AU2022271212A1 - Chimeric antigen receptors with mage-a4 specificity and uses thereof - Google Patents

Chimeric antigen receptors with mage-a4 specificity and uses thereof Download PDF

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Publication number
AU2022271212A1
AU2022271212A1 AU2022271212A AU2022271212A AU2022271212A1 AU 2022271212 A1 AU2022271212 A1 AU 2022271212A1 AU 2022271212 A AU2022271212 A AU 2022271212A AU 2022271212 A AU2022271212 A AU 2022271212A AU 2022271212 A1 AU2022271212 A1 AU 2022271212A1
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Australia
Prior art keywords
seq
antigen
mage
amino acid
acid sequence
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AU2022271212A
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AU2022271212A9 (en
Inventor
Kevin BRAY
Frank DELFINO
David DILILLO
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Regeneron Pharmaceuticals Inc
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Regeneron Pharmaceuticals Inc
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Publication of AU2022271212A1 publication Critical patent/AU2022271212A1/en
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2239/10—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the structure of the chimeric antigen receptor [CAR]
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    • A61K2239/27—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by targeting or presenting multiple antigens
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C—CHEMISTRY; METALLURGY
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    • C07K2317/52—Constant or Fc region; Isotype
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C07K2319/00—Fusion polypeptide
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  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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AU2022271212A 2021-05-04 2022-05-03 Chimeric antigen receptors with mage-a4 specificity and uses thereof Pending AU2022271212A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202163184183P 2021-05-04 2021-05-04
US63/184,183 2021-05-04
US202163239293P 2021-08-31 2021-08-31
US63/239,293 2021-08-31
PCT/US2022/027463 WO2022235662A1 (en) 2021-05-04 2022-05-03 Chimeric antigen receptors with mage-a4 specificity and uses thereof

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AU2022271212A1 true AU2022271212A1 (en) 2023-11-30
AU2022271212A9 AU2022271212A9 (en) 2023-12-07

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US (1) US20240226163A1 (https=)
EP (1) EP4333876A1 (https=)
JP (1) JP2024516308A (https=)
KR (1) KR20240005854A (https=)
AU (1) AU2022271212A1 (https=)
BR (1) BR112023023067A2 (https=)
CA (1) CA3217914A1 (https=)
CL (1) CL2023003282A1 (https=)
CO (1) CO2023016595A2 (https=)
IL (1) IL308231A (https=)
MX (1) MX2023013075A (https=)
WO (1) WO2022235662A1 (https=)

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US12435444B2 (en) 2021-03-09 2025-10-07 Cdr-Life Ag Rabbit-derived antigen binding protein nucleic acid libraries and methods of making the same
CA3264474A1 (en) 2022-09-14 2024-03-21 Cdr-Life Ag MAGE-A4 DOUBLE T LYMPHOCYTE ENGAGEMENT
US20250144200A1 (en) 2023-11-06 2025-05-08 Novavax, Inc. Intranasal immunogenic compositions

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KR20230025662A (ko) * 2020-05-05 2023-02-22 리제너론 파마슈티칼스 인코포레이티드 Cd28 제타 및 cd3 제타를 포함하는 car

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