AU3731393A - Process for the preparation of 0-(4-(4-piperidinyl)butyl)-tyrosine derivatives as fibrinogen receptor antagonists - Google Patents

Process for the preparation of 0-(4-(4-piperidinyl)butyl)-tyrosine derivatives as fibrinogen receptor antagonists

Info

Publication number
AU3731393A
AU3731393A AU37313/93A AU3731393A AU3731393A AU 3731393 A AU3731393 A AU 3731393A AU 37313/93 A AU37313/93 A AU 37313/93A AU 3731393 A AU3731393 A AU 3731393A AU 3731393 A AU3731393 A AU 3731393A
Authority
AU
Australia
Prior art keywords
piperidinyl
butyl
preparation
receptor antagonists
fibrinogen receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU37313/93A
Other languages
English (en)
Inventor
John Y.L. Chung
David L. Hughes
Dalian Zhao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of AU3731393A publication Critical patent/AU3731393A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU37313/93A 1992-02-28 1993-02-24 Process for the preparation of 0-(4-(4-piperidinyl)butyl)-tyrosine derivatives as fibrinogen receptor antagonists Abandoned AU3731393A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84369092A 1992-02-28 1992-02-28
US843690 1992-02-28

Publications (1)

Publication Number Publication Date
AU3731393A true AU3731393A (en) 1993-09-13

Family

ID=25290743

Family Applications (1)

Application Number Title Priority Date Filing Date
AU37313/93A Abandoned AU3731393A (en) 1992-02-28 1993-02-24 Process for the preparation of 0-(4-(4-piperidinyl)butyl)-tyrosine derivatives as fibrinogen receptor antagonists

Country Status (12)

Country Link
US (1) US5312923A (enExample)
CN (1) CN1040534C (enExample)
AU (1) AU3731393A (enExample)
CZ (1) CZ282770B6 (enExample)
FI (1) FI106024B (enExample)
HU (1) HU223578B1 (enExample)
RO (1) RO115724B1 (enExample)
RU (1) RU2113432C1 (enExample)
SK (1) SK280164B6 (enExample)
TW (1) TW232008B (enExample)
WO (1) WO1993016994A1 (enExample)
YU (1) YU13293A (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL121202A (en) 1996-07-01 2001-08-26 Lilly Co Eli Hypoglycemic and hypolipidemic compounds, process for their preparation, pharmaceutial compositions comprising same, and uses thereof
US6623981B2 (en) * 1998-01-27 2003-09-23 Bristol-Myers Squibb Company Detection of patients at risk for developing integrin antagonist/agonist mediated disease states
GB9812088D0 (en) * 1998-06-05 1998-08-05 Celltech Therapeutics Ltd Chemical compounds
ES2221410T3 (es) * 1998-07-31 2004-12-16 Eli Lilly And Company Derivados heterociclil sulfamida.
US6518244B2 (en) 2000-03-09 2003-02-11 Intimax Corporation Combinations of heparin cofactor II agonist and platelet IIb/IIIa antagonist, and uses thereof
CN102241622A (zh) * 2010-05-13 2011-11-16 上海医药工业研究院 一种制备盐酸替罗非班的方法
CN101870672B (zh) * 2010-07-05 2011-08-24 武汉同源药业有限公司 一种化合物盐酸替罗非班的制备方法
CN101898998B (zh) * 2010-08-25 2012-09-19 武汉武药科技有限公司 一种盐酸替罗非班中间体的制备方法
CN102875449B (zh) * 2012-10-15 2014-08-06 天津南开允公医药科技有限公司 盐酸替罗非班异构体分离方法及d构型盐酸替罗非班定量方法
CN103848775A (zh) * 2012-11-29 2014-06-11 上海信谊药厂有限公司 制备盐酸替罗非班的方法
CN109608387A (zh) * 2019-01-02 2019-04-12 海门慧聚药业有限公司 盐酸替罗非班的制备
CN111100066B (zh) * 2019-11-29 2021-07-30 石药集团恩必普药业有限公司 一种盐酸替罗非班中间体及盐酸替罗非班的制备方法
CN115181058B (zh) * 2021-04-01 2024-06-11 武汉武药科技有限公司 组合物及其质量控制方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3412138A (en) * 1965-12-17 1968-11-19 Ibm Alkylation of tyrosine
NZ239846A (en) * 1990-09-27 1994-11-25 Merck & Co Inc Sulphonamide derivatives and pharmaceutical compositions thereof

Also Published As

Publication number Publication date
HU223578B1 (hu) 2004-09-28
SK102494A3 (en) 1995-04-12
CN1040534C (zh) 1998-11-04
FI943934L (fi) 1994-10-05
FI943934A0 (fi) 1994-08-26
HU9402462D0 (en) 1994-10-28
RU2113432C1 (ru) 1998-06-20
SK280164B6 (sk) 1999-09-10
RU94041212A (ru) 1996-06-20
FI106024B (fi) 2000-11-15
CZ205694A3 (en) 1995-10-18
TW232008B (enExample) 1994-10-11
YU13293A (sh) 1997-07-31
CZ282770B6 (cs) 1997-10-15
HUT70545A (en) 1995-10-30
CN1076442A (zh) 1993-09-22
RO115724B1 (ro) 2000-05-30
US5312923A (en) 1994-05-17
WO1993016994A1 (en) 1993-09-02

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