AU2021237717A1 - Methods of isolating T-cells and T-cell receptors from tumor by single-cell analysis for immunotherapy - Google Patents

Methods of isolating T-cells and T-cell receptors from tumor by single-cell analysis for immunotherapy Download PDF

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Publication number
AU2021237717A1
AU2021237717A1 AU2021237717A AU2021237717A AU2021237717A1 AU 2021237717 A1 AU2021237717 A1 AU 2021237717A1 AU 2021237717 A AU2021237717 A AU 2021237717A AU 2021237717 A AU2021237717 A AU 2021237717A AU 2021237717 A1 AU2021237717 A1 AU 2021237717A1
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cells
antigen
gene expression
expression profile
tcr
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Inventor
Kenichi Hanada
Sri Krishna
Frank J. LOWERY III
Paul F. Robbins
Steven A. Rosenberg
James C. Yang
Rami Yoseph
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US Department of Health and Human Services
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Government of the United States of America
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    • C12N5/0602—Vertebrate cells
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/32—T-cell receptors [TCR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4201—Neoantigens
    • A—HUMAN NECESSITIES
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AU2021237717A 2020-03-20 2021-03-19 Methods of isolating T-cells and T-cell receptors from tumor by single-cell analysis for immunotherapy Pending AU2021237717A1 (en)

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US202062992701P 2020-03-20 2020-03-20
US62/992,701 2020-03-20
PCT/US2021/023240 WO2021188954A1 (en) 2020-03-20 2021-03-19 Methods of isolating t-cells and t-cell receptors from tumor by single-cell analysis for immunotherapy

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US (1) US20230138309A1 (https=)
EP (1) EP4121515A1 (https=)
JP (1) JP2023526156A (https=)
KR (1) KR20220157435A (https=)
CN (1) CN115485370A (https=)
AU (1) AU2021237717A1 (https=)
CA (1) CA3171559A1 (https=)
IL (1) IL296629A (https=)
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US20220257656A1 (en) * 2019-07-10 2022-08-18 National Cancer Center Specific marker for identifying t cells specifically attacking cancer cells
MX2023011151A (es) 2021-03-23 2024-01-18 Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen Rechts Receptores de celulas t reactivas a antigenos.
WO2025032194A1 (en) * 2023-08-08 2025-02-13 Ospedale San Raffaele S.R.L. T-cell receptors
EP4603599A1 (en) 2024-02-13 2025-08-20 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Identification of reactive t cell receptors
EP4603598A1 (en) 2024-02-13 2025-08-20 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Identification of reactive t cells
WO2025184104A1 (en) * 2024-02-26 2025-09-04 The Medical College Of Wisconsin, Inc. Methods of detecting neoantigen-specific t cells and t cell receptor sequences

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US8034334B2 (en) 2002-09-06 2011-10-11 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Immunotherapy with in vitro-selected antigen-specific lymphocytes after non-myeloablative lymphodepleting chemotherapy
US8383099B2 (en) 2009-08-28 2013-02-26 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Adoptive cell therapy with young T cells
US20120244133A1 (en) 2011-03-22 2012-09-27 The United States of America, as represented by the Secretary, Department of Health and Methods of growing tumor infiltrating lymphocytes in gas-permeable containers
JP6599450B2 (ja) 2014-10-02 2019-10-30 アメリカ合衆国 がん特異的突然変異に対し抗原特異性を有するｔ細胞を単離する方法
AU2014407539B2 (en) 2014-10-02 2020-10-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of isolating T cell receptors having antigenic specificity for a cancer-specific mutation
EP3234130B1 (en) * 2014-12-19 2020-11-25 The Broad Institute, Inc. Methods for profiling the t-cell- receptor repertoire
WO2016179006A1 (en) * 2015-05-01 2016-11-10 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of isolating t cells and t cell receptors having antigenic specificity for a cancer-specific mutation from peripheral blood
WO2017048614A1 (en) * 2015-09-15 2017-03-23 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of isolating tumor-reactive t cell receptors from tumor or peripheral blood
WO2017191274A2 (en) * 2016-05-04 2017-11-09 Curevac Ag Rna encoding a therapeutic protein
JP2019532997A (ja) * 2016-11-03 2019-11-14 ジュノー セラピューティクス インコーポレイテッド Ｔ細胞療法とｂｔｋ阻害剤との併用療法
KR20190098747A (ko) * 2016-12-05 2019-08-22 주노 쎄러퓨티크스 인코퍼레이티드 입양 세포 치료법을 위한 조작된 세포의 제조방법
WO2018106972A1 (en) * 2016-12-07 2018-06-14 La Jolla Institute For Allergy And Immunology Compositions for cancer treatment and methods and uses for cancer treatment and prognosis
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EP3622092A4 (en) * 2017-05-11 2021-06-23 The Broad Institute, Inc. METHODS AND COMPOSITIONS OF USE OF CD8 + TUMOR-INFILTRATING LYMPHOCYTE SUBTYPES AND GENE SIGNATURES THEREOF
ES3000510T3 (en) * 2017-06-09 2025-02-28 Providence Health & Services Oregon Tumor-infiltrating t-cells for use in the treatment of cancer
US20210263012A1 (en) * 2017-11-17 2021-08-26 The Broad Institute, Inc. Methods and compositions for modulating immune responses and lymphocyte activity
US20220033774A1 (en) * 2018-04-16 2022-02-03 The Regents Of The University Of California Compositions and methods for cytotoxic cd4+ t cells

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CN115485370A (zh) 2022-12-16
US20230138309A1 (en) 2023-05-04
JP2023526156A (ja) 2023-06-21
IL296629A (en) 2022-11-01
EP4121515A1 (en) 2023-01-25
WO2021188954A1 (en) 2021-09-23
CA3171559A1 (en) 2021-09-23
KR20220157435A (ko) 2022-11-29

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