AU2021357826B2 - Prefusion-stabilized hmpv f proteins - Google Patents

Prefusion-stabilized hmpv f proteins

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Publication number
AU2021357826B2
AU2021357826B2 AU2021357826A AU2021357826A AU2021357826B2 AU 2021357826 B2 AU2021357826 B2 AU 2021357826B2 AU 2021357826 A AU2021357826 A AU 2021357826A AU 2021357826 A AU2021357826 A AU 2021357826A AU 2021357826 B2 AU2021357826 B2 AU 2021357826B2
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AU
Australia
Prior art keywords
engineered
protein
nucleic acid
hmpv
seq
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Active
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AU2021357826A
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English (en)
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AU2021357826A9 (en
AU2021357826A1 (en
Inventor
Ching-Lin Hsieh
Jason MCLELLAN
Scott Rush
Nianshuang WANG
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The University of Texas System
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The University of Texas System
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Publication of AU2021357826A1 publication Critical patent/AU2021357826A1/en
Publication of AU2021357826A9 publication Critical patent/AU2021357826A9/en
Priority to AU2025208554A priority Critical patent/AU2025208554B2/en
Application granted granted Critical
Publication of AU2021357826B2 publication Critical patent/AU2021357826B2/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/08—RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18311—Metapneumovirus, e.g. avian pneumovirus
    • C12N2760/18322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18311—Metapneumovirus, e.g. avian pneumovirus
    • C12N2760/18334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2021357826A 2020-10-09 2021-10-07 Prefusion-stabilized hmpv f proteins Active AU2021357826B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2025208554A AU2025208554B2 (en) 2020-10-09 2025-07-28 Prefusion-stabilized hmpv f proteins

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063089978P 2020-10-09 2020-10-09
US63/089,978 2020-10-09
PCT/US2021/053944 WO2022076669A1 (en) 2020-10-09 2021-10-07 Prefusion-stabilized hmpv f proteins

Related Child Applications (1)

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AU2025208554A Division AU2025208554B2 (en) 2020-10-09 2025-07-28 Prefusion-stabilized hmpv f proteins

Publications (3)

Publication Number Publication Date
AU2021357826A1 AU2021357826A1 (en) 2023-05-11
AU2021357826A9 AU2021357826A9 (en) 2023-07-13
AU2021357826B2 true AU2021357826B2 (en) 2026-08-13

Family

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Family Applications (1)

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AU2021357826A Active AU2021357826B2 (en) 2020-10-09 2021-10-07 Prefusion-stabilized hmpv f proteins

Country Status (14)

Country Link
US (4) US11919927B2 (enExample)
EP (1) EP4225364A4 (enExample)
JP (2) JP7660671B2 (enExample)
KR (3) KR102984315B1 (enExample)
CN (1) CN116615235A (enExample)
AU (1) AU2021357826B2 (enExample)
CA (1) CA3195015A1 (enExample)
CO (1) CO2023005373A2 (enExample)
IL (3) IL320367A (enExample)
MX (1) MX2023004078A (enExample)
NZ (1) NZ798475A (enExample)
PE (1) PE20231439A1 (enExample)
WO (1) WO2022076669A1 (enExample)
ZA (1) ZA202506489B (enExample)

