AU2021102712A4

AU2021102712A4 - Insecticide

Info

Publication number: AU2021102712A4
Application number: AU2021102712A
Authority: AU
Inventors: Gray BOSTON
Original assignee: Pharmachem Australia Pty Ltd
Current assignee: Pharmachem Australia Pty Ltd
Priority date: 2021-05-20
Filing date: 2021-05-20
Publication date: 2021-08-05
Anticipated expiration: 2029-05-20

Abstract

The present invention is directed to a pour-on topical insecticide formulation for an animal including a synthetic pyrethroid and at least one mineral oil. Ill 14 10 6-12 16 ~/\~ /2 :ljt~tsYT7@\ 7' 6 A V 2 /1 if. 145' / V / -- -.-- ~-~-~ 2 -~ 2 I ' I /~ X~~J~>< / ii' .3 Is Figure

Description

Ill

14 10

6-12 16

/2 :ljt~tsYT7@\ 7' ~/\~

6

2 A V /1

if. 145' / V / -- -.-- ~-~-~ 2 -~

2 I

/~ '

X~~J~>< / I

ii'

.3

Is

Figure

INSECTICIDE

FIELD OF INVENTION The present invention relates to a topical insecticide formulation and method of using the topical insecticide formulation. In particular, the present invention relates, but is not limited, to a pour-on topical insecticide for animals including horses. Reference to the pour-on topical insecticide for horses is provided by way of example but the invention is not limited to this use.

BACKGROUND OF THE INVENTION Insect pests including flies and biting insects can cause annoyance, discomfort and/or irritation to animal pets and livestock including horses. Insect infestations by biting insects are often intensely itchy, causing considerable annoyance and discomfort to the animal. Insect pest also causes serious health problem to the animals by acting as vectors for bacteria and viruses. Bacteria and viruses can be transmitted directly by the insects from the blood, mucus or lesions of one animal to another animal. Different methods have been used for insect control. One method is through facility and environment hygiene maintenance. However, hygiene maintenance is not always effective and constant maintenance is required which can be time consuming. Other insect control methods include the use of physical barriers such as masks, body sheets and boots, and the use of biological methods. Physical barriers have limitations in that they typically do not provide full body protection and can result in overheating. Biological control can have disadvantages in that it may be expensive and may have ecological effects. Another method for combating insects is through chemical control including insecticide. Insecticide can be topically applied to the outer surface of the animal as a spray. However, the effectiveness of such spray is short lived and generally requires constant reapplication to maintain the effect, which is time consuming and impractical for an animal's caretaker. In addition, the caretaker may be exposed to the insecticide spray during the application to the animal, which may result in irritation or toxic side effects. Alternatively, insecticide can be topically applied to the animal as a wipe-on application. However, to minimize or to avoid any potential irritation or toxic side effect to the caretaker, it is generally recommended to wear a mitt or gloves for wiping the insecticide on the animals, which can be time-consuming and impractical.

OBJECT OF THE INVENTION It is an objective of the present invention to overcome or at least alleviate one or more of the disadvantages or problems with insect control for an animal described above and/or provide the consumer with a useful or commercial alternative.

SUMMARY OF THE INVENTION In one aspect, the present invention broadly resides in a pour-on topical insecticide formulation for an animal including: a synthetic pyrethroid; and at least one mineral oil. Preferably, the synthetic pyrethroid includes but not limited to one or more of the following: bifenthrin, cyfluthrin, cyhalothrin, cypermethrin, d-phenothrin, deltamethrin, fenvalerate, flumethrin, lambda-cyhalothrin, and permethrin. Preferably, the synthetic pyrethroid is permethrin. In another embodiment, the synthetic pyrethroid is deltamethrin. Preferably, the synthetic pyrethroid has a concentration of between 1 to 10% w/v, more preferably between 7 to 9 % w/v. Preferably, the synthetic pyrethroid has a concentration of substantially 8.7 % w/v. Preferably, the synthetic pyrethroid has a cis:trans isomer ratio between 20:80 to 80:20. More preferably, the synthetic pyrethroid has a cis:trans isomer ratio of substantially 25:75, 40:60 or 80:20. Most preferably, the synthetic pyrethroid has a cis:trans isomer ratio of substantially 25:75. Preferably, the at least one mineral oil is used as a solvent for dissolving the synthetic pyrethroid. Preferably, the at least one mineral oil can act as an emollient. Preferably, the at least one mineral oil is a food grade white mineral oil. Preferably, the white mineral oil is composed of saturated hydrocarbon. Preferably, the saturated hydrocarbon has carbon numbers predominantly in the range of C15 through C50. Preferably, the pour-on topical insecticide formulation has a viscosity of not greater than 20 cP at 400C. More preferably, the pour-on topical insecticide formulation has a viscosity of not greater than 15 cP at 400C.

