AU2021219233A1 - Immune cells overexpressing cell signaling regulatory factor introduced from outside and use thereof - Google Patents

Immune cells overexpressing cell signaling regulatory factor introduced from outside and use thereof Download PDF

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AU2021219233A1
AU2021219233A1 AU2021219233A AU2021219233A AU2021219233A1 AU 2021219233 A1 AU2021219233 A1 AU 2021219233A1 AU 2021219233 A AU2021219233 A AU 2021219233A AU 2021219233 A AU2021219233 A AU 2021219233A AU 2021219233 A1 AU2021219233 A1 AU 2021219233A1
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protein
domain
fragment
cells
car
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ChoonJu JEON
Namchul Jung
Hoeon Kim
Yu Wang
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Beijing Yongtai Ruike Biotechnology Co Ltd
Pharos Vaccine Inc
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Beijing Yongtai Ruike Biotechnology Co Ltd
Pharos Vaccine Inc
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CA3057306A1 (en) * 2017-03-22 2018-09-27 Novartis Ag Biomarkers and car t cell therapies with enhanced efficacy
JP2020524512A (ja) * 2017-06-21 2020-08-20 アイセル・ジーン・セラピューティクス・エルエルシー キメラ抗体受容体(CARs)の組成物およびその使用方法
CN108218999B (zh) * 2018-01-02 2021-06-11 广东省人民医院(广东省医学科学院) 分泌il-7的嵌合抗原受体、病毒载体、表达细胞及制备方法与药物
CN109265565B (zh) * 2018-10-10 2021-06-01 苏州大学 一种携带分子开关的抗CD79b嵌合抗原受体及其修饰的免疫细胞和应用
WO2020123947A1 (en) * 2018-12-14 2020-06-18 Bluebird Bio, Inc. Dimerizing agent regulated immunoreceptor complexes

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