AU2021262281B2 - 1,5-dihydro-2,4-benzodiazepine-3-one derivative and application thereof - Google Patents
1,5-dihydro-2,4-benzodiazepine-3-one derivative and application thereof Download PDFInfo
- Publication number
- AU2021262281B2 AU2021262281B2 AU2021262281A AU2021262281A AU2021262281B2 AU 2021262281 B2 AU2021262281 B2 AU 2021262281B2 AU 2021262281 A AU2021262281 A AU 2021262281A AU 2021262281 A AU2021262281 A AU 2021262281A AU 2021262281 B2 AU2021262281 B2 AU 2021262281B2
- Authority
- AU
- Australia
- Prior art keywords
- formula
- compound represented
- methyl
- preparation
- linear
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010330893 | 2020-04-26 | ||
| CN202010330893.1 | 2020-04-26 | ||
| CN202110288141 | 2021-03-17 | ||
| CN202110288141.8 | 2021-03-17 | ||
| PCT/CN2021/089660 WO2021218863A1 (zh) | 2020-04-26 | 2021-04-25 | 1,5-二氢-2,4-苯二氮䓬-3-酮衍生物及其应用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2021262281A1 AU2021262281A1 (en) | 2022-11-24 |
| AU2021262281B2 true AU2021262281B2 (en) | 2024-11-28 |
Family
ID=78374068
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2021262281A Active AU2021262281B2 (en) | 2020-04-26 | 2021-04-25 | 1,5-dihydro-2,4-benzodiazepine-3-one derivative and application thereof |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US12559471B2 (https=) |
| EP (1) | EP4144725B1 (https=) |
| JP (1) | JP7693709B2 (https=) |
| KR (1) | KR102832951B1 (https=) |
| CN (1) | CN115667236B (https=) |
| AU (1) | AU2021262281B2 (https=) |
| BR (1) | BR112022021228A2 (https=) |
| CA (1) | CA3172692C (https=) |
| WO (1) | WO2021218863A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115605202B (zh) | 2020-03-26 | 2025-10-28 | 盐野义制药株式会社 | 具有血清素受体结合活性的芳香族杂环衍生物 |
| CN121039114A (zh) | 2023-04-21 | 2025-11-28 | 江苏恩华药业股份有限公司 | 1,5-二氢-2,4-苯二氮䓬-3-酮衍生物枸橼酸盐的晶型、制备方法及其应用 |
| WO2025044768A1 (zh) * | 2023-08-29 | 2025-03-06 | 江苏恩华药业股份有限公司 | 1,5-二氢-2,4-苯二氮䓬-3-酮衍生物的制备方法和其中间体及其制备方法 |
| CN120329280A (zh) * | 2024-01-17 | 2025-07-18 | 江苏恩华药业股份有限公司 | 取代的1,2,4-四氢-3h-苯并二氮䓬-3-酮衍生物及其应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60161986A (ja) * | 1983-12-24 | 1985-08-23 | Nippon Soda Co Ltd | イミダゾ（１，５−ａ）ピリジン−３−オン誘導体及びその製造方法 |
| ES2197160T3 (es) * | 1992-12-21 | 2004-01-01 | Smithkline Beecham Corp | Antagonistas fibronogeno bicicliclos. |
| EP0960104B1 (en) * | 1996-04-17 | 2004-06-16 | Bristol-Myers Squibb Pharma Company | N-(amidinophenyl)-n'-(subst.)-3h-2,4-benzodiazepin-3-one derivatives as factor xa inhibitors |
| UA60311C2 (uk) * | 1996-10-02 | 2003-10-15 | Смітклайн Бічам Корпорейшн | Антагоністи рецептора вітронектину, спосіб одержання цих сполук та фармацевтична композиція |
| GT199800109A (es) * | 1997-08-06 | 2000-01-13 | Derivados de n-sulfonilglicinalquiniloxifenetilamida microbicidas. | |
| JP2003503476A (ja) * | 1999-07-06 | 2003-01-28 | バーテックス ファーマシューティカルズ インコーポレイテッド | 環化アミド誘導体 |
| SI1720836T1 (sl) * | 2004-02-25 | 2014-06-30 | Eli Lilly And Company | 6-substituirani 2,3,4,5-tetrahidro-1h-benzo (d)azepini kot agonisti 5-ht2c receptorja |
| KR101594898B1 (ko) | 2005-07-15 | 2016-02-18 | 알바니 몰레큘라 리써치, 인크. | 아릴- 및 헤테로아릴-치환된 테트라히드로벤자제핀, 및 노르에피네프린, 도파민 및 세로토닌의 재흡수를 차단하기 위한 용도 |
| US7473778B2 (en) * | 2005-12-24 | 2009-01-06 | Boehringer Ingelheim International Gmbh | 3-(4-piperidinyl)-2,3,4,5-tetrahydro-1,3-benzodiazepin-2(1H)-one |