Preferably, the pour-on topical insecticide formulation has a surface tension of below 50 dynes per cm. More preferably, the pour-on topical insecticide formulation has a surface tension of below 30 dynes per cm. Preferably, the pour-on topical insecticide formulation has a density of 0.7 to 1 g/ml at 400C. More preferably, the pour-on topical insecticide formulation has a density of substantially 0.85 to 0.9 g/ml at 400C. Preferably, the pour-on topical insecticide formulation further includes at least one vegetable oil. Preferably, the at least one vegetable oil is used as a spreader. Preferably, the at least one vegetable oil is a soybean oil. Preferably, the at least one mineral oil allows spreading of the pour-on insecticide formulation over the exterior of an animal body. Preferably, the at least one vegetable oil allows spreading of the pour-on insecticide formulation over the exterior of an animal body. Preferably, the at least one mineral oil and at least one vegetable oil allow spreading of the pour-on insecticide formulation over the exterior of an animal body. Preferably, the pour-on topical insecticide formulation is stable at room temperature. Preferably, the pour-on topical insecticide formulation is stable at substantially 20 to 300C. Preferably, the pour-on topical insecticide formulation has a shelf life of substantially 20 to 40 months when stored below substantially 300C. More preferably, the pour-on topical insecticide formulation has a shelf life of substantially 30 months when stored below substantially 300C. In another aspect, the present invention broadly resides in a pour-on topical insecticide formulation for an animal including: a synthetic pyrethroid; at least one mineral oil as solvent; and at least one vegetable oil as spreader, wherein the concentration of the synthetic pyrethroid is between 1 to 10 %w/v. In another aspect, the present invention broadly resides in a system for applying a pour-on topical insecticide formulation as herein described to an animal, the system including a container with an opening, wherein the insecticide formulation can be poured out of the container through the opening and onto the animal. Preferably, the pour-on topical insecticide formulation is contained within the container.

In one embodiment, the container includes a measuring chamber. Preferably, a desired amount of the insecticide formulation is measured by the measuring chamber and then poured out of the measuring chamber through the opening and onto the animal. In another embodiment, the container includes a nozzle. Preferably, the nozzle is located at the opening of the container. Preferably, the insecticide formulation can be poured from the container through the nozzle to the animal. In one embodiment, the container is squeezable such that the insecticide formulation can be poured out from the container. In another embodiment, the container can be tilted such that the insecticide formulation can poured out of the container due to gravity. In another embodiment, the container can be tilted and squeezed such that the insecticide formulation can poured out of the container due to gravity. Preferably, the system further includes a lid that covers the opening of the container. In one embodiment, the lid can be used as a measuring cup for the insecticide formulation. Preferably, the insecticide formulation can be poured from the container through the opening to the lid to measure a desired amount of the insecticide formulation to be poured onto the animal. In another aspect, the present invention broadly resides in a pour-on topical insecticide treatment for an animal using an insecticide formulation as herein described, wherein substantially 6 to 30 mL of the formulation is applied to the exterior of the animal. Preferably, the treatment is applied to the exterior of the animal at a rate of substantially 6 to 9 ml of the formulation per 100 kg body of the animal. More preferably, the treatment is applied to the exterior of the animal at a rate of substantially 6 ml of the formulation per 100 kg body weight of the animal. Preferably, the treatment is effective against insects including synthetic pyrethroid susceptible nuisance flies, Musca supp., Stomoxys calcitrans, Haematobia irritans exigua, Culex spp., Aedes spp., and Culicoides spp. In another aspect, the present invention broadly resides in a method of applying a pour-on insecticide formulation as described herein to an exterior of an animal, the method includes applying an effective dose of the formulation over the body of the animal. Preferably, the effective dose is substantially 6 to 30 ml.

Preferably, the step of applying the formulation includes applying the formulation at a rate of substantially 6 to 9 ml of the formulation per 100 kg body of the animal. More preferably, the step of applying the formulation includes applying the formulation at a rate of substantially 6 ml of the formulation per 100 kg body weight of the animal. Preferably, the step of applying the formulation over the body includes applying the formulation substantially from the neck and along the backline of the animal. Preferably, the step of applying the formulation over the body includes applying the formulation substantially along the backline from behind the ears to the rump of the animal. In one embodiment, the step of applying the formulation includes applying the formulation at least once a week. In another embodiment, the step of applying the formulation includes applying the formulation at least once every six weeks. Preferably the animal is a horse. In another aspect, the present invention broadly resides in a method of alleviating insects infesting an exterior of an animal with a formulation as described herein, the method includes applying an effective dose of the formulation to the exterior of the animal. In another aspect, the present invention broadly resides in a pour-on topical insecticide formulation for an animal including: a synthetic pyrethroid; and at least one solvent oil. Preferably, the at least one solvent oil is a mineral oil. In another aspect, the present invention broadly resides in a pour-on topical insecticide formulation for an animal including: a synthetic pyrethroid; at least one solvent oil; and at least one spreader oil. Preferably, the at least one spreader oil is a vegetable oil. The features described with respect to one aspect also apply where applicable to all other aspects of the invention. Furthermore, different combinations of described features are herein described and claimed even when not expressly stated.

BRIEF DESCRIPTION OF THE DRAWINGS In order that the present invention can be more readily understood reference will now be made to the accompanying drawings which illustrate a preferred embodiment of the invention and wherein: Figure 1 is a perspective view of how to apply the pour-on insecticide formulation over the body of the animal according to an embodiment of the present invention.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT The present invention is further described by the following preferred embodiment. With reference to figure 1, there is shown a perspective view of applying the abovementioned pour-on insecticide formulation 12 on an animal 10 with an example of a horse. The pour-on insecticide formulation 12 was prepared by mixing the following components: 87 g/L (i.e., 8.7% w/v) of permethrin with a cis:trans ratio of 25:75 was added to food grade white mineral oil (CAS No. 8042-47-5) as the solvent and RBD (refined, bleached, deodorized) soybean oil (CAS No. 8001-22-7) as the spreader. A stability test confirmed that the formulation 12 is stable at 300C and has a shelf life of 30 months when stored below 300C. Permethrin (CAS No 52645-53-1) is a type I synthetic pyrethroid. It is an ester of the dichloro-analogue of chrysanthemic acid, and 3-phenoxybenzyl alcohol. The permethrin used is a mixture of four stereoisomers of the configuration [1R,3S],

[1R,3R], [1S,3R] and [1S,3S]. Permethrin is a yellow brown viscous liquid with a characteristic aromatic odour and is virtually insoluble in water (<0.00495 to 0.18 mg/L at 200C), but readily soluble in most organic solvents. The molecule is fat soluble with a Log Pow of 4.67 +/- 0.01 at 250C. Permethrin does not absorb at >290 nm which indicates that the molecule is not susceptible to breakdown by light. The molecule is non-volatile (2.155 x 10-6 Pa at 200C) and is not classified as being flammable, explosive or oxidising. In Australia, permethrin cis:trans 25:75 is approved for topical application on dogs and horses as an ectoparasiticide. The pour-on insecticide formulation 12 has spreading characteristics that results in maximum coverage of the animal so that the active constituent permethrin can be delivered to the sites of insect pest attack. The suitable spreading characteristics includes a viscosity of not greater than 15 cP at 400C, a surface tension below 30 dynes/cm, and a density of approximately 0.85 - 0.9 g/mL at 400C The food grade white mineral oil used as the solvent for permethrin and the RBD soybean oil used as the spreader in formulation 12 are not schedule as a poison according to the Standard for the Uniform Scheduling of Drugs and Poisons. There are no toxic or irritant effects known to associate with the food grade white mineral oil and the RBD soybean oil. In addition, both the food grade white mineral oil and the RBD soybean oil individually possess the required spreading characteristics that are suitable for the formulation 12. Such spreading characteristics are maintained when the white mineral oil and the RBD soybean oil are mixed together. The food grade white mineral oil and the RBD soybean oil are also recognized as emollients that provides a moisturising and protective effect on the skin. As shown in figure 1, the pour-on insecticide formulation 12 is poured from container 14. Arrow 16 shows the direction of pouring the formulation 12 over the body of the animal 10. The formulation 12 is poured along the backline of the animal 10 starting from behind the ears to the mane and then to the rump area of animal 10. The formulation 12 is applied at a rate of 6ml per 100 kg body weight of the animal 10. That is, 6ml of the formulation 12 is applied to animal 10 with a body weight up to 100 kg; 12 ml of the formulation 12 is applied to animal 10 with a body weight between 101 to 200 kg; 18 ml of the formulation 12 is applied to animal 10 with a body weight between 201 to 300 kg; and 30 ml is applied to animal 10 with a body weight over 300 kg. However, not more than 30 ml is applied to the exterior of animal 10. The formulation 12 can be used to prevent Culicoides spp. biting horses and causing the allergic reaction to these bites known as "Queensland Itch". The formulation 12 is applied at least once weekly at the beginning of the Queensland itch season and is repeated as necessary. The formulation 12 can also be used as a treatment to assist in the control of nuisance flies that irritate or transmit diseases to horses. The formulation 12 is applied at least one every six weeks or as required depending on insect pressure.

ADVANTAGES An advantage of the preferred embodiment of the present invention includes providing an alternative option of a topical insecticide formulation that is safe to use on horses and for the caretaker who applies the formulation. Another advantage of the preferred embodiment of the present invention includes providing an alternative topical insecticide formulation that is simple and practical for the caretaker to pour on and spread over the exterior of the horse. A further advantage of the preferred embodiment of the present invention includes providing an alternative topical insecticide treatment that can effectively kills the insect pest for horses. Another advantage of the preferred embodiment of the present invention includes providing an alternative topical insecticide treatment that has a moisturising and protective effect on the skin of the horses to which the formulation is applied. A further advantage of the preferred embodiment of the present invention includes providing an alternative topical insecticide formulation that is stable at room temperature for storage.

VARIATIONS While the foregoing has been given by way of illustrative example of this invention, all such and other modifications and variations thereto as would be apparent to persons skilled in the art are deemed to fall within the broad scope and ambit of this invention as is herein set forth. Throughout the description and claims of this specification the word "comprise" and variations of that word such as "comprises" and "comprising", are not intended to exclude other additives, components, integers or steps.

Claims

1. A pour-on topical insecticide formulation for an animal including: a synthetic pyrethroid; and at least one mineral oil.

2. The pour-on topical insecticide formulation as claimed in claim 1, wherein the synthetic pyrethroid is permethrin, and wherein the permethrin has a concentration of substantially 8.7 % w/v, and wherein the permethrin has a cis:trans isomer ratio of substantially 25:75, and wherein the formulation further includes at least one vegetable oil, and wherein the formulation has a viscosity of not greater than 15 cP at 400C, a surface tension of below 30 dynes per cm, and or a density of substantially 0.85 to 0.9 g/ml at 400C.

3. A system for applying a pour-on topical insecticide formulation as claimed in claim 1 or 2 to an animal, the system including a container with an opening, wherein the insecticide formulation can be poured out of the container through the opening and onto the animal.

4. The system as claimed in claim 3, wherein the container includes a measuring chamber or a nozzle; wherein the container is squeezable or can be tilted such that the insecticide formulation can be poured out from the container; and wherein the system further includes a lid that covers the opening of the container.

5. A method of applying a pour-on insecticide formulation as claimed in claim 1 or 2 to an exterior of an animal, the method includes applying an effective dose of the formulation over the body of the animal, wherein the effective dose is substantially 6 to 30 ml.

16 1/1

Figure 1 12