AU2021409732A1 - Compositions and methods for reducing hla-a in a cell - Google Patents

Compositions and methods for reducing hla-a in a cell Download PDF

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Publication number
AU2021409732A1
AU2021409732A1 AU2021409732A AU2021409732A AU2021409732A1 AU 2021409732 A1 AU2021409732 A1 AU 2021409732A1 AU 2021409732 A AU2021409732 A AU 2021409732A AU 2021409732 A AU2021409732 A AU 2021409732A AU 2021409732 A1 AU2021409732 A1 AU 2021409732A1
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hla
chr6
cell
cells
engineered
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AU2021409732A
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AU2021409732A9 (en
Inventor
Surbhi GOEL
Reynald Michael LESCARBEAU
Bradley Andrew MURRAY
Srijani SRIDHAR
Yong Zhang
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Intellia Therapeutics Inc
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Intellia Therapeutics Inc
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/10—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the structure of the chimeric antigen receptor [CAR]
    • A61K2239/11—Antigen recognition domain
    • A61K2239/15—Non-antibody based
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
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    • C12N2310/315—Phosphorothioates
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2510/00—Genetically modified cells

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  • General Health & Medical Sciences (AREA)
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  • Immunology (AREA)
  • Genetics & Genomics (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AU2021409732A 2020-12-23 2021-12-22 Compositions and methods for reducing hla-a in a cell Pending AU2021409732A1 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US202063130095P 2020-12-23 2020-12-23
US63/130,095 2020-12-23
US202163250996P 2021-09-30 2021-09-30
US63/250,996 2021-09-30
US202163254970P 2021-10-12 2021-10-12
US63/254,970 2021-10-12
US202163288492P 2021-12-10 2021-12-10
US63/288,492 2021-12-10
PCT/US2021/064930 WO2022140586A2 (en) 2020-12-23 2021-12-22 Compositions and methods for reducing hla-a in a cell

Publications (2)

Publication Number Publication Date
AU2021409732A1 true AU2021409732A1 (en) 2023-07-20
AU2021409732A9 AU2021409732A9 (en) 2024-07-18

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AU2021409732A Pending AU2021409732A1 (en) 2020-12-23 2021-12-22 Compositions and methods for reducing hla-a in a cell

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US (1) US20240024478A1 (https=)
EP (1) EP4267724A2 (https=)
JP (1) JP2024500858A (https=)
KR (1) KR20230124664A (https=)
AU (1) AU2021409732A1 (https=)
CA (1) CA3206284A1 (https=)
CL (2) CL2023001860A1 (https=)
CO (1) CO2023009612A2 (https=)
CR (1) CR20230320A (https=)
IL (1) IL303971A (https=)
MX (1) MX2023007466A (https=)
TW (1) TW202239959A (https=)
WO (1) WO2022140586A2 (https=)

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IL320066A (en) * 2022-10-05 2025-06-01 Garuda Therapeutics Inc Immunocompatible cells for allogeneic cell therapies to cover global, ethnic, or disease-specific populations
WO2025038646A1 (en) 2023-08-14 2025-02-20 Intellia Therapeutics, Inc. Cd70 car-t compositions and methods for cell-based therapy
WO2025038637A1 (en) 2023-08-14 2025-02-20 Intellia Therapeutics, Inc. Compositions and methods for genetically modifying transforming growth factor beta receptor type 2 (tgfβr2)
WO2025038642A1 (en) 2023-08-14 2025-02-20 Intellia Therapeutics, Inc. Compositions and methods for genetically modifying cd70
IL326191A (en) 2023-08-14 2026-03-01 Intellia Therapeutics Inc Compositions and methods for genetic modification of transforming growth factor beta receptor type 2 (tgfβr2)
WO2025049432A1 (en) * 2023-08-28 2025-03-06 Intellia Therapeutics, Inc. Methods for editing hla-a in cells pre-screened for the absence of one or both alleles of hla-h*01
WO2025049481A1 (en) * 2023-08-28 2025-03-06 Intellia Therapeutics, Inc. Methods of editing an hla-a gene in vitro
WO2025128871A2 (en) 2023-12-13 2025-06-19 Renagade Therapeutics Management Inc. Lipid nanoparticles comprising coding rna molecules for use in gene editing and as vaccines and therapeutic agents
WO2025255308A1 (en) 2024-06-07 2025-12-11 Intellia Therapeutics, Inc. Cd8 co-receptor chimeric polypeptides in tcr cell therapy

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Publication number Publication date
TW202239959A (zh) 2022-10-16
WO2022140586A3 (en) 2022-08-04
EP4267724A2 (en) 2023-11-01
MX2023007466A (es) 2023-08-18
KR20230124664A (ko) 2023-08-25
CA3206284A1 (en) 2022-06-30
CR20230320A (es) 2023-10-23
AU2021409732A9 (en) 2024-07-18
WO2022140586A2 (en) 2022-06-30
IL303971A (en) 2023-08-01
CL2023001860A1 (es) 2024-02-09
JP2024500858A (ja) 2024-01-10
US20240024478A1 (en) 2024-01-25
CL2023003086A1 (es) 2024-05-03
CO2023009612A2 (es) 2023-08-09

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