MX2023011151A - Receptores de celulas t reactivas a antigenos. - Google Patents

Receptores de celulas t reactivas a antigenos.

Info

Publication number
MX2023011151A
MX2023011151A MX2023011151A MX2023011151A MX2023011151A MX 2023011151 A MX2023011151 A MX 2023011151A MX 2023011151 A MX2023011151 A MX 2023011151A MX 2023011151 A MX2023011151 A MX 2023011151A MX 2023011151 A MX2023011151 A MX 2023011151A
Authority
MX
Mexico
Prior art keywords
cell
cancer
reactive
identifying
present
Prior art date
Application number
MX2023011151A
Other languages
English (en)
Inventor
Michael Platten
Chin Leng Tan
Edward Green
Katharina Lindner
Lukas Bunse
Khwab Sanghvi
Original Assignee
Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen Rechts
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen Rechts filed Critical Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen Rechts
Publication of MX2023011151A publication Critical patent/MX2023011151A/es

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/7051—T-cell receptor (TcR)-CD3 complex

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Food Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Mycology (AREA)
  • Toxicology (AREA)
  • General Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente invención se refiere a un método para identificar una célula T reactiva a células presentadoras de un antígeno activador de células T (célula T reactiva al cáncer), que comprende (a) determinar la expresión de al menos uno de CCL4, CCL4L2, CCL3, CCL3L1 y CXCL13 en células T a partir de una muestra de un sujeto; y (b) identificar una célula T reactiva al cáncer con base en la determinación del paso (a). La presente invención también se refiere a un método para identificar un TCR que se une a una célula cancerosa de un sujeto, dicho método comprende (A) identificar una célula T reactiva al cáncer de acuerdo con el método mencionado (B) de proporcionar las secuencias de aminoácidos de al menos las regiones determinantes de la complementariedad (CDR) del TCR de la célula T reactiva al cáncer identificada en el paso (A); y, por lo tanto, (C) identificar un TCR que se une a una célula cancerosa. La presente invención se refiere también a otros métodos y células T reactivas al cáncer relacionadas con los mismos.
MX2023011151A 2021-03-23 2022-03-23 Receptores de celulas t reactivas a antigenos. MX2023011151A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP21164371 2021-03-23
PCT/EP2022/057672 WO2022200456A1 (en) 2021-03-23 2022-03-23 Antigen reactive t-cell receptors

Publications (1)

Publication Number Publication Date
MX2023011151A true MX2023011151A (es) 2024-01-18

Family

ID=75203049

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2023011151A MX2023011151A (es) 2021-03-23 2022-03-23 Receptores de celulas t reactivas a antigenos.
MX2023011152A MX2023011152A (es) 2021-03-23 2022-03-23 Receptores de celulas t reactivas a antigenos.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2023011152A MX2023011152A (es) 2021-03-23 2022-03-23 Receptores de celulas t reactivas a antigenos.

Country Status (9)

Country Link
EP (2) EP4314343A1 (es)
JP (2) JP2024511444A (es)
KR (2) KR20230159841A (es)
CN (2) CN117062918A (es)
AU (2) AU2022242012A1 (es)
CA (2) CA3210818A1 (es)
IL (2) IL306056A (es)
MX (2) MX2023011151A (es)
WO (2) WO2022200456A1 (es)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3622092A4 (en) 2017-05-11 2021-06-23 The Broad Institute, Inc. METHODS AND COMPOSITIONS OF USE OF CD8 + TUMOR-INFILTRATING LYMPHOCYTE SUBTYPES AND GENE SIGNATURES THEREOF
EP3695408A4 (en) 2017-10-02 2021-12-15 The Broad Institute, Inc. METHODS AND COMPOSITIONS FOR DETECTING AND MODULATING A GENETIC SIGNATURE OF IMMUNOTHERAPY RESISTANCE IN CANCER
WO2020092455A2 (en) * 2018-10-29 2020-05-07 The Broad Institute, Inc. Car t cell transcriptional atlas
GB201910605D0 (en) * 2019-07-24 2019-09-04 Immetacyte Ltd Tumour infltracting lymphocyte therapy amd uses thereo
CN115485370A (zh) 2020-03-20 2022-12-16 美国卫生和人力服务部 通过单细胞分析从肿瘤分离t细胞和t细胞受体以用于免疫疗法的方法

Also Published As

Publication number Publication date
WO2022200457A1 (en) 2022-09-29
IL306056A (en) 2023-11-01
KR20230159840A (ko) 2023-11-22
EP4314343A1 (en) 2024-02-07
MX2023011152A (es) 2024-01-18
AU2022242012A1 (en) 2023-10-05
CN117043359A (zh) 2023-11-10
CA3210811A1 (en) 2022-09-29
AU2022242698A1 (en) 2023-10-05
AU2022242012A9 (en) 2024-02-22
AU2022242698A9 (en) 2024-02-22
KR20230159841A (ko) 2023-11-22
WO2022200456A1 (en) 2022-09-29
JP2024512036A (ja) 2024-03-18
JP2024511444A (ja) 2024-03-13
EP4314342A1 (en) 2024-02-07
CN117062918A (zh) 2023-11-14
IL306051A (en) 2023-11-01
CA3210818A1 (en) 2022-09-29

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