AU3375697A - Cc chemokine receptor 5, antibodies thereto, transgenic animals - Google Patents

Cc chemokine receptor 5, antibodies thereto, transgenic animals

Info

Publication number
AU3375697A
AU3375697A AU33756/97A AU3375697A AU3375697A AU 3375697 A AU3375697 A AU 3375697A AU 33756/97 A AU33756/97 A AU 33756/97A AU 3375697 A AU3375697 A AU 3375697A AU 3375697 A AU3375697 A AU 3375697A
Authority
AU
Australia
Prior art keywords
antibodies
transgenic animals
chemokine receptor
chemokine
receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU33756/97A
Other languages
English (en)
Inventor
Ghalib Alkhatib
Edward A. Berger
Christopher C. Broder
Christophe Combadiere
Yu Feng
Paul E Kennedy
Philip M Murphy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Department of Health and Human Services
Original Assignee
US Department of Health and Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21788278&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU3375697(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by US Department of Health and Human Services filed Critical US Department of Health and Human Services
Publication of AU3375697A publication Critical patent/AU3375697A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7158—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for chemokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • AIDS & HIV (AREA)
  • Public Health (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU33756/97A 1996-05-28 1997-05-28 Cc chemokine receptor 5, antibodies thereto, transgenic animals Abandoned AU3375697A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1850896P 1996-05-28 1996-05-28
US60018508 1996-05-28
PCT/US1997/009586 WO1997045543A2 (fr) 1996-05-28 1997-05-28 Recepteur 5 de cc chemokine, anticorps diriges contre ce dernier et animaux transgeniques

Publications (1)

Publication Number Publication Date
AU3375697A true AU3375697A (en) 1998-01-05

Family

ID=21788278

Family Applications (1)

Application Number Title Priority Date Filing Date
AU33756/97A Abandoned AU3375697A (en) 1996-05-28 1997-05-28 Cc chemokine receptor 5, antibodies thereto, transgenic animals

Country Status (4)

Country Link
US (6) US20030195348A1 (fr)
EP (1) EP0975749A2 (fr)
AU (1) AU3375697A (fr)
WO (1) WO1997045543A2 (fr)

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US6743594B1 (en) 1995-06-06 2004-06-01 Human Genome Sciences, Inc. Methods of screening using human G-protein chemokine receptor HDGNR10 (CCR5)
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US6265184B1 (en) 1995-12-20 2001-07-24 Icos Corporation Polynucleotides encoding chemokine receptor 88C
US7118859B2 (en) * 1996-01-17 2006-10-10 Progenics Pharmaceuticals, Inc. Methods for inhibiting HIV-1 infection
EP0883687B1 (fr) * 1996-03-01 2004-10-27 Euroscreen S.A. Recepteur-5 de chimiokine cc, recepteur de chimiokines cc, leurs derives et leurs applications
US6344545B1 (en) * 1996-06-14 2002-02-05 Progenics Pharmaceuticals, Inc. Method for preventing HIV-1 infection of CD4+ cells
US7858298B1 (en) 1996-04-01 2010-12-28 Progenics Pharmaceuticals Inc. Methods of inhibiting human immunodeficiency virus type 1 (HIV-1) infection through the administration of CCR5 chemokine receptor antagonists
US5939320A (en) * 1996-05-20 1999-08-17 New York University G-coupled receptors associated with macrophage-trophic HIV, and diagnostic and therapeutic uses thereof
US6258527B1 (en) 1996-05-20 2001-07-10 The Aaron Diamond Aids Research Center Methods of identifying g-coupled receptors associated with macrophage-trophic HIV, and diagnostic and therapeutic uses thereof
US20040086528A1 (en) * 1996-06-14 2004-05-06 Progenics Pharmaceuticals, Inc. Uses of a chemokine receptor for inhibiting HIV-1 infection
US6057102A (en) * 1996-08-08 2000-05-02 The Aaron Diamond Aids Research Center HIV coreceptor mutants
US6388055B1 (en) 1996-10-03 2002-05-14 Smithkline Beecham Corporation Mouse CC-CKR5 receptor polypeptide
US6528625B1 (en) * 1996-10-28 2003-03-04 Millennium Pharmaceuticals, Inc. Anti-CCR5 antibodies and kits comprising same
US6153431A (en) * 1997-05-30 2000-11-28 Fond Mondiale Rech & Prev Sida Human immunodeficiency virus co-receptor variants associated with resistance to virus infection
AU3044697A (en) * 1997-06-24 1999-01-04 Norman Godin A composition for specific immunoprotection and method for obtaining said comp osition
US7067117B1 (en) 1997-09-11 2006-06-27 Cambridge University Technical Services, Ltd. Compounds and methods to inhibit or augment an inflammatory response
WO1999014378A2 (fr) * 1997-09-19 1999-03-25 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Procedes d'utilisation de l'interleukine 4 (il-4) pour traiter l 'infection par le virus de l'immunodeficience humaine
FR2771423A1 (fr) * 1997-11-21 1999-05-28 Transgene Sa Vecteurs permettant d'inhiber ou retarder la liaison d'un virus d'immunodeficience et/ou sa penetration dans une cellule cible
DE69921609T2 (de) 1998-01-15 2005-10-27 King's College London Ribozymale nukleinsäure die ccr5 oder cxcr4 schneiden
US6100087A (en) * 1998-03-11 2000-08-08 City Of Hope Ribozymes targeted to human CCR5 mRNA
EP1100527A2 (fr) 1998-06-01 2001-05-23 University Of Maryland Biotechnology Institute Complexes d'antagonistes a ligand pour recepteur et leur application dans le traitement ou la prophylaxie de maladies declenchees par un recepteur
US6475718B2 (en) 1998-09-08 2002-11-05 Schering Aktiengesellschaft Methods and compositions for modulating the interaction between the APJ receptor and the HIV virus
US20080015348A1 (en) * 1998-12-16 2008-01-17 Progenics Pharmaceuticals, Inc. Nucleic acids encoding polypeptides of anti-CCR5 antibodies
EP2088158A3 (fr) * 1998-12-16 2010-01-20 Progenics Pharmaceuticals, Inc. Anticorp monoclonal contre le récepteur CCR5 de chimokine.
US20040228869A1 (en) * 1998-12-16 2004-11-18 Progenics Pharmaceuticals, Inc. Synergistic inhibition of HIV-1 fusion and attachment, compositions and antibodies thereto
EP1900376A3 (fr) * 1998-12-16 2008-10-15 Progenics Pharmaceuticals, Inc. Inhibition synergique de la fusion et la fixation de l'HIV-1 sur des compositions et anticorps
AU6941000A (en) * 1999-08-27 2001-03-26 United States Of America, Represented By The Secretary, Department Of Health And Human Services, The Polypeptides that bind hiv gp120 and related nucleic acids, antibodies, compositions, and methods of use
US7304127B2 (en) 1999-08-27 2007-12-04 United States Of America As Represented By The Secretary, Department Of Health And Human Services Polypeptides that bind HIV gp120 and related nucleic acids, antibodies, compositions, and methods of use
CA2389196A1 (fr) 1999-10-28 2001-05-03 Nissui Pharmaceutical Co., Ltd. Peptides cycliques et vaccins contre le sida
GB9930443D0 (en) 1999-12-22 2000-02-16 King S College London Novel use of heat shock proteins
US7138119B2 (en) 2000-09-15 2006-11-21 Progenics Pharmaceuticals, Inc. Compositions and methods for inhibition of HIV-1 infection
EP1207202A1 (fr) * 2000-11-16 2002-05-22 Mölling, Karin, Inst. für med. Virologie der Uni. Zürich Molécules d'acide nucléique interagissant avec le récepteur de chémokines et d'autres membres de la famille de récepteurs de chémokines
US7175988B2 (en) 2001-02-09 2007-02-13 Human Genome Sciences, Inc. Human G-protein Chemokine Receptor (CCR5) HDGNR10
US7060273B2 (en) * 2001-04-06 2006-06-13 Progenics Pharmaceuticals, Inc. Methods for inhibiting HIV-1 infection
US7393934B2 (en) 2001-12-21 2008-07-01 Human Genome Sciences, Inc. Human G-protein chemokine receptor (CCR5) HDGNR10
US7122185B2 (en) 2002-02-22 2006-10-17 Progenics Pharmaceuticals, Inc. Anti-CCR5 antibody
WO2004070002A2 (fr) * 2002-11-18 2004-08-19 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention Lignees cellulaires et sequences d'acides nucleiques hotes associees a des maladies infectieuses
WO2004072233A2 (fr) * 2003-02-10 2004-08-26 Regeneron Pharmaceuticals, Inc. Proteines de fusion specifiques au hiv et methodes d'utilisation therapeutique et de diagnostic
WO2005105841A2 (fr) 2004-03-12 2005-11-10 Human Genome Sciences, Inc. Récepteur humain (ccr5) hdgnr10 de chimiokine de la protéine g
TW200720289A (en) * 2005-04-01 2007-06-01 Hoffmann La Roche Antibodies against CCR5 and uses thereof
ES2438019T3 (es) * 2005-07-22 2014-01-15 Cytodyn, Inc. Procedimientos para reducir la carga viral en pacientes infectados por el VIH-1
EP1934605B1 (fr) * 2005-09-22 2014-03-26 Prosci Incorporated Polypeptides glycosyles produits dans des mutants de levure et methodes d'utilisation
CA2635722A1 (fr) * 2006-02-03 2007-08-09 Nelson M. Karp Modele animal pour une pathologie induite par le vih
ZA200806722B (en) * 2006-02-03 2010-02-24 Nelson M Karp Animal model for HIV induced disease
US20100275278A1 (en) * 2006-02-03 2010-10-28 Karp Nelson M Animal model for hiv induced disease
WO2008019817A1 (fr) 2006-08-17 2008-02-21 F. Hoffmann-La Roche Ag Conjugué d'un anticorps dirigé contre le ccr5 et peptide antifusiogène
TW200817438A (en) * 2006-08-17 2008-04-16 Hoffmann La Roche A conjugate of an antibody against CCR5 and an antifusogenic peptide
JP4960459B2 (ja) 2006-09-29 2012-06-27 エフ．ホフマン−ラ ロシュ アーゲー Ｃｃｒ５に対する抗体およびその使用
PE20081785A1 (es) * 2007-02-19 2009-01-12 Novartis Ag Derivados de ciclohexil-amida del acido aril carboxilico
TW200902544A (en) 2007-03-13 2009-01-16 Hoffmann La Roche Peptide-complement conjugates
US20090074766A1 (en) * 2007-09-14 2009-03-19 Ketas Thomas J Methods of inhibiting HIV-2 infection
WO2013024022A1 (fr) 2011-08-12 2013-02-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Méthodes et compositions pharmaceutiques pour traiter l'hypertension pulmonaire
US11629196B2 (en) 2020-04-27 2023-04-18 Incelldx, Inc. Method of treating SARS-CoV-2-associated hypercytokinemia by administering a human monoclonal antibody (PRO-140) that inhibits CCR5/CCL5 binding interactions

