CA2635722A1 - Modele animal pour une pathologie induite par le vih - Google Patents

Info

Publication number

CA2635722A1

CA2635722A1 CA002635722A CA2635722A CA2635722A1 CA 2635722 A1 CA2635722 A1 CA 2635722A1 CA 002635722 A CA002635722 A CA 002635722A CA 2635722 A CA2635722 A CA 2635722A CA 2635722 A1 CA2635722 A1 CA 2635722A1

Authority

CA

Canada

Prior art keywords

hiv

proteins

animal

protein

cellular

Prior art date

2006-02-03

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

• Espacenet
• Global Dossier
• CIPO
• Discuss

• 238000010171 animal model Methods 0.000 title claims abstract description 26
• 201000010099 disease Diseases 0.000 title abstract description 11
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract description 11
• 108090000623 proteins and genes Proteins 0.000 claims abstract description 278
• 102000004169 proteins and genes Human genes 0.000 claims abstract description 256
• 241001465754 Metazoa Species 0.000 claims abstract description 83
• 210000004837 gut-associated lymphoid tissue Anatomy 0.000 claims abstract description 31
• 239000000203 mixture Substances 0.000 claims abstract description 30
• 241000700605 Viruses Species 0.000 claims abstract description 26
• 230000028993 immune response Effects 0.000 claims abstract description 23
• 238000004519 manufacturing process Methods 0.000 claims abstract description 12
• 235000018102 proteins Nutrition 0.000 claims description 244
• 241000725303 Human immunodeficiency virus Species 0.000 claims description 149
• 210000004027 cell Anatomy 0.000 claims description 94
• 241000713772 Human immunodeficiency virus 1 Species 0.000 claims description 80
• 230000001413 cellular effect Effects 0.000 claims description 73
• 210000002845 virion Anatomy 0.000 claims description 67
• 230000027455 binding Effects 0.000 claims description 63
• 101710149951 Protein Tat Proteins 0.000 claims description 58
• 108020004414 DNA Proteins 0.000 claims description 49
• 102100037111 Uracil-DNA glycosylase Human genes 0.000 claims description 43
• 238000000034 method Methods 0.000 claims description 42
• 101000716102 Homo sapiens T-cell surface glycoprotein CD4 Proteins 0.000 claims description 28
• 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 claims description 28
• 108010085238 Actins Proteins 0.000 claims description 27
• 102000007469 Actins Human genes 0.000 claims description 27
• -1 Ran GTP Proteins 0.000 claims description 25
• 230000010076 replication Effects 0.000 claims description 24
• 210000000170 cell membrane Anatomy 0.000 claims description 23
• 108010068106 Cyclin T Proteins 0.000 claims description 21
• 102000002435 Cyclin T Human genes 0.000 claims description 21
• 102100036220 PC4 and SFRS1-interacting protein Human genes 0.000 claims description 21
• 230000001900 immune effect Effects 0.000 claims description 21
• 108010053085 Complement Factor H Proteins 0.000 claims description 20
• 102000016550 Complement Factor H Human genes 0.000 claims description 20
• 108700030796 Tsg101 Proteins 0.000 claims description 17
• 101150072717 Tsg101 gene Proteins 0.000 claims description 17
• 230000037361 pathway Effects 0.000 claims description 17
• 102100039373 Membrane cofactor protein Human genes 0.000 claims description 16
• 102000040945 Transcription factor Human genes 0.000 claims description 16
• 108091023040 Transcription factor Proteins 0.000 claims description 16
• 102100035875 C-C chemokine receptor type 5 Human genes 0.000 claims description 15
• 102100031650 C-X-C chemokine receptor type 4 Human genes 0.000 claims description 15
• 208000031886 HIV Infections Diseases 0.000 claims description 15
• 102100038885 Histone acetyltransferase p300 Human genes 0.000 claims description 15
• 101000922348 Homo sapiens C-X-C chemokine receptor type 4 Proteins 0.000 claims description 15
• 230000010354 integration Effects 0.000 claims description 15
• 101710149870 C-C chemokine receptor type 5 Proteins 0.000 claims description 14
• 102000006354 HLA-DR Antigens Human genes 0.000 claims description 14
• 108010058597 HLA-DR Antigens Proteins 0.000 claims description 14
• 102000052866 Amino Acyl-tRNA Synthetases Human genes 0.000 claims description 13
• 108700028939 Amino Acyl-tRNA Synthetases Proteins 0.000 claims description 13
• 101100536311 Drosophila melanogaster Taldo gene Proteins 0.000 claims description 13
• 101100480526 Drosophila melanogaster tal-1A gene Proteins 0.000 claims description 13
• 101100205917 Drosophila melanogaster tal-2A gene Proteins 0.000 claims description 13
• 101100312937 Drosophila melanogaster tal-3A gene Proteins 0.000 claims description 13
• 101100312939 Drosophila melanogaster tal-AA gene Proteins 0.000 claims description 13
• 101100098715 Mus musculus Taldo1 gene Proteins 0.000 claims description 13
• 101100205913 Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) tal1 gene Proteins 0.000 claims description 13
• 102000035181 adaptor proteins Human genes 0.000 claims description 13
• 108091005764 adaptor proteins Proteins 0.000 claims description 13
• 101150106193 tal gene Proteins 0.000 claims description 13
• 102100024457 Cyclin-dependent kinase 9 Human genes 0.000 claims description 12
• 101000736086 Felis catus PC4 and SFRS1-interacting protein Proteins 0.000 claims description 12
• 101000980930 Homo sapiens Cyclin-dependent kinase 9 Proteins 0.000 claims description 12
• 102100037877 Intercellular adhesion molecule 1 Human genes 0.000 claims description 12
• 108090000848 Ubiquitin Proteins 0.000 claims description 12
• 102000044159 Ubiquitin Human genes 0.000 claims description 12
• 102000005962 receptors Human genes 0.000 claims description 12
• 108020003175 receptors Proteins 0.000 claims description 12
• 108010064593 Intercellular Adhesion Molecule-1 Proteins 0.000 claims description 11
• 102100033344 Programmed cell death 6-interacting protein Human genes 0.000 claims description 11
• 238000005516 engineering process Methods 0.000 claims description 11
• 102100025222 CD63 antigen Human genes 0.000 claims description 10
• 102100039196 CX3C chemokine receptor 1 Human genes 0.000 claims description 10
• 101000934368 Homo sapiens CD63 antigen Proteins 0.000 claims description 10
• 101000736088 Homo sapiens PC4 and SFRS1-interacting protein Proteins 0.000 claims description 10
• 101710122673 Ran GTPase-activating protein Proteins 0.000 claims description 10
• 102000014914 Carrier Proteins Human genes 0.000 claims description 9
• 101710146216 Membrane cofactor protein Proteins 0.000 claims description 9
• 108091005804 Peptidases Proteins 0.000 claims description 9
• 239000004365 Protease Substances 0.000 claims description 9
• 108020004566 Transfer RNA Proteins 0.000 claims description 9
• 108091008324 binding proteins Proteins 0.000 claims description 9
• 102100022002 CD59 glycoprotein Human genes 0.000 claims description 8
• 101000897400 Homo sapiens CD59 glycoprotein Proteins 0.000 claims description 8
• 108010064548 Lymphocyte Function-Associated Antigen-1 Proteins 0.000 claims description 8
• 102000009572 RNA Polymerase II Human genes 0.000 claims description 8
• 108010009460 RNA Polymerase II Proteins 0.000 claims description 8
• 102000006834 complement receptors Human genes 0.000 claims description 8
• 108010047295 complement receptors Proteins 0.000 claims description 8
• 102000004506 Blood Proteins Human genes 0.000 claims description 7
• 108010017384 Blood Proteins Proteins 0.000 claims description 7
• 102000020313 Cell-Penetrating Peptides Human genes 0.000 claims description 7
• 108010051109 Cell-Penetrating Peptides Proteins 0.000 claims description 7
• 102100020903 Ezrin Human genes 0.000 claims description 7
• 101000961414 Homo sapiens Membrane cofactor protein Proteins 0.000 claims description 7
• 102000035195 Peptidases Human genes 0.000 claims description 7
• 101150052863 THY1 gene Proteins 0.000 claims description 7
• 102100023543 Vascular cell adhesion protein 1 Human genes 0.000 claims description 7
• 108010055671 ezrin Proteins 0.000 claims description 7
• 102100037151 Barrier-to-autointegration factor Human genes 0.000 claims description 6
• 102100025618 C-X-C chemokine receptor type 6 Human genes 0.000 claims description 6
• 102100027221 CD81 antigen Human genes 0.000 claims description 6
• 102100027217 CD82 antigen Human genes 0.000 claims description 6
• 108090000835 CX3C Chemokine Receptor 1 Proteins 0.000 claims description 6
• 108010061304 CXCR6 Receptors Proteins 0.000 claims description 6
• 101710163595 Chaperone protein DnaK Proteins 0.000 claims description 6
• 102100030886 Complement receptor type 1 Human genes 0.000 claims description 6
• 102100029095 Exportin-1 Human genes 0.000 claims description 6
• 102100023416 G-protein coupled receptor 15 Human genes 0.000 claims description 6
• 102100031181 Glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 claims description 6
• 101710178376 Heat shock 70 kDa protein Proteins 0.000 claims description 6
• 101710152018 Heat shock cognate 70 kDa protein Proteins 0.000 claims description 6
• 101000740067 Homo sapiens Barrier-to-autointegration factor Proteins 0.000 claims description 6
• 101000914479 Homo sapiens CD81 antigen Proteins 0.000 claims description 6
• 101000914469 Homo sapiens CD82 antigen Proteins 0.000 claims description 6
• 101000727061 Homo sapiens Complement receptor type 1 Proteins 0.000 claims description 6
• 101000829794 Homo sapiens G-protein coupled receptor 15 Proteins 0.000 claims description 6
• 241000713340 Human immunodeficiency virus 2 Species 0.000 claims description 6
• 101710160987 Uracil-DNA glycosylase Proteins 0.000 claims description 6
• 108010000134 Vascular Cell Adhesion Molecule-1 Proteins 0.000 claims description 6
• 102100036973 X-ray repair cross-complementing protein 5 Human genes 0.000 claims description 6
• 108010029777 actin interacting protein 1 Proteins 0.000 claims description 6
• 108700002148 exportin 1 Proteins 0.000 claims description 6
• 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 claims description 6
• 108010093345 lens epithelium-derived growth factor Proteins 0.000 claims description 6
• 102000005912 ran GTP Binding Protein Human genes 0.000 claims description 6
• 108010005597 ran GTP Binding Protein Proteins 0.000 claims description 6
• 108010038798 Actin Depolymerizing Factors Proteins 0.000 claims description 5
• 102000015693 Actin Depolymerizing Factors Human genes 0.000 claims description 5
• 102100024167 C-C chemokine receptor type 3 Human genes 0.000 claims description 5
• 101710149862 C-C chemokine receptor type 3 Proteins 0.000 claims description 5
• 102100036305 C-C chemokine receptor type 8 Human genes 0.000 claims description 5
• 102100021198 Chemerin-like receptor 2 Human genes 0.000 claims description 5
• 241001044073 Cypa Species 0.000 claims description 5
• 108090001126 Furin Proteins 0.000 claims description 5
• 101000716063 Homo sapiens C-C chemokine receptor type 8 Proteins 0.000 claims description 5
• 101000750094 Homo sapiens Chemerin-like receptor 2 Proteins 0.000 claims description 5
• 102100037871 Intercellular adhesion molecule 3 Human genes 0.000 claims description 5
• 108091054455 MAP kinase family Proteins 0.000 claims description 5
• 102000043136 MAP kinase family Human genes 0.000 claims description 5
• 102100027869 Moesin Human genes 0.000 claims description 5
• 101150044134 US28 gene Proteins 0.000 claims description 5
• 101710124921 X-ray repair cross-complementing protein 5 Proteins 0.000 claims description 5
