AU2021106291A4 - Vegetable and fruit extract formula for preventing and treating type II diabetes and preparation method thereof - Google Patents
Vegetable and fruit extract formula for preventing and treating type II diabetes and preparation method thereof Download PDFInfo
- Publication number
- AU2021106291A4 AU2021106291A4 AU2021106291A AU2021106291A AU2021106291A4 AU 2021106291 A4 AU2021106291 A4 AU 2021106291A4 AU 2021106291 A AU2021106291 A AU 2021106291A AU 2021106291 A AU2021106291 A AU 2021106291A AU 2021106291 A4 AU2021106291 A4 AU 2021106291A4
- Authority
- AU
- Australia
- Prior art keywords
- ethanol
- extract
- extracting
- parts
- solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 239000000284 extract Substances 0.000 title claims abstract description 52
- 235000013311 vegetables Nutrition 0.000 title claims abstract description 31
- 235000013399 edible fruits Nutrition 0.000 title claims abstract description 16
- 238000002360 preparation method Methods 0.000 title claims abstract description 14
- 208000001072 type 2 diabetes mellitus Diseases 0.000 title description 4
- 206010012601 diabetes mellitus Diseases 0.000 claims abstract description 30
- 235000003145 Hippophae rhamnoides Nutrition 0.000 claims abstract description 21
- 244000185386 Thladiantha grosvenorii Species 0.000 claims abstract description 21
- 235000011171 Thladiantha grosvenorii Nutrition 0.000 claims abstract description 21
- 244000247812 Amorphophallus rivieri Species 0.000 claims abstract description 15
- 235000001206 Amorphophallus rivieri Nutrition 0.000 claims abstract description 15
- 229920002752 Konjac Polymers 0.000 claims abstract description 15
- 235000010485 konjac Nutrition 0.000 claims abstract description 14
- 239000000252 konjac Substances 0.000 claims abstract description 14
- 238000002156 mixing Methods 0.000 claims abstract description 12
- 244000046146 Pueraria lobata Species 0.000 claims abstract description 9
- 235000010575 Pueraria lobata Nutrition 0.000 claims abstract description 9
- 235000007866 Chamaemelum nobile Nutrition 0.000 claims abstract description 4
- 235000007232 Matricaria chamomilla Nutrition 0.000 claims abstract description 4
- 240000000950 Hippophae rhamnoides Species 0.000 claims abstract 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 102
- 239000002904 solvent Substances 0.000 claims description 36
- 238000003756 stirring Methods 0.000 claims description 36
- 238000007873 sieving Methods 0.000 claims description 30
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 30
- 239000000706 filtrate Substances 0.000 claims description 18
- 239000007788 liquid Substances 0.000 claims description 14
- 238000010298 pulverizing process Methods 0.000 claims description 14
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 12
- 239000002021 butanolic extract Substances 0.000 claims description 12
- 239000012535 impurity Substances 0.000 claims description 12
- 239000011347 resin Substances 0.000 claims description 12
- 229920005989 resin Polymers 0.000 claims description 12
- 244000061456 Solanum tuberosum Species 0.000 claims description 10
- 235000002595 Solanum tuberosum Nutrition 0.000 claims description 10
- 239000000843 powder Substances 0.000 claims description 9
- 239000000463 material Substances 0.000 claims description 8
- 238000000605 extraction Methods 0.000 claims description 7
- RXUWDKBZZLIASQ-UHFFFAOYSA-N Puerarin Natural products OCC1OC(Oc2c(O)cc(O)c3C(=O)C(=COc23)c4ccc(O)cc4)C(O)C(O)C1O RXUWDKBZZLIASQ-UHFFFAOYSA-N 0.000 claims description 6
- 239000003480 eluent Substances 0.000 claims description 6
- 238000001704 evaporation Methods 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 6
- 229930182478 glucoside Natural products 0.000 claims description 6
- -1 glucoside polysaccharide Chemical class 0.000 claims description 6
- 229920001282 polysaccharide Polymers 0.000 claims description 6
- 239000005017 polysaccharide Substances 0.000 claims description 6
- HKEAFJYKMMKDOR-VPRICQMDSA-N puerarin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1C1=C(O)C=CC(C2=O)=C1OC=C2C1=CC=C(O)C=C1 HKEAFJYKMMKDOR-VPRICQMDSA-N 0.000 claims description 6
- 238000001035 drying Methods 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- 244000042664 Matricaria chamomilla Species 0.000 claims description 3
- 235000003228 Lactuca sativa Nutrition 0.000 claims description 2
- 240000008415 Lactuca sativa Species 0.000 claims description 2
- 244000131360 Morinda citrifolia Species 0.000 claims 1
- 235000008898 Morinda citrifolia Nutrition 0.000 claims 1
- 235000017524 noni Nutrition 0.000 claims 1
- 239000000126 substance Substances 0.000 abstract description 10
- 238000000227 grinding Methods 0.000 abstract description 6
- 239000002994 raw material Substances 0.000 abstract description 4
- 238000005516 engineering process Methods 0.000 abstract description 3
- 231100000614 poison Toxicity 0.000 abstract description 2
- 239000003440 toxic substance Substances 0.000 abstract description 2
- 240000003538 Chamaemelum nobile Species 0.000 abstract 1
- 238000011282 treatment Methods 0.000 description 41
- 239000008280 blood Substances 0.000 description 29
- 210000004369 blood Anatomy 0.000 description 29
- 239000003814 drug Substances 0.000 description 17
- 241000229143 Hippophae Species 0.000 description 16
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 13
- 239000008103 glucose Substances 0.000 description 13
- 230000000694 effects Effects 0.000 description 12
- 229940079593 drug Drugs 0.000 description 10
- 239000000419 plant extract Substances 0.000 description 8
- 102000017011 Glycated Hemoglobin A Human genes 0.000 description 7
- 108010014663 Glycated Hemoglobin A Proteins 0.000 description 7
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 description 7
- 235000005911 diet Nutrition 0.000 description 7
- 230000037213 diet Effects 0.000 description 7
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 7
- 235000012055 fruits and vegetables Nutrition 0.000 description 6
- 150000002632 lipids Chemical class 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 231100000331 toxic Toxicity 0.000 description 5
- 230000002588 toxic effect Effects 0.000 description 5
- 235000004936 Bromus mango Nutrition 0.000 description 4
- 240000007228 Mangifera indica Species 0.000 description 4
- 235000014826 Mangifera indica Nutrition 0.000 description 4
- 235000009184 Spondias indica Nutrition 0.000 description 4
- 230000001684 chronic effect Effects 0.000 description 4
- 238000004140 cleaning Methods 0.000 description 4
- 230000003247 decreasing effect Effects 0.000 description 4
- 208000030159 metabolic disease Diseases 0.000 description 4
- 230000000291 postprandial effect Effects 0.000 description 4
- 238000002203 pretreatment Methods 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 230000006378 damage Effects 0.000 description 3
- 210000003734 kidney Anatomy 0.000 description 3
- 230000007774 longterm Effects 0.000 description 3
- 208000024172 Cardiovascular disease Diseases 0.000 description 2
- 229920000881 Modified starch Polymers 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 208000016097 disease of metabolism Diseases 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 229940068517 fruit extracts Drugs 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 201000001421 hyperglycemia Diseases 0.000 description 2
- 230000002218 hypoglycaemic effect Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 235000012054 meals Nutrition 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 238000004806 packaging method and process Methods 0.000 description 2
- 239000000049 pigment Substances 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 201000004569 Blindness Diseases 0.000 description 1
- 208000008960 Diabetic foot Diseases 0.000 description 1
- 241000282414 Homo sapiens Species 0.000 description 1
- 208000031226 Hyperlipidaemia Diseases 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 208000001647 Renal Insufficiency Diseases 0.000 description 1
- 238000002266 amputation Methods 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000009693 chronic damage Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 210000001508 eye Anatomy 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000007902 hard capsule Substances 0.000 description 1
- 210000002216 heart Anatomy 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 201000006370 kidney failure Diseases 0.000 description 1
- 235000004213 low-fat Nutrition 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 201000001119 neuropathy Diseases 0.000 description 1
- 230000007823 neuropathy Effects 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 229940126701 oral medication Drugs 0.000 description 1
- 208000033808 peripheral neuropathy Diseases 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000012353 t test Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/746—Morinda
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/17—Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
This invention provides vegetable and fruit extract formula for preventing and
treating type Il diabetes and preparation method thereof, which comprises the
following components in parts by weight: 5-30 parts of longevity vegetable, 4-20 parts
of konjac, 3-15 parts of sea buckthorn, 2-10 parts of kudzuvine root, 2-10 parts of
momordica grosvenori and 2-10 parts of chamomile fruit. The invention is not as
simple as simply grinding the main raw materials, mixing them evenly, but extracting
the main substances needed by the invention item by item through advanced
technology, removing toxic substances, leaving only useful components, and then
scientifically formulating them.
Description
Vegetable and fruit extract formula for preventing and treating type Il diabetes and preparation method thereof
TECHNICAL FIELD The invention relates to plant extract for preventing and treating diabetes, in particular to a formula of a vegetable and fruit extract for preventing and treating type Il diabetes and preparation method thereof.
BACKGROUND Diabetes mellitus is a chronic and multifactorial metabolic disease group characterized by hyperglycemia, and it is a metabolic disease group characterized by chronic increase of blood glucose level. Long-term hyperglycemia in diabetes can cause multi-system damage, especially chronic damage and dysfunction of eyes, kidneys, heart, blood vessels and nerves. If diabetes is not adequately controlled, it will also cause some complications. Serious complications include: cardiovascular disease, renal failure, blindness, neuropathy, diabetic foot (even amputation), etc. The incidence of diabetes is on the rise globally, and its mortality is second only to cardiovascular and cerebrovascular diseases. According to the statistics of the health department in 2017, there are nearly 60 million patients with type I diabetes, 80 million patients with type Il diabetes and more than 100 million diabetes precursors in China. The country needs to spend huge special medical subsidy funds for severe patients with type I diabetes every year. Diabetes brings a heavy burden to social economy and personal life, and it is extremely urgent to actively prevent and treat diabetes. At present, patients with type 2 diabetes are treated by oral drugs. Because of the characteristics of long-term medication, chemical drugs will inevitably bring certain toxic and side effects to patients, and even cause "drug-induced diseases".Chemical drugs can only cure the symptoms, while controlling blood sugar, they also do further harm to liver and kidney, which accelerates the pace of complications for patients with typeII diabetes.
"The homology of medicine and food" is one of the most valuable contributions to human beings in Chinese original medicine. Traditional Chinese medicine has always emphasized that "medicine therapy is not as good as diet therapy". In view of the current situation that long-term use of chemical drugs has certain toxic and side effects, people have turned their attention to Chinese herbal medicines or food materials with hypoglycemic effect. People are generally restricted by technology to decoct medicines, stir-fry them or eat them raw, all of which suffer from weak hypoglycemic effect and other biotoxicity. Traditional Chinese medicine or health care products are decocted at high temperature, and the bioactivity of each Chinese medicine or nutrient component is destroyed by high temperature, which is the fundamental reason that western medicine almost monopolizes the clinical treatment of diabetes. Moreover, the toxic and side effects caused by taking chemical drugs for a long time will damage the liver and kidney of diabetic patients and increase the risk of complications induced by type I1 diabetes patients. Therefore, we propose a formula of fruit and vegetable extract for preventing and treating type Il diabetes and its preparation method.
SUMMARY The purpose of the present invention is to solve the shortcomings in the prior art, and provide a vegetable and fruit extract formula and a preparation method for preventing and treating type Il diabetes, which are applied in the field of chronic blood sugar metabolic diseases, are composed of pure natural vegetable and fruit extracts, have no toxic and side effects, and have no external added anticorrosion and pigment chemical reagents, and are used for preventing and treating type Il diabetes. In order to achieve the above purpose, the invention provides the following technical scheme: the vegetable and fruit composition for preventing and treating type II diabetes is characterized by comprising the following raw material components in parts by weight: -30 parts of Solanum tuberosum, 4-20 parts of konjac, 3-15 parts of seabuckthorn, 2 parts of kudzu vine root, 2-10 parts of momordica grosvenori and 2-10 parts of chamomile fruit. Preferably, the preparation method of vegetable and fruit plant extracts for preventing and treating type I diabetes comprises the following steps:
S1, drying the cleaned lettuce, konjac, seabuckthorn, kudzu vine root, grosvenor momordica grosvenori and shelled chamomile at low temperature for later use. S2, crushing the longevity vegetable, sieving with a sieve of 80-100 meshes, using % ethanol as a solvent with a solid-to-liquid ratio of 1:10, fully stirring, standing for 12 hours, extracting at : 45°Cfor 30 minutes, separating to obtain the longevity vegetable extract, and recovering the ethanol residue from the filtrate for further extraction and reuse. S3, mixing the residue of Tianguo and the residue of Longevity Vegetable, using % ethanol as solvent, with a solid-liquid ratio of 1:15, fully stirring, extracting at 5450 C for 50 minutes, filtering out the ethanol, extracting with n-butanol to obtain n-butanol extract, concentrating the n-butanol extract with reduced pressure evaporation method until a proper amount of water is washed away, and eluting with 30%-100% ethanol solution to obtain the eluent S4, pulverizing seabuckthorn, sieving with 80-100 mesh sieve, using 60% ethanol as solvent, stirring thoroughly, standing for 12 hours, extracting at 5450 C for 30 minutes, and recovering ethanol from filtrate to obtain seabuckthorn extract. S5, pulverizing radix puerariae, sieving with a 100-120 mesh sieve, using water as a solvent with a solid-liquid ratio of 1: 20, fully stirring, extracting under negative pressure of 0.lmmHg-1.OmmHg below 45 0C for 90 minutes, removing impurities from the water extract with macroporous resin, and concentrating under reduced pressure to obtain puerarin extracts. S6, crushing momordica grosvenori, sieving with 80-100 mesh sieve, using water as solvent, stirring thoroughly, extracting under negative pressure of 0.lmmHg 1.OmmHg below 45 0C for 60 minutes, removing impurities from water extract with macroporous resin, and concentrating under reduced pressure to obtain momordica grosvenori extract. S7, pulverizing konjac, sieving with 80-100 mesh sieve, using 40% ethanol as solvent, stirring thoroughly, standing for 12 hours, extracting at 5450 C for 30 minutes, and recovering ethanol from filtrate to obtain glucoside polysaccharide.
S8. all the above materials are mixed according to a certain proportion, sent to a vacuum vacuum dryer with a vacuum degree ofO.lmmHg-1.OmmHg, and dried at < °C to obtain extract powder. Technical effects and advantages of the invention: 1. Compared with the existing diabetes drugs, the present invention has no side effects: the existing diabetes drugs are almost all chemical drugs, and the side effects are harmful to patients. The formula ingredients of the present invention are all derived from safe and nontoxic fruits and vegetables. 2. The invention is not as simple as simply grinding and mixing the main raw materials, but extracting the main substances required by the invention item by item by advanced technology, removing toxic substances, leaving only useful ingredients, and then making scientific formulation. 3. The invention breaks away from the theory that traditional Chinese medicines need to be decocted and boiled at high temperature, and adopts a low-temperature extraction technology in the preparation process, so that the activity of various nutrients is not damaged, and the bioavailability is optimized. 4. Formula science: After repeated testing and verification, the best formula can be reached, which is full of the ingenuity of R&D personnel and the sweat of hard work during trial and error.
DESCRIPTION OF THE INVENTION In order to make the purpose, technical scheme and advantages of the present invention clearer, the present invention will be further described in detail with specific examples. It should be understood that the specific embodiments described herein are only used to explain the present invention, and are not used to limit the present invention. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in the field without creative labor belong to the scope of protection of the present invention. Embodiment 1 The invention relates to a preparation method of vegetable and fruit plant extracts for preventing and treating type 11 diabetes, which comprises the following steps of:
S1, cleaning 50 kg of longevity vegetable, 40 kg of konjac, 30 kg of sea buckthorn, kg of kudzu root and 20 kg of momordica grosvenori, shelling 20 kg of mango, and airing at low temperature for later use. S2, crushing the Solanum tuberosum L., sieving with 80-100 mesh sieve, using 45% ethanol as solvent with a solid-to-liquid ratio of 1: 10, stirring thoroughly, standing for 12 hours, extracting at 545 0C for 30 minutes, separating to obtain about 5 kg of Solanum tuberosum L. extract, and recovering the ethanol residue from the filtrate for further extraction and reuse. S3, mixing the residue of Tianguo and the residue of Longevity Vegetable, using % ethanol as solvent, with a solid-liquid ratio of 1: 15, fully stirring, extracting at 5450 C for 50 minutes, filtering out the ethanol, extracting with n-butanol to obtain n-butanol extract, concentrating the n-butanol extract with reduced pressure evaporation method until a proper amount of water is washed away, and eluting with 30%-100% ethanol solution to obtain the eluent S4, pulverizing seabuckthorn, sieving with 80-100 mesh sieve, using 60% ethanol as solvent, stirring thoroughly, standing for 12 hours, extracting at 5450 C for 30 minutes, and recovering ethanol from filtrate to obtain about 4 kg of seabuckthorn extract. S5, pulverizing radix puerariae, sieving with a 100-120 mesh sieve, using water as a solvent, stirring thoroughly, extracting under negative pressure of 0.1mmHg-1.mmHg below45 °Cfor 90 minutes, removing impurities from the water extract with macroporous resin, and concentrating under reduced pressure to obtain about 3kg of puerarin extract. S6, crushing Siraitia grosvenorii, sieving with 80-100 mesh sieve, using water as solvent, stirring thoroughly, extracting under negative pressure of0.mmHg-1.mmHg below 45°Cfor 60 minutes, removing impurities from the water extract with macroporous resin, and concentrating under reduced pressure to obtain about 3kg of Siraitia grosvenorii extract. S7, grinding konjac, sieving with 80-100 mesh sieve, using 40% ethanol as solvent, stirring thoroughly, standing for 12 hours, extracting at 545 0C for 30 minutes, and recovering ethanol from filtrate to obtain about 6 kg of glucoside polysaccharide;
S8, mixing about 26 kg of all the above materials, send them to a vacuum vacuum dryer with a vacuum degree of 0.1mmHg-1.OmmHg, dry at 545 0C to obtain about 10 kg of extract powder, and package the finished product. Embodiment 2 The invention relates to a preparation method of vegetable and fruit plant extracts for preventing and treating type I diabetes, which comprises the following steps of: S1, cleaning 50 kg of longevity vegetable, 40 kg of konjac, 30 kg of sea buckthorn, kg of kudzu root and 20 kg of momordica grosvenori, shelling 20 kg of mango, and airing at low temperature for later use. S2, crushing the Solanum tuberosum L., sieving with 80-100 mesh sieve, using 45% ethanol as solvent with a solid-to-liquid ratio of 1: 10, stirring thoroughly, standing for 12 hours, extracting at 545 0C for 30 minutes, separating to obtain about 5 kg of Solanum tuberosum L. extract, and recovering the ethanol residue from the filtrate for further extraction and reuse. S3, mixing the residue of Tianguo and the residue of Longevity Vegetable, using % ethanol as solvent, with a solid-liquid ratio of 1: 15, fully stirring, extracting at 5450 C for 50 minutes, filtering out the ethanol, extracting with n-butanol to obtain n-butanol extract, concentrating the n-butanol extract with reduced pressure evaporation method until a proper amount of water is washed away, and eluting with 30%-100% ethanol solution to obtain the eluent. S4, pulverizing seabuckthorn, sieving with 80-100 mesh sieve, using 60% ethanol as solvent, stirring thoroughly, standing for 12 hours, extracting at 5450 C for 30 minutes, and recovering ethanol from filtrate to obtain about 4 kg of seabuckthorn extract. S5, pulverizing radix puerariae, sieving with a 100-120 mesh sieve, using water as a solvent, stirring thoroughly, extracting under negative pressure of 0.1mmHg-1.mmHg below 45 °C for 90 minutes, removing impurities from the water extract with macroporous resin, and concentrating under reduced pressure to obtain about 3kg of puerarin extract. S6, crushing Siraitia grosvenorii, sieving with 80-100 mesh sieve, using water as solvent, stirring thoroughly, extracting under negative pressure of0.mmHg-1.mmHg below 45 °C for 60 minutes, removing impurities from the water extract with macroporous resin, and concentrating under reduced pressure to obtain about 3kg of Siraitia grosvenorii extract. S7, grinding konjac, sieving with 80-100 mesh sieve, using 40% ethanol as solvent, stirring thoroughly, standing for 12 hours, extracting at 545 0C for 30 minutes, and recovering ethanol from filtrate to obtain about 6 kg of glucoside polysaccharide; S8. Mixing about 26 kg of all the above substances, add 1 kg of modified corn starch as an auxiliary material, fully and uniformly granulate by a granulator, and send the granulated materials to a vacuum dryer with a vacuum degree of 0.1mmHg-1.mmHg, and prepare about 11 kg of granules after drying, and package the finished products. Embodiment 3 The invention relates to a preparation method of vegetable and fruit plant extracts for preventing and treating type I diabetes, which comprises the following steps of: S1, cleaning 50 kg of longevity vegetable, 40 kg of konjac, 30 kg of sea buckthorn, kg of kudzu root and 20 kg of momordica grosvenori, shelling 20 kg of mango, and airing at low temperature for later use. S2, crushing the Solanum tuberosum L., sieving with 80-100 mesh sieve, using 45% ethanol as solvent with a solid-to-liquid ratio of 1: 10, stirring thoroughly, standing for 12 hours, extracting at 545 0C for 30 minutes, separating to obtain about 5 kg of Solanum tuberosum L. extract, and recovering the ethanol residue from the filtrate for further extraction and reuse. S3, mixing the residue of Tianguo and the residue of Longevity Vegetable, using % ethanol as solvent, with a solid-liquid ratio of 1: 15, fully stirring, extracting at 5450 C for 50 minutes, filtering out the ethanol, extracting with n-butanol to obtain n-butanol extract, concentrating the n-butanol extract with reduced pressure evaporation method until a proper amount of water is washed away, and eluting with 30%-100% ethanol solution to obtain the eluent. S4, pulverizing seabuckthorn, sieving with 80-100 mesh sieve, using 60% ethanol as solvent, stirring thoroughly, standing for 12 hours, extracting at 5450 C for 30 minutes, and recovering ethanol from filtrate to obtain about 4 kg of seabuckthorn extract. S5, pulverizing radix puerariae, sieving with a 100-120 mesh sieve, using water as solvent, stirring thoroughly, extracting under negative pressure of0.mmHg-1.mmHg below 45 °C for 90 minutes, removing impurities from the water extract with macroporous resin, and concentrating under reduced pressure to obtain about 3kg of puerarin extract. S6, crushing Siraitia grosvenorii, sieving with 80-100 mesh sieve, using water as solvent, stirring thoroughly, extracting under negative pressure of0.mmHg-1.mmHg below 45 °C for 60 minutes, removing impurities from the water extract with macroporous resin, and concentrating under reduced pressure to obtain about 3kg of Siraitia grosvenorii extract; S7, grinding konjac, sieving with 80-100 mesh sieve, using 40% ethanol as solvent, stirring thoroughly, standing for 12 hours, extracting at 545 0C for 30 minutes, and recovering ethanol from filtrate to obtain about 6 kg of glucoside polysaccharide; S8, mixing about 26 kg of all the above substances, sending the mixture to a vacuum vacuum dryer with a vacuum degree of0.mmHg-1.OmmHg, and drying at 545 0C to obtain about 10 kg of extract powder; S10, adding 1kg of modified corn starch as an auxiliary material, fully and uniformly tabletting by a tabletting machine to obtain a tablet of about 11kg, and packaging the finished product. Embodiment 4 The invention relates to a preparation method of vegetable and fruit plant extracts for preventing and treating type I diabetes, which comprises the following steps of: S1, cleaning 50 kg of longevity vegetable, 40 kg of konjac, 30 kg of sea buckthorn, kg of kudzu root and 20 kg of momordica grosvenori, shelling 20 kg of mango, and airing at low temperature for later use. S2, crushing the Solanum tuberosum L., sieving with 80-100 mesh sieve, using 45% ethanol as solvent with a solid-to-liquid ratio of 1:10, stirring thoroughly, standing for 12 hours, extracting at 545 0C for 30 minutes, separating to obtain about 5 kg of Solanum tuberosum L. extract, and recovering the ethanol residue from the filtrate for further extraction and reuse. S3, mixing the residue of Tianguo and the residue of Longevity Vegetable, using % ethanol as solvent, with a solid-liquid ratio of 1:15, fully stirring, extracting at 5450 C for 50 minutes, filtering out the ethanol, extracting with n-butanol to obtain n-butanol extract, concentrating the n-butanol extract with reduced pressure evaporation method until a proper amount of water is washed away, and eluting with 30%-100% ethanol solution to obtain the eluent. S4, pulverizing seabuckthorn, sieving with 80-100 mesh sieve, using 60% ethanol as solvent, stirring thoroughly, standing for 12 hours, extracting at 5450 C for 30 minutes, and recovering ethanol from filtrate to obtain about 4 kg of seabuckthorn extract. S5, pulverizing radix puerariae, sieving with a 100-120 mesh sieve, using water as a solvent, stirring thoroughly, extracting under negative pressure of 0.1mmHg-1.mmHg below 45C for 90 minutes, removing impurities from the water extract with macroporous resin, and concentrating under reduced pressure to obtain about 3kg of puerarin extract. S6, crushing Siraitia grosvenorii, sieving with 80-100 mesh sieve, using water as solvent, stirring thoroughly, extracting under negative pressure of0.mmHg-1.mmHg below 45C for 60 minutes, removing impurities from the water extract with macroporous resin, and concentrating under reduced pressure to obtain about 3kg of Siraitia grosvenorii extract. S7, grinding konjac, sieving with 80-100 mesh sieve, using 40% ethanol as solvent, stirring thoroughly, standing for 12 hours, extracting at 545 0C for 30 minutes, and recovering ethanol from filtrate to obtain about 6 kg of glucoside polysaccharide; S8, mixing about 26 kg of all the above substances, sending the mixture to a vacuum vacuum dryer with a vacuum degree of0.mmHg-1.OmmHg, and drying at 545 0C to obtain about 10 kg of extract powder; S10, about 10kg of the extract powder is sent to a capsule filling machine to be made into a hard capsule or a soft capsule packaging finished product. Test embodiment 1 (1) Test materials: The extract powder prepared in embodiment (2) Subjects: 48 patients with typeIIdiabetes mellitus, including 26 males and 22 females, with a course of 1-3 years. Patients were divided into two groups, with 24 patients in each group and 12 males and 12 females in the control group, with an average age of (55.83±2.85) years. In the treatment group, there were 14 males and 10 females with an average age of (58.94±2.95) years. All patients were type 2 diabetic patients with hyperlipidemia. 48 patients were not treated with insulin before the trial. There was no significant difference in height, weight, sex and age between the two groups (P>0.05). (3) Treatment method: Control group: before treatment, the blood lipid and blood sugar were detected, and the diet of patients was managed according to the diabetes diet, which was low in fat and salt. In addition, patients should be reminded to exercise properly after eating; Treatment group: before treatment, the blood lipid and blood sugar were detected, and the patients were managed according to diabetes diet and exercised moderately. On this basis, the patients were provided with oral treatment of the fruit and vegetable plant extract powder of the present invention, taking 8g each morning and evening before fasting for 30 days. (4) Evaluation criteria of therapeutic effect: significant effect: blood lipid and blood sugar decreased obviously. Effective: Both blood lipid and blood sugar decreased, with little decrease. Ineffective: There is no obvious change in blood lipid and blood sugar before treatment. Total effective rate = (effective cases+effective cases)/total cases x100%. (5) Observation index: Fasting blood glucose and postprandial blood glucose of patients in two groups were detected once on the 7th day, 15th day and 30th day respectively, for three times in total. Glycosylated hemoglobin and triglyceride were detected once on the 15th and 30th day, respectively. The specific changes of fasting blood glucose, postprandial blood glucose, glycosylated hemoglobin and triglyceride were observed during 30 days. (6) Statistical method: SPSS16.0 statistical software was used to analyze the data of the above treatments. The measurement data were expressed by mean standard deviation (xs), and the t test was carried out. The counting data were tested by X2 test. When P < 0.05, the difference was statistically significant. (7) Results: Table 1 Comparison of fasting blood glucose level between two groups before and after treatment Table 1 Comparison of fasting blood glucose level between two groups before and after treatment [FBG(mmol/L)]
Group n Pre-treatment 7 Days 15 Days 30 Days
Comparison group 24 7.39±0.82 7.23±0.61 7.04±0.59 6_72±0.56
Treatment group 24 7.41i0 79k 6.95±0.65 6.22±0.47 5.64±0.51A
It can be seen from Table 2 that there is no significant difference in fasting blood glucose level between the two groups before treatment (* P > 0.05), which is comparable. After 30 days of treatment, fasting blood glucose in the treatment group was significantly lower than that in the control group (A P < 0.05). Table 2 Comparison of postprandial blood glucose levels between the two groups before and after treatment Table 2 Comparison of postprandial blood glucose levels between the two groups before and after treatment [2h FBG(mmol/L)]
Group n Pre-treatment 7 Days 15 Days 30 Days
Comparisongroup 24 13.11±131 12.42±115 11.63±124 10.94±1.15 Treatment group 24 13.08g1.23- 11.12±l06 9.47g1.25 7.89±1.28A
It can be seen from Table 2 that there is no significant difference in blood glucose level between the two groups before treatment and 2 hours after meal (* P > 0.05), which is comparable. After 30 days of treatment, the blood glucose in the treatment group 2 hours after meal was significantly lower than that in the control group (A P < 0.05). Table 3 Comparison of glycosylated hemoglobin level between two groups before and after treatment Table 3 Comparison of glycosylated hemoglobin level between two groups before and after treatment [HbA1c FBG(mmol/L)]
Group n Pre-treatment 15 Days 30 Days
Comparison group 24 671±028 654k0.15 652+022
Treatment group 24 6680.31 641+0.23 6.03i0.24AL
Z -1.512 -2.547 -3. 672
It can be seen from Table 3 that there is no significant difference in glycosylated hemoglobin level between the two groups before treatment (* P > 0.05), which is comparable. After 30 days of treatment, the glycosylated hemoglobin in the treatment group decreased after 30 days compared with that before treatment (A P < 0.05), and the glycosylated hemoglobin in the treatment group was lower than that in the control group after 30 days (A P < 0.05). Table 4 Comparison of triglyceride levels between the two groups before and after treatment Table 4 Comparison of triglyceride level between two groups before and after treatment
[TG(mmol/L)] Group n Pre-treatment 15 Days 30 Days
Comparison group 24 4-3±07 40±05 3.8±0.6
Treatment group 24 4.2 0.8* 3.4tD.6 2.5±0-7,
It can be seen from Table 4 that there is no significant difference in triglyceride level between the two groups before treatment (* P > 0.05), which is comparable. After 30 days of treatment, the triglyceride in the treatment group was significantly lower than that in the control group (A P < 0.05). Table 5 Comparison of the effects of various indexes between the two groups before and after treatment Table 5 Comparison of the effect of each index between the two groups before and after treatment [I (%)]
Group n FBG(%) 2hPBG(%) HbAlc(%) TG( Comparison group 24 1 9.07% 1 16_55% 12.83% 1 11.63% Treatment group L 24 12388% 73968% 19-3% 4048%
It can be seen from Table 5 that the two groups of patients were managed according to diabetes diet. After low fat, low salt and moderate exercise management, the blood sugar and triglyceride indexes of the control group decreased after 30 days; On the premise of the above diet and exercise management, after taking the fruit and vegetable plant extract powder orally for 30 days, the indexes of the treatment group were significantly reduced, and the patients in the treatment group achieved better treatment effect.
To sum up, on the basis of scientific diet and proper exercise, diabetic patients can take the combined formula of fruit and vegetable extract orally, which can effectively reduce blood sugar and blood fat, and the raw materials of the invention are all derived from fruits and vegetables, which can be taken for a long time, and have positive significance for preventing and treating type I diabetes. To sum up, compared with the prior art, the vegetable and fruit extract formula and the preparation method for preventing and treating type 11 diabetes provided by the invention provide a vegetable and fruit extract combination formula which is applied in the field of chronic blood sugar metabolic diseases, is composed of pure natural vegetable and fruit extracts, has no toxic and side effects, does not have external added anticorrosion and pigment chemical reagents, and is used for preventing and treating type Il diabetes. Finally, it should be noted that the above is only a preferred embodiment of the present invention, and is not used to limit the present invention. Although the present invention has been described in detail with reference to the foregoing embodiments, for those skilled in the art, they can still modify the technical solutions described in the foregoing embodiments, or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the protection of the present invention.
Claims (1)
- THE CLAIMS DEFINING THE INVENTION ARE AS FOLLOWS: 1. A preparation method of a vegetable and fruit composition for preventing and treating type Il diabetes, comprising 5-30 parts by weight of Solanum tuberosum, 4-20 parts by weight of Amorphophallus konjac, 3-15 parts by weight of Hippophae rhamnoides, 2-10 parts by weight of Morinda citrifolia, 2-10 parts by weight of Pueraria lobata and 2-10 parts by weight of Siraitia grosvenorii, which is characterized by comprising the following steps: S1, drying the cleaned lettuce, konjac, seabuckthorn, kudzu vine root, grosvenor momordica grosvenori and shelled chamomile at low temperature for later use. S2, crushing the longevity vegetable, sieving with a sieve of 80-100 meshes, using % ethanol as a solvent with a solid-to-liquid ratio of 1: 10, fully stirring, standing for 12 hours, extracting at5 45C for 30 minutes, separating to obtain the longevity vegetable extract, and recovering the ethanol residue from the filtrate for further extraction and reuse. S3, mixing the residue of Tianguo and the residue of Longevity Vegetable, using % ethanol as solvent, with a solid-liquid ratio of 1:15, fully stirring, extracting at 5450 C for 50 minutes, filtering out the ethanol, extracting with n-butanol to obtain n-butanol extract, concentrating the n-butanol extract with reduced pressure evaporation method until a proper amount of water is washed away, and eluting with 30%-100% ethanol solution to obtain the eluent. S4, pulverizing seabuckthorn, sieving with 80-100 mesh sieve, using 60% ethanol as solvent, stirring thoroughly, standing for 12 hours, extracting at 5450 C for 30 minutes, and recovering ethanol from filtrate to obtain seabuckthorn extract. S5, pulverizing radix puerariae, sieving with a 100-120 mesh sieve, using water as a solvent with a solid-liquid ratio of 1: 20, fully stirring, extracting for 90 minutes at a temperature below 45°C and a vacuum degree of 0.mmHg-1.mmHg, removing impurities from the water extract with macroporous resin, and concentrating under reduced pressure to obtain puerarin extracts. S6, crushing momordica grosvenori, sieving with 80-100 mesh sieve, using water as solvent, stirring thoroughly, extracting under negative pressure of 0.lmmHg 1.0mmHg below 45°C for 60 minutes, removing impurities from water extract with macroporous resin, and concentrating under reduced pressure to obtain momordica grosvenori extract. S7, pulverizing konjac, sieving with 80-100 mesh sieve, using 40% ethanol as solvent, stirring thoroughly, standing for 12 hours, extracting at 5450 C for 30 minutes, and recovering ethanol from filtrate to obtain glucoside polysaccharide. S8. all the above materials are mixed according to a certain proportion, sent to a vacuum vacuum dryerwith a vacuum degree of0.1mmHg-1.OmmHg, and dried at545°C to obtain extract powder.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2021106291A AU2021106291A4 (en) | 2021-08-21 | 2021-08-21 | Vegetable and fruit extract formula for preventing and treating type II diabetes and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2021106291A AU2021106291A4 (en) | 2021-08-21 | 2021-08-21 | Vegetable and fruit extract formula for preventing and treating type II diabetes and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2021106291A4 true AU2021106291A4 (en) | 2021-11-04 |
Family
ID=78488444
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2021106291A Ceased AU2021106291A4 (en) | 2021-08-21 | 2021-08-21 | Vegetable and fruit extract formula for preventing and treating type II diabetes and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| AU (1) | AU2021106291A4 (en) |
-
2021
- 2021-08-21 AU AU2021106291A patent/AU2021106291A4/en not_active Ceased
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106666312A (en) | Health-care food for assisting blood glucose decreasing and preparation method of granule and capsule thereof | |
| CN104288501A (en) | Blood glucose reducing particle and preparation method thereof | |
| CN104431064B (en) | A kind of blood-sugar reducing tea and preparation method thereof | |
| CN106176918A (en) | A kind of Hyperglycemic health care compositions comprising leaf of Cyclocarya paliurus Iljinskaja and Radix Puerariae | |
| CN106819833A (en) | A kind of noodles of hypoglycemic Adjust-blood lipid and preparation method thereof | |
| CN105341893A (en) | Composition for assisting in reducing blood glucose and application | |
| CN108434191A (en) | A kind of composition and preparation method thereof with effects of losing weight and lowering blood sugar and blood lipid | |
| AU2021106291A4 (en) | Vegetable and fruit extract formula for preventing and treating type II diabetes and preparation method thereof | |
| CN112385841A (en) | Medicated diet composition for type 2 diabetes and preparation method thereof | |
| CN101167781A (en) | Orally-administered hypoglycemic sweet potato leaf single prescription traditional Chinese medicine and preparation method thereof | |
| CN106692742A (en) | Traditional Chinese compound medicine for regulating blood sugar and preparation method of traditional Chinese compound medicine | |
| CN113663043B (en) | Composition with alpha-glucosidase inhibition effect and preparation method and application thereof | |
| CN107136269B (en) | Cyclocarya paliurus and bitter gourd blood sugar reducing tea and preparation method thereof | |
| CN106309736B (en) | Anti-fatigue Chinese medicinal composition and its preparation method and application | |
| CN108553559B (en) | Formula and preparation method of vegetable and fruit extract for preventing and treating type II diabetes | |
| CN115137770A (en) | Preparation method of traditional Chinese medicine product with efficacy of reducing blood fat and blood pressure | |
| KR102198434B1 (en) | Pharmaceutical composition for preventing or treating hyperlipidemia using natural plants, preparation method and preparation thereof | |
| CN106619972B (en) | Capsule for reducing blood sugar containing hirsutella hepiali Chen et Shen mycelium powder, and its preparation method and application | |
| CN111603522A (en) | Chili leaf composition with blood sugar reducing effect and preparation method and application thereof | |
| CN107397808A (en) | A kind of balsam pear, hawthorn health food preparation method of auxiliary hyperglycemic blood fat | |
| CN106177416B (en) | A kind of traditional Chinese medicinal composition with effect of reducing blood sugar and preparation method thereof | |
| CN110801469A (en) | Functional food for regulating blood sugar and preparation method thereof | |
| CN103751255A (en) | Pachymaran composition for decreasing blood sugar and preparation method thereof | |
| CN103054895A (en) | Medicine composition for preventing and treating obesity | |
| CN102614404A (en) | Health product with auxiliary effect on reducing blood glucose and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGI | Letters patent sealed or granted (innovation patent) | ||
| MK22 | Patent ceased section 143a(d), or expired - non payment of renewal fee or expiry |