AU2022368927A1 - Rnai agents for inhibiting expression of matrix metalloproteinase 7(mmp7), compositions thereof, and methods of use - Google Patents

Rnai agents for inhibiting expression of matrix metalloproteinase 7(mmp7), compositions thereof, and methods of use Download PDF

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Publication number
AU2022368927A1
AU2022368927A1 AU2022368927A AU2022368927A AU2022368927A1 AU 2022368927 A1 AU2022368927 A1 AU 2022368927A1 AU 2022368927 A AU2022368927 A AU 2022368927A AU 2022368927 A AU2022368927 A AU 2022368927A AU 2022368927 A1 AU2022368927 A1 AU 2022368927A1
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Australia
Prior art keywords
mmp7
rnai agent
nucleotides
nucleotide
sense strand
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Pending
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AU2022368927A
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English (en)
Inventor
Erik W. Bush
Anthony Nicholas
Tao Pei
Tingting YUAN
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Arrowhead Pharmaceuticals Inc
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Arrowhead Pharmaceuticals Inc
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • A—HUMAN NECESSITIES
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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AU2022368927A 2021-10-22 2022-10-21 Rnai agents for inhibiting expression of matrix metalloproteinase 7(mmp7), compositions thereof, and methods of use Pending AU2022368927A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US202163270849P 2021-10-22 2021-10-22
US63/270,849 2021-10-22
US202263308289P 2022-02-09 2022-02-09
US63/308,289 2022-02-09
US202263345654P 2022-05-25 2022-05-25
US63/345,654 2022-05-25
PCT/US2022/078498 WO2023070082A2 (en) 2021-10-22 2022-10-21 Rnai agents for inhibiting expression of matrix metalloproteinase 7(mmp7), compositions thereof, and methods of use

Publications (1)

Publication Number Publication Date
AU2022368927A1 true AU2022368927A1 (en) 2024-04-11

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AU2022368927A Pending AU2022368927A1 (en) 2021-10-22 2022-10-21 Rnai agents for inhibiting expression of matrix metalloproteinase 7(mmp7), compositions thereof, and methods of use

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Country Link
US (1) US20230265437A1 (https=)
EP (1) EP4419689A2 (https=)
JP (1) JP2024539193A (https=)
KR (1) KR20240099296A (https=)
AU (1) AU2022368927A1 (https=)
CA (1) CA3235224A1 (https=)
CL (1) CL2024001175A1 (https=)
CO (1) CO2024005110A2 (https=)
IL (1) IL312239A (https=)
MX (1) MX2024004912A (https=)
PE (1) PE20241185A1 (https=)
TW (1) TW202334416A (https=)
WO (1) WO2023070082A2 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2024302964A1 (en) * 2023-06-13 2025-12-18 Tuojie Biotech (Shanghai) Co., Ltd. Sirna targeting mmp7, sirna conjugate and medical use thereof
KR20260046154A (ko) 2023-07-28 2026-04-06 장춘 진사이언스 파마슈티컬 씨오., 엘티디. siRNA 및 이의 조성물
WO2025152967A1 (zh) * 2024-01-15 2025-07-24 武汉人福创新药物研发中心有限公司 靶向αvβ6的化合物及其用途
WO2025228156A1 (zh) * 2024-04-30 2025-11-06 北京炫景瑞医药科技有限公司 肾靶向的双链寡核苷酸缀合物及其用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030194704A1 (en) * 2002-04-03 2003-10-16 Penn Sharron Gaynor Human genome-derived single exon nucleic acid probes useful for gene expression analysis two
US20050118625A1 (en) * 2003-10-02 2005-06-02 Mounts William M. Nucleic acid arrays for detecting gene expression associated with human osteoarthritis and human proteases
WO2006092795A2 (en) * 2005-03-01 2006-09-08 Qbi Enterprises Ltd. Oligoribonucleotides and methods of use thereof for treatment of ocular scarring and other fibrotic conditions
JP7445594B2 (ja) * 2017-11-01 2024-03-07 アローヘッド ファーマシューティカルズ インコーポレイテッド インテグリンリガンドおよびその使用
US12372530B2 (en) * 2017-11-15 2025-07-29 Beth Israel Deaconess Medical Center, Inc. Markers for the diagnosis and treatment of non-alcoholic steatohepatitis (NASH) and advanced liver fibrosis
JP2023541422A (ja) * 2020-09-11 2023-10-02 アローヘッド ファーマシューティカルズ インコーポレイテッド インテグリン標的化リガンド及びその使用

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PE20241185A1 (es) 2024-06-03
CA3235224A1 (en) 2023-04-27
WO2023070082A2 (en) 2023-04-27
TW202334416A (zh) 2023-09-01
CO2024005110A2 (es) 2024-05-30
MX2024004912A (es) 2024-05-06
KR20240099296A (ko) 2024-06-28
CL2024001175A1 (es) 2024-12-20
US20230265437A1 (en) 2023-08-24
WO2023070082A3 (en) 2023-07-06
IL312239A (en) 2024-06-01
JP2024539193A (ja) 2024-10-28
EP4419689A2 (en) 2024-08-28

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