• 108010071525 moesin Proteins 0.000 claims description 5
• 230000006663 ubiquitin-proteasome pathway Effects 0.000 claims description 5
• 108010009575 CD55 Antigens Proteins 0.000 claims description 4
• 102000011412 Complement 3d Receptors Human genes 0.000 claims description 4
• 108010023729 Complement 3d Receptors Proteins 0.000 claims description 4
• PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims description 4
• 108010036949 Cyclosporine Proteins 0.000 claims description 4
• 101000876610 Dictyostelium discoideum Extracellular signal-regulated kinase 2 Proteins 0.000 claims description 4
• 102100029721 DnaJ homolog subfamily B member 1 Human genes 0.000 claims description 4
• 108010042283 HSP40 Heat-Shock Proteins Proteins 0.000 claims description 4
• 101001052493 Homo sapiens Mitogen-activated protein kinase 1 Proteins 0.000 claims description 4
• 101000835860 Homo sapiens SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 Proteins 0.000 claims description 4
• 101000649937 Homo sapiens Vacuolar protein sorting-associated protein 28 homolog Proteins 0.000 claims description 4
• 102100025390 Integrin beta-2 Human genes 0.000 claims description 4
• 108010064600 Intercellular Adhesion Molecule-3 Proteins 0.000 claims description 4
• 102100035133 Lysosome-associated membrane glycoprotein 1 Human genes 0.000 claims description 4
• 102100024193 Mitogen-activated protein kinase 1 Human genes 0.000 claims description 4
• 102100027913 Peptidyl-prolyl cis-trans isomerase FKBP1A Human genes 0.000 claims description 4
• 102100025746 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 Human genes 0.000 claims description 4
• 108010006877 Tacrolimus Binding Protein 1A Proteins 0.000 claims description 4
• 102100028227 Vacuolar protein sorting-associated protein 28 homolog Human genes 0.000 claims description 4
• 229940079593 drug Drugs 0.000 claims description 4
• 239000003814 drug Substances 0.000 claims description 4
• 108010004483 APOBEC-3G Deaminase Proteins 0.000 claims description 3
• 102100040266 DNA dC->dU-editing enzyme APOBEC-3F Human genes 0.000 claims description 3
• 102100038076 DNA dC->dU-editing enzyme APOBEC-3G Human genes 0.000 claims description 3
• 108010036652 HSC70 Heat-Shock Proteins Proteins 0.000 claims description 3
• 102100027421 Heat shock cognate 71 kDa protein Human genes 0.000 claims description 3
• 102100039165 Heat shock protein beta-1 Human genes 0.000 claims description 3
• 101000964377 Homo sapiens DNA dC->dU-editing enzyme APOBEC-3F Proteins 0.000 claims description 3
• 101001023379 Homo sapiens Lysosome-associated membrane glycoprotein 1 Proteins 0.000 claims description 3
• 101000803689 Homo sapiens Vacuolar protein sorting-associated protein 4B Proteins 0.000 claims description 3
• 108010008212 Integrin alpha4beta1 Proteins 0.000 claims description 3
• 101001128814 Pandinus imperator Pandinin-1 Proteins 0.000 claims description 3
• 101710075830 VPS37B Proteins 0.000 claims description 3
• 102100037940 Vacuolar protein sorting-associated protein 37B Human genes 0.000 claims description 3
• 102100035086 Vacuolar protein sorting-associated protein 4B Human genes 0.000 claims description 3
• 108020004418 ribosomal RNA Proteins 0.000 claims description 3
• 102000002464 Galactosidases Human genes 0.000 claims description 2
• 108010093031 Galactosidases Proteins 0.000 claims description 2
• 230000008878 coupling Effects 0.000 claims description 2
• 238000010168 coupling process Methods 0.000 claims description 2
• 238000005859 coupling reaction Methods 0.000 claims description 2
• CNWINRVXAYPOMW-FCNJXWMTSA-N 1-stearoyl-2-arachidonoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-biphosphate Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)O[C@H](COC(=O)CCCCCCCCCCCCCCCCC)COP(O)(=O)O[C@@H]1[C@H](O)[C@H](O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H]1O CNWINRVXAYPOMW-FCNJXWMTSA-N 0.000 claims 2
• NPOAOTPXWNWTSH-UHFFFAOYSA-N 3-hydroxy-3-methylglutaric acid Chemical compound OC(=O)CC(O)(C)CC(O)=O NPOAOTPXWNWTSH-UHFFFAOYSA-N 0.000 claims 2
• 102100038222 60 kDa heat shock protein, mitochondrial Human genes 0.000 claims 2
• 101100165655 Arabidopsis thaliana BRO1 gene Proteins 0.000 claims 2
• 101000890609 Bos taurus A-kinase anchor protein 5 Proteins 0.000 claims 2
• 108010058432 Chaperonin 60 Proteins 0.000 claims 2
• 101100485279 Drosophila melanogaster emb gene Proteins 0.000 claims 2
• 102000004961 Furin Human genes 0.000 claims 2
• 102000009012 HMGA Proteins Human genes 0.000 claims 2
• 108010049069 HMGA Proteins Proteins 0.000 claims 2
• 101710100504 Heat shock protein beta-1 Proteins 0.000 claims 2
• 101000793362 Homo sapiens Apelin receptor Proteins 0.000 claims 2
• 101100082597 Homo sapiens PDCD6IP gene Proteins 0.000 claims 2
• 101710148794 Intercellular adhesion molecule 2 Proteins 0.000 claims 2
• 102100037872 Intercellular adhesion molecule 2 Human genes 0.000 claims 2
• 101000735561 Mus musculus Protein-arginine deiminase type-6 Proteins 0.000 claims 2
• 101150094313 XPO1 gene Proteins 0.000 claims 2
• 235000021120 animal protein Nutrition 0.000 claims 2
• 229960001265 ciclosporin Drugs 0.000 claims 2
• 229930182912 cyclosporin Natural products 0.000 claims 2
• 208000015181 infectious disease Diseases 0.000 abstract description 17
• 230000004913 activation Effects 0.000 abstract description 11
• 102000003839 Human Proteins Human genes 0.000 abstract description 10
• 108090000144 Human Proteins Proteins 0.000 abstract description 10
• 230000000295 complement effect Effects 0.000 abstract description 10
• 230000002779 inactivation Effects 0.000 abstract description 3
• 210000000349 chromosome Anatomy 0.000 description 73
• 230000003612 virological effect Effects 0.000 description 58
• 230000006870 function Effects 0.000 description 42
• 230000003993 interaction Effects 0.000 description 36
• 238000013518 transcription Methods 0.000 description 36
• 230000035897 transcription Effects 0.000 description 36
• 210000001744 T-lymphocyte Anatomy 0.000 description 34
• 230000000694 effects Effects 0.000 description 34
• 230000014509 gene expression Effects 0.000 description 34
• 101000807668 Homo sapiens Uracil-DNA glycosylase Proteins 0.000 description 29
• 235000001014 amino acid Nutrition 0.000 description 29
• 229940024606 amino acid Drugs 0.000 description 28
• 150000001413 amino acids Chemical class 0.000 description 28
• 239000000427 antigen Substances 0.000 description 27
• 108091007433 antigens Proteins 0.000 description 25
• 102000036639 antigens Human genes 0.000 description 25
• 230000001404 mediated effect Effects 0.000 description 23
• 230000003834 intracellular effect Effects 0.000 description 22
• 230000001419 dependent effect Effects 0.000 description 21
• 239000012528 membrane Substances 0.000 description 21
• 102100034349 Integrase Human genes 0.000 description 20
• 210000004379 membrane Anatomy 0.000 description 20
• 108091032973 (ribonucleotides)n+m Proteins 0.000 description 19
• 210000004443 dendritic cell Anatomy 0.000 description 19
• 210000002540 macrophage Anatomy 0.000 description 19
• 101000897441 Homo sapiens Cyclin-O Proteins 0.000 description 18
• 108700020134 Human immunodeficiency virus 1 nef Proteins 0.000 description 18
• 108010061833 Integrases Proteins 0.000 description 17
• 241001529936 Murinae Species 0.000 description 17
• 108700018351 Major Histocompatibility Complex Proteins 0.000 description 16
• 230000004044 response Effects 0.000 description 16
• 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 description 16
• 230000032258 transport Effects 0.000 description 16
• 210000003719 b-lymphocyte Anatomy 0.000 description 15
• 210000004940 nucleus Anatomy 0.000 description 15
• 230000001105 regulatory effect Effects 0.000 description 15
• 229960005486 vaccine Drugs 0.000 description 15
• 101000882390 Homo sapiens Histone acetyltransferase p300 Proteins 0.000 description 13
• 241000699666 Mus <mouse, genus> Species 0.000 description 13
• 101000978776 Mus musculus Neurogenic locus notch homolog protein 1 Proteins 0.000 description 13
• ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical group O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 description 13
• 210000000234 capsid Anatomy 0.000 description 13
• 108020004999 messenger RNA Proteins 0.000 description 13
• 230000008569 process Effects 0.000 description 13
• 239000011269 tar Substances 0.000 description 13
• 210000001519 tissue Anatomy 0.000 description 13
• 230000029812 viral genome replication Effects 0.000 description 13
• 108010072220 Cyclophilin A Proteins 0.000 description 12
• 238000010348 incorporation Methods 0.000 description 12
• 239000003446 ligand Substances 0.000 description 12
• 108010006519 Molecular Chaperones Proteins 0.000 description 11
• 102100034539 Peptidyl-prolyl cis-trans isomerase A Human genes 0.000 description 11
• 230000015556 catabolic process Effects 0.000 description 11
• 210000001163 endosome Anatomy 0.000 description 11
• 210000001616 monocyte Anatomy 0.000 description 11
• 230000035882 stress Effects 0.000 description 11
• 230000008685 targeting Effects 0.000 description 11
• 241000894006 Bacteria Species 0.000 description 10
• 108091000080 Phosphotransferase Proteins 0.000 description 10
• 240000004808 Saccharomyces cerevisiae Species 0.000 description 10
• 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 10
• 108020000999 Viral RNA Proteins 0.000 description 10
• 230000001086 cytosolic effect Effects 0.000 description 10
• 238000006731 degradation reaction Methods 0.000 description 10
• 210000004698 lymphocyte Anatomy 0.000 description 10
• 102000020233 phosphotransferase Human genes 0.000 description 10
• 108090000765 processed proteins & peptides Proteins 0.000 description 10
• 230000009885 systemic effect Effects 0.000 description 10
• 101710177291 Gag polyprotein Proteins 0.000 description 9
• 102100022339 Integrin alpha-L Human genes 0.000 description 9
• 230000006907 apoptotic process Effects 0.000 description 9
• 230000024203 complement activation Effects 0.000 description 9
• 230000036039 immunity Effects 0.000 description 9
• 230000035772 mutation Effects 0.000 description 9
• 239000002245 particle Substances 0.000 description 9
• 108010077544 Chromatin Proteins 0.000 description 8
• 102000016574 Complement C3-C5 Convertases Human genes 0.000 description 8
• 108010067641 Complement C3-C5 Convertases Proteins 0.000 description 8
• 108700020129 Human immunodeficiency virus 1 p31 integrase Proteins 0.000 description 8
• 108700002010 MHC class II transactivator Proteins 0.000 description 8
• 101710149136 Protein Vpr Proteins 0.000 description 8
• 108010072685 Uracil-DNA Glycosidase Proteins 0.000 description 8
• 210000003483 chromatin Anatomy 0.000 description 8
• 238000011161 development Methods 0.000 description 8
• 230000018109 developmental process Effects 0.000 description 8
• 210000002919 epithelial cell Anatomy 0.000 description 8
• 239000003550 marker Substances 0.000 description 8
• 230000007246 mechanism Effects 0.000 description 8
• 230000002441 reversible effect Effects 0.000 description 8
• 230000019491 signal transduction Effects 0.000 description 8
• 230000002103 transcriptional effect Effects 0.000 description 8
• 101000737574 Homo sapiens Complement factor H Proteins 0.000 description 7
• 108700005092 MHC Class II Genes Proteins 0.000 description 7
• 108090001074 Nucleocapsid Proteins Proteins 0.000 description 7
• 108010029485 Protein Isoforms Proteins 0.000 description 7
• 102000001708 Protein Isoforms Human genes 0.000 description 7
• 230000015572 biosynthetic process Effects 0.000 description 7
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 7
• 230000022131 cell cycle Effects 0.000 description 7
• 210000004292 cytoskeleton Anatomy 0.000 description 7
• 210000002889 endothelial cell Anatomy 0.000 description 7
• 230000003511 endothelial effect Effects 0.000 description 7
• 230000017188 evasion or tolerance of host immune response Effects 0.000 description 7
• 230000004927 fusion Effects 0.000 description 7
• 238000010353 genetic engineering Methods 0.000 description 7
• 239000000833 heterodimer Substances 0.000 description 7
• 102000045512 human CFH Human genes 0.000 description 7
• 210000000265 leukocyte Anatomy 0.000 description 7
• 244000052769 pathogen Species 0.000 description 7
• 230000001177 retroviral effect Effects 0.000 description 7
• 238000010839 reverse transcription Methods 0.000 description 7
• 230000010415 tropism Effects 0.000 description 7
• 230000006490 viral transcription Effects 0.000 description 7
• 102000016736 Cyclin Human genes 0.000 description 6
• 108050006400 Cyclin Proteins 0.000 description 6
• 108090000626 DNA-directed RNA polymerases Proteins 0.000 description 6
• 102000004163 DNA-directed RNA polymerases Human genes 0.000 description 6
• 101710170658 Endogenous retrovirus group K member 10 Gag polyprotein Proteins 0.000 description 6
• 101710186314 Endogenous retrovirus group K member 21 Gag polyprotein Proteins 0.000 description 6
• 101710162093 Endogenous retrovirus group K member 24 Gag polyprotein Proteins 0.000 description 6
• 101710094596 Endogenous retrovirus group K member 8 Gag polyprotein Proteins 0.000 description 6
• 101710177443 Endogenous retrovirus group K member 9 Gag polyprotein Proteins 0.000 description 6
• 102100028972 HLA class I histocompatibility antigen, A alpha chain Human genes 0.000 description 6
• 102100028976 HLA class I histocompatibility antigen, B alpha chain Human genes 0.000 description 6
• 102100028970 HLA class I histocompatibility antigen, alpha chain E Human genes 0.000 description 6
• 108010075704 HLA-A Antigens Proteins 0.000 description 6
• 108010058607 HLA-B Antigens Proteins 0.000 description 6
• 101000901154 Homo sapiens Complement C3 Proteins 0.000 description 6
• 101000986085 Homo sapiens HLA class I histocompatibility antigen, alpha chain E Proteins 0.000 description 6
• 101710203526 Integrase Proteins 0.000 description 6
• 102100034078 Phosphofurin acidic cluster sorting protein 1 Human genes 0.000 description 6
• 101710135643 Phosphofurin acidic cluster sorting protein 1 Proteins 0.000 description 6
• ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 6
• 230000035508 accumulation Effects 0.000 description 6
• 238000009825 accumulation Methods 0.000 description 6
• 230000030741 antigen processing and presentation Effects 0.000 description 6
• 210000000612 antigen-presenting cell Anatomy 0.000 description 6
• 230000020411 cell activation Effects 0.000 description 6
• 230000021164 cell adhesion Effects 0.000 description 6
• 239000002299 complementary DNA Substances 0.000 description 6
• 201000003740 cowpox Diseases 0.000 description 6
• 210000000805 cytoplasm Anatomy 0.000 description 6
• 238000010172 mouse model Methods 0.000 description 6
• 210000000633 nuclear envelope Anatomy 0.000 description 6
• 210000001986 peyer's patch Anatomy 0.000 description 6
• 210000002381 plasma Anatomy 0.000 description 6
• 239000013612 plasmid Substances 0.000 description 6
• 102000004196 processed proteins & peptides Human genes 0.000 description 6
• 239000000047 product Substances 0.000 description 6
• 230000006798 recombination Effects 0.000 description 6
• 238000005215 recombination Methods 0.000 description 6
• 230000008439 repair process Effects 0.000 description 6
• 230000005945 translocation Effects 0.000 description 6
• 102000035160 transmembrane proteins Human genes 0.000 description 6
• 108091005703 transmembrane proteins Proteins 0.000 description 6
• 230000028973 vesicle-mediated transport Effects 0.000 description 6
• 102000053602 DNA Human genes 0.000 description 5
• 230000033616 DNA repair Effects 0.000 description 5
• 108010086672 Endosomal Sorting Complexes Required for Transport Proteins 0.000 description 5
• 102000006770 Endosomal Sorting Complexes Required for Transport Human genes 0.000 description 5
• 102000004190 Enzymes Human genes 0.000 description 5
• 108090000790 Enzymes Proteins 0.000 description 5
• 241000282412 Homo Species 0.000 description 5
• 230000004570 RNA-binding Effects 0.000 description 5
• HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 5
• 230000003197 catalytic effect Effects 0.000 description 5
• 230000009089 cytolysis Effects 0.000 description 5
• 229940088598 enzyme Drugs 0.000 description 5
• 230000012010 growth Effects 0.000 description 5
• 229960002897 heparin Drugs 0.000 description 5
• 229920000669 heparin Polymers 0.000 description 5
• 210000000987 immune system Anatomy 0.000 description 5
• 238000000338 in vitro Methods 0.000 description 5
• 230000004807 localization Effects 0.000 description 5
• 239000011159 matrix material Substances 0.000 description 5
• 210000003470 mitochondria Anatomy 0.000 description 5
• 210000000822 natural killer cell Anatomy 0.000 description 5
• 230000026731 phosphorylation Effects 0.000 description 5
• 238000006366 phosphorylation reaction Methods 0.000 description 5
• 239000002243 precursor Substances 0.000 description 5
• 238000012552 review Methods 0.000 description 5
• 230000035939 shock Effects 0.000 description 5
• 230000001629 suppression Effects 0.000 description 5
• 230000014616 translation Effects 0.000 description 5
• 229940035893 uracil Drugs 0.000 description 5
• 239000013598 vector Substances 0.000 description 5
• 239000011701 zinc Substances 0.000 description 5
• 229910052725 zinc Inorganic materials 0.000 description 5
• HCHFRAXBELVCGG-JYFOCSDGSA-N (2z,3z)-2,3-bis[(4-methoxyphenyl)methylidene]butanedinitrile Chemical compound C1=CC(OC)=CC=C1\C=C(/C#N)\C(\C#N)=C\C1=CC=C(OC)C=C1 HCHFRAXBELVCGG-JYFOCSDGSA-N 0.000 description 4
• 102100034871 C-C motif chemokine 8 Human genes 0.000 description 4
• 108010041397 CD4 Antigens Proteins 0.000 description 4
• OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 4
• 101100507655 Canis lupus familiaris HSPA1 gene Proteins 0.000 description 4
• 108010055204 Chemokine CCL8 Proteins 0.000 description 4
• 102100034239 Emerin Human genes 0.000 description 4
• HCHFRAXBELVCGG-UHFFFAOYSA-N Emerin Natural products C1=CC(OC)=CC=C1C=C(C#N)C(C#N)=CC1=CC=C(OC)C=C1 HCHFRAXBELVCGG-UHFFFAOYSA-N 0.000 description 4
• 101710168592 Gag-Pol polyprotein Proteins 0.000 description 4
• 208000037357 HIV infectious disease Diseases 0.000 description 4
• 102100028971 HLA class I histocompatibility antigen, C alpha chain Human genes 0.000 description 4
• 102100028967 HLA class I histocompatibility antigen, alpha chain G Human genes 0.000 description 4
• 102000025850 HLA-A2 Antigen Human genes 0.000 description 4
• 108010074032 HLA-A2 Antigen Proteins 0.000 description 4
• 108010052199 HLA-C Antigens Proteins 0.000 description 4
• 108010024164 HLA-G Antigens Proteins 0.000 description 4
• HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 4
• 102100022846 Histone acetyltransferase KAT2B Human genes 0.000 description 4
• 108010033040 Histones Proteins 0.000 description 4
• 101000910488 Homo sapiens Cyclin-T1 Proteins 0.000 description 4
• 101000663222 Homo sapiens Serine/arginine-rich splicing factor 1 Proteins 0.000 description 4
• 206010062016 Immunosuppression Diseases 0.000 description 4
• ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 4
• 102000003960 Ligases Human genes 0.000 description 4
• 108090000364 Ligases Proteins 0.000 description 4
• 108010052285 Membrane Proteins Proteins 0.000 description 4
• 101710151805 Mitochondrial intermediate peptidase 1 Proteins 0.000 description 4
• 241000699670 Mus sp. Species 0.000 description 4
• 229910019142 PO4 Inorganic materials 0.000 description 4
• 102000003993 Phosphatidylinositol 3-kinases Human genes 0.000 description 4
• 108090000430 Phosphatidylinositol 3-kinases Proteins 0.000 description 4
• 108010076039 Polyproteins Proteins 0.000 description 4
• 108010012271 Positive Transcriptional Elongation Factor B Proteins 0.000 description 4
• 102000007568 Proto-Oncogene Proteins c-fos Human genes 0.000 description 4
• 108010071563 Proto-Oncogene Proteins c-fos Proteins 0.000 description 4
• 230000018199 S phase Effects 0.000 description 4
• 102100037044 Serine/arginine-rich splicing factor 1 Human genes 0.000 description 4
• 108010047827 Sialic Acid Binding Immunoglobulin-like Lectins Proteins 0.000 description 4
• 102000007073 Sialic Acid Binding Immunoglobulin-like Lectins Human genes 0.000 description 4
• 102100023132 Transcription factor Jun Human genes 0.000 description 4
• 108020005202 Viral DNA Proteins 0.000 description 4
• 230000021736 acetylation Effects 0.000 description 4
• 238000006640 acetylation reaction Methods 0.000 description 4
• 229910052791 calcium Inorganic materials 0.000 description 4
• 239000011575 calcium Substances 0.000 description 4
• 150000001720 carbohydrates Chemical class 0.000 description 4
• 235000014633 carbohydrates Nutrition 0.000 description 4
• 230000034303 cell budding Effects 0.000 description 4
• 230000003081 coactivator Effects 0.000 description 4
• 210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 4
• 108010056197 emerin Proteins 0.000 description 4
• 230000002121 endocytic effect Effects 0.000 description 4
• 230000012202 endocytosis Effects 0.000 description 4
• 230000004992 fission Effects 0.000 description 4
• 210000001035 gastrointestinal tract Anatomy 0.000 description 4
• 230000002068 genetic effect Effects 0.000 description 4
• 102000051997 human CCNT1 Human genes 0.000 description 4
• 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 description 4
• 230000008629 immune suppression Effects 0.000 description 4
• 230000001506 immunosuppresive effect Effects 0.000 description 4
• 230000001939 inductive effect Effects 0.000 description 4
• 108010028930 invariant chain Proteins 0.000 description 4
• 238000006317 isomerization reaction Methods 0.000 description 4
• 230000000670 limiting effect Effects 0.000 description 4
• 150000002632 lipids Chemical class 0.000 description 4
• 210000001165 lymph node Anatomy 0.000 description 4
• 210000004962 mammalian cell Anatomy 0.000 description 4
• 230000002438 mitochondrial effect Effects 0.000 description 4
• 238000004806 packaging method and process Methods 0.000 description 4
• 239000010452 phosphate Substances 0.000 description 4
• 229920001184 polypeptide Polymers 0.000 description 4
• 230000002062 proliferating effect Effects 0.000 description 4
• 230000001681 protective effect Effects 0.000 description 4
• 125000005629 sialic acid group Chemical group 0.000 description 4
• 241000894007 species Species 0.000 description 4
• 238000012546 transfer Methods 0.000 description 4
• 230000034512 ubiquitination Effects 0.000 description 4
• 238000010798 ubiquitination Methods 0.000 description 4
• 230000029302 virus maturation Effects 0.000 description 4
• 102000040650 (ribonucleotides)n+m Human genes 0.000 description 3
• 108091006112 ATPases Proteins 0.000 description 3
• 229930024421 Adenine Natural products 0.000 description 3
• GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 description 3
• 102000057290 Adenosine Triphosphatases Human genes 0.000 description 3
