AU2021440597A1 - Composition and method for oral treatment of leukemia - Google Patents

Composition and method for oral treatment of leukemia Download PDF

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Publication number
AU2021440597A1
AU2021440597A1 AU2021440597A AU2021440597A AU2021440597A1 AU 2021440597 A1 AU2021440597 A1 AU 2021440597A1 AU 2021440597 A AU2021440597 A AU 2021440597A AU 2021440597 A AU2021440597 A AU 2021440597A AU 2021440597 A1 AU2021440597 A1 AU 2021440597A1
Authority
AU
Australia
Prior art keywords
leukemia
compound
cytotoxic agent
pharmaceutically acceptable
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
AU2021440597A
Other languages
English (en)
Inventor
Bruce Horowitz
Aru NARENDRAN
Edward V. Pershing
Dominic Rodrigues
Eric A. Wachter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UTI LP
Provectus Pharmatech Inc
Original Assignee
UTI LP
Provectus Pharmatech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UTI LP, Provectus Pharmatech Inc filed Critical UTI LP
Publication of AU2021440597A1 publication Critical patent/AU2021440597A1/en
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365Lactones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52Purines, e.g. adenine
    • A61K31/522Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2021440597A 2021-04-16 2021-04-16 Composition and method for oral treatment of leukemia Pending AU2021440597A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2021/027702 WO2022220841A1 (fr) 2021-04-16 2021-04-16 Composition et méthode de traitement oral de la leucémie

Publications (1)

Publication Number Publication Date
AU2021440597A1 true AU2021440597A1 (en) 2022-11-10

Family

ID=83640921

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2021440597A Pending AU2021440597A1 (en) 2021-04-16 2021-04-16 Composition and method for oral treatment of leukemia

Country Status (8)

Country Link
EP (1) EP4117668A4 (fr)
JP (1) JP2023529262A (fr)
KR (1) KR20230171854A (fr)
CN (1) CN115955969A (fr)
AU (1) AU2021440597A1 (fr)
CA (1) CA3175637A1 (fr)
MX (1) MX2022012945A (fr)
WO (1) WO2022220841A1 (fr)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7648695B2 (en) * 1998-08-06 2010-01-19 Provectus Pharmatech, Inc. Medicaments for chemotherapeutic treatment of disease
KR20070022308A (ko) * 2004-05-10 2007-02-26 로버트 에프 호프만 암 치료용 약제학적 조성물
EP3543256A1 (fr) * 2009-01-12 2019-09-25 Cytomx Therapeutics Inc. Compositions d anticorps modifiées et leurs procédés de production et d'utilisation
US8765725B2 (en) * 2012-05-08 2014-07-01 Aciex Therapeutics, Inc. Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof
WO2018047917A1 (fr) * 2016-09-09 2018-03-15 国立大学法人 東京大学 Effet antitumoral synergétique d'une combinaison de la protéine hmg, de l'anticorps anti-cd4 ou d'un agent de contrôle de point de contrôle immunitaire
US20220152217A9 (en) * 2017-04-12 2022-05-19 Aura Biosciences, Inc. Targeted combination therapy
JP2020517618A (ja) * 2017-04-21 2020-06-18 エピザイム,インコーポレイティド Ehmt2阻害剤との併用療法
JP7116252B2 (ja) * 2018-05-16 2022-08-09 プロヴェクタス ファーマテック,インク. 難治性小児固形腫瘍に対するハロゲン化キサンテンのインビトロ(in vitoro)および異種移植片での抗腫瘍活性

Also Published As

Publication number Publication date
JP2023529262A (ja) 2023-07-10
WO2022220841A1 (fr) 2022-10-20
CA3175637A1 (fr) 2022-10-20
MX2022012945A (es) 2023-03-16
EP4117668A4 (fr) 2023-12-06
EP4117668A1 (fr) 2023-01-18
KR20230171854A (ko) 2023-12-21
CN115955969A (zh) 2023-04-11

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