CN115485370A - 通过单细胞分析从肿瘤分离t细胞和t细胞受体以用于免疫疗法的方法 - Google Patents

通过单细胞分析从肿瘤分离t细胞和t细胞受体以用于免疫疗法的方法 Download PDF

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CN115485370A
CN115485370A CN202180022592.5A CN202180022592A CN115485370A CN 115485370 A CN115485370 A CN 115485370A CN 202180022592 A CN202180022592 A CN 202180022592A CN 115485370 A CN115485370 A CN 115485370A
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cells
antigen
gene expression
hla
tcr
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斯里·克里希纳
弗兰克·J·洛瑞三世
花田贤一
詹姆斯·C·阳
史蒂文·A·罗森伯格
保罗·F·罗宾斯
拉米·约瑟夫
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US Department of Health and Human Services
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CN202180022592.5A 2020-03-20 2021-03-19 通过单细胞分析从肿瘤分离t细胞和t细胞受体以用于免疫疗法的方法 Pending CN115485370A (zh)

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US202062992701P 2020-03-20 2020-03-20
US62/992,701 2020-03-20
PCT/US2021/023240 WO2021188954A1 (en) 2020-03-20 2021-03-19 Methods of isolating t-cells and t-cell receptors from tumor by single-cell analysis for immunotherapy

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US (1) US20230138309A1 (https=)
EP (1) EP4121515A1 (https=)
JP (1) JP2023526156A (https=)
KR (1) KR20220157435A (https=)
CN (1) CN115485370A (https=)
AU (1) AU2021237717A1 (https=)
CA (1) CA3171559A1 (https=)
IL (1) IL296629A (https=)
WO (1) WO2021188954A1 (https=)

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US20220257656A1 (en) * 2019-07-10 2022-08-18 National Cancer Center Specific marker for identifying t cells specifically attacking cancer cells
MX2023011151A (es) 2021-03-23 2024-01-18 Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen Rechts Receptores de celulas t reactivas a antigenos.
WO2025032194A1 (en) * 2023-08-08 2025-02-13 Ospedale San Raffaele S.R.L. T-cell receptors
EP4603599A1 (en) 2024-02-13 2025-08-20 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Identification of reactive t cell receptors
EP4603598A1 (en) 2024-02-13 2025-08-20 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Identification of reactive t cells
WO2025184104A1 (en) * 2024-02-26 2025-09-04 The Medical College Of Wisconsin, Inc. Methods of detecting neoantigen-specific t cells and t cell receptor sequences

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WO2018106972A1 (en) * 2016-12-07 2018-06-14 La Jolla Institute For Allergy And Immunology Compositions for cancer treatment and methods and uses for cancer treatment and prognosis
CN110139669A (zh) * 2016-11-03 2019-08-16 朱诺治疗学股份有限公司 T细胞疗法和btk抑制剂的组合疗法
CN110249046A (zh) * 2016-12-05 2019-09-17 朱诺治疗学股份有限公司 用于过继细胞疗法的工程化细胞的产生

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US20120244133A1 (en) 2011-03-22 2012-09-27 The United States of America, as represented by the Secretary, Department of Health and Methods of growing tumor infiltrating lymphocytes in gas-permeable containers
JP6599450B2 (ja) 2014-10-02 2019-10-30 アメリカ合衆国 がん特異的突然変異に対し抗原特異性を有するｔ細胞を単離する方法
AU2014407539B2 (en) 2014-10-02 2020-10-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of isolating T cell receptors having antigenic specificity for a cancer-specific mutation
EP3234130B1 (en) * 2014-12-19 2020-11-25 The Broad Institute, Inc. Methods for profiling the t-cell- receptor repertoire
WO2016179006A1 (en) * 2015-05-01 2016-11-10 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of isolating t cells and t cell receptors having antigenic specificity for a cancer-specific mutation from peripheral blood
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WO2017048614A1 (en) * 2015-09-15 2017-03-23 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of isolating tumor-reactive t cell receptors from tumor or peripheral blood
CN110139669A (zh) * 2016-11-03 2019-08-16 朱诺治疗学股份有限公司 T细胞疗法和btk抑制剂的组合疗法
CN110249046A (zh) * 2016-12-05 2019-09-17 朱诺治疗学股份有限公司 用于过继细胞疗法的工程化细胞的产生
WO2018106972A1 (en) * 2016-12-07 2018-06-14 La Jolla Institute For Allergy And Immunology Compositions for cancer treatment and methods and uses for cancer treatment and prognosis

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AU2021237717A1 (en) 2022-10-20
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EP4121515A1 (en) 2023-01-25
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