• 241000282709 Aotus trivirgatus Species 0.000 description 3
• 102100037904 CD9 antigen Human genes 0.000 description 3
• 101710184994 Complement control protein Proteins 0.000 description 3
• 230000004543 DNA replication Effects 0.000 description 3
• 206010011968 Decreased immune responsiveness Diseases 0.000 description 3
• 102100021238 Dynamin-2 Human genes 0.000 description 3
• 102100035233 Furin Human genes 0.000 description 3
• 102000003886 Glycoproteins Human genes 0.000 description 3
• 108090000288 Glycoproteins Proteins 0.000 description 3
• 101000817607 Homo sapiens Dynamin-2 Proteins 0.000 description 3
• 101001047006 Homo sapiens Histone acetyltransferase KAT2B Proteins 0.000 description 3
• 101001046683 Homo sapiens Integrin alpha-L Proteins 0.000 description 3
• 108060003951 Immunoglobulin Proteins 0.000 description 3
• 102000004195 Isomerases Human genes 0.000 description 3
• 108090000769 Isomerases Proteins 0.000 description 3
• 101710125418 Major capsid protein Proteins 0.000 description 3
• 241000124008 Mammalia Species 0.000 description 3
• 102000018697 Membrane Proteins Human genes 0.000 description 3
• 241000283973 Oryctolagus cuniculus Species 0.000 description 3
• 102000019014 Positive Transcriptional Elongation Factor B Human genes 0.000 description 3
• 102000001253 Protein Kinase Human genes 0.000 description 3
• 101710188315 Protein X Proteins 0.000 description 3
• 108090000412 Protein-Tyrosine Kinases Proteins 0.000 description 3
• 102000004022 Protein-Tyrosine Kinases Human genes 0.000 description 3
• 102100035100 Transcription factor p65 Human genes 0.000 description 3
• 102000006275 Ubiquitin-Protein Ligases Human genes 0.000 description 3
• 206010046865 Vaccinia virus infection Diseases 0.000 description 3
• 108010003533 Viral Envelope Proteins Proteins 0.000 description 3
• 102100036976 X-ray repair cross-complementing protein 6 Human genes 0.000 description 3
• 101710124907 X-ray repair cross-complementing protein 6 Proteins 0.000 description 3
• 229960000643 adenine Drugs 0.000 description 3
• 125000000266 alpha-aminoacyl group Chemical group 0.000 description 3
• 230000002238 attenuated effect Effects 0.000 description 3
• 239000002775 capsule Substances 0.000 description 3
• 239000000969 carrier Substances 0.000 description 3
• 238000012790 confirmation Methods 0.000 description 3
• 230000006378 damage Effects 0.000 description 3
• 150000001982 diacylglycerols Chemical class 0.000 description 3
• 230000004069 differentiation Effects 0.000 description 3
• 230000003828 downregulation Effects 0.000 description 3
• 210000002472 endoplasmic reticulum Anatomy 0.000 description 3
• 210000001842 enterocyte Anatomy 0.000 description 3
• 235000013305 food Nutrition 0.000 description 3
• 210000002288 golgi apparatus Anatomy 0.000 description 3
• 239000003102 growth factor Substances 0.000 description 3
• 102000018358 immunoglobulin Human genes 0.000 description 3
• 238000001727 in vivo Methods 0.000 description 3
• 230000002401 inhibitory effect Effects 0.000 description 3
• 239000007924 injection Substances 0.000 description 3
• 238000002347 injection Methods 0.000 description 3
• 102000006495 integrins Human genes 0.000 description 3
• 108010044426 integrins Proteins 0.000 description 3
• 239000000543 intermediate Substances 0.000 description 3
• 210000005061 intracellular organelle Anatomy 0.000 description 3
• 238000005304 joining Methods 0.000 description 3
• 235000018977 lysine Nutrition 0.000 description 3
• 210000004779 membrane envelope Anatomy 0.000 description 3
• 230000034217 membrane fusion Effects 0.000 description 3
• 230000011278 mitosis Effects 0.000 description 3
• 210000002487 multivesicular body Anatomy 0.000 description 3
• 102000039446 nucleic acids Human genes 0.000 description 3
• 108020004707 nucleic acids Proteins 0.000 description 3
• 150000007523 nucleic acids Chemical class 0.000 description 3
• 210000003463 organelle Anatomy 0.000 description 3
• 238000012545 processing Methods 0.000 description 3
• 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 3
• 108060006633 protein kinase Proteins 0.000 description 3
• 238000007634 remodeling Methods 0.000 description 3
• 210000003935 rough endoplasmic reticulum Anatomy 0.000 description 3
• 239000000758 substrate Substances 0.000 description 3
• 230000004083 survival effect Effects 0.000 description 3
• 210000003412 trans-golgi network Anatomy 0.000 description 3
• 238000013519 translation Methods 0.000 description 3
• 208000007089 vaccinia Diseases 0.000 description 3
• 230000002792 vascular Effects 0.000 description 3
• UHDGCWIWMRVCDJ-UHFFFAOYSA-N 1-beta-D-Xylofuranosyl-NH-Cytosine Natural products O=C1N=C(N)C=CN1C1C(O)C(O)C(CO)O1 UHDGCWIWMRVCDJ-UHFFFAOYSA-N 0.000 description 2
• 102000004899 14-3-3 Proteins Human genes 0.000 description 2
• NOIRDLRUNWIUMX-UHFFFAOYSA-N 2-amino-3,7-dihydropurin-6-one;6-amino-1h-pyrimidin-2-one Chemical compound NC=1C=CNC(=O)N=1.O=C1NC(N)=NC2=C1NC=N2 NOIRDLRUNWIUMX-UHFFFAOYSA-N 0.000 description 2
• KZMAWJRXKGLWGS-UHFFFAOYSA-N 2-chloro-n-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-n-(3-methoxypropyl)acetamide Chemical compound S1C(N(C(=O)CCl)CCCOC)=NC(C=2C=CC(OC)=CC=2)=C1 KZMAWJRXKGLWGS-UHFFFAOYSA-N 0.000 description 2
• LJQLQCAXBUHEAZ-UWTATZPHSA-N 3-phospho-D-glyceroyl dihydrogen phosphate Chemical compound OP(=O)(O)OC[C@@H](O)C(=O)OP(O)(O)=O LJQLQCAXBUHEAZ-UWTATZPHSA-N 0.000 description 2
• 208000030507 AIDS Diseases 0.000 description 2
• 108020005098 Anticodon Proteins 0.000 description 2
• 101710145634 Antigen 1 Proteins 0.000 description 2
• 102100038080 B-cell receptor CD22 Human genes 0.000 description 2
• 102100031092 C-C motif chemokine 3 Human genes 0.000 description 2
• 101710155856 C-C motif chemokine 3 Proteins 0.000 description 2
• 102100031102 C-C motif chemokine 4 Human genes 0.000 description 2
• 101150012716 CDK1 gene Proteins 0.000 description 2
• 101150035324 CDK9 gene Proteins 0.000 description 2
• 101100289995 Caenorhabditis elegans mac-1 gene Proteins 0.000 description 2
• 101100191590 Caenorhabditis elegans rpt-2 gene Proteins 0.000 description 2
• 101100262777 Caenorhabditis elegans umps-1 gene Proteins 0.000 description 2
• 108090000565 Capsid Proteins Proteins 0.000 description 2
• 241000700199 Cavia porcellus Species 0.000 description 2
• 102100023321 Ceruloplasmin Human genes 0.000 description 2
• 102100038274 Charged multivesicular body protein 4b Human genes 0.000 description 2
• 101710163821 Charged multivesicular body protein 4b Proteins 0.000 description 2
• 108010055165 Chemokine CCL4 Proteins 0.000 description 2
• 102000019034 Chemokines Human genes 0.000 description 2
• 108010012236 Chemokines Proteins 0.000 description 2
• 108010019874 Clathrin Proteins 0.000 description 2
• 102000005853 Clathrin Human genes 0.000 description 2
• 102000000989 Complement System Proteins Human genes 0.000 description 2
• 108010069112 Complement System Proteins Proteins 0.000 description 2
• 229930105110 Cyclosporin A Natural products 0.000 description 2
• UHDGCWIWMRVCDJ-PSQAKQOGSA-N Cytidine Natural products O=C1N=C(N)C=CN1[C@@H]1[C@@H](O)[C@@H](O)[C@H](CO)O1 UHDGCWIWMRVCDJ-PSQAKQOGSA-N 0.000 description 2
• 102000018832 Cytochromes Human genes 0.000 description 2
• 108010052832 Cytochromes Proteins 0.000 description 2
• 108010037897 DC-specific ICAM-3 grabbing nonintegrin Proteins 0.000 description 2
• 102000052510 DNA-Binding Proteins Human genes 0.000 description 2
• 230000004568 DNA-binding Effects 0.000 description 2
• 101710096438 DNA-binding protein Proteins 0.000 description 2
• 102100032049 E3 ubiquitin-protein ligase LRSAM1 Human genes 0.000 description 2
• 102100039715 Endogenous retrovirus group K member 6 Gag polyprotein Human genes 0.000 description 2
• 102100038132 Endogenous retrovirus group K member 6 Pro protein Human genes 0.000 description 2
• 101710091045 Envelope protein Proteins 0.000 description 2
• 108050001049 Extracellular proteins Proteins 0.000 description 2
• 241000233866 Fungi Species 0.000 description 2
• 230000010337 G2 phase Effects 0.000 description 2
• 229940033330 HIV vaccine Drugs 0.000 description 2
• 241000556773 HIV-1 group N Species 0.000 description 2
• 102100028966 HLA class I histocompatibility antigen, alpha chain F Human genes 0.000 description 2
• 102100030595 HLA class II histocompatibility antigen gamma chain Human genes 0.000 description 2
• 102100034051 Heat shock protein HSP 90-alpha Human genes 0.000 description 2
• 102100031000 Hepatoma-derived growth factor Human genes 0.000 description 2
• SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 description 2
• 102100034523 Histone H4 Human genes 0.000 description 2
• 101000986080 Homo sapiens HLA class I histocompatibility antigen, alpha chain F Proteins 0.000 description 2
• 101001082627 Homo sapiens HLA class II histocompatibility antigen gamma chain Proteins 0.000 description 2
• 101000935040 Homo sapiens Integrin beta-2 Proteins 0.000 description 2
• 101000680858 Homo sapiens RPA-interacting protein Proteins 0.000 description 2
• 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 description 2
• 101000611023 Homo sapiens Tumor necrosis factor receptor superfamily member 6 Proteins 0.000 description 2
• 101001022129 Homo sapiens Tyrosine-protein kinase Fyn Proteins 0.000 description 2
• 101001074035 Homo sapiens Zinc finger protein GLI2 Proteins 0.000 description 2
• 101150062179 II gene Proteins 0.000 description 2
• 102100034353 Integrase Human genes 0.000 description 2
• 102000008070 Interferon-gamma Human genes 0.000 description 2
• 108010074328 Interferon-gamma Proteins 0.000 description 2
• 102000014150 Interferons Human genes 0.000 description 2
• 108010050904 Interferons Proteins 0.000 description 2
• 108010002350 Interleukin-2 Proteins 0.000 description 2
• COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 2
• 101150048357 Lamp1 gene Proteins 0.000 description 2
• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 2
• 239000004472 Lysine Substances 0.000 description 2
• 102000043131 MHC class II family Human genes 0.000 description 2
• 108091054438 MHC class II family Proteins 0.000 description 2
• 108091022875 Microtubule Proteins 0.000 description 2
• 102000029749 Microtubule Human genes 0.000 description 2
• 108020005196 Mitochondrial DNA Proteins 0.000 description 2
• 102000005431 Molecular Chaperones Human genes 0.000 description 2
• 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 description 2
• 108091008877 NK cell receptors Proteins 0.000 description 2
• 102000010648 Natural Killer Cell Receptors Human genes 0.000 description 2
• 206010028980 Neoplasm Diseases 0.000 description 2
• 108020003217 Nuclear RNA Proteins 0.000 description 2
• 102000043141 Nuclear RNA Human genes 0.000 description 2
• 108091028043 Nucleic acid sequence Proteins 0.000 description 2
• 108091007960 PI3Ks Proteins 0.000 description 2
• 102000009353 PWWP domains Human genes 0.000 description 2
• 108050000223 PWWP domains Proteins 0.000 description 2
• 108010020062 Peptidylprolyl Isomerase Proteins 0.000 description 2
• 102000009658 Peptidylprolyl Isomerase Human genes 0.000 description 2
• 108010021757 Polynucleotide 5'-Hydroxyl-Kinase Proteins 0.000 description 2
• 102000008422 Polynucleotide 5'-hydroxyl-kinase Human genes 0.000 description 2
• 241000288906 Primates Species 0.000 description 2
• 102000004245 Proteasome Endopeptidase Complex Human genes 0.000 description 2
• 108090000708 Proteasome Endopeptidase Complex Proteins 0.000 description 2
