GB2613900B - Novel compounds and methods of use thereof - Google Patents

Novel compounds and methods of use thereof Download PDF

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Publication number
GB2613900B
GB2613900B GB2118559.0A GB202118559A GB2613900B GB 2613900 B GB2613900 B GB 2613900B GB 202118559 A GB202118559 A GB 202118559A GB 2613900 B GB2613900 B GB 2613900B
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United Kingdom
Prior art keywords
methods
novel compounds
novel
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
GB2118559.0A
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English (en)
Other versions
GB2613900A (en
Inventor
Fex Tomas
Faijerson Saljo Jonas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cereno Scientific AB
Original Assignee
Cereno Scientific AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to GB2118559.0A priority Critical patent/GB2613900B/en
Application filed by Cereno Scientific AB filed Critical Cereno Scientific AB
Priority to IL313669A priority patent/IL313669A/en
Priority to EP22839416.9A priority patent/EP4452917A1/en
Priority to AU2022422574A priority patent/AU2022422574A1/en
Priority to MX2024007654A priority patent/MX2024007654A/es
Priority to CA3242987A priority patent/CA3242987A1/en
Priority to US18/721,594 priority patent/US20250066282A1/en
Priority to PCT/GB2022/053318 priority patent/WO2023118846A1/en
Priority to CN202280084449.3A priority patent/CN118613464A/zh
Priority to JP2024538134A priority patent/JP2025500459A/ja
Priority to KR1020247024372A priority patent/KR20240152301A/ko
Publication of GB2613900A publication Critical patent/GB2613900A/en
Application granted granted Critical
Publication of GB2613900B publication Critical patent/GB2613900B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/126—Acids containing more than four carbon atoms
    • C07C53/128—Acids containing more than four carbon atoms the carboxylic group being bound to a carbon atom bound to at least two other carbon atoms, e.g. neo-acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/377—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
    • C07C51/38—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups by decarboxylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB2118559.0A 2021-12-20 2021-12-20 Novel compounds and methods of use thereof Active GB2613900B (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
GB2118559.0A GB2613900B (en) 2021-12-20 2021-12-20 Novel compounds and methods of use thereof
CN202280084449.3A CN118613464A (zh) 2021-12-20 2022-12-20 丙戊酸的新型类似物以及使用其的药物治疗方法
AU2022422574A AU2022422574A1 (en) 2021-12-20 2022-12-20 Novel analogs of valproic acid and methods of medical treatment using the same
MX2024007654A MX2024007654A (es) 2021-12-20 2022-12-20 Nuevos analogos del acido valproico y metodos de tratamiento medico que usan el mismo.
CA3242987A CA3242987A1 (en) 2021-12-20 2022-12-20 NEW VALPROIC ACID ANALOGUES AND MEDICAL TREATMENT METHODS USING THESE
US18/721,594 US20250066282A1 (en) 2021-12-20 2022-12-20 Novel analogs of valproic acid and methods of medical treatment using the same
IL313669A IL313669A (en) 2021-12-20 2022-12-20 New analogs of valproic acid and methods of medical treatment with their help
EP22839416.9A EP4452917A1 (en) 2021-12-20 2022-12-20 Novel analogs of valproic acid and methods of medical treatment using the same
JP2024538134A JP2025500459A (ja) 2021-12-20 2022-12-20 バルプロ酸の新規類似体及びそれを用いた治療方法
KR1020247024372A KR20240152301A (ko) 2021-12-20 2022-12-20 발프로산의 새로운 유사체 및 이를 이용한 의학적 치료 방법
PCT/GB2022/053318 WO2023118846A1 (en) 2021-12-20 2022-12-20 Novel analogs of valproic acid and methods of medical treatment using the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2118559.0A GB2613900B (en) 2021-12-20 2021-12-20 Novel compounds and methods of use thereof

Publications (2)

Publication Number Publication Date
GB2613900A GB2613900A (en) 2023-06-21
GB2613900B true GB2613900B (en) 2024-01-17

Family

ID=84887257

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2118559.0A Active GB2613900B (en) 2021-12-20 2021-12-20 Novel compounds and methods of use thereof

Country Status (11)

Country Link
US (1) US20250066282A1 (https=)
EP (1) EP4452917A1 (https=)
JP (1) JP2025500459A (https=)
KR (1) KR20240152301A (https=)
CN (1) CN118613464A (https=)
AU (1) AU2022422574A1 (https=)
CA (1) CA3242987A1 (https=)
GB (1) GB2613900B (https=)
IL (1) IL313669A (https=)
MX (1) MX2024007654A (https=)
WO (1) WO2023118846A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2644641A (en) * 2024-09-24 2026-04-29 Cereno Scient Ab New methods
WO2026068561A1 (en) 2024-09-24 2026-04-02 Cereno Scientific Ab Valproic acid for use in treating pulmonary arterial hypertension
GB2644610A (en) * 2024-09-27 2026-04-22 Cereno Scient Ab New methods
WO2026068552A1 (en) 2024-09-24 2026-04-02 Cereno Scientific Ab Deuterated valproic acid compounds for use in treating pulmonary arterial hypertension

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100143507A1 (en) * 2008-12-09 2010-06-10 Auspex Pharmaceuticals, Inc. Carboxylic acid inhibitors of histone deacetylase, gaba transaminase and sodium channel
EP2362865A2 (en) * 2008-10-28 2011-09-07 Concert Pharmaceuticals Inc. Deuterated 2-propylpentanoic acid compounds
EP3203997A2 (en) * 2014-10-08 2017-08-16 Cereno Scientific AB Compounds and compositions for the treatment or prevention of pathological conditions associated with excess fibrin deposition and/or thrombus formation
EP3439649A1 (en) * 2016-04-08 2019-02-13 Cereno Scientific AB Delayed release pharmaceutical formulations comprising valproic acid, and uses thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2362865A2 (en) * 2008-10-28 2011-09-07 Concert Pharmaceuticals Inc. Deuterated 2-propylpentanoic acid compounds
US20100143507A1 (en) * 2008-12-09 2010-06-10 Auspex Pharmaceuticals, Inc. Carboxylic acid inhibitors of histone deacetylase, gaba transaminase and sodium channel
EP3203997A2 (en) * 2014-10-08 2017-08-16 Cereno Scientific AB Compounds and compositions for the treatment or prevention of pathological conditions associated with excess fibrin deposition and/or thrombus formation
EP3439649A1 (en) * 2016-04-08 2019-02-13 Cereno Scientific AB Delayed release pharmaceutical formulations comprising valproic acid, and uses thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Journal of Chromatography B, vol. 276, 1983, Hoffman D J et al., "Resolution of valproic acid from deuterated analogues and their quantitation in plasma using capillary gas chromatography", p. 301-309. *

Also Published As

Publication number Publication date
GB2613900A (en) 2023-06-21
CN118613464A (zh) 2024-09-06
IL313669A (en) 2024-08-01
KR20240152301A (ko) 2024-10-21
CA3242987A1 (en) 2023-06-29
MX2024007654A (es) 2024-07-04
AU2022422574A1 (en) 2024-07-18
EP4452917A1 (en) 2024-10-30
US20250066282A1 (en) 2025-02-27
WO2023118846A1 (en) 2023-06-29
JP2025500459A (ja) 2025-01-09

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