AU2021364314C1 - DNA-containing polynucleotides and guides for CRISPR type V systems, and methods of making and using the same - Google Patents

DNA-containing polynucleotides and guides for CRISPR type V systems, and methods of making and using the same Download PDF

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AU2021364314C1
AU2021364314C1 AU2021364314A AU2021364314A AU2021364314C1 AU 2021364314 C1 AU2021364314 C1 AU 2021364314C1 AU 2021364314 A AU2021364314 A AU 2021364314A AU 2021364314 A AU2021364314 A AU 2021364314A AU 2021364314 C1 AU2021364314 C1 AU 2021364314C1
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Paul Daniel Donohoue
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Caribou Biosciences Inc
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • C07K2319/00—Fusion polypeptide
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    • C12N2310/00—Structure or type of the nucleic acid
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AU2021364314A 2020-10-19 2021-10-18 DNA-containing polynucleotides and guides for CRISPR type V systems, and methods of making and using the same Active AU2021364314C1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US202063093459P 2020-10-19 2020-10-19
US63/093,459 2020-10-19
US202063127648P 2020-12-18 2020-12-18
US63/127,648 2020-12-18
US202163229870P 2021-08-05 2021-08-05
US63/229,870 2021-08-05
PCT/US2021/055394 WO2022086846A2 (en) 2020-10-19 2021-10-18 Dna-containing polynucleotides and guides for crispr type v systems, and methods of making and using the same

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AU2021364314A1 AU2021364314A1 (en) 2023-03-16
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AU2021364314C1 true AU2021364314C1 (en) 2025-02-20

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WO2024046307A1 (zh) * 2022-08-29 2024-03-07 北京迅识科技有限公司 一种突变的v型crispr酶及其应用
AU2023353989A1 (en) 2022-09-30 2025-02-27 Caribou Biosciences, Inc. Anti-ror1 chimeric antigen receptors (cars), cells expressing the cars and related methods
WO2024102434A1 (en) 2022-11-10 2024-05-16 Senda Biosciences, Inc. Rna compositions comprising lipid nanoparticles or lipid reconstructed natural messenger packs
EP4584283A1 (en) 2022-11-14 2025-07-16 Caribou Biosciences, Inc. Anti-cll-1 chimeric antigen receptors, engineered cells and related methods
AU2024236558A1 (en) 2023-03-15 2025-10-09 Renagade Therapeutics Management Inc. Delivery of gene editing systems and methods of use thereof
EP4704886A1 (en) * 2023-05-01 2026-03-11 Caribou Biosciences, Inc. Treatment of autoimmune diseases with bcma-targeting engineered immune cells
WO2025006880A1 (en) 2023-06-29 2025-01-02 Caribou Biosciences, Inc. Diagnostic and therapeutic methods for use with ror1 antagonists
WO2025024679A1 (en) * 2023-07-26 2025-01-30 Caribou Biosciences, Inc. In vitro validation methods for car-t cell therapies
AU2024335327A1 (en) 2023-09-01 2026-03-26 Renagade Therapeutics Management Inc. Gene editing systems, compositions, and methods for treatment of vexas syndrome
WO2025117745A1 (en) 2023-12-01 2025-06-05 Caribou Biosciences, Inc. Methods and compositions for improving precision of endonuclease-mediated genome editing
WO2025174765A1 (en) 2024-02-12 2025-08-21 Renagade Therapeutics Management Inc. Lipid nanoparticles comprising coding rna molecules for use in gene editing and as vaccines and therapeutic agents
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CN119881333B (zh) * 2025-01-27 2025-11-28 上海市肿瘤研究所 一种dna纳米花级联crispr系统的蛋白标志物检测平台及其构建方法和应用

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WO2022086846A2 (en) 2022-04-28
KR20230090337A (ko) 2023-06-21
JP2023546158A (ja) 2023-11-01
EP4229198A2 (en) 2023-08-23
JP7698715B2 (ja) 2025-06-25
AU2021364314A1 (en) 2023-03-16
WO2022086846A3 (en) 2022-07-21
MX2023004505A (es) 2023-05-10
IL302220A (en) 2023-06-01
WO2022086846A9 (en) 2023-06-15
CA3198905A1 (en) 2022-04-28
AU2021364314B2 (en) 2024-11-21
US20250027078A1 (en) 2025-01-23

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