AU2021402415A1 - Cocrystal of a cdk inhibitor - Google Patents
Cocrystal of a cdk inhibitor Download PDFInfo
- Publication number
- AU2021402415A1 AU2021402415A1 AU2021402415A AU2021402415A AU2021402415A1 AU 2021402415 A1 AU2021402415 A1 AU 2021402415A1 AU 2021402415 A AU2021402415 A AU 2021402415A AU 2021402415 A AU2021402415 A AU 2021402415A AU 2021402415 A1 AU2021402415 A1 AU 2021402415A1
- Authority
- AU
- Australia
- Prior art keywords
- compound
- formula
- fumarate
- cocrystal
- mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
- C07C57/13—Dicarboxylic acids
- C07C57/15—Fumaric acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN202041055174 | 2020-12-18 | ||
| IN202041055174 | 2020-12-18 | ||
| PCT/IB2021/061895 WO2022130304A1 (en) | 2020-12-18 | 2021-12-17 | Cocrystal of a cdk inhibitor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2021402415A1 true AU2021402415A1 (en) | 2023-07-06 |
Family
ID=80001496
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2021402415A Abandoned AU2021402415A1 (en) | 2020-12-18 | 2021-12-17 | Cocrystal of a cdk inhibitor |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20240059669A1 (https=) |
| EP (1) | EP4263534A1 (https=) |
| JP (1) | JP2023554492A (https=) |
| KR (1) | KR20230159363A (https=) |
| CN (1) | CN116685326A (https=) |
| AU (1) | AU2021402415A1 (https=) |
| CA (1) | CA3202198A1 (https=) |
| CL (1) | CL2023001753A1 (https=) |
| CO (1) | CO2023009368A2 (https=) |
| CR (1) | CR20230261A (https=) |
| DO (1) | DOP2023000126A (https=) |
| EC (1) | ECSP23054131A (https=) |
| IL (1) | IL303738A (https=) |
| MX (1) | MX2023007218A (https=) |
| PE (1) | PE20231441A1 (https=) |
| TW (1) | TW202241881A (https=) |
| WO (1) | WO2022130304A1 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022084930A2 (en) * | 2020-10-22 | 2022-04-28 | Aurigene Discovery Technologies Limited | Cancer therapy using a combination of cdk7 inhibitor with an anti-microtubule agent |
| US12084453B2 (en) | 2021-12-10 | 2024-09-10 | Incyte Corporation | Bicyclic amines as CDK12 inhibitors |
| WO2023224961A1 (en) | 2022-05-16 | 2023-11-23 | Exelixis, Inc. | Cancer therapy using a combination of a cdk7 inhibitor with an oral serd |
| TW202508595A (zh) | 2023-05-04 | 2025-03-01 | 美商銳新醫藥公司 | 用於ｒａｓ相關疾病或病症之組合療法 |
| US20250049810A1 (en) | 2023-08-07 | 2025-02-13 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| AU2024360465A1 (en) | 2023-10-12 | 2026-04-09 | Revolution Medicines, Inc. | Macrocyclic ras inhibitors |
| WO2025171296A1 (en) | 2024-02-09 | 2025-08-14 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025217307A1 (en) | 2024-04-09 | 2025-10-16 | Revolution Medicines, Inc. | Methods for predicting response to a ras(on) inhibitor and combination therapies |
| TW202547461A (zh) | 2024-05-17 | 2025-12-16 | 美商銳新醫藥公司 | Ｒａｓ抑制劑 |
| WO2025255438A1 (en) | 2024-06-07 | 2025-12-11 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| CN118772106A (zh) * | 2024-06-07 | 2024-10-15 | 山东大学 | 伊马替尼-没食子酸共晶、其溶剂化物、制备方法和应用 |
| WO2025265060A1 (en) | 2024-06-21 | 2025-12-26 | Revolution Medicines, Inc. | Therapeutic compositions and methods for managing treatment-related effects |
| WO2026006747A1 (en) | 2024-06-28 | 2026-01-02 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026015790A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015801A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015796A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015825A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Use of ras inhibitor for treating pancreatic cancer |
| WO2026050446A1 (en) | 2024-08-29 | 2026-03-05 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026072904A2 (en) | 2024-09-26 | 2026-04-02 | Revolution Medicines, Inc. | Compositions and methods for treating lung cancer |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI3302448T1 (sl) | 2015-06-04 | 2024-03-29 | Aurigene Oncology Limited | Substituirani heterociklični derivati kot inhibitorji cdk |
-
2021
- 2021-12-17 PE PE2023001908A patent/PE20231441A1/es unknown
- 2021-12-17 AU AU2021402415A patent/AU2021402415A1/en not_active Abandoned
- 2021-12-17 EP EP21848027.5A patent/EP4263534A1/en active Pending
- 2021-12-17 WO PCT/IB2021/061895 patent/WO2022130304A1/en not_active Ceased
- 2021-12-17 TW TW110147455A patent/TW202241881A/zh unknown
- 2021-12-17 MX MX2023007218A patent/MX2023007218A/es unknown
- 2021-12-17 CN CN202180085401.XA patent/CN116685326A/zh active Pending
- 2021-12-17 CA CA3202198A patent/CA3202198A1/en active Pending
- 2021-12-17 US US18/257,962 patent/US20240059669A1/en active Pending
- 2021-12-17 JP JP2023537470A patent/JP2023554492A/ja active Pending
- 2021-12-17 CR CR20230261A patent/CR20230261A/es unknown
- 2021-12-17 KR KR1020237024297A patent/KR20230159363A/ko active Pending
- 2021-12-17 IL IL303738A patent/IL303738A/en unknown
-
2023
- 2023-06-15 CL CL2023001753A patent/CL2023001753A1/es unknown
- 2023-06-16 DO DO2023000126A patent/DOP2023000126A/es unknown
- 2023-07-14 CO CONC2023/0009368A patent/CO2023009368A2/es unknown
- 2023-07-18 EC ECSENADI202354131A patent/ECSP23054131A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CO2023009368A2 (es) | 2023-09-29 |
| KR20230159363A (ko) | 2023-11-21 |
| ECSP23054131A (es) | 2023-09-29 |
| EP4263534A1 (en) | 2023-10-25 |
| WO2022130304A1 (en) | 2022-06-23 |
| CN116685326A (zh) | 2023-09-01 |
| MX2023007218A (es) | 2023-07-27 |
| CA3202198A1 (en) | 2022-06-23 |
| JP2023554492A (ja) | 2023-12-27 |
| US20240059669A1 (en) | 2024-02-22 |
| CR20230261A (es) | 2023-10-04 |
| IL303738A (en) | 2023-08-01 |
| TW202241881A (zh) | 2022-11-01 |
| PE20231441A1 (es) | 2023-09-14 |
| DOP2023000126A (es) | 2023-11-30 |
| CL2023001753A1 (es) | 2024-02-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20240059669A1 (en) | Cocrystal of a cdk inhibitor | |
| JP6882299B2 (ja) | 多環式ｔｌｒ７／８アンタゴニスト及び免疫障害の治療におけるそれらの使用 | |
| CN120548318A (zh) | Kras g12d抑制剂和其用途 | |
| US10023577B2 (en) | Crystalline form of JAK kinase inhibitor bisulfate and a preparation method thereof | |
| TWI698428B (zh) | Mdm2抑制劑之製備方法及結晶型 | |
| KR101424013B1 (ko) | 1-(3-시아노-1-아이소프로필-인돌-5-일)피라졸-4-카르복실산의 결정형과 그의 제조방법 | |
| JP2015514060A (ja) | 上皮成長因子受容体キナーゼ阻害剤の固体形態 | |
| JP2021523208A (ja) | ピリミジン誘導体の医薬塩及び障害の処置方法 | |
| WO2017152707A1 (zh) | 吡啶胺基嘧啶衍生物甲磺酸盐的结晶形式及其制备和应用 | |
| CN117203208A (zh) | 靶向活化与失活态kras g12d的抑制剂 | |
| WO2021233133A1 (zh) | 用作ret激酶抑制剂的化合物及其应用 | |
| JP2012255038A (ja) | 異常な細胞増殖の治療用のピリミジン誘導体 | |
| US20230174545A1 (en) | Heterocyclic compounds as bet inhibitors | |
| EA028059B1 (ru) | Твердые формы n-((s)-2,3-дигидроксипропил)-3-(2-фтор-4-йодфениламино)изоникотинамида | |
| KR102847760B1 (ko) | 디아미노피리미딘 화합물 또는 이의 수화물의 고체 형태, 이의 제조 방법 및 이의 용도 | |
| US20210053951A1 (en) | Salt Forms Of 4-Cyano-N-(4,4-Dimethylcyclohex-1-EN-1-YL)-6-(2,2,6,6-Tetramethyltetrahydro-2H-Pyran-4-YL)Pyridin-3-YL)-1H-Imidazole-2-Carboximide | |
| CN103269700A (zh) | 用于癌症治疗的鬼臼苦素多晶型b或c | |
| HK40099717A (zh) | Cdk抑制剂的共晶体 | |
| EA050691B1 (ru) | Сокристалл ингибитора cdk | |
| TW202102487A (zh) | N-(5-((4-乙基哌𠯤-1-基)甲基)吡啶-2-基)-5-氟-4-(3-異丙基-2-甲基-2h-吲唑-5-基)嘧啶-2-胺及其鹽的結晶與非晶型以及其製備方法與醫療用途 | |
| KR102522788B1 (ko) | 카모스타트 및 니클로사마이드를 포함하는 공결정, 이를 포함하는 약학 조성물 및 이의 제조 방법 | |
| TW202543626A (zh) | 新穎結晶相形式 | |
| WO2020222189A1 (en) | Crystalline form of 6-[4-[1-(propan-2-yl)piperidin-4-yl]-1,4-diazepan-1-yl]-n-(pyrdin-4-yl)pyridine-2-carboxamide | |
| WO2020222190A1 (en) | Crystalline form of 6-[4-[1 -(propan-2-yl)piperidin-4-yl]-1,4-diazepan-1 -yl]-n-(pyrdin-4-yl)pyridine-2-carboxamide | |
| CA2914854C (en) | Polymorph forms of icotinib maleate and uses thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK1 | Application lapsed section 142(2)(a) - no request for examination in relevant period |