AU4397097A - Soluble polypeptides with activity of the ns3 serine protease of hepatitis c virus, and process for their preparation and isolation - Google Patents

Soluble polypeptides with activity of the ns3 serine protease of hepatitis c virus, and process for their preparation and isolation

Info

Publication number
AU4397097A
AU4397097A AU43970/97A AU4397097A AU4397097A AU 4397097 A AU4397097 A AU 4397097A AU 43970/97 A AU43970/97 A AU 43970/97A AU 4397097 A AU4397097 A AU 4397097A AU 4397097 A AU4397097 A AU 4397097A
Authority
AU
Australia
Prior art keywords
hepatitis
virus
isolation
activity
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU43970/97A
Other languages
English (en)
Inventor
Stefano Colloca
Raffaele De Francesco
Maria Chiara Nardi
Christian Steinkuhler
Licia Tomei
Anna Tramontano
Andrea Urbani
Rosa Letizia Vitale
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Istituto di Ricerche di Biologia Molecolare P Angeletti SpA
Original Assignee
Istituto di Ricerche di Biologia Molecolare P Angeletti SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Istituto di Ricerche di Biologia Molecolare P Angeletti SpA filed Critical Istituto di Ricerche di Biologia Molecolare P Angeletti SpA
Publication of AU4397097A publication Critical patent/AU4397097A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/503—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses
    • C12N9/506—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses derived from RNA viruses

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU43970/97A 1996-09-17 1997-09-17 Soluble polypeptides with activity of the ns3 serine protease of hepatitis c virus, and process for their preparation and isolation Abandoned AU4397097A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITRM96A0632 1996-09-17
ITRM960632 IT1285158B1 (it) 1996-09-17 1996-09-17 Polipeptidi solubili con l'attivita' di serino-proteasi di ns3 del virus dell'epatite c, e procedimento per la loro preparazione e il
PCT/IT1997/000228 WO1998012308A1 (fr) 1996-09-17 1997-09-17 Polypeptides solubles a activite de serine protease ns3 du virus de l'hepatite c et leur procede de preparation et d'isolement

Publications (1)

Publication Number Publication Date
AU4397097A true AU4397097A (en) 1998-04-14

Family

ID=11404423

Family Applications (1)

Application Number Title Priority Date Filing Date
AU43970/97A Abandoned AU4397097A (en) 1996-09-17 1997-09-17 Soluble polypeptides with activity of the ns3 serine protease of hepatitis c virus, and process for their preparation and isolation

Country Status (6)

Country Link
EP (1) EP0950094A1 (fr)
JP (1) JP2001500735A (fr)
AU (1) AU4397097A (fr)
CA (1) CA2264487A1 (fr)
IT (1) IT1285158B1 (fr)
WO (1) WO1998012308A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9806815D0 (en) * 1998-03-30 1998-05-27 Hoffmann La Roche Amino acid derivatives
EP1141255A4 (fr) 1999-01-08 2002-09-11 Bristol Myers Squibb Co Formes modifiees de la protease ns3 du virus de l'hepatite c
CZ2003195A3 (cs) 2000-07-21 2003-04-16 Schering Corporation Peptidové inhibitory serinové proteázy NS3 a farmaceutický prostředek
BR0112540A (pt) 2000-07-21 2003-06-24 Schering Corp Peptìdios como inibidores da ns-3-serina protease do vìrus da hepatite c
US7244721B2 (en) 2000-07-21 2007-07-17 Schering Corporation Peptides as NS3-serine protease inhibitors of hepatitis C virus
US7494660B2 (en) 2003-10-27 2009-02-24 Vertex Pharmaceuticals Incorporated HCV NS3-NS4A protease resistance mutants
US7705138B2 (en) 2005-11-11 2010-04-27 Vertex Pharmaceuticals Incorporated Hepatitis C virus variants
HUE029110T2 (en) 2009-07-31 2017-02-28 Baxalta GmbH Cell culture medium for ADAMTS protein expression

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0571554A1 (fr) * 1991-01-14 1993-12-01 James N. Gamble Institute Of Medical Research Polypeptides immunogeniques structuraux de base ayant des epitopes pour vhc, anticorps, sequences de polynucleotides, vaccins et methodes
US5843752A (en) * 1995-05-12 1998-12-01 Schering Corporation Soluble active hepatitis C virus protease
IT1277914B1 (it) * 1995-08-22 1997-11-12 Angeletti P Ist Richerche Bio Procedimento per produrre - in forma pura e in quantita' elevate - polipeptidi con l'attivita' proteolitica della proteasi ns3 di hcv, e

Also Published As

Publication number Publication date
WO1998012308A1 (fr) 1998-03-26
ITRM960632A1 (it) 1998-03-17
JP2001500735A (ja) 2001-01-23
CA2264487A1 (fr) 1998-03-26
IT1285158B1 (it) 1998-06-03
EP0950094A1 (fr) 1999-10-20

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Legal Events

Date Code Title Description
MK5 Application lapsed section 142(2)(e) - patent request and compl. specification not accepted