| US20100222326A1 (en) | 2007-04-27 | 2010-09-02 | Ucb Pharma, S.A. | New Heterocyclic Derivatives Useful For The Treatment of CNS Disorders |
| JP5502733B2 (ja) * | 2007-07-26 | 2014-05-28 | エフ．ホフマン−ラ ロシュ アーゲー | ５−ｈｔ２ａ及びｄ３受容体の二重のモジュレーター |
| US9309200B2 (en) * | 2011-05-12 | 2016-04-12 | AbbVie Deutschland GmbH & Co. KG | Benzazepine derivatives, pharmaceutical compositions containing them, and their use in therapy |
| EP3409658B9 (en) * | 2016-01-29 | 2024-07-17 | ONO Pharmaceutical Co., Ltd. | Tetrahydronaphthalene derivative |
-
2021
- 2021-04-25 JP JP2022563189A patent/JP7693709B2/ja active Active
- 2021-04-25 CA CA3172692A patent/CA3172692C/en active Active
- 2021-04-25 BR BR112022021228A patent/BR112022021228A2/pt unknown
- 2021-04-25 KR KR1020227040086A patent/KR102832951B1/ko active Active
- 2021-04-25 EP EP21796540.9A patent/EP4144725B1/en active Active
- 2021-04-25 WO PCT/CN2021/089660 patent/WO2021218863A1/zh not_active Ceased
- 2021-04-25 CN CN202180029971.7A patent/CN115667236B/zh active Active
- 2021-04-25 AU AU2021262281A patent/AU2021262281B2/en active Active
-
2022
- 2022-10-20 US US18/048,340 patent/US12559471B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP7693709B2 (ja) | 2025-06-17 |
| BR112022021228A2 (pt) | 2022-12-06 |
| JP2023522078A (ja) | 2023-05-26 |
| EP4144725B1 (en) | 2025-11-26 |
| KR102832951B1 (ko) | 2025-07-10 |
| AU2021262281A1 (en) | 2022-11-24 |
| US12559471B2 (en) | 2026-02-24 |
| EP4144725A1 (en) | 2023-03-08 |
| WO2021218863A1 (zh) | 2021-11-04 |
| CN115667236A (zh) | 2023-01-31 |
| CA3172692C (en) | 2024-05-14 |
| US20230132621A1 (en) | 2023-05-04 |
| CA3172692A1 (en) | 2021-11-04 |
| CN115667236B (zh) | 2024-04-26 |
| EP4144725C0 (en) | 2025-11-26 |
| KR20230004662A (ko) | 2023-01-06 |
| EP4144725A4 (en) | 2023-10-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2021262281B2 (en) | 1,5-dihydro-2,4-benzodiazepine-3-one derivative and application thereof | |
| CN101679403B (zh) | 噁二唑衍生物配体及其作为亲代谢性谷氨酸受体增效剂842的用途 | |
| KR102102587B1 (ko) | 피리미디닐 티로신 키나아제 억제제 | |
| EP3990451A1 (en) | Fused imidazole derivatives as il-17 modulators | |
| US20080306088A1 (en) | Metabotropic Glutamate Receptor Oxadiazole Ligands and Their Use as Potentiators 841 | |
| CN101268077A (zh) | 三环苯并咪唑及其作为代谢型谷氨酸受体调节剂的用途 | |
| WO2002087569A1 (en) | Bisarylimidazolyl fatty acid amide hydrolase inhibitors | |
| CA3199816A1 (en) | Dicyclopropylmethyl derivatives as il-17 modulators | |
| CN116444484B (zh) | 1,5-二氢-2,4-苯二氮䓬-3-酮衍生物的盐及应用 | |
| JP2023522078A5 (https=) | ||
| WO2018227058A1 (en) | Piperidinone formyl peptide 2 receptor agonists | |
| JP2014508172A (ja) | Ｍｇｌｕｒ５受容体のアロステリック調節剤としての置換イミダゾピリミジン−５（６ｈ）−オン | |
| CN113549006B (zh) | 一种酰胺衍生物及其应用 | |
| MXPA04008626A (es) | Derivados de amino isoxazolina sustituidos y su uso como antidepresivos. | |
| KR20180014732A (ko) | 이미다조디아제핀 화합물 | |
| HK40080583A (en) | 1,5-dihydro-2,4-benzodiazepine-3-one derivative and application thereof | |
| HUE033448T2 (en) | Janus kinase inhibitor N-cyanomethylamides | |
| HK40080583B (zh) | 1，5-二氢-2，4-苯二氮䓬-3-酮衍生物及其应用 | |
| JPWO2012115097A1 (ja) | グリシントランスポーター阻害物質 | |
| TW201307300A (zh) | 趨代謝性麩胺酸受體調節劑 | |
| HK1209284B (zh) | 嘧啶基酪氨酸激酶抑制劑 | |
| AU2002258973A1 (en) | Bisarylimidazolyl fatty acid amide hydrolase inhibitors | |
| NZ614321B2 (en) | Glycine transporter-inhibiting substances |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) |