EP1141255A4 - Formes modifiees de la protease ns3 du virus de l'hepatite c - Google Patents

Formes modifiees de la protease ns3 du virus de l'hepatite c

Info

Publication number
EP1141255A4
EP1141255A4 EP00903153A EP00903153A EP1141255A4 EP 1141255 A4 EP1141255 A4 EP 1141255A4 EP 00903153 A EP00903153 A EP 00903153A EP 00903153 A EP00903153 A EP 00903153A EP 1141255 A4 EP1141255 A4 EP 1141255A4
Authority
EP
European Patent Office
Prior art keywords
hepatitis
protease
virus
modified forms
modified
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00903153A
Other languages
German (de)
English (en)
Other versions
EP1141255A1 (fr
Inventor
Michael Wittekind
Steven Weinheimer
Yaqun Zhang
Valentina Goldfarb
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of EP1141255A1 publication Critical patent/EP1141255A1/fr
Publication of EP1141255A4 publication Critical patent/EP1141255A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/503—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses
    • C12N9/506—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses derived from RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
EP00903153A 1999-01-08 2000-01-06 Formes modifiees de la protease ns3 du virus de l'hepatite c Withdrawn EP1141255A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11527199P 1999-01-08 1999-01-08
US115271P 1999-01-08
PCT/US2000/000345 WO2000040707A1 (fr) 1999-01-08 2000-01-06 Formes modifiees de la protease ns3 du virus de l'hepatite c

Publications (2)

Publication Number Publication Date
EP1141255A1 EP1141255A1 (fr) 2001-10-10
EP1141255A4 true EP1141255A4 (fr) 2002-09-11

Family

ID=22360293

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00903153A Withdrawn EP1141255A4 (fr) 1999-01-08 2000-01-06 Formes modifiees de la protease ns3 du virus de l'hepatite c

Country Status (7)

Country Link
US (2) US6333186B1 (fr)
EP (1) EP1141255A4 (fr)
JP (1) JP2002534084A (fr)
AU (1) AU2494100A (fr)
CA (1) CA2359971A1 (fr)
IL (1) IL143798A0 (fr)
WO (1) WO2000040707A1 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050074465A1 (en) * 1999-11-24 2005-04-07 Michael Houghton HCV fusion proteins with modified NS3 domains
US6986892B1 (en) * 1999-11-24 2006-01-17 Chiron Corporation Immunogenic Hepatitis C virus non-structural polypeptides
US7491808B2 (en) * 2000-06-15 2009-02-17 Novartis Vaccines And Diagnostics, Inc. HCV non-structural protein mutants and uses thereof
AU2003202914A1 (en) * 2002-01-07 2003-07-24 Sequoia Pharmaceuticals Broad spectrum inhibitors
KR20050086843A (ko) * 2002-11-26 2005-08-30 트리펩 아베 증강인자 성분으로서의 ｃ형 간염 바이러스 비구조 단백질4ａ(ｎｓ4ａ)
JP5070055B2 (ja) * 2004-08-27 2012-11-07 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド 改変タンパク分解性切断部位を有するｈｃｖ多エピトープ融合抗原およびその使用
US7625724B2 (en) * 2005-08-25 2009-12-01 Board Of Regents, The University Of Texas System MAVS in the prevention and treatment of viral diseases
WO2016160046A1 (fr) * 2015-03-27 2016-10-06 Ortho-Clinical Diagnostics, Inc. Polypeptides ns4a/ns3 modifié du vhc et leurs utilisations
JP6841428B2 (ja) * 2015-06-10 2021-03-10 公立大学法人 富山県立大学 活性型変異酵素の製造方法および新規活性型変異酵素、並びに可溶性化変異タンパク質の製造方法
CN113330520A (zh) 2018-12-04 2021-08-31 华盛顿大学 用于控制蛋白质功能和相互作用的试剂和方法
CA3135428A1 (fr) 2019-03-29 2020-10-08 Trustees Of Boston University Modulation de recepteur antigenique chimerique (car)
WO2021009692A1 (fr) 2019-07-15 2021-01-21 Medimmune Limited Systèmes tripartites pour la dimérisation de protéines et procédés d'utilisation
US11572565B2 (en) 2020-07-21 2023-02-07 Trustees Of Boston University Inducible control of gene expression

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE433460T1 (de) 1990-04-04 2009-06-15 Novartis Vaccines & Diagnostic Protease von hepatitis c virus
IT1272179B (it) 1994-02-23 1997-06-16 Angeletti P Ist Richerche Bio Metodologia per riprodurre in vitro l'attivita' proteolitica della proteasi ns3 del virus hcv.
US5843752A (en) 1995-05-12 1998-12-01 Schering Corporation Soluble active hepatitis C virus protease
IT1277914B1 (it) 1995-08-22 1997-11-12 Angeletti P Ist Richerche Bio Procedimento per produrre - in forma pura e in quantita' elevate - polipeptidi con l'attivita' proteolitica della proteasi ns3 di hcv, e
US6153579A (en) 1996-09-12 2000-11-28 Vertex Pharmaceuticals, Incorporated Crystallizable compositions comprising a hepatitis C virus NS3 protease domain/NS4A complex
IT1285158B1 (it) 1996-09-17 1998-06-03 Angeletti P Ist Richerche Bio Polipeptidi solubili con l'attivita' di serino-proteasi di ns3 del virus dell'epatite c, e procedimento per la loro preparazione e il

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
SALI D L ET AL: "Serine protease of Hepatitis C virus expressed in insect cells as the NS3/4A complex", BIOCHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, PA, US, vol. 37, no. 10, 1998, pages 3392 - 3401, XP002159433, ISSN: 0006-2960 *
See also references of WO0040707A1 *
SUDO K ET AL: "ESTABLISHMENT OF AN IN VITRO ASSAY SYSTEM FOR SCREENING HEPATITIS CVIRUS PROTEASE INHIBITORS USING HIGH PERFORMANCE LIQUID CHROMATOGRAPHY", ANTIVIRAL RESEARCH, ELSEVIER SCIENCE BV., AMSTERDAM, NL, vol. 32, no. 1, 1996, pages 9 - 18, XP000608038, ISSN: 0166-3542 *
YASUAKI SHIMIZU ET AL: "IDENRIFICATION OF THE SEQUENCE ON NS4A REQUIRED FOR ENHANCED CLEAVAGE OF THE NS5A/5B SITE BY HEPATITIS C VIRUS NS3 PROTEASE", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 70, no. 1, 1996, pages 127 - 132, XP000577885, ISSN: 0022-538X *

Also Published As

Publication number Publication date
WO2000040707A1 (fr) 2000-07-13
CA2359971A1 (fr) 2000-07-13
US6800456B2 (en) 2004-10-05
US6333186B1 (en) 2001-12-25
JP2002534084A (ja) 2002-10-15
AU2494100A (en) 2000-07-24
EP1141255A1 (fr) 2001-10-10
IL143798A0 (en) 2002-04-21
US20020106642A1 (en) 2002-08-08

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