AU2022422574A1 - Novel analogs of valproic acid and methods of medical treatment using the same - Google Patents
Novel analogs of valproic acid and methods of medical treatment using the same Download PDFInfo
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/001—Acyclic or carbocyclic compounds
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/377—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
- C07C51/38—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups by decarboxylation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
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- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
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- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2118559.0 | 2021-12-20 | ||
| GB2118559.0A GB2613900B (en) | 2021-12-20 | 2021-12-20 | Novel compounds and methods of use thereof |
| PCT/GB2022/053318 WO2023118846A1 (en) | 2021-12-20 | 2022-12-20 | Novel analogs of valproic acid and methods of medical treatment using the same |
Publications (1)
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| AU2022422574A1 true AU2022422574A1 (en) | 2024-07-18 |
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| AU2022422574A Pending AU2022422574A1 (en) | 2021-12-20 | 2022-12-20 | Novel analogs of valproic acid and methods of medical treatment using the same |
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|---|---|
| US (1) | US20250066282A1 (https=) |
| EP (1) | EP4452917A1 (https=) |
| JP (1) | JP2025500459A (https=) |
| KR (1) | KR20240152301A (https=) |
| CN (1) | CN118613464A (https=) |
| AU (1) | AU2022422574A1 (https=) |
| CA (1) | CA3242987A1 (https=) |
| GB (1) | GB2613900B (https=) |
| IL (1) | IL313669A (https=) |
| MX (1) | MX2024007654A (https=) |
| WO (1) | WO2023118846A1 (https=) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| GB2644641A (en) * | 2024-09-24 | 2026-04-29 | Cereno Scient Ab | New methods |
| WO2026068561A1 (en) | 2024-09-24 | 2026-04-02 | Cereno Scientific Ab | Valproic acid for use in treating pulmonary arterial hypertension |
| GB2644610A (en) * | 2024-09-27 | 2026-04-22 | Cereno Scient Ab | New methods |
| WO2026068552A1 (en) | 2024-09-24 | 2026-04-02 | Cereno Scientific Ab | Deuterated valproic acid compounds for use in treating pulmonary arterial hypertension |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US20120071554A1 (en) * | 2008-10-28 | 2012-03-22 | Liu Julie F | Deuterated 2-propylpentanoic acid compounds |
| US20100143507A1 (en) * | 2008-12-09 | 2010-06-10 | Auspex Pharmaceuticals, Inc. | Carboxylic acid inhibitors of histone deacetylase, gaba transaminase and sodium channel |
| GB201417828D0 (en) * | 2014-10-08 | 2014-11-19 | Cereno Scient Ab | New methods and compositions |
| RU2760304C2 (ru) * | 2016-04-08 | 2021-11-23 | Серено Сайентифик Аб | Фармацевтические составы с отсроченным высвобождением, содержащие вальпроевую кислоту, и их применение |
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2021
- 2021-12-20 GB GB2118559.0A patent/GB2613900B/en active Active
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2022
- 2022-12-20 MX MX2024007654A patent/MX2024007654A/es unknown
- 2022-12-20 CA CA3242987A patent/CA3242987A1/en active Pending
- 2022-12-20 JP JP2024538134A patent/JP2025500459A/ja active Pending
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- 2022-12-20 CN CN202280084449.3A patent/CN118613464A/zh active Pending
- 2022-12-20 US US18/721,594 patent/US20250066282A1/en active Pending
- 2022-12-20 KR KR1020247024372A patent/KR20240152301A/ko active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| GB2613900A (en) | 2023-06-21 |
| CN118613464A (zh) | 2024-09-06 |
| IL313669A (en) | 2024-08-01 |
| KR20240152301A (ko) | 2024-10-21 |
| CA3242987A1 (en) | 2023-06-29 |
| MX2024007654A (es) | 2024-07-04 |
| GB2613900B (en) | 2024-01-17 |
| EP4452917A1 (en) | 2024-10-30 |
| US20250066282A1 (en) | 2025-02-27 |
| WO2023118846A1 (en) | 2023-06-29 |
| JP2025500459A (ja) | 2025-01-09 |
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