AU2022294208A1 - Treatment or prevention of ischaemia reperfusion injury - Google Patents

Treatment or prevention of ischaemia reperfusion injury Download PDF

Info

Publication number
AU2022294208A1
AU2022294208A1 AU2022294208A AU2022294208A AU2022294208A1 AU 2022294208 A1 AU2022294208 A1 AU 2022294208A1 AU 2022294208 A AU2022294208 A AU 2022294208A AU 2022294208 A AU2022294208 A AU 2022294208A AU 2022294208 A1 AU2022294208 A1 AU 2022294208A1
Authority
AU
Australia
Prior art keywords
composition
use according
salt
malonate
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
AU2022294208A
Other languages
English (en)
Inventor
Thomas Krieg
Michael P Murphy
Hiran A PRAG
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cambridge Enterprise Ltd
Original Assignee
Cambridge Enterprise Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cambridge Enterprise Ltd filed Critical Cambridge Enterprise Ltd
Publication of AU2022294208A1 publication Critical patent/AU2022294208A1/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2022294208A 2021-06-16 2022-06-08 Treatment or prevention of ischaemia reperfusion injury Pending AU2022294208A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB2108594.9A GB202108594D0 (en) 2021-06-16 2021-06-16 Treatment or prevention of ischaemia reperfusion injury
GB2108594.9 2021-06-16
PCT/GB2022/051436 WO2022263792A1 (en) 2021-06-16 2022-06-08 Treatment or prevention of ischaemia reperfusion injury

Publications (1)

Publication Number Publication Date
AU2022294208A1 true AU2022294208A1 (en) 2024-01-25

Family

ID=76954409

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2022294208A Pending AU2022294208A1 (en) 2021-06-16 2022-06-08 Treatment or prevention of ischaemia reperfusion injury

Country Status (7)

Country Link
US (1) US20240252457A1 (https=)
EP (1) EP4355315A1 (https=)
JP (1) JP2024522767A (https=)
AU (1) AU2022294208A1 (https=)
CA (1) CA3222535A1 (https=)
GB (1) GB202108594D0 (https=)
WO (1) WO2022263792A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201918022D0 (en) * 2019-12-09 2020-01-22 Cambridge Entpr Ltd Treatment or prevention of Ischaemic Stroke Reperfusion Injury
WO2025125766A1 (en) 2023-12-12 2025-06-19 Cambridge Enterprise Limited Treatment or prevention of ischaemia reperfusion injury

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201411937D0 (en) * 2014-07-03 2014-08-20 Medical Res Council Succinate dehydrogenase inhibitors (SDH's)
EP3416634A4 (en) * 2016-02-15 2019-10-09 Artyomov, Maxim IMMUNOMODULATORY AGENTS AND METHOD FOR USE THEREOF
GB201918022D0 (en) * 2019-12-09 2020-01-22 Cambridge Entpr Ltd Treatment or prevention of Ischaemic Stroke Reperfusion Injury

Also Published As

Publication number Publication date
GB202108594D0 (en) 2021-07-28
CA3222535A1 (en) 2022-12-22
JP2024522767A (ja) 2024-06-21
US20240252457A1 (en) 2024-08-01
WO2022263792A1 (en) 2022-12-22
EP4355315A1 (en) 2024-04-24

Similar Documents

Publication Publication Date Title
Bochelen et al. Calcineurin inhibitors FK506 and SDZ ASM 981 alleviate the outcome of focal cerebral ischemic/reperfusion injury
JP2008525468A (ja) ポストコンディショニング臓器保護作用を増強する治療補助薬
US20240252457A1 (en) Treatment or Prevention of Ischaemia Reperfusion Injury
KR20170005497A (ko) 관상과 동맥의 동맥류성 지주하막출혈의 치료를 위한 조성물 및 방법
Fu et al. Recombinant human erythropoietin preconditioning attenuates liver ischemia reperfusion injury through the phosphatidylinositol-3 kinase/AKT/endothelial nitric oxide synthase pathway
EP4072522B1 (en) Malonate salt for use in the treatment or prevention of ischaemic stroke reperfusion injury
US20140322315A1 (en) Cysteamine and/or cystamine for treating ischemic injury
US5512573A (en) Use of phthaloylhydrazide derivatives as anti-hypoxic and defensive agents
TWI464147B (zh) 吲哚氫胺酸和吲哚啉氫胺酸於治療心臟衰竭或神經損傷的用途
JP2018508479A (ja) 虚血性脳卒中を予防・治療するための薬物の調製におけるビフェノールの使用
KR20180086431A (ko) L-오르니틴 페닐아세테이트의 제제
AU2010277725B2 (en) Otamixaban for treatment of elderly and renal impaired non-ST elevation myocardial infarction patients
WO2025125766A1 (en) Treatment or prevention of ischaemia reperfusion injury
WO2006117165A2 (en) Means and methods for the treatment of head injuries and stroke
CN113677202B (zh) 靶向线粒体的异缩酮/isolevuglandin清除剂
TW201500042A (zh) 與血液透析有關的低血壓的治療
WO2009091134A2 (en) Pharmaceutical composition for sepsis and septic shock
US9597322B2 (en) Otamixaban for use in the treatment of non-ST elevation acute coronary syndrome in patients planned to undergo coronary artery bypass grafting
US20220347163A1 (en) Compositions and methods for providing cardioprotective effects
EP4556472A1 (en) Use of pyridone derivative
KR20090128479A (ko) 암 치료를 위한 경요도 절제술 후 방광내 아파지퀀 투여
WO2019071171A1 (en) Method of treating sickle cell disease
JPWO2006035673A1 (ja) 虚血性心臓傷害の新保護法