AU2021309548A1 - Inhibitors of complement factor C3 and their medical uses - Google Patents
Inhibitors of complement factor C3 and their medical uses Download PDFInfo
- Publication number
- AU2021309548A1 AU2021309548A1 AU2021309548A AU2021309548A AU2021309548A1 AU 2021309548 A1 AU2021309548 A1 AU 2021309548A1 AU 2021309548 A AU2021309548 A AU 2021309548A AU 2021309548 A AU2021309548 A AU 2021309548A AU 2021309548 A1 AU2021309548 A1 AU 2021309548A1
- Authority
- AU
- Australia
- Prior art keywords
- compstatin
- pharmaceutically acceptable
- acceptable salt
- compstatin analogue
- sar
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/472—Complement proteins, e.g. anaphylatoxin, C3a, C5a
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Transplantation (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP20186297.6 | 2020-07-16 | ||
EP20186297 | 2020-07-16 | ||
PCT/EP2021/069798 WO2022013374A1 (en) | 2020-07-16 | 2021-07-15 | Inhibitors of complement factor c3 and their medical uses |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2021309548A1 true AU2021309548A1 (en) | 2023-02-23 |
Family
ID=71661768
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2021309548A Pending AU2021309548A1 (en) | 2020-07-16 | 2021-07-15 | Inhibitors of complement factor C3 and their medical uses |
Country Status (11)
Country | Link |
---|---|
US (1) | US20230287051A1 (es) |
EP (1) | EP4182023A1 (es) |
JP (1) | JP2023538807A (es) |
KR (1) | KR20230039718A (es) |
CN (1) | CN116209671A (es) |
AU (1) | AU2021309548A1 (es) |
CA (1) | CA3185730A1 (es) |
CO (1) | CO2023001411A2 (es) |
IL (1) | IL299870A (es) |
MX (1) | MX2023000679A (es) |
WO (1) | WO2022013374A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2022210988B9 (en) | 2021-01-20 | 2024-02-22 | Viking Therapeutics, Inc. | Compositions and methods for the treatment of metabolic and liver disorders |
WO2024110878A1 (en) * | 2022-11-24 | 2024-05-30 | Amyndas Pharmaceuticals Us Llc | Compstatin analogs for vector-based therapy |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2248772C (en) | 1996-03-13 | 2007-06-12 | John D. Lambris | Novel peptides which inhibit complement activation |
ATE290014T1 (de) | 1996-09-09 | 2005-03-15 | Zealand Pharma As | Festphasen-peptidsynthese |
AU4648197A (en) | 1997-09-17 | 1999-04-05 | Burnham Institute, The | Peptides and peptidomimetics for inhibiting complement activation |
ATE525082T1 (de) | 2002-09-20 | 2011-10-15 | Univ Pennsylvania | Compstatin-analoga mit verbesserter wirkung |
WO2007044668A2 (en) | 2005-10-08 | 2007-04-19 | Potentia Pharmaceuticals, Inc. | Compstatin and analogs thereof for eye disorders |
CN101400692B (zh) | 2005-11-28 | 2013-01-02 | 宾夕法尼亚州大学理事会 | 有效的c3补体抑制素类似物 |
WO2008153963A1 (en) | 2007-06-08 | 2008-12-18 | The Trustees Of The University Of Pennsylvania | Structure of compstatin-c3 complex and use for rational drug design |
WO2012040259A2 (en) * | 2010-09-23 | 2012-03-29 | The Trustees Of The University Of Pennsylvania | Modified compstatin with improved stability and binding properties |
JP6249949B2 (ja) | 2011-09-07 | 2017-12-20 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | 薬物動態特性の改善されたコンプスタチンアナログ |
US9512180B2 (en) | 2012-12-19 | 2016-12-06 | The Regents Of The University Of California | Compstatin analogs |
JP2021515759A (ja) * | 2018-02-27 | 2021-06-24 | セトペー エスペーベー 3 コマンディト セルスカブ | コンプスタチン類似体及びその医療用途 |
-
2021
- 2021-07-15 US US18/016,490 patent/US20230287051A1/en active Pending
- 2021-07-15 MX MX2023000679A patent/MX2023000679A/es unknown
- 2021-07-15 EP EP21742144.5A patent/EP4182023A1/en active Pending
- 2021-07-15 IL IL299870A patent/IL299870A/en unknown
- 2021-07-15 CN CN202180062742.5A patent/CN116209671A/zh active Pending
- 2021-07-15 JP JP2023502703A patent/JP2023538807A/ja active Pending
- 2021-07-15 WO PCT/EP2021/069798 patent/WO2022013374A1/en unknown
- 2021-07-15 KR KR1020237005557A patent/KR20230039718A/ko unknown
- 2021-07-15 AU AU2021309548A patent/AU2021309548A1/en active Pending
- 2021-07-15 CA CA3185730A patent/CA3185730A1/en active Pending
-
2023
- 2023-02-09 CO CONC2023/0001411A patent/CO2023001411A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
IL299870A (en) | 2023-03-01 |
KR20230039718A (ko) | 2023-03-21 |
US20230287051A1 (en) | 2023-09-14 |
CA3185730A1 (en) | 2022-01-20 |
MX2023000679A (es) | 2023-04-18 |
EP4182023A1 (en) | 2023-05-24 |
CN116209671A (zh) | 2023-06-02 |
CO2023001411A2 (es) | 2023-02-16 |
WO2022013374A1 (en) | 2022-01-20 |
JP2023538807A (ja) | 2023-09-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP2020128443A (ja) | インターロイキン23受容体の経口ペプチド阻害剤および炎症性腸疾患を処置するためのそれらの使用 | |
AU2018210174B2 (en) | Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases | |
EP3062823B1 (en) | Novel polypeptides | |
US11965039B2 (en) | Compstatin analogues and their medical uses | |
CN108348580A (zh) | 白细胞介素-23受体的肽抑制剂以及其治疗炎症性疾病的用途 | |
TW202140517A (zh) | 介白素-23受體之肽抑制劑及其治療發炎性疾病之用途 | |
EP4272751A2 (en) | Compstatin analogues and their medical uses | |
US20230287051A1 (en) | Inhibitors of complement factor c3 and their medical uses | |
CA2931694C (en) | Fatty acid derivatives of dimeric peptide ligands of psd-95 and use thereof for treating excitotoxic disease | |
JP6583411B2 (ja) | 薬物複合体 | |
US10421785B2 (en) | Delta receptor agonist peptides and use thereof | |
Bowerman et al. | Aromatic Versus Hydrophobic Contributions to Amyloid Peptide Self-Assembly |