• 108090000315 Protein Kinase C Proteins 0.000 description 2
• 102000003923 Protein Kinase C Human genes 0.000 description 2
• 102000015097 RNA Splicing Factors Human genes 0.000 description 2
• 108010039259 RNA Splicing Factors Proteins 0.000 description 2
• 238000010357 RNA editing Methods 0.000 description 2
• 230000026279 RNA modification Effects 0.000 description 2
• 239000013616 RNA primer Substances 0.000 description 2
• 102100022419 RPA-interacting protein Human genes 0.000 description 2
• 101100273253 Rhizopus niveus RNAP gene Proteins 0.000 description 2
• 108010029176 Sialic Acid Binding Ig-like Lectin 1 Proteins 0.000 description 2
• 102100032855 Sialoadhesin Human genes 0.000 description 2
• 108020004682 Single-Stranded DNA Proteins 0.000 description 2
• 102100021669 Stromal cell-derived factor 1 Human genes 0.000 description 2
• 101710088580 Stromal cell-derived factor 1 Proteins 0.000 description 2
• 229930006000 Sucrose Natural products 0.000 description 2
• CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
• 230000006044 T cell activation Effects 0.000 description 2
• 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 description 2
• 210000000447 Th1 cell Anatomy 0.000 description 2
• AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 2
• 239000004473 Threonine Substances 0.000 description 2
• 102000004243 Tubulin Human genes 0.000 description 2
• 108090000704 Tubulin Proteins 0.000 description 2
• 102100040403 Tumor necrosis factor receptor superfamily member 6 Human genes 0.000 description 2
• 102100035221 Tyrosine-protein kinase Fyn Human genes 0.000 description 2
• 108010083111 Ubiquitin-Protein Ligases Proteins 0.000 description 2
• 101150115214 VPS28 gene Proteins 0.000 description 2
• 108010067390 Viral Proteins Proteins 0.000 description 2
• 102100035558 Zinc finger protein GLI2 Human genes 0.000 description 2
• 238000010521 absorption reaction Methods 0.000 description 2
• 230000003213 activating effect Effects 0.000 description 2
• 239000012190 activator Substances 0.000 description 2
• 238000004458 analytical method Methods 0.000 description 2
• 230000001640 apoptogenic effect Effects 0.000 description 2
• 230000033590 base-excision repair Effects 0.000 description 2
• SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 description 2
• 230000033228 biological regulation Effects 0.000 description 2
• 230000005540 biological transmission Effects 0.000 description 2
• 210000004899 c-terminal region Anatomy 0.000 description 2
• 229910052799 carbon Inorganic materials 0.000 description 2
• 108010089576 carboxy-terminal domain kinase Proteins 0.000 description 2
• 210000004970 cd4 cell Anatomy 0.000 description 2
• 238000004113 cell culture Methods 0.000 description 2
• 230000010261 cell growth Effects 0.000 description 2
• 230000009087 cell motility Effects 0.000 description 2
• 230000033077 cellular process Effects 0.000 description 2
• 230000036755 cellular response Effects 0.000 description 2
• 230000005754 cellular signaling Effects 0.000 description 2
• 229940106189 ceramide Drugs 0.000 description 2
• 238000006243 chemical reaction Methods 0.000 description 2
• 229930193282 clathrin Natural products 0.000 description 2
• 230000002596 correlated effect Effects 0.000 description 2
• UHDGCWIWMRVCDJ-ZAKLUEHWSA-N cytidine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O1 UHDGCWIWMRVCDJ-ZAKLUEHWSA-N 0.000 description 2
• 230000021953 cytokinesis Effects 0.000 description 2
• 230000001461 cytolytic effect Effects 0.000 description 2
• 210000005220 cytoplasmic tail Anatomy 0.000 description 2
• 230000021040 cytoplasmic transport Effects 0.000 description 2
• 230000007423 decrease Effects 0.000 description 2
• 230000030609 dephosphorylation Effects 0.000 description 2
• 238000006209 dephosphorylation reaction Methods 0.000 description 2
• 230000003831 deregulation Effects 0.000 description 2
• 238000010494 dissociation reaction Methods 0.000 description 2
• 230000005593 dissociations Effects 0.000 description 2
• 238000009826 distribution Methods 0.000 description 2
• 230000011559 double-strand break repair via nonhomologous end joining Effects 0.000 description 2
• 108010078428 env Gene Products Proteins 0.000 description 2
• 230000006353 environmental stress Effects 0.000 description 2
• 230000002255 enzymatic effect Effects 0.000 description 2
• 210000000981 epithelium Anatomy 0.000 description 2
• 210000001808 exosome Anatomy 0.000 description 2
• 210000002950 fibroblast Anatomy 0.000 description 2
• 238000009472 formulation Methods 0.000 description 2
• BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 2
• 150000004676 glycans Chemical group 0.000 description 2
• 230000034659 glycolysis Effects 0.000 description 2
• 210000004524 haematopoietic cell Anatomy 0.000 description 2
• 210000003958 hematopoietic stem cell Anatomy 0.000 description 2
• 206010073071 hepatocellular carcinoma Diseases 0.000 description 2
• 108010052188 hepatoma-derived growth factor Proteins 0.000 description 2
• 230000005745 host immune response Effects 0.000 description 2
• 210000005260 human cell Anatomy 0.000 description 2
• 230000002209 hydrophobic effect Effects 0.000 description 2
• 210000002865 immune cell Anatomy 0.000 description 2
• 239000000411 inducer Substances 0.000 description 2
• 230000002458 infectious effect Effects 0.000 description 2
• 230000008798 inflammatory stress Effects 0.000 description 2
• 230000000977 initiatory effect Effects 0.000 description 2
• 229960000367 inositol Drugs 0.000 description 2
• CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 2
• 230000002452 interceptive effect Effects 0.000 description 2
• 229940079322 interferon Drugs 0.000 description 2
• 229960003130 interferon gamma Drugs 0.000 description 2
• 230000010189 intracellular transport Effects 0.000 description 2
• 230000021633 leukocyte mediated immunity Effects 0.000 description 2
• 239000007788 liquid Substances 0.000 description 2
• 230000033001 locomotion Effects 0.000 description 2
• 125000003588 lysine group Chemical class [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 2
• 230000002132 lysosomal effect Effects 0.000 description 2
• 210000003712 lysosome Anatomy 0.000 description 2
• 230000001868 lysosomic effect Effects 0.000 description 2
• 230000035800 maturation Effects 0.000 description 2
• 102000006240 membrane receptors Human genes 0.000 description 2
• 230000031864 metaphase Effects 0.000 description 2
• 210000004688 microtubule Anatomy 0.000 description 2
• 230000011144 microtubule bundle formation Effects 0.000 description 2
• 239000003226 mitogen Substances 0.000 description 2
• 230000004001 molecular interaction Effects 0.000 description 2
• 230000004899 motility Effects 0.000 description 2
• 210000004877 mucosa Anatomy 0.000 description 2
• 230000016273 neuron death Effects 0.000 description 2
• 210000000440 neutrophil Anatomy 0.000 description 2
• 239000002773 nucleotide Substances 0.000 description 2
• 125000003729 nucleotide group Chemical group 0.000 description 2
• 230000001717 pathogenic effect Effects 0.000 description 2
• COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 2
• NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
• 230000010399 physical interaction Effects 0.000 description 2
• 230000008884 pinocytosis Effects 0.000 description 2
• 210000004180 plasmocyte Anatomy 0.000 description 2
• 230000023603 positive regulation of transcription initiation, DNA-dependent Effects 0.000 description 2
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
• 239000013615 primer Substances 0.000 description 2
• 230000001566 pro-viral effect Effects 0.000 description 2
• 230000004063 proteosomal degradation Effects 0.000 description 2
• 150000003254 radicals Chemical class 0.000 description 2
• 230000022983 regulation of cell cycle Effects 0.000 description 2
• 230000000284 resting effect Effects 0.000 description 2
• 108091008146 restriction endonucleases Proteins 0.000 description 2
• 210000003705 ribosome Anatomy 0.000 description 2
• CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 2
• 230000003248 secreting effect Effects 0.000 description 2
• 210000002966 serum Anatomy 0.000 description 2
• SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 description 2
• 230000011664 signaling Effects 0.000 description 2
• 229940083538 smallpox vaccine Drugs 0.000 description 2
• 239000000243 solution Substances 0.000 description 2
• 230000000392 somatic effect Effects 0.000 description 2
• 101150040990 stau gene Proteins 0.000 description 2
• 210000002536 stromal cell Anatomy 0.000 description 2
• 239000000126 substance Substances 0.000 description 2
• 239000005720 sucrose Substances 0.000 description 2
• 235000000346 sugar Nutrition 0.000 description 2
• 230000008093 supporting effect Effects 0.000 description 2
• 239000003826 tablet Substances 0.000 description 2
• 238000012360 testing method Methods 0.000 description 2
• RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 description 2
• 239000003053 toxin Substances 0.000 description 2
• 231100000765 toxin Toxicity 0.000 description 2
• 108700012359 toxins Proteins 0.000 description 2
• 230000009261 transgenic effect Effects 0.000 description 2
• 230000029069 type 2 immune response Effects 0.000 description 2
• 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 2
• 241001515965 unidentified phage Species 0.000 description 2
• 241001430294 unidentified retrovirus Species 0.000 description 2
• 239000003981 vehicle Substances 0.000 description 2
• 229940088594 vitamin Drugs 0.000 description 2
• 239000011782 vitamin Substances 0.000 description 2
• 235000013343 vitamin Nutrition 0.000 description 2
• 229930003231 vitamin Natural products 0.000 description 2
• 230000004572 zinc-binding Effects 0.000 description 2
• 108700020469 14-3-3 Proteins 0.000 description 1
• 102100027962 2-5A-dependent ribonuclease Human genes 0.000 description 1
• 108010000834 2-5A-dependent ribonuclease Proteins 0.000 description 1
• 108010087671 AAA Proteins Proteins 0.000 description 1
• 102000009067 AAA Proteins Human genes 0.000 description 1
• 108010079649 APOBEC-1 Deaminase Proteins 0.000 description 1
• 101710152894 ATP-binding cassette sub-family E member 1 Proteins 0.000 description 1
• 102100020969 ATP-binding cassette sub-family E member 1 Human genes 0.000 description 1
• RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
• 108010013043 Acetylesterase Proteins 0.000 description 1
• 108010063503 Actinin Proteins 0.000 description 1
• 102000010825 Actinin Human genes 0.000 description 1
• WPWUFUBLGADILS-WDSKDSINSA-N Ala-Pro Chemical compound C[C@H](N)C(=O)N1CCC[C@H]1C(O)=O WPWUFUBLGADILS-WDSKDSINSA-N 0.000 description 1
• 102000002260 Alkaline Phosphatase Human genes 0.000 description 1
• 108020004774 Alkaline Phosphatase Proteins 0.000 description 1
• DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 1
• 108010013534 Auxilins Proteins 0.000 description 1
• 102100032412 Basigin Human genes 0.000 description 1
• 241000283698 Bubalus Species 0.000 description 1
• 102100040397 C->U-editing enzyme APOBEC-1 Human genes 0.000 description 1
• YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 description 1
• 101150013553 CD40 gene Proteins 0.000 description 1
• 102100032912 CD44 antigen Human genes 0.000 description 1
• 108010040163 CREB-Binding Protein Proteins 0.000 description 1
• 102100021975 CREB-binding protein Human genes 0.000 description 1
