AU2022287033B2 - Pyridopyrimidine derivatives useful as wee1 kinase inhibitors - Google Patents

Pyridopyrimidine derivatives useful as wee1 kinase inhibitors Download PDF

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Publication number
AU2022287033B2
AU2022287033B2 AU2022287033A AU2022287033A AU2022287033B2 AU 2022287033 B2 AU2022287033 B2 AU 2022287033B2 AU 2022287033 A AU2022287033 A AU 2022287033A AU 2022287033 A AU2022287033 A AU 2022287033A AU 2022287033 B2 AU2022287033 B2 AU 2022287033B2
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Australia
Prior art keywords
cancer
compound
tumor
cell
lymphoma
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AU2022287033A
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AU2022287033A1 (en
Inventor
Oren GILAD
Joseph Vacca
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Aprea Therapeutics Inc
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Aprea Therapeutics Inc
Aprea Therapeutics Inc
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Publication of AU2022287033A1 publication Critical patent/AU2022287033A1/en
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Priority to AU2025204724A priority Critical patent/AU2025204724A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2022287033A 2021-06-04 2022-06-03 Pyridopyrimidine derivatives useful as wee1 kinase inhibitors Active AU2022287033B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2025204724A AU2025204724A1 (en) 2021-06-04 2025-06-23 Pyridopyrimidine derivatives useful as wee1 kinase inhibitors

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163196744P 2021-06-04 2021-06-04
US63/196,744 2021-06-04
PCT/US2022/032203 WO2022256680A1 (en) 2021-06-04 2022-06-03 Pyridopyrimidine derivatives useful as wee1 kinase inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2025204724A Division AU2025204724A1 (en) 2021-06-04 2025-06-23 Pyridopyrimidine derivatives useful as wee1 kinase inhibitors

Publications (2)

Publication Number Publication Date
AU2022287033A1 AU2022287033A1 (en) 2024-01-18
AU2022287033B2 true AU2022287033B2 (en) 2025-04-17

Family

ID=82321319

Family Applications (2)

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AU2022287033A Active AU2022287033B2 (en) 2021-06-04 2022-06-03 Pyridopyrimidine derivatives useful as wee1 kinase inhibitors
AU2025204724A Pending AU2025204724A1 (en) 2021-06-04 2025-06-23 Pyridopyrimidine derivatives useful as wee1 kinase inhibitors

Family Applications After (1)

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AU2025204724A Pending AU2025204724A1 (en) 2021-06-04 2025-06-23 Pyridopyrimidine derivatives useful as wee1 kinase inhibitors

Country Status (10)

Country Link
US (1) US20240254123A1 (enExample)
EP (1) EP4347592A1 (enExample)
JP (1) JP2024522304A (enExample)
KR (1) KR102997319B1 (enExample)
CN (1) CN117794932A (enExample)
AU (2) AU2022287033B2 (enExample)
CA (1) CA3225152A1 (enExample)
IL (1) IL309037A (enExample)
MX (1) MX2023014466A (enExample)
WO (1) WO2022256680A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20240158972A (ko) 2022-03-07 2024-11-05 데비오팜 인터네셔날 에스 에이 소세포 폐암의 치료 방법
EP4777102A1 (en) 2023-09-14 2026-07-22 Debiopharm International SA Combination of a wee1 inhibitor and a pkmyt1 inhibitor
CN120189510A (zh) * 2023-12-21 2025-06-24 北京哲源科技有限责任公司 一种并环化合物的应用
TW202541810A (zh) 2023-12-22 2025-11-01 瑞士商德彪製藥國際公司 治療實體腫瘤之方法
WO2025186213A1 (en) 2024-03-04 2025-09-12 Debiopharm International S.A. Combination of a wee1 inhibitor and a topoisomerase 1 inhibitor

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013126656A1 (en) * 2012-02-23 2013-08-29 Abbvie Inc. Pyridopyrimidinone inhibitors of kinases
WO2014167347A1 (en) * 2013-04-11 2014-10-16 Almac Discovery Limited 2-aminopyrido[4,3-d]pyrimidin-5-one derivatives and their use as wee-1 inhibitors
WO2018011570A1 (en) * 2016-07-12 2018-01-18 Almac Discovery Limited Wee-1 inhibiting pyridopyrimidinone compounds
WO2019138227A1 (en) * 2018-01-10 2019-07-18 Almac Discovery Limited Pharmaceutical compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030044406A1 (en) 2001-03-02 2003-03-06 Christine Dingivan Methods of preventing or treating inflammatory or autoimmune disorders by administering CD2 antagonists in combination with other prophylactic or therapeutic agents
PE20080695A1 (es) * 2006-04-27 2008-06-28 Banyu Pharma Co Ltd Derivados de dihidropirazolopirimidinona como inhibidores de quinasa weel
MX2020001235A (es) * 2017-08-01 2020-07-20 Recurium Ip Holdings Llc Análogos de 1,2-dihidro-3h-pirazolo[3,4-d]pirimidin-3-ona.

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013126656A1 (en) * 2012-02-23 2013-08-29 Abbvie Inc. Pyridopyrimidinone inhibitors of kinases
WO2014167347A1 (en) * 2013-04-11 2014-10-16 Almac Discovery Limited 2-aminopyrido[4,3-d]pyrimidin-5-one derivatives and their use as wee-1 inhibitors
WO2018011570A1 (en) * 2016-07-12 2018-01-18 Almac Discovery Limited Wee-1 inhibiting pyridopyrimidinone compounds
WO2019138227A1 (en) * 2018-01-10 2019-07-18 Almac Discovery Limited Pharmaceutical compounds

Also Published As

Publication number Publication date
AU2022287033A1 (en) 2024-01-18
WO2022256680A1 (en) 2022-12-08
MX2023014466A (es) 2024-05-02
KR102997319B1 (ko) 2026-07-30
EP4347592A1 (en) 2024-04-10
US20240254123A1 (en) 2024-08-01
AU2025204724A1 (en) 2025-07-10
CA3225152A1 (en) 2022-12-08
KR20240044409A (ko) 2024-04-04
CN117794932A (zh) 2024-03-29
JP2024522304A (ja) 2024-06-13
IL309037A (en) 2024-02-01

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