JP2024522304A - Ｗｅｅ１キナーゼ阻害剤として有用なピリドピリミジン誘導体 - Google Patents

Ｗｅｅ１キナーゼ阻害剤として有用なピリドピリミジン誘導体 Download PDF

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Publication number
JP2024522304A
JP2024522304A JP2024518956A JP2024518956A JP2024522304A JP 2024522304 A JP2024522304 A JP 2024522304A JP 2024518956 A JP2024518956 A JP 2024518956A JP 2024518956 A JP2024518956 A JP 2024518956A JP 2024522304 A JP2024522304 A JP 2024522304A
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cancer
compound
tumor
cell
lymphoma
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JP2024518956A
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Japanese (ja)
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JP2024522304A5 (enExample
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ギラッド、オーレン
ヴァッカ、ジョセフ
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アプレラ セラピューティクス、インク．
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Publication of JP2024522304A publication Critical patent/JP2024522304A/ja
Publication of JP2024522304A5 publication Critical patent/JP2024522304A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2024518956A 2021-06-04 2022-06-03 Ｗｅｅ１キナーゼ阻害剤として有用なピリドピリミジン誘導体 Pending JP2024522304A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163196744P 2021-06-04 2021-06-04
US63/196,744 2021-06-04
PCT/US2022/032203 WO2022256680A1 (en) 2021-06-04 2022-06-03 Pyridopyrimidine derivatives useful as wee1 kinase inhibitors

Publications (2)

Publication Number Publication Date
JP2024522304A true JP2024522304A (ja) 2024-06-13
JP2024522304A5 JP2024522304A5 (enExample) 2025-06-10

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ID=82321319

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JP2024518956A Pending JP2024522304A (ja) 2021-06-04 2022-06-03 Ｗｅｅ１キナーゼ阻害剤として有用なピリドピリミジン誘導体

Country Status (10)

Country Link
US (1) US20240254123A1 (enExample)
EP (1) EP4347592A1 (enExample)
JP (1) JP2024522304A (enExample)
KR (1) KR102997319B1 (enExample)
CN (1) CN117794932A (enExample)
AU (2) AU2022287033B2 (enExample)
CA (1) CA3225152A1 (enExample)
IL (1) IL309037A (enExample)
MX (1) MX2023014466A (enExample)
WO (1) WO2022256680A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20240158972A (ko) 2022-03-07 2024-11-05 데비오팜 인터네셔날 에스 에이 소세포 폐암의 치료 방법
EP4777102A1 (en) 2023-09-14 2026-07-22 Debiopharm International SA Combination of a wee1 inhibitor and a pkmyt1 inhibitor
CN120189510A (zh) * 2023-12-21 2025-06-24 北京哲源科技有限责任公司 一种并环化合物的应用
TW202541810A (zh) 2023-12-22 2025-11-01 瑞士商德彪製藥國際公司 治療實體腫瘤之方法
WO2025186213A1 (en) 2024-03-04 2025-09-12 Debiopharm International S.A. Combination of a wee1 inhibitor and a topoisomerase 1 inhibitor

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007126128A1 (ja) * 2006-04-27 2007-11-08 Banyu Pharmaceutical Co., Ltd. ジヒドロピラゾロピリミジノン誘導体
JP2015511245A (ja) * 2012-02-23 2015-04-16 アッヴィ・インコーポレイテッド ピリドピリミジノン系キナーゼ阻害薬
JP2016516763A (ja) * 2013-04-11 2016-06-09 アルマック・ディスカバリー・リミテッドＡｌｍａｃ Ｄｉｓｃｏｖｅｒｙ Ｌｉｍｉｔｅｄ ２−アミノピリド［４，３−Ｄ］ピリミジン−５−オン誘導体及びＷｅｅ−１阻害薬としてのそれらの使用
WO2018011570A1 (en) * 2016-07-12 2018-01-18 Almac Discovery Limited Wee-1 inhibiting pyridopyrimidinone compounds
WO2019138227A1 (en) * 2018-01-10 2019-07-18 Almac Discovery Limited Pharmaceutical compounds
JP2020529993A (ja) * 2017-08-01 2020-10-15 リキュリウム アイピー ホールディングス リミテッド ライアビリティー カンパニー １，２−ジヒドロ−３Ｈ−ピラゾロ［３，４−ｄ］ピリミジン−３−オン類似体

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030044406A1 (en) 2001-03-02 2003-03-06 Christine Dingivan Methods of preventing or treating inflammatory or autoimmune disorders by administering CD2 antagonists in combination with other prophylactic or therapeutic agents

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007126128A1 (ja) * 2006-04-27 2007-11-08 Banyu Pharmaceutical Co., Ltd. ジヒドロピラゾロピリミジノン誘導体
JP2015511245A (ja) * 2012-02-23 2015-04-16 アッヴィ・インコーポレイテッド ピリドピリミジノン系キナーゼ阻害薬
JP2016516763A (ja) * 2013-04-11 2016-06-09 アルマック・ディスカバリー・リミテッドＡｌｍａｃ Ｄｉｓｃｏｖｅｒｙ Ｌｉｍｉｔｅｄ ２−アミノピリド［４，３−Ｄ］ピリミジン−５−オン誘導体及びＷｅｅ−１阻害薬としてのそれらの使用
WO2018011570A1 (en) * 2016-07-12 2018-01-18 Almac Discovery Limited Wee-1 inhibiting pyridopyrimidinone compounds
JP2020529993A (ja) * 2017-08-01 2020-10-15 リキュリウム アイピー ホールディングス リミテッド ライアビリティー カンパニー １，２−ジヒドロ−３Ｈ−ピラゾロ［３，４−ｄ］ピリミジン−３−オン類似体
WO2019138227A1 (en) * 2018-01-10 2019-07-18 Almac Discovery Limited Pharmaceutical compounds

Also Published As

Publication number Publication date
AU2022287033B2 (en) 2025-04-17
AU2022287033A1 (en) 2024-01-18
WO2022256680A1 (en) 2022-12-08
MX2023014466A (es) 2024-05-02
KR102997319B1 (ko) 2026-07-30
EP4347592A1 (en) 2024-04-10
US20240254123A1 (en) 2024-08-01
AU2025204724A1 (en) 2025-07-10
CA3225152A1 (en) 2022-12-08
KR20240044409A (ko) 2024-04-04
CN117794932A (zh) 2024-03-29
IL309037A (en) 2024-02-01

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