• 101000741929 Caenorhabditis elegans Serine/threonine-protein phosphatase 2A catalytic subunit Proteins 0.000 description 1
• 101100298824 Caenorhabditis elegans rpt-1 gene Proteins 0.000 description 1
• 101710167800 Capsid assembly scaffolding protein Proteins 0.000 description 1
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
• 108010078791 Carrier Proteins Proteins 0.000 description 1
• 102100028003 Catenin alpha-1 Human genes 0.000 description 1
• 101710106619 Catenin alpha-3 Proteins 0.000 description 1
• 102000011068 Cdc42 Human genes 0.000 description 1
• 108050001278 Cdc42 Proteins 0.000 description 1
• 102000016289 Cell Adhesion Molecules Human genes 0.000 description 1
• 108010067225 Cell Adhesion Molecules Proteins 0.000 description 1
• 108010001857 Cell Surface Receptors Proteins 0.000 description 1
• 241000282693 Cercopithecidae Species 0.000 description 1
• 102000052603 Chaperonins Human genes 0.000 description 1
• 108700021022 Chaperonins Proteins 0.000 description 1
• 102100038275 Charged multivesicular body protein 4a Human genes 0.000 description 1
• 101710163818 Charged multivesicular body protein 4a Proteins 0.000 description 1
• 102000009016 Cholera Toxin Human genes 0.000 description 1
• 108010049048 Cholera Toxin Proteins 0.000 description 1
• 108010078015 Complement C3b Proteins 0.000 description 1
• 102100025680 Complement decay-accelerating factor Human genes 0.000 description 1
• 108090000056 Complement factor B Proteins 0.000 description 1
• 102000003712 Complement factor B Human genes 0.000 description 1
• 102100040132 Complement factor H-related protein 1 Human genes 0.000 description 1
• 102100035326 Complement factor H-related protein 2 Human genes 0.000 description 1
• 102100035321 Complement factor H-related protein 3 Human genes 0.000 description 1
• 102100035324 Complement factor H-related protein 4 Human genes 0.000 description 1
• 102100035325 Complement factor H-related protein 5 Human genes 0.000 description 1
• 102000005636 Cyclic AMP Response Element-Binding Protein Human genes 0.000 description 1
• 108010045171 Cyclic AMP Response Element-Binding Protein Proteins 0.000 description 1
• IVOMOUWHDPKRLL-KQYNXXCUSA-N Cyclic adenosine monophosphate Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=CN=C2N)=C2N=C1 IVOMOUWHDPKRLL-KQYNXXCUSA-N 0.000 description 1
• 108010060385 Cyclin B1 Proteins 0.000 description 1
• 102100026846 Cytidine deaminase Human genes 0.000 description 1
• 108010031325 Cytidine deaminase Proteins 0.000 description 1
• 102000004127 Cytokines Human genes 0.000 description 1
• 108090000695 Cytokines Proteins 0.000 description 1
• MNQZXJOMYWMBOU-VKHMYHEASA-N D-glyceraldehyde Chemical compound OC[C@@H](O)C=O MNQZXJOMYWMBOU-VKHMYHEASA-N 0.000 description 1
• 102000012410 DNA Ligases Human genes 0.000 description 1
• 108010061982 DNA Ligases Proteins 0.000 description 1
• 108010008286 DNA nucleotidylexotransferase Proteins 0.000 description 1
• 238000012270 DNA recombination Methods 0.000 description 1
• 102100022204 DNA-dependent protein kinase catalytic subunit Human genes 0.000 description 1
• 102100029764 DNA-directed DNA/RNA polymerase mu Human genes 0.000 description 1
• 102000016911 Deoxyribonucleases Human genes 0.000 description 1
• 108010053770 Deoxyribonucleases Proteins 0.000 description 1
• 229920000045 Dermatan sulfate Polymers 0.000 description 1
• 101100495892 Dictyostelium discoideum chmp4 gene Proteins 0.000 description 1
• 108700019745 Disks Large Homolog 4 Proteins 0.000 description 1
• 102000047174 Disks Large Homolog 4 Human genes 0.000 description 1
• 102100025682 Dystroglycan 1 Human genes 0.000 description 1
• 108010071885 Dystroglycans Proteins 0.000 description 1
• 101710087802 E3 ubiquitin-protein ligase LRSAM1 Proteins 0.000 description 1
• 102100031443 E3 ubiquitin-protein ligase RAD18 Human genes 0.000 description 1
• 108700034637 EC 3.2.-.- Proteins 0.000 description 1
• 241000196324 Embryophyta Species 0.000 description 1
• 101000600890 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) G2-specific protein kinase nimA Proteins 0.000 description 1
• 101100059559 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) nimX gene Proteins 0.000 description 1
• 108010042407 Endonucleases Proteins 0.000 description 1
• 102000004533 Endonucleases Human genes 0.000 description 1
• 101710121417 Envelope glycoprotein Proteins 0.000 description 1
• 101001065501 Escherichia phage MS2 Lysis protein Proteins 0.000 description 1
• 241000206602 Eukaryota Species 0.000 description 1
• 108060002716 Exonuclease Proteins 0.000 description 1
• 206010015866 Extravasation Diseases 0.000 description 1
• 102000003971 Fibroblast Growth Factor 1 Human genes 0.000 description 1
• 108090000386 Fibroblast Growth Factor 1 Proteins 0.000 description 1
• 102000003974 Fibroblast growth factor 2 Human genes 0.000 description 1
• 108090000379 Fibroblast growth factor 2 Proteins 0.000 description 1
• 102100038651 Four and a half LIM domains protein 1 Human genes 0.000 description 1
• 101710127220 Four and a half LIM domains protein 1 Proteins 0.000 description 1
• 108020000949 Fungal DNA Proteins 0.000 description 1
• 102100032340 G2/mitotic-specific cyclin-B1 Human genes 0.000 description 1
• 108090001064 Gelsolin Proteins 0.000 description 1
• 102000004878 Gelsolin Human genes 0.000 description 1
• 229920002306 Glycocalyx Polymers 0.000 description 1
• 108010031186 Glycoside Hydrolases Proteins 0.000 description 1
• 102000005744 Glycoside Hydrolases Human genes 0.000 description 1
• 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 description 1
• 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 description 1
• 108010045100 HSP27 Heat-Shock Proteins Proteins 0.000 description 1
• 101710113864 Heat shock protein 90 Proteins 0.000 description 1
• 102100022557 Hepatocyte growth factor-regulated tyrosine kinase substrate Human genes 0.000 description 1
• 102100029009 High mobility group protein HMG-I/HMG-Y Human genes 0.000 description 1
• 102100039869 Histone H2B type F-S Human genes 0.000 description 1
• 101710083341 Histone acetyltransferase KAT2B Proteins 0.000 description 1
• 101000884305 Homo sapiens B-cell receptor CD22 Proteins 0.000 description 1
• 101000946926 Homo sapiens C-C chemokine receptor type 5 Proteins 0.000 description 1
• 101100005713 Homo sapiens CD4 gene Proteins 0.000 description 1
• 101000868273 Homo sapiens CD44 antigen Proteins 0.000 description 1
• 101000738354 Homo sapiens CD9 antigen Proteins 0.000 description 1
• 101000890732 Homo sapiens Complement factor H-related protein 1 Proteins 0.000 description 1
• 101000878135 Homo sapiens Complement factor H-related protein 2 Proteins 0.000 description 1
• 101000878136 Homo sapiens Complement factor H-related protein 3 Proteins 0.000 description 1
• 101000878133 Homo sapiens Complement factor H-related protein 4 Proteins 0.000 description 1
• 101000878134 Homo sapiens Complement factor H-related protein 5 Proteins 0.000 description 1
• 101000619536 Homo sapiens DNA-dependent protein kinase catalytic subunit Proteins 0.000 description 1
• 101001065747 Homo sapiens E3 ubiquitin-protein ligase LRSAM1 Proteins 0.000 description 1
• 101001130401 Homo sapiens E3 ubiquitin-protein ligase RAD18 Proteins 0.000 description 1
• 101001016865 Homo sapiens Heat shock protein HSP 90-alpha Proteins 0.000 description 1
• 101000986380 Homo sapiens High mobility group protein HMG-I/HMG-Y Proteins 0.000 description 1
• 101001035372 Homo sapiens Histone H2B type F-S Proteins 0.000 description 1
• 101001059713 Homo sapiens Inner nuclear membrane protein Man1 Proteins 0.000 description 1
• 101000994375 Homo sapiens Integrin alpha-4 Proteins 0.000 description 1
• 101000935043 Homo sapiens Integrin beta-1 Proteins 0.000 description 1
• 101000599852 Homo sapiens Intercellular adhesion molecule 1 Proteins 0.000 description 1
• 101000599862 Homo sapiens Intercellular adhesion molecule 3 Proteins 0.000 description 1
• 101000608935 Homo sapiens Leukosialin Proteins 0.000 description 1
• 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 description 1
• 101000588377 Homo sapiens N-acylneuraminate cytidylyltransferase Proteins 0.000 description 1
• 101000788412 Homo sapiens Probable methyltransferase TARBP1 Proteins 0.000 description 1
• 101500026142 Homo sapiens Processed cyclic AMP-responsive element-binding protein 3 Proteins 0.000 description 1
• 101001072338 Homo sapiens Proliferating cell nuclear antigen Proteins 0.000 description 1
• 101000725943 Homo sapiens RNA polymerase II subunit A C-terminal domain phosphatase Proteins 0.000 description 1
• 101001059454 Homo sapiens Serine/threonine-protein kinase MARK2 Proteins 0.000 description 1
• 101000800116 Homo sapiens Thy-1 membrane glycoprotein Proteins 0.000 description 1
• 101001050288 Homo sapiens Transcription factor Jun Proteins 0.000 description 1
• 101000680666 Homo sapiens Tripartite motif-containing protein 5 Proteins 0.000 description 1
• 101000613251 Homo sapiens Tumor susceptibility gene 101 protein Proteins 0.000 description 1
• 101000804921 Homo sapiens X-ray repair cross-complementing protein 5 Proteins 0.000 description 1
• 108700020121 Human Immunodeficiency Virus-1 rev Proteins 0.000 description 1
• 241000709701 Human poliovirus 1 Species 0.000 description 1
• 108010016648 Immunophilins Proteins 0.000 description 1
• 102000000521 Immunophilins Human genes 0.000 description 1
• 206010061218 Inflammation Diseases 0.000 description 1
• 102100028799 Inner nuclear membrane protein Man1 Human genes 0.000 description 1
• 102100032818 Integrin alpha-4 Human genes 0.000 description 1
• 102100025304 Integrin beta-1 Human genes 0.000 description 1
• 241000274177 Juniperus sabina Species 0.000 description 1
• 208000007766 Kaposi sarcoma Diseases 0.000 description 1
• DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 1
• ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
• 102100023981 Lamina-associated polypeptide 2, isoform alpha Human genes 0.000 description 1
• 102000006835 Lamins Human genes 0.000 description 1
• 108010047294 Lamins Proteins 0.000 description 1
• 101710173438 Late L2 mu core protein Proteins 0.000 description 1
• 102000004856 Lectins Human genes 0.000 description 1
• 108090001090 Lectins Proteins 0.000 description 1
• ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
• 101710097668 Leucine aminopeptidase 2 Proteins 0.000 description 1
• 102100039564 Leukosialin Human genes 0.000 description 1
• 206010025323 Lymphomas Diseases 0.000 description 1
• 101710116782 Lysosome-associated membrane glycoprotein 1 Proteins 0.000 description 1
• 102000019149 MAP kinase activity proteins Human genes 0.000 description 1
• 108040008097 MAP kinase activity proteins Proteins 0.000 description 1
• FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
• 102000012750 Membrane Glycoproteins Human genes 0.000 description 1
• 108010090054 Membrane Glycoproteins Proteins 0.000 description 1
• 108060004795 Methyltransferase Proteins 0.000 description 1
• 102000006404 Mitochondrial Proteins Human genes 0.000 description 1
• 108010058682 Mitochondrial Proteins Proteins 0.000 description 1
• 101000910487 Mus musculus Cyclin-T1 Proteins 0.000 description 1
• 101100482085 Mus musculus Trim30a gene Proteins 0.000 description 1
• CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 description 1
• 101150091206 Nfkbia gene Proteins 0.000 description 1
• 108091092724 Noncoding DNA Proteins 0.000 description 1
• 102000007999 Nuclear Proteins Human genes 0.000 description 1
