AU2021101134A4 - A stable medical liquid enteral nutrition composition and its preparation method - Google Patents
A stable medical liquid enteral nutrition composition and its preparation method Download PDFInfo
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- AU2021101134A4 AU2021101134A4 AU2021101134A AU2021101134A AU2021101134A4 AU 2021101134 A4 AU2021101134 A4 AU 2021101134A4 AU 2021101134 A AU2021101134 A AU 2021101134A AU 2021101134 A AU2021101134 A AU 2021101134A AU 2021101134 A4 AU2021101134 A4 AU 2021101134A4
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- oil
- enteral nutrition
- nutrition composition
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- 239000007788 liquid Substances 0.000 title claims abstract description 67
- 235000016709 nutrition Nutrition 0.000 title claims abstract description 47
- 230000035764 nutrition Effects 0.000 title claims abstract description 41
- 239000000203 mixture Substances 0.000 title claims abstract description 39
- 238000002360 preparation method Methods 0.000 title claims abstract description 23
- 229910052500 inorganic mineral Inorganic materials 0.000 claims abstract description 31
- 239000011707 mineral Substances 0.000 claims abstract description 31
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 21
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- 239000003995 emulsifying agent Substances 0.000 claims abstract description 12
- 150000001720 carbohydrates Chemical class 0.000 claims abstract description 11
- 235000013325 dietary fiber Nutrition 0.000 claims abstract description 11
- 239000003381 stabilizer Substances 0.000 claims abstract description 7
- 238000000034 method Methods 0.000 claims abstract description 6
- 239000002904 solvent Substances 0.000 claims abstract description 3
- 235000010755 mineral Nutrition 0.000 claims description 29
- 238000003756 stirring Methods 0.000 claims description 19
- 238000005303 weighing Methods 0.000 claims description 18
- 238000002156 mixing Methods 0.000 claims description 17
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- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 13
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- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 description 1
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- UIERGBJEBXXIGO-UHFFFAOYSA-N thiamine mononitrate Chemical compound [O-][N+]([O-])=O.CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N UIERGBJEBXXIGO-UHFFFAOYSA-N 0.000 description 1
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- 235000013337 tricalcium citrate Nutrition 0.000 description 1
- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
- A23L2/66—Proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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Abstract
The invention belongs to the technical field of food for special medical purposes, and
particularly relates to a stable medical liquid enteral nutrition composition and its preparation
method. The formula of the enteral nutrition composition per IL is as follows: 36.25-83.05g
of protein, 23.7-56.2g of fat, 103.5-245.7g of carbohydrate, 0~41.5g of dietary fiber,
0.36-0.87g of vitamin premix, 1.86~4.58g of mineral premix I and 14.24-31.49g of mineral
premix II, 0.72~4.19g of emulsifier, 0.68-2.75g of stabilizer. The solvent is water. The
invention reduces the loss of vitamins by optimizing the preparation process flow, and makes
the enteral nutrition composition have good stability. The invention has the advantages of
simple process, easy operation, easy continuous production and wide industrialization
prospect.
Description
A stable medical liquid enteral nutrition composition and its
preparation method
The invention belongs to the technical field of food for special medical purposes
and particularly relates to a stable medical liquid enteral nutrition composition and its
preparation method.
Enteral nutrition preparation, combined with drugs or surgical treatment, can
promote the prognosis of diseases and improve the nutritional status of patients.
According to statistics, 60%~70% of the patients need nutrition therapy in China. with
the "acceleration" of China's aging society, China's clinical nutrition field is facing huge
market demand.
Compared with powder products, liquid enteral nutrition preparation can be eaten
directly or fed by tube in clinical application, and it is more convenient to use. However,
as an extremely complex food system, liquid enteral nutrition preparation is prone to
interactions between various nutrients, which increases the loss of vitamin in the
production process. In addition, it also affects the stability of the product, and is prone to
protein precipitation, fat floating and other stratification phenomena, which seriously
limits its clinical application.
To solve the technical problems of easy loss of vitamins and poor product stability
in liquid enteral nutrition preparation, the invention provides a medical liquid enteral
nutrition composition and its preparation method.
Specifically, the invention provides a preparation method of a medical liquid enteral
nutrition composition. The raw materials of the medical liquid enteral nutrition
composition include protein, fat, emulsifier, carbohydrate, dietary fiber, vitamins,
minerals and stabilizers. The preparation method comprises the following steps:
1) Preparation of fat emulsion
(1) Weighing protein and water-soluble emulsifier according to the proportion,
adding into pure water at 40-60°C, and stirring until completely dissolved to obtain a
protein phase;
(2) Weighing fat and oil-soluble emulsifier according to the proportion, and stirring
at 40-80°C until being evenly mixed to obtain an oil phase;
(3) Adding the oil phase obtained in step (2) to the protein phase obtained in step
(1), shearing and stirring; Homogenizing the obtained feed liquid to obtain fat emulsion;
2) Weighing carbohydrate, dietary fiber and stabilize according to the proportion,
adding the carbohydrate, dietary fiber and stabilizer into pure water at 40-60°C, and
stirring until completely dissolved to obtain liquid A;
3) Adding the liquid A into the fat emulsion, and uniformly mixing to obtain liquid
4) Weighing mineral premix I according to the proportion, adding into pure water at
-60°C, stirring to completely dissolve, adding into the liquid B, and mixing evenly to
obtain liquid C;
The mineral premix I contains copper, magnesium, iron and zinc, and the dosage of
each element can be adjusted reasonably according to the needs;
5) Weighing mineral premix II according to the proportion, adding it into pure water
at 40-60°C, stirring to completely dissolve, adding it into the liquid C at a flow rate not
higher than 23L/min, and mixing evenly to obtain liquid D;
The mineral premix II contains sodium, potassium, manganese, calcium,
phosphorus, chlorine and selenium, and the dosage of each element can be adjusted
reasonably according to the needs;
6) Weighing the vitamin premix according to the proportion, adding the into pure
water at 25~40°C, stirring and completely dissolving, adding the into the liquid D at a
flow rate not higher than 12 L/min, and uniformly mixing to obtain liquid E;
7) Cooling the liquid E to below 30°C to obtain liquid F;
8) Homogenizing and filtering the liquid F; Or further comprises the steps of
sterilizing and filling the filtered liquid.
Further, the protein of the present invention is selected from one or more of
concentrated milk protein, isolated soy protein, casein, hydrolyzed whey protein, soy
peptide, concentrated whey protein, isolated whey protein, sodium caseinate, calcium
caseinate, pea protein, collagen peptide, etc.
Further, the fat of the present invention is selected from one or more of low erucic
acid rapeseed oil, corn oil, coconut oil, high oleic acid sunflower oil, medium chain
triglyceride, soybean oil, peanut oil, linseed oil, perilla seed oil, palm oil, DHA algae oil,
fish oil, etc.
Further, the carbohydrate of the present invention is selected from one or more of
glucose syrup, glucose syrup dry powder, maltodextrin, sucrose, glucose, fructose, etc.
Further, the dietary fiber of the present invention is selected from one or more of
inulin, polydextrose, galactooligosaccharide, fructooligosaccharide, polyfructose,
raffinose, stachyose, resistant dextrin, resistant starch, soybean polysaccharide, etc.
Further, the composition and dosage of the vitamin premix of the invention can be
adjusted according to the nutrient content of the medical liquid enteral nutrition
composition of the present invention.
Further, the vitamin premix of the present invention contains one or more of the
following components: vitamin A, vitamin D, vitamin E, vitamin Ki, vitamin Bi, vitamin
B2, vitamin B6, vitamin B12, nicotinamide, folic acid, pantothenic acid, vitamin C, biotin
and iodine.
Preferably, the components and contents of the vitamin premix of the present
invention are shown in the following table:
Nutritional ingredient Content
Vitamin A, pg RE/g 1397.088-2594.59
Vitamin D, pg/g 26.46~49.14
Vitamin E, mg a-TE/g 19.845-36.855
Vitamin Ki, pg/g 139.709-259.459
Vitamin B1 , mg/g 1.905-3.538
Vitamin B 2 , mg/g 1.905-3.538
Vitamin B6 , mg/g 1.905-3.538
Vitamin B 12 , pg/g 4.2336-7.8624
Nicotinamide, mg/g 19.0512-35.3808
Folic acid, pg/g 384.1992-713.513
Pantoic acid, mg/g 5.8212-10.8108
Vitamin C, mg/g 396.9-737.1
Biotin, pg/g 63.504~117.936
Iodine, pg/g 158.76-294.84
Furthermore, the vitamin A of the invention is selected from one or more of vitamin
A palmitate, vitamin A acetate, p-carotene and all-trans retinol; Vitamin D comes from
cholecalciferol (vitamin D3) and ergocalciferol (vitamin D2). The vitamin E is selected
from one or two of d-a-tocopherol, dl-a-tocopherol, d-a-tocopherol acetate, dl-a
tocopherol acetate, mixed tocopherol concentrate, d-a-tocopherol succinate and dl-a
tocopherol succinate. The vitamin Bi is selected from one or two of thiamine
hydrochloride and thiamine nitrate; The vitamin B2 is selected from one or two of
riboflavin and riboflavin -5'- sodium phosphate; The vitamin B6 is selected from one or
two of pyridoxine hydrochloride and pyridoxine 5'- phosphate. The vitamin B12 is
selected from one or two of cyanocobalamin, nicotinic acid cyanocobalamin and
hydroxycobalamin. Nicotinamide is selected from one or two of nicotinic acid and nicotinamide. Folic acid is selected from folic acid; Pantothenic acid is selected from one or two of D- calcium pantothenate and D- sodium pantothenate. The vitamin C is selected from one or two of ascorbic acid, L-sodium ascorbate, L-calcium ascorbate, L-potassium ascorbate and ascorbyl palmitate; Biotin is derived from D- biotin; Iodine is selected from one or two of potassium iodide, potassium iodate and sodium iodide.
Furthermore, the composition and dosage of the mineral premix I can be adjusted
according to the mineral content of the final product of the medical liquid enteral
nutrition composition. Preferably, the components and contents of the mineral premix I
are shown in the following table:
Nutritional ingredient Content
Copper, pg/g 144.06-267.54
Magnesium, mg/g 56.595~105.105
Iron, mg/g 3.087-5.733
Zinc, mg/g 2.058-3.822
Further, the copper in the invention is slected from one or two of copper sulfate, copper gluconate, copper citrate and copper carbonate; Magnesium is selected from one or more of magnesium sulfate, magnesium oxide, magnesium carbonate, magnesium chloride, magnesium hydrogen phosphate and magnesium gluconate; Iron is selected from one or more of ferrous sulfate, ferrous gluconate, ferric pyrophosphate, ferric ammonium citrate, ferrous fumarate and ferric citrate. The zinc is selected from one or two of zinc sulfate, zinc gluconate, zinc oxide, zinc lactate, zinc citrate, zinc chloride and zinc acetate.
Furthermore, the composition and dosage of the mineral premix II can be adjusted according to the mineral content of the final product of the medical liquid enteral nutrition composition. Preferably, the components and contents of the mineral premix II are shown in the following table:
Nutritional ingredient Content
Sodium, mg/g 26.25-63.00
Potassium, mg/g 35.70-85.68
Manganese, pg/g 88.2~163.8
Calcium, mg/g 6.72-43.68
Phosphorus, mg/g 19.81-36.80
Chlorine, mg/g 22.75~42.25
Selenium, pg/g 1.47-2.73
Further, the sodium is selected from one or more of sodium bicarbonate, sodium
dihydrogen phosphate, sodium citrate, sodium chloride and disodium hydrogen
phosphate; Potassium is selected from one or more of potassium gluconate, potassium
chloride, potassium citrate, potassium dihydrogen phosphate and dipotassium hydrogen
phosphate; Manganese is selected from one or two of manganese sulfate, manganese
chloride, manganese carbonate, manganese citrate and manganese gluconate; Calcium is
selected from one or more of calcium carbonate, calcium gluconate, calcium citrate, L
calcium lactate, calcium chloride, calcium phosphate, calcium hydrogen phosphate,
calcium oxide and calcium sulfate. The phosphorus is selected from one or more of
sodium dihydrogen phosphate, disodium hydrogen phosphate, potassium dihydrogen
phosphate, dipotassium hydrogen phosphate, calcium phosphate and calcium hydrogen
phosphate; The chlorine is selected from one or more of sodium chloride, potassium
chloride, manganese chloride and calcium chloride; Selenium is selected from one or
more of sodium selenate and sodium selenite.
Further, the water-soluble emulsifier is selected from one or more of polyglycerol
fatty acid ester, sucrose fatty acid ester, diacetyl tartaric acid monoglyceride, etc. The oil
soluble emulsifier is selected from one or more of soybean phospholipid, monoglyceride
and succinic monoglyceride.
Further, the stabilizer of the present invention is selected from one or more of
carrageenan, microcrystalline cellulose, sodium carboxymethyl cellulose, xanthan gum,
gellan gum, pectin, hydroxypropyl starch, locust bean gum, etc.
In the specific embodiment of the invention, the formula of the medical liquid enteral nutrition composition per IL is as follows: 36.25-83.05g of protein, 23.7-56.2g of fat, 103.5-245.7g of carbohydrate (based on dry basis), 0~41.5g of dietary fiber, 0.36-0.87g of vitamin premix, 1.86~4.58g of mineral premix I, 14.24-31.49g of mineral premix II, 0.72~4.19g of emulsifier, 0.68-2.75g of stabilizer. The solvent (or carrier) is water (balance).
In addition, it should be understood that the terms "including", "including" and "containing" in this paper also include "by ... composed of ","by ... constitute ""by . . made ",etc.
The invention also comprises the medical liquid enteral nutrition composition prepared by the method.
In a specific embodiment of the invention, the medical liquid enteral nutrition composition contains the following components per IL:
Component Content
Protein, g 27.5-62.9
Fat, g 23.7-56.2
Linoleic acid, g 22.22
a -linolenic acid, g 20.556
Carbohydrates, g 93.1~212.9
Vitamin A, pg RE 469-2250
Vitamin D, pg 8.89-31.4
Vitamin E, mg a-TE 8.74~466
Vitamin Ki, pg 46.9
Vitamin B1, mg 21.07
Vitamin B2 ,mg 21.05
Vitamin B6 , mg 1.03 -39.97
Vitamin B 1 2 , pg 21.4
Nicotinic acid (nicotinamide), mg 10-199.87
Folic acid, pg 234 -666
Pantothenic acid, mg >3.56
Vitamin c, mg 106.7 ~133.2
Biotin, pg >21.3
Sodium, mg >889
Potassium, mg >1209
Copper, pg 497-5000
Magnesium, mg >195
Iron, mg 10.7-23
Zinc, mg 7.11~22
Manganese, pg 2133-6110
Calcium, mg 569~1332
Phosphorus, mg 427-803
Iodine, pg 71.1~133.9
Chlorine, mg 1066-2180
Selenium, pg 35.6-222
Dietary fiber, g <27
Further, the pH of the medical enteral nutrition composition is 6.0-7.2; Preferably
6.5-6.9.
Further, the particle size of the medical enteral nutrition composition is not higher
than 650nm; Preferably 230~420 nm.
Furthermore, the (- potential of the medical enteral nutrition composition is not
lower than-20mV; Preferably-25 ~ -35 mV.
The invention also includes the application of the medical enteral nutrition
composition in preparing enteral nutrition preparations.
Beneficial effects
According to the requirements of GB29922 on the types and contents of nutrients in complete nutritional formula foods, and referring to the 2013 edition of China DRIs, the formula of the medical liquid enteral nutrition composition is reasonably designed; By optimizing the preparation process of fat emulsion and controlling the feeding of mineral premix and vitamin premix, the emulsifying effect of fat was greatly improved, the influence of minerals on the stability of emulsion system was avoided, the loss of vitamins in the process was reduced, and the product stability was effectively improved. The method has the advantages of simple process, easy operation, easy continuous production and wide industrialization prospect.
In the following examples, the composition and content of vitamin premix used are
as follows:
Component Content (mg/g)
Vitamin A palmitate 11.2985
Cholecalciferol 0.0331
dl-a- tocopherol acetate 37.465
Phytonadione 0.1749
Thiamine hydrochloride 2.4722
Riboflavin 2.3965
Vitamin B6 2.3724
Cyanocobalamin 0.0061
Nicotinamide 23.4847
Folic acid 0.5311
D- Calcium pantothenate 8.3415
L- Ascorbic acid 486.8182
D- Biotin 0.0795
Potassium iodate 0.2573
Maltodextrin 424.269
In the following examples, the composition and content of mineral premix I used are
as follows:
Component Content (mg/g)
Copper sulfate 0.7235
Magnesium sulfate 535.0368
Ferrous sulfate 12.5267
Zinc sulfate 7.3066
Maltodextrin 444.4064
In the following examples, the composition and content of mineral premix II are as
follows:
Component Content (mg/g)
Sodium chloride 88.1315
Sodium dihydrogen phosphate 125.4912
Potassium chloride 76.5903
Potassium citrate 351.0165
Manganese sulfate 0.4995
Calcium carbonate 26.5096
Sodium selenite 0.0053
Maltodextrin 261.064
Example 1
A stable medical liquid enteral nutrition composition, which formula of the enteral
nutrition composition per IL is as follows: 28.3g of concentrated milk protein, 8.4g of
isolated soy protein, 21.5g of low erucic acid rapeseed oil, 7.6g of corn oil, 4.2g of
coconut oil, 185g of glucose syrup, 2g of inulin, 3g of polydextrose, 0.66g of vitamin
premix, 3.43g of mineral premix I, 16.72g of mineral premix II, 7.2g of sodