AU2021378290B2 - Affinity reagents having enhanced binding and detection characteristics - Google Patents
Affinity reagents having enhanced binding and detection characteristicsInfo
- Publication number
- AU2021378290B2 AU2021378290B2 AU2021378290A AU2021378290A AU2021378290B2 AU 2021378290 B2 AU2021378290 B2 AU 2021378290B2 AU 2021378290 A AU2021378290 A AU 2021378290A AU 2021378290 A AU2021378290 A AU 2021378290A AU 2021378290 B2 AU2021378290 B2 AU 2021378290B2
- Authority
- AU
- Australia
- Prior art keywords
- binding
- components
- detectable
- nucleic acid
- probe
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6811—Selection methods for production or design of target specific oligonucleotides or binding molecules
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6832—Enhancement of hybridisation reaction
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063112607P | 2020-11-11 | 2020-11-11 | |
| US63/112,607 | 2020-11-11 | ||
| US202063132170P | 2020-12-30 | 2020-12-30 | |
| US63/132,170 | 2020-12-30 | ||
| US202163227080P | 2021-07-29 | 2021-07-29 | |
| US63/227,080 | 2021-07-29 | ||
| PCT/US2021/058851 WO2022103887A1 (en) | 2020-11-11 | 2021-11-10 | Affinity reagents having enhanced binding and detection characteristics |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2021378290A1 AU2021378290A1 (en) | 2023-06-29 |
| AU2021378290B2 true AU2021378290B2 (en) | 2025-10-30 |
Family
ID=78824678
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2021378290A Active AU2021378290B2 (en) | 2020-11-11 | 2021-11-10 | Affinity reagents having enhanced binding and detection characteristics |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US11692217B2 (enExample) |
| EP (1) | EP4244382A1 (enExample) |
| JP (1) | JP2023549350A (enExample) |
| KR (1) | KR20230118570A (enExample) |
| AU (1) | AU2021378290B2 (enExample) |
| CA (1) | CA3196729A1 (enExample) |
| WO (1) | WO2022103887A1 (enExample) |
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| CA3135206A1 (en) * | 2019-04-29 | 2020-11-05 | Pierre Indermuhle | Methods and systems for integrated on-chip single-molecule detection |
| AU2021378290B2 (en) * | 2020-11-11 | 2025-10-30 | Nautilus Subsidiary, Inc. | Affinity reagents having enhanced binding and detection characteristics |
| EP4075140A1 (en) * | 2021-04-12 | 2022-10-19 | Technische Universität München | Nucleic acid origami platforms and their uses |
| CA3227872A1 (en) | 2021-09-09 | 2023-03-16 | James Henry JOLY | Characterization and localization of protein modifications |
| AU2022402132A1 (en) | 2021-11-30 | 2024-05-30 | Nautilus Subsidiary, Inc. | Particle-based isolation of proteins and other analytes |
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| WO2024030954A1 (en) | 2022-08-03 | 2024-02-08 | Nautilus Subsidiary, Inc. | Chemical modification of antibodies and functional fragments thereof |
| US20240093270A1 (en) * | 2022-08-12 | 2024-03-21 | Nautilus Subsidiary, Inc. | Generation and selection of affinity reagents |
| US12347527B2 (en) * | 2022-08-23 | 2025-07-01 | Leica Microsystems Cms Gmbh | Data storage device and method for storing data using an oligonucleotide nanostructure backbone and labels with dyes |
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| EP4666071A2 (en) | 2023-02-13 | 2025-12-24 | Nautilus Subsidiary, Inc. | Affinity reagents having artificial polymer scaffolds |
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| US20250066841A1 (en) * | 2023-08-24 | 2025-02-27 | Nautilus Subsidiary, Inc. | Compositions and methods for detecting binding interactions under equilibrium or non-equilibrium conditions |
| US20250189519A1 (en) | 2023-12-11 | 2025-06-12 | Nautilus Subsidiary, Inc. | Methods and compositions of particle-based arrays |
| US20250298016A1 (en) | 2024-03-22 | 2025-09-25 | Nautilus Subsidiary, Inc. | Plasmonic particle systems for single-analyte assays |
| WO2025212417A1 (en) | 2024-04-01 | 2025-10-09 | Nautilus Subsidiary, Inc. | Single molecule-resolved characterization of affinity reagent kinetics and thermodynamics |
| US20250305034A1 (en) | 2024-04-01 | 2025-10-02 | Nautilus Subsidiary, Inc. | Nanostructures for modulation of analyte conformation |
| WO2025215336A1 (en) * | 2024-04-09 | 2025-10-16 | Printzymes Ltd | Improvements relating to three-dimensional printing |
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| US20260049981A1 (en) | 2024-06-27 | 2026-02-19 | Nautilus Subsidiary, Inc. | Enrichment of particle reagents for array-based assays |
| WO2026008147A1 (en) * | 2024-07-04 | 2026-01-08 | Leica Microsystems Cms Gmbh | Label, marker and method for analysing a biological sample |
| CN119198800B (zh) * | 2024-09-25 | 2025-10-03 | 中国科学院上海高等研究院 | 一种利用双模态生物正交球形核酸探针进行原代神经元细胞成像的方法 |
| WO2026072625A1 (en) | 2024-09-27 | 2026-04-02 | Nautilus Subsidiary, Inc. | Single analyte characterization under equilibrium binding conditions |
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