• 108010089610 Nuclear Proteins Proteins 0.000 description 1
• 102000003789 Nuclear pore complex proteins Human genes 0.000 description 1
• 108090000163 Nuclear pore complex proteins Proteins 0.000 description 1
• 101710163270 Nuclease Proteins 0.000 description 1
• 108010047956 Nucleosomes Proteins 0.000 description 1
• BZQFBWGGLXLEPQ-UHFFFAOYSA-N O-phosphoryl-L-serine Natural products OC(=O)C(N)COP(O)(O)=O BZQFBWGGLXLEPQ-UHFFFAOYSA-N 0.000 description 1
• FCRBUBVOBCGSBG-ZBRNBAAYSA-N OC(=O)[C@@H]1CCCN1.OC(=O)[C@@H](N)COP(O)(O)=O Chemical compound OC(=O)[C@@H]1CCCN1.OC(=O)[C@@H](N)COP(O)(O)=O FCRBUBVOBCGSBG-ZBRNBAAYSA-N 0.000 description 1
• 102000015636 Oligopeptides Human genes 0.000 description 1
• 108010038807 Oligopeptides Proteins 0.000 description 1
• 241001327682 Oncorhynchus mykiss irideus Species 0.000 description 1
• 101150050704 PRKDC gene Proteins 0.000 description 1
• 241001494479 Pecora Species 0.000 description 1
• 102100040283 Peptidyl-prolyl cis-trans isomerase B Human genes 0.000 description 1
• 101710111214 Peptidyl-prolyl cis-trans isomerase C Proteins 0.000 description 1
• 102100031653 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 Human genes 0.000 description 1
• 206010057249 Phagocytosis Diseases 0.000 description 1
• 108700019535 Phosphoprotein Phosphatases Proteins 0.000 description 1
• 102000045595 Phosphoprotein Phosphatases Human genes 0.000 description 1
• 108010089430 Phosphoproteins Proteins 0.000 description 1
• 102000007982 Phosphoproteins Human genes 0.000 description 1
• 102000012425 Polycomb-Group Proteins Human genes 0.000 description 1
• 108010022429 Polycomb-Group Proteins Proteins 0.000 description 1
• 101710130420 Probable capsid assembly scaffolding protein Proteins 0.000 description 1
• 102100025214 Probable methyltransferase TARBP1 Human genes 0.000 description 1
• 102400000755 Processed cyclic AMP-responsive element-binding protein 3 Human genes 0.000 description 1
• 108700020978 Proto-Oncogene Proteins 0.000 description 1
• 102000052575 Proto-Oncogene Human genes 0.000 description 1
• 108091008109 Pseudogenes Proteins 0.000 description 1
• 102000057361 Pseudogenes Human genes 0.000 description 1
• 102100023922 Putative tyrosine-protein phosphatase auxilin Human genes 0.000 description 1
• 102100027669 RNA polymerase II subunit A C-terminal domain phosphatase Human genes 0.000 description 1
• 241000700159 Rattus Species 0.000 description 1
• 108090000873 Receptor Protein-Tyrosine Kinases Proteins 0.000 description 1
• 102000004278 Receptor Protein-Tyrosine Kinases Human genes 0.000 description 1
• 108020004511 Recombinant DNA Proteins 0.000 description 1
• 102000007056 Recombinant Fusion Proteins Human genes 0.000 description 1
• 108010008281 Recombinant Fusion Proteins Proteins 0.000 description 1
• 241000702263 Reovirus sp. Species 0.000 description 1
• 108010083644 Ribonucleases Proteins 0.000 description 1
• 102000006382 Ribonucleases Human genes 0.000 description 1
• 102000000341 S-Phase Kinase-Associated Proteins Human genes 0.000 description 1
• 108010055623 S-Phase Kinase-Associated Proteins Proteins 0.000 description 1
• 102000014400 SH2 domains Human genes 0.000 description 1
• 108050003452 SH2 domains Proteins 0.000 description 1
• 102000001332 SRC Human genes 0.000 description 1
• 108060006706 SRC Proteins 0.000 description 1
• 241000607142 Salmonella Species 0.000 description 1
• 101710204410 Scaffold protein Proteins 0.000 description 1
• 102400001107 Secretory component Human genes 0.000 description 1
• 229940124639 Selective inhibitor Drugs 0.000 description 1
• MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
• 102100029666 Serine/arginine-rich splicing factor 2 Human genes 0.000 description 1
• 101710123513 Serine/arginine-rich splicing factor 2 Proteins 0.000 description 1
• 102100028904 Serine/threonine-protein kinase MARK2 Human genes 0.000 description 1
• 241000607768 Shigella Species 0.000 description 1
• 108010029157 Sialic Acid Binding Ig-like Lectin 2 Proteins 0.000 description 1
• 108010029180 Sialic Acid Binding Ig-like Lectin 3 Proteins 0.000 description 1
• 108010032838 Sialoglycoproteins Proteins 0.000 description 1
• 102000007365 Sialoglycoproteins Human genes 0.000 description 1
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
• 241000187432 Streptomyces coelicolor Species 0.000 description 1
• 230000029662 T-helper 1 type immune response Effects 0.000 description 1
• 241000255588 Tephritidae Species 0.000 description 1
• 102100033523 Thy-1 membrane glycoprotein Human genes 0.000 description 1
• 101710114283 Translation initiation factor RLI1 Proteins 0.000 description 1
• 101800001690 Transmembrane protein gp41 Proteins 0.000 description 1
• 102100022405 Tripartite motif-containing protein 5 Human genes 0.000 description 1
• 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 description 1
• 102100040879 Tumor susceptibility gene 101 protein Human genes 0.000 description 1
• 108091005966 Type III transmembrane proteins Proteins 0.000 description 1
• IVOMOUWHDPKRLL-UHFFFAOYSA-N UNPD107823 Natural products O1C2COP(O)(=O)OC2C(O)C1N1C(N=CN=C2N)=C2N=C1 IVOMOUWHDPKRLL-UHFFFAOYSA-N 0.000 description 1
• 241000700618 Vaccinia virus Species 0.000 description 1
• 241000700647 Variola virus Species 0.000 description 1
• 102100021164 Vasodilator-stimulated phosphoprotein Human genes 0.000 description 1
• 241000607626 Vibrio cholerae Species 0.000 description 1
• 102000003970 Vinculin Human genes 0.000 description 1
• 108090000384 Vinculin Proteins 0.000 description 1
• 108700005077 Viral Genes Proteins 0.000 description 1
• 208000036142 Viral infection Diseases 0.000 description 1
• 230000010530 Virus Neutralization Effects 0.000 description 1
• 101100273808 Xenopus laevis cdk1-b gene Proteins 0.000 description 1
• 241000607734 Yersinia <bacteria> Species 0.000 description 1
• 239000002253 acid Substances 0.000 description 1
• 150000007513 acids Chemical class 0.000 description 1
• 230000009471 action Effects 0.000 description 1
• 102000019997 adhesion receptor Human genes 0.000 description 1
• 108010013985 adhesion receptor Proteins 0.000 description 1
• 230000002411 adverse Effects 0.000 description 1
• 108010087924 alanylproline Proteins 0.000 description 1
• 230000019552 anatomical structure morphogenesis Effects 0.000 description 1
• 230000003466 anti-cipated effect Effects 0.000 description 1
• 230000000798 anti-retroviral effect Effects 0.000 description 1
• 230000014102 antigen processing and presentation of exogenous peptide antigen via MHC class I Effects 0.000 description 1
• 230000000890 antigenic effect Effects 0.000 description 1
• 210000000436 anus Anatomy 0.000 description 1
• 239000007864 aqueous solution Substances 0.000 description 1
• 210000004436 artificial bacterial chromosome Anatomy 0.000 description 1
• 210000001106 artificial yeast chromosome Anatomy 0.000 description 1
• 235000009582 asparagine Nutrition 0.000 description 1
• 229960001230 asparagine Drugs 0.000 description 1
• 210000001130 astrocyte Anatomy 0.000 description 1
• 230000001363 autoimmune Effects 0.000 description 1
• 230000001580 bacterial effect Effects 0.000 description 1
• 210000004082 barrier epithelial cell Anatomy 0.000 description 1
• 230000004888 barrier function Effects 0.000 description 1
• 230000009286 beneficial effect Effects 0.000 description 1
• 239000013060 biological fluid Substances 0.000 description 1
• 230000031018 biological processes and functions Effects 0.000 description 1
• 125000005340 bisphosphate group Chemical group 0.000 description 1
• 210000004369 blood Anatomy 0.000 description 1
• 239000008280 blood Substances 0.000 description 1
• 210000004556 brain Anatomy 0.000 description 1
• 244000309466 calf Species 0.000 description 1
• 102000007588 cdc25 Phosphatases Human genes 0.000 description 1
• 108010046616 cdc25 Phosphatases Proteins 0.000 description 1
• 230000023402 cell communication Effects 0.000 description 1
• 230000011712 cell development Effects 0.000 description 1
• 230000003915 cell function Effects 0.000 description 1
• 210000003855 cell nucleus Anatomy 0.000 description 1
• 210000002421 cell wall Anatomy 0.000 description 1
• 230000008614 cellular interaction Effects 0.000 description 1
• 239000001913 cellulose Substances 0.000 description 1
• 229920002678 cellulose Polymers 0.000 description 1
• ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 description 1
• 230000008859 change Effects 0.000 description 1
• 230000001876 chaperonelike Effects 0.000 description 1
• 210000001612 chondrocyte Anatomy 0.000 description 1
• 238000004587 chromatography analysis Methods 0.000 description 1
• 239000013611 chromosomal DNA Substances 0.000 description 1
• 210000002806 clathrin-coated vesicle Anatomy 0.000 description 1
• 230000004186 co-expression Effects 0.000 description 1
• 210000002314 coated vesicle Anatomy 0.000 description 1
• ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 description 1
• 239000005516 coenzyme A Substances 0.000 description 1
• 229940093530 coenzyme a Drugs 0.000 description 1
• 230000001276 controlling effect Effects 0.000 description 1
• 230000002079 cooperative effect Effects 0.000 description 1
• 230000009133 cooperative interaction Effects 0.000 description 1
• 230000001054 cortical effect Effects 0.000 description 1
• 239000006071 cream Substances 0.000 description 1
• 229940095074 cyclic amp Drugs 0.000 description 1
• 108010048032 cyclophilin B Proteins 0.000 description 1
• 235000018417 cysteine Nutrition 0.000 description 1
• XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
• 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 1
• LEVWYRKDKASIDU-IMJSIDKUSA-N cystine group Chemical group C([C@@H](C(=O)O)N)SSC[C@@H](C(=O)O)N LEVWYRKDKASIDU-IMJSIDKUSA-N 0.000 description 1
• OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical group NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 description 1
• 230000034994 death Effects 0.000 description 1
• 230000003247 decreasing effect Effects 0.000 description 1
• 230000007547 defect Effects 0.000 description 1
• 230000007123 defense Effects 0.000 description 1
• 230000002939 deleterious effect Effects 0.000 description 1
• 238000012217 deletion Methods 0.000 description 1
• 230000037430 deletion Effects 0.000 description 1
• 229940119679 deoxyribonucleases Drugs 0.000 description 1
• 230000008021 deposition Effects 0.000 description 1
• 238000009795 derivation Methods 0.000 description 1
• AVJBPWGFOQAPRH-FWMKGIEWSA-L dermatan sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](OS([O-])(=O)=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](C([O-])=O)O1 AVJBPWGFOQAPRH-FWMKGIEWSA-L 0.000 description 1
• 229940051593 dermatan sulfate Drugs 0.000 description 1
• 230000009504 deubiquitination Effects 0.000 description 1
• 229950006137 dexfosfoserine Drugs 0.000 description 1
• 238000006471 dimerization reaction Methods 0.000 description 1
• 230000005782 double-strand break Effects 0.000 description 1
• 230000002222 downregulating effect Effects 0.000 description 1
• 210000003981 ectoderm Anatomy 0.000 description 1
• 230000002500 effect on skin Effects 0.000 description 1
• 210000002308 embryonic cell Anatomy 0.000 description 1
• 108010075324 emt protein-tyrosine kinase Proteins 0.000 description 1
• 239000000839 emulsion Substances 0.000 description 1
• 210000003038 endothelium Anatomy 0.000 description 1
• 239000003623 enhancer Substances 0.000 description 1