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KR20230107621A (ko) 2020-11-13 2023-07-17 아이코사백스, 인크. 메타뉴모바이러스에 대한 단백질-기반 나노입자 백신
JP2024544054A (ja) * 2021-11-30 2024-11-27 サノフィ パスツール インコーポレイテッド ヒトメタニューモウイルスのウイルスベクターに基づくワクチン
EP4448802A1 (en) * 2021-12-16 2024-10-23 Janssen Vaccines & Prevention B.V. Stabilized pre-fusion hmpv fusion proteins
AU2023269241A1 (en) * 2022-05-12 2024-11-21 Msd International Business Gmbh Stabilized pre-fusion hmpv fusion proteins
CN119371495B (zh) * 2022-09-29 2025-10-21 北京昌平实验室 一种融合前构象的呼吸道合胞病毒重组融合蛋白、其制备方法及用途
CN120548194A (zh) 2023-01-18 2025-08-26 辉瑞公司 针对呼吸道疾病的疫苗
US12649790B2 (en) 2023-07-03 2026-06-09 Medicovestor, Inc. Proteins that bind SP17 including fully-human anti-SP17 antibodies
US12624097B2 (en) 2023-07-03 2026-05-12 Medicovestor, Inc. Nucleic acids, vectors, and cells that encode anti-Sp17 antibodies and other Sp17 binding proteins
US12319747B2 (en) 2023-07-03 2025-06-03 Medicovestor, Inc. Methods of using anti-SP17 immunotherapeutics
US12364777B2 (en) 2023-10-20 2025-07-22 Medicovestor, Inc. Homodimeric antibodies for use in treating cancers and methods of use
WO2025119162A1 (zh) * 2023-12-04 2025-06-12 深圳深信生物科技有限公司 偏肺病毒(mpv)疫苗
WO2025126071A1 (en) 2023-12-14 2025-06-19 Pfizer Inc. Rna molecules
US12121587B1 (en) 2023-12-26 2024-10-22 Medicovestor, Inc. Dimeric antibodies
WO2025144636A1 (en) * 2023-12-26 2025-07-03 The Scripps Research Institute ENGINEERED hMPV F PROTEIN IMMUNOGENS AND RELATED VACCINES
US12116410B1 (en) 2023-12-26 2024-10-15 Medicovestor, Inc. Methods of manufacturing dimeric antibodies
WO2025144914A1 (en) * 2023-12-26 2025-07-03 Medicovestor, Inc. Dimeric antibodies and their methods of manufacture
US12600795B2 (en) 2023-12-26 2026-04-14 Medicovestor, Inc. Oligomeric IgG for immunotherapeutics and diagnostics
US12673991B2 (en) 2023-12-26 2026-07-07 Medicovestor, Inc. Methods of crosslinking IgG
WO2025163460A2 (en) 2024-01-30 2025-08-07 Pfizer Inc. Vaccines against respiratory diseases
WO2025260634A1 (zh) * 2024-06-19 2025-12-26 厦门万泰沧海生物技术有限公司 Rsv和hmpv融合f蛋白及其用途
WO2026018181A1 (en) 2024-07-17 2026-01-22 Pfizer Inc. Immunogenic compositions and uses thereof
WO2026033492A1 (en) * 2024-08-08 2026-02-12 Vicebio Limited Chimeric fusion proteins as human metapneumovirus (hmpv) vaccines
WO2026104647A1 (en) * 2024-11-15 2026-05-21 Astrazeneca Ab Vaccine

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WO2019233842A1 (en) * 2018-06-08 2019-12-12 F. Hoffmann-La Roche Ag Peptidic linker with reduced post-translational modification
WO2021222639A2 (en) * 2020-04-29 2021-11-04 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Recombinant human metapneumovirus f proteins and their use
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Publication number Publication date
JP2023544834A (ja) 2023-10-25
CN116615235A (zh) 2023-08-18
WO2022076669A1 (en) 2022-04-14
KR20250139413A (ko) 2025-09-23
AU2021357826A9 (en) 2023-07-13
CA3195015A1 (en) 2022-04-14
AU2025208554A1 (en) 2025-08-21
US20250257102A1 (en) 2025-08-14
JP7660671B2 (ja) 2025-04-11
AU2021357826A1 (en) 2023-05-11
US20240140994A1 (en) 2024-05-02
PE20231439A1 (es) 2023-09-14
ZA202506489B (en) 2026-04-29
EP4225364A4 (en) 2025-02-26
NZ798475A (en) 2026-03-27
EP4225364A1 (en) 2023-08-16
CO2023005373A2 (es) 2023-05-19
US20240376158A1 (en) 2024-11-14
US11919927B2 (en) 2024-03-05
KR102860080B1 (ko) 2025-09-15
KR20230084201A (ko) 2023-06-12
US12077563B2 (en) 2024-09-03
IL301950A (en) 2023-06-01
IL301950B2 (en) 2025-09-01
KR102984315B1 (ko) 2026-07-01
MX2023004078A (es) 2023-05-24
US12304930B2 (en) 2025-05-20
IL320367A (en) 2025-06-01
US20230357327A1 (en) 2023-11-09
KR20250140124A (ko) 2025-09-24
IL321500A (en) 2025-08-01
JP2025102893A (ja) 2025-07-08
IL301950B1 (en) 2025-05-01

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