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EP0310136B1 (fr) * 1987-10-02 1997-02-26 The Rockefeller University Médiateur inflammatoire dérivé des macrophages (MIP-1 alpha et MIP-1 bêta)
US5440021A (en) * 1991-03-29 1995-08-08 Chuntharapai; Anan Antibodies to human IL-8 type B receptor
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EP0630405B1 (fr) 1992-11-17 1998-04-08 Icos Corporation Nouveau recepteur V28 du genre sept-transmembrane
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US6743594B1 (en) * 1995-06-06 2004-06-01 Human Genome Sciences, Inc. Methods of screening using human G-protein chemokine receptor HDGNR10 (CCR5)
US6265184B1 (en) * 1995-12-20 2001-07-24 Icos Corporation Polynucleotides encoding chemokine receptor 88C
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EP0883687B1 (fr) * 1996-03-01 2004-10-27 Euroscreen S.A. Recepteur-5 de chimiokine cc, recepteur de chimiokines cc, leurs derives et leurs applications
US6344545B1 (en) * 1996-06-14 2002-02-05 Progenics Pharmaceuticals, Inc. Method for preventing HIV-1 infection of CD4+ cells
AU728512B2 (en) * 1996-04-02 2001-01-11 Progenics Pharmaceuticals, Inc. Method for preventing HIV-1 infection of CD4+ cells
US5939320A (en) * 1996-05-20 1999-08-17 New York University G-coupled receptors associated with macrophage-trophic HIV, and diagnostic and therapeutic uses thereof
EP0956044A4 (fr) 1996-06-14 2005-01-05 Progenics Pharm Inc Utilisations d'un recepteur de la chemokine dans l'inhibition de l'infection par le vih-1
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Also Published As

Publication number Publication date
US20110117101A1 (en) 2011-05-19
US8198042B2 (en) 2012-06-12
US7374872B2 (en) 2008-05-20
US20030195348A1 (en) 2003-10-16
US20040259785A1 (en) 2004-12-23
EP0975749A2 (fr) 2000-02-02
US20080241167A1 (en) 2008-10-02
US7151087B2 (en) 2006-12-19
US20050118677A1 (en) 2005-06-02
WO1997045543A2 (fr) 1997-12-04
WO1997045543A3 (fr) 1998-05-07
US20070087990A1 (en) 2007-04-19

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