• 230000002708 enhancing effect Effects 0.000 description 1
• 230000007613 environmental effect Effects 0.000 description 1
• 230000009088 enzymatic function Effects 0.000 description 1
• 230000004890 epithelial barrier function Effects 0.000 description 1
• 238000011156 evaluation Methods 0.000 description 1
• 102000013165 exonuclease Human genes 0.000 description 1
• 239000000284 extract Substances 0.000 description 1
• 230000036251 extravasation Effects 0.000 description 1
• 229930182830 galactose Natural products 0.000 description 1
• 150000002270 gangliosides Chemical class 0.000 description 1
• 239000007897 gelcap Substances 0.000 description 1
• 230000030279 gene silencing Effects 0.000 description 1
• 102000034356 gene-regulatory proteins Human genes 0.000 description 1
• 108091006104 gene-regulatory proteins Proteins 0.000 description 1
• 210000001102 germinal center b cell Anatomy 0.000 description 1
• 210000004517 glycocalyx Anatomy 0.000 description 1
• 150000002339 glycosphingolipids Chemical class 0.000 description 1
• 230000013595 glycosylation Effects 0.000 description 1
• 238000006206 glycosylation reaction Methods 0.000 description 1
• 210000003714 granulocyte Anatomy 0.000 description 1
• UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical class O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 description 1
• 230000036541 health Effects 0.000 description 1
• 230000002607 hemopoietic effect Effects 0.000 description 1
• 208000006454 hepatitis Diseases 0.000 description 1
• 231100000283 hepatitis Toxicity 0.000 description 1
• 108010023829 hepatocyte growth factor-regulated tyrosine kinase substrate Proteins 0.000 description 1
• 230000007062 hydrolysis Effects 0.000 description 1
• 238000006460 hydrolysis reaction Methods 0.000 description 1
• 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
• 230000008073 immune recognition Effects 0.000 description 1
• 230000006058 immune tolerance Effects 0.000 description 1
• 230000005847 immunogenicity Effects 0.000 description 1
• 239000007943 implant Substances 0.000 description 1
• 238000002513 implantation Methods 0.000 description 1
• 230000008676 import Effects 0.000 description 1
• 238000010874 in vitro model Methods 0.000 description 1
• 230000004054 inflammatory process Effects 0.000 description 1
• 238000001802 infusion Methods 0.000 description 1
• 239000004615 ingredient Substances 0.000 description 1
• 239000003999 initiator Substances 0.000 description 1
• 230000015788 innate immune response Effects 0.000 description 1
• 210000005007 innate immune system Anatomy 0.000 description 1
• 238000011081 inoculation Methods 0.000 description 1
• 239000002054 inoculum Substances 0.000 description 1
• 230000008611 intercellular interaction Effects 0.000 description 1
• 210000002490 intestinal epithelial cell Anatomy 0.000 description 1
• 210000000936 intestine Anatomy 0.000 description 1
• 230000010039 intracellular degradation Effects 0.000 description 1
• 244000000056 intracellular parasite Species 0.000 description 1
• 230000004068 intracellular signaling Effects 0.000 description 1
• 150000002500 ions Chemical class 0.000 description 1
• 210000002510 keratinocyte Anatomy 0.000 description 1
• 210000003292 kidney cell Anatomy 0.000 description 1
• 210000005053 lamin Anatomy 0.000 description 1
• 210000001821 langerhans cell Anatomy 0.000 description 1
• 210000002429 large intestine Anatomy 0.000 description 1
• 239000002523 lectin Substances 0.000 description 1
• 230000003902 lesion Effects 0.000 description 1
• 231100000518 lethal Toxicity 0.000 description 1
• 230000001665 lethal effect Effects 0.000 description 1
• 239000002502 liposome Substances 0.000 description 1
• 210000005210 lymphoid organ Anatomy 0.000 description 1
• 210000003563 lymphoid tissue Anatomy 0.000 description 1
• 206010025382 macrocytosis Diseases 0.000 description 1
• 229910052749 magnesium Inorganic materials 0.000 description 1
• 239000011777 magnesium Substances 0.000 description 1
• 230000003211 malignant effect Effects 0.000 description 1
• 210000001161 mammalian embryo Anatomy 0.000 description 1
• 239000000463 material Substances 0.000 description 1
• 230000013011 mating Effects 0.000 description 1
• 108020004084 membrane receptors Proteins 0.000 description 1
• 230000004060 metabolic process Effects 0.000 description 1
• 230000001394 metastastic effect Effects 0.000 description 1
• 206010061289 metastatic neoplasm Diseases 0.000 description 1
• 210000003632 microfilament Anatomy 0.000 description 1
• 230000002025 microglial effect Effects 0.000 description 1
• 210000000110 microvilli Anatomy 0.000 description 1
• 230000005012 migration Effects 0.000 description 1
• 238000013508 migration Methods 0.000 description 1
• 230000002297 mitogenic effect Effects 0.000 description 1
• 230000000394 mitotic effect Effects 0.000 description 1
• 230000004048 modification Effects 0.000 description 1
• 238000012986 modification Methods 0.000 description 1
• 230000004879 molecular function Effects 0.000 description 1
• 210000003205 muscle Anatomy 0.000 description 1
• 230000001338 necrotic effect Effects 0.000 description 1
• 230000001537 neural effect Effects 0.000 description 1
• 238000006386 neutralization reaction Methods 0.000 description 1
• VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 description 1
• 230000004942 nuclear accumulation Effects 0.000 description 1
• 230000012223 nuclear import Effects 0.000 description 1
• 230000025308 nuclear transport Effects 0.000 description 1
• 210000001623 nucleosome Anatomy 0.000 description 1
• 230000030648 nucleus localization Effects 0.000 description 1
• 239000002674 ointment Substances 0.000 description 1
• 150000002482 oligosaccharides Polymers 0.000 description 1
• 108010006198 p300-CBP-associated factor Proteins 0.000 description 1
• 230000035515 penetration Effects 0.000 description 1
• 108010044156 peptidyl-prolyl cis-trans isomerase b Proteins 0.000 description 1
• 210000004976 peripheral blood cell Anatomy 0.000 description 1
• 230000002093 peripheral effect Effects 0.000 description 1
• 210000001539 phagocyte Anatomy 0.000 description 1
• 239000008194 pharmaceutical composition Substances 0.000 description 1
• 239000000825 pharmaceutical preparation Substances 0.000 description 1
• 125000001095 phosphatidyl group Chemical group 0.000 description 1
• 108010055837 phosphocarrier protein HPr Proteins 0.000 description 1
• 230000000865 phosphorylative effect Effects 0.000 description 1
• BZQFBWGGLXLEPQ-REOHCLBHSA-N phosphoserine Chemical compound OC(=O)[C@@H](N)COP(O)(O)=O BZQFBWGGLXLEPQ-REOHCLBHSA-N 0.000 description 1
• 239000006187 pill Substances 0.000 description 1
• 210000002826 placenta Anatomy 0.000 description 1
• 238000006116 polymerization reaction Methods 0.000 description 1
• 230000004911 positive regulation of CREB transcription factor activity Effects 0.000 description 1
• 230000004481 post-translational protein modification Effects 0.000 description 1
• 230000012357 postreplication repair Effects 0.000 description 1
• 230000003389 potentiating effect Effects 0.000 description 1
• 239000000843 powder Substances 0.000 description 1
• 238000002360 preparation method Methods 0.000 description 1
• 101710082686 probable leucine aminopeptidase 2 Proteins 0.000 description 1
• 230000001737 promoting effect Effects 0.000 description 1
• 230000012846 protein folding Effects 0.000 description 1
• 230000006916 protein interaction Effects 0.000 description 1
• 238000001243 protein synthesis Methods 0.000 description 1
• 230000017854 proteolysis Effects 0.000 description 1
• 230000036647 reaction Effects 0.000 description 1
• 230000007115 recruitment Effects 0.000 description 1
• 239000006215 rectal suppository Substances 0.000 description 1
• 238000004064 recycling Methods 0.000 description 1
• 230000003014 reinforcing effect Effects 0.000 description 1
• 230000003252 repetitive effect Effects 0.000 description 1
• 230000003362 replicative effect Effects 0.000 description 1
• 230000001850 reproductive effect Effects 0.000 description 1
• 210000003660 reticulum Anatomy 0.000 description 1
• 210000004739 secretory vesicle Anatomy 0.000 description 1
• 230000007781 signaling event Effects 0.000 description 1
• 210000003491 skin Anatomy 0.000 description 1
• 102000030938 small GTPase Human genes 0.000 description 1
• 108060007624 small GTPase Proteins 0.000 description 1
• 210000000813 small intestine Anatomy 0.000 description 1
• 239000011780 sodium chloride Substances 0.000 description 1
• 239000002904 solvent Substances 0.000 description 1
• 210000000952 spleen Anatomy 0.000 description 1
• 239000007921 spray Substances 0.000 description 1
• 108010087686 src-Family Kinases Proteins 0.000 description 1
• 102000009076 src-Family Kinases Human genes 0.000 description 1
• 230000006641 stabilisation Effects 0.000 description 1
• 238000011105 stabilization Methods 0.000 description 1
• 230000004936 stimulating effect Effects 0.000 description 1
• 238000003860 storage Methods 0.000 description 1
• 230000004960 subcellular localization Effects 0.000 description 1
• 238000006467 substitution reaction Methods 0.000 description 1
• 239000013589 supplement Substances 0.000 description 1
• 239000000829 suppository Substances 0.000 description 1
• 208000010648 susceptibility to HIV infection Diseases 0.000 description 1
• 239000000725 suspension Substances 0.000 description 1
• 230000002459 sustained effect Effects 0.000 description 1
• 210000002182 synaptic membrane Anatomy 0.000 description 1
• 208000006379 syphilis Diseases 0.000 description 1
• 230000001839 systemic circulation Effects 0.000 description 1
• 239000011273 tar residue Substances 0.000 description 1
• 230000033863 telomere maintenance Effects 0.000 description 1
• 230000016853 telophase Effects 0.000 description 1
• 229940113082 thymine Drugs 0.000 description 1
• 230000000699 topical effect Effects 0.000 description 1
• 230000005758 transcription activity Effects 0.000 description 1
• 102000021986 transcription factor binding proteins Human genes 0.000 description 1
• 108091012338 transcription factor binding proteins Proteins 0.000 description 1
• 238000010361 transduction Methods 0.000 description 1
• 230000026683 transduction Effects 0.000 description 1
• 238000001890 transfection Methods 0.000 description 1
• 230000001052 transient effect Effects 0.000 description 1
• 102000027257 transmembrane receptors Human genes 0.000 description 1
• 108091008578 transmembrane receptors Proteins 0.000 description 1
• 230000018412 transposition, RNA-mediated Effects 0.000 description 1
• 239000001226 triphosphate Substances 0.000 description 1
• 235000011178 triphosphate Nutrition 0.000 description 1
• UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 description 1
• 210000005167 vascular cell Anatomy 0.000 description 1
• 229940124549 vasodilator Drugs 0.000 description 1
• 239000003071 vasodilator agent Substances 0.000 description 1
• 108010054220 vasodilator-stimulated phosphoprotein Proteins 0.000 description 1
• 229940118696 vibrio cholerae Drugs 0.000 description 1
• 108090000195 villin Proteins 0.000 description 1
• 101710114500 viral Ubiquitin Proteins 0.000 description 1
• 230000007501 viral attachment Effects 0.000 description 1
• 230000007486 viral budding Effects 0.000 description 1
• 230000009385 viral infection Effects 0.000 description 1
• 244000052613 viral pathogen Species 0.000 description 1
• 230000017613 viral reproduction Effects 0.000 description 1