JP2024500858A - 細胞中のｈｌａ－ａを低減するための組成物及び方法 - Google Patents

細胞中のｈｌａ－ａを低減するための組成物及び方法 Download PDF

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JP2024500858A
JP2024500858A JP2023537689A JP2023537689A JP2024500858A JP 2024500858 A JP2024500858 A JP 2024500858A JP 2023537689 A JP2023537689 A JP 2023537689A JP 2023537689 A JP2023537689 A JP 2023537689A JP 2024500858 A JP2024500858 A JP 2024500858A
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hla
chr6
cell
cells
engineered
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JPWO2022140586A5 (https=
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ゴエル，サービ
ザン，ヨン
マイケル レスカルボ―，レイナルド
アンドリュー ミュレー，ブラッドリー
スリダー，スリジャニ
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インテリア セラピューティクス，インコーポレイテッド
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    • A61K40/41—Vertebrate antigens
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/10—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the structure of the chimeric antigen receptor [CAR]
    • A61K2239/11—Antigen recognition domain
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]

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JP2023537689A 2020-12-23 2021-12-22 細胞中のｈｌａ－ａを低減するための組成物及び方法 Pending JP2024500858A (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US202063130095P 2020-12-23 2020-12-23
US63/130,095 2020-12-23
US202163250996P 2021-09-30 2021-09-30
US63/250,996 2021-09-30
US202163254970P 2021-10-12 2021-10-12
US63/254,970 2021-10-12
US202163288492P 2021-12-10 2021-12-10
US63/288,492 2021-12-10
PCT/US2021/064930 WO2022140586A2 (en) 2020-12-23 2021-12-22 Compositions and methods for reducing hla-a in a cell

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JP2024500858A true JP2024500858A (ja) 2024-01-10
JPWO2022140586A5 JPWO2022140586A5 (https=) 2025-07-08
JP2024500858A5 JP2024500858A5 (https=) 2025-07-08

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US (1) US20240024478A1 (https=)
EP (1) EP4267724A2 (https=)
JP (1) JP2024500858A (https=)
KR (1) KR20230124664A (https=)
AU (1) AU2021409732A1 (https=)
CA (1) CA3206284A1 (https=)
CL (2) CL2023001860A1 (https=)
CO (1) CO2023009612A2 (https=)
CR (1) CR20230320A (https=)
IL (1) IL303971A (https=)
MX (1) MX2023007466A (https=)
TW (1) TW202239959A (https=)
WO (1) WO2022140586A2 (https=)

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AU2024324870A1 (en) 2023-08-14 2026-02-12 Intellia Therapeutics, Inc. Compositions and methods for genetically modifying transforming growth factor beta receptor type 2 (tgfβr2)
TW202521564A (zh) 2023-08-14 2025-06-01 美商英特利亞醫療公司 用於基於細胞之療法的ｃｄ７０ ｃａｒ－ｔ組合物及方法
TW202515994A (zh) 2023-08-14 2025-04-16 美商英特利亞醫療公司 用於對ｃｄ７０進行基因修飾之組合物及方法
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WO2025049481A1 (en) * 2023-08-28 2025-03-06 Intellia Therapeutics, Inc. Methods of editing an hla-a gene in vitro
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WO2025255308A1 (en) 2024-06-07 2025-12-11 Intellia Therapeutics, Inc. Cd8 co-receptor chimeric polypeptides in tcr cell therapy

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CA3206284A1 (en) 2022-06-30
IL303971A (en) 2023-08-01
MX2023007466A (es) 2023-08-18
EP4267724A2 (en) 2023-11-01
WO2022140586A2 (en) 2022-06-30
WO2022140586A3 (en) 2022-08-04
CL2023003086A1 (es) 2024-05-03
TW202239959A (zh) 2022-10-16
CO2023009612A2 (es) 2023-08-09
US20240024478A1 (en) 2024-01-25
AU2021409732A9 (en) 2024-07-18
CR20230320A (es) 2023-10-23
KR20230124664A (ko) 2023-08-25
CL2023001860A1 (es) 2024-02-09

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