research Foundation UURF
Original Assignee
University of Utah Research Foundation UURF
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Utah Research Foundation UURF filed Critical University of Utah Research Foundation UURF
Publication of AU4503201A publication Critical patent/AU4503201A/en
Abandoned legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G01N21/7746—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the waveguide coupled to a cavity resonator

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nanotechnology (AREA)
  • Plasma & Fusion (AREA)
  • Composite Materials (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Materials Engineering (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Optical Measuring Cells (AREA)
AU45032/01A 1999-10-14 2000-10-12 Resonant optical cavities for high-sensitivity, high-throughput biological sensors and methods Abandoned AU4503201A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15936699P 1999-10-14 1999-10-14
US60159366 1999-10-14
PCT/US2000/041138 WO2001040757A2 (fr) 1999-10-14 2000-10-12 Cavites optiques resonnantes destinees a des biodetecteurs a grande sensibilite et a haut rendement et procedes utilisant ces biodetecteurs

Publications (1)

Publication Number Publication Date
AU4503201A true AU4503201A (en) 2001-06-12

Family

ID=22572303

Family Applications (1)

Application Number Title Priority Date Filing Date
AU45032/01A Abandoned AU4503201A (en) 1999-10-14 2000-10-12 Resonant optical cavities for high-sensitivity, high-throughput biological sensors and methods

Country Status (5)

Country Link
EP (1) EP1221051A4 (fr)
JP (1) JP2003515737A (fr)
AU (1) AU4503201A (fr)
CA (1) CA2384977A1 (fr)
WO (1) WO2001040757A2 (fr)

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US20020061848A1 (en) * 2000-07-20 2002-05-23 Ajay Bhatia Compounds and methods for treatment and diagnosis of chlamydial infection
US6777244B2 (en) * 2000-12-06 2004-08-17 Hrl Laboratories, Llc Compact sensor using microcavity structures
US7283707B1 (en) 2001-07-25 2007-10-16 Oewaves, Inc. Evanescently coupling light between waveguides and whispering-gallery mode optical resonators
US6853479B1 (en) 2001-08-30 2005-02-08 Oewaves, Inc. Apparatus and method for coupling light between an optical resonator and a semiconductor chip with a minimum number of components and alignment steps
US7399445B2 (en) 2002-01-11 2008-07-15 Canon Kabushiki Kaisha Chemical sensor
US6879752B1 (en) 2002-04-03 2005-04-12 Oewaves, Inc. Film spacer for setting the gap between an optical coupler and a whispering-gallery mode optical resonator
US20040184711A1 (en) 2002-06-20 2004-09-23 Kenneth Bradley Optical switches and routers and optical filters
US7781217B2 (en) * 2002-10-02 2010-08-24 California Institute Of Technology Biological and chemical microcavity resonant sensors and methods of detecting molecules
DE60326971D1 (en) 2002-10-11 2009-05-14 Canon Kk Sensor
US20050070027A1 (en) 2003-09-30 2005-03-31 Jacques Gollier Double resonance interrogation of grating-coupled waveguides
US7444045B2 (en) 2003-10-14 2008-10-28 3M Innovative Properties Company Hybrid sphere-waveguide resonators
US7259855B2 (en) 2003-10-14 2007-08-21 3M Innovative Properties Company Porous microsphere resonators
AU2005248419C1 (en) * 2004-05-26 2011-03-10 Genera Biosystems Limited Biosensor using whispering gallery modes in microspheres
MXPA06013728A (es) * 2004-05-26 2007-05-09 Genera Biosystems Pty Ltd Biosensor que usa modos por galeria de murmullos en microesferas.
US7271379B2 (en) * 2004-05-27 2007-09-18 3M Innovative Properties Company Dielectric microcavity fluorosensors excited with a broadband light source
US7352933B2 (en) * 2004-05-27 2008-04-01 3M Innovative Properties Company Dielectric microcavity sensors
US7257279B2 (en) 2004-09-20 2007-08-14 3M Innovative Properties Company Systems and methods for biosensing and microresonator sensors for same
JP4565061B2 (ja) * 2004-10-06 2010-10-20 地方独立行政法人山口県産業技術センター 光分岐回路及びセンサ
JP2007047051A (ja) * 2005-08-10 2007-02-22 Nippon Telegr & Teleph Corp <Ntt> 多層屈折率測定装置
US7389025B2 (en) * 2006-03-29 2008-06-17 3M Innovative Properties Company Coupling light into microresonators
US7532790B2 (en) 2006-03-29 2009-05-12 3M Innovative Properties Company Method of coupling light into microresonators
US7486855B2 (en) 2006-12-27 2009-02-03 3M Innovative Properties Company Optical microresonator
US7933022B2 (en) 2006-12-01 2011-04-26 3M Innovative Properties Company Integrated optical disk resonator
US7702202B2 (en) 2006-12-01 2010-04-20 3M Innovative Properties Company Optical microresonator
US7512298B2 (en) 2006-12-01 2009-03-31 3M Innovative Properties Company Optical sensing methods
US7903240B2 (en) 2006-12-01 2011-03-08 3M Innovative Properties Company Optical sensing device
US7903906B2 (en) 2006-12-01 2011-03-08 3M Innovative Properties Company Optical sensing devices and methods
CA2601836C (fr) * 2007-05-21 2017-02-28 Adam Densmore Biocapteur de guide d'onde photonique en silicium
US7796262B1 (en) 2007-05-31 2010-09-14 Nomadics, Inc. Integrated optical resonator device for measuring chemical and biological analyte concentrations
JP5424229B2 (ja) * 2007-09-28 2014-02-26 独立行政法人産業技術総合研究所 酸化膜を用いた光導波モードセンサー及びその製造方法
US8107081B2 (en) 2007-10-01 2012-01-31 California Institute Of Technology Micro-cavity gas and vapor sensors and detection methods
EP2208052A2 (fr) * 2007-11-06 2010-07-21 Nxp B.V. Dispositif biocapteur et procédé de détection de particules biologiques
US8092855B2 (en) 2007-11-28 2012-01-10 California Institute Of Technology Click chemistry surface functionalization for resonant micro-cavity sensors
JP5288143B2 (ja) * 2007-12-31 2013-09-11 富士レビオ株式会社 キャビティーモード光学検出の為のマイクロ共鳴体のクラスター
US8593638B2 (en) 2008-10-02 2013-11-26 California Institute Of Technology Split frequency sensing methods and systems
JP2012507706A (ja) * 2008-11-05 2012-03-29 富士レビオ株式会社 生物学的材料の生物化学的及び／又は生物力学的変化の検知方法及び生物学的材料の分析方法
US8368899B2 (en) * 2009-08-18 2013-02-05 Ofs Fitel, Llc Coiled evanescent optical sensor
JPWO2013080432A1 (ja) * 2011-11-28 2015-04-27 ソニー株式会社 ケミカルセンサ、ケミカルセンサモジュール、化学物質検出装置及び化学物質検出方法
CN102841054B (zh) * 2012-09-27 2015-07-29 复旦大学 一种耦合微腔光子分子的生物化学传感器
CN107014777B (zh) * 2017-03-30 2019-12-03 电子科技大学 聚合物微盘与液体微腔级联的高灵敏度生化传感器
CN110763654B (zh) * 2019-11-29 2023-03-17 江西师范大学 一种倾斜型高品质光学传感器及其制备方法
CN115078320A (zh) * 2022-05-17 2022-09-20 南京邮电大学 一种降低微腔核酸探测极限的方法及探测装置

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GB8902803D0 (en) * 1989-02-08 1989-03-30 Plessey Co Plc A method for detecting optical phase changes during biosensor operation,biosensing apparatus and a biosensor adapted for use in the same
US5244636A (en) * 1991-01-25 1993-09-14 Trustees Of Tufts College Imaging fiber optic array sensors, apparatus, and methods for concurrently detecting multiple analytes of interest in a fluid sample
CA2069537A1 (fr) * 1991-06-07 1992-12-08 Thomas A. Cook Systeme d'analyse a sorties multiples utilisant un capteur d'ondes evanescentes
US5745231A (en) * 1995-06-12 1998-04-28 American Research Corporation Of Virginia Method of fluorescence analysis comprising evanescent wave excitation and out-of-plane photodetection
US6287871B1 (en) * 1996-03-19 2001-09-11 University Of Utah Research Foundation System for determining analyte concentration
US5943136A (en) * 1997-10-31 1999-08-24 The United States Of America As Represented By The Secretary Of Commerce Intra-cavity total reflection for high sensitivity measurement of optical properties
US5835231A (en) * 1997-10-31 1998-11-10 The United States Of America As Represented By The Secretary Of Commerce Broad band intra-cavity total reflection chemical sensor
EP1066507B1 (fr) * 1998-01-23 2002-07-03 Torsana Biosensor A/S Detection d'une substance par les modifications de l'indice de refraction
US6210910B1 (en) * 1998-03-02 2001-04-03 Trustees Of Tufts College Optical fiber biosensor array comprising cell populations confined to microcavities

Also Published As

Publication number Publication date
EP1221051A2 (fr) 2002-07-10
WO2001040757A3 (fr) 2002-03-14
WO2001040757A2 (fr) 2001-06-07
EP1221051A4 (fr) 2003-03-05
CA2384977A1 (fr) 2001-06-07
JP2003515737A (ja) 2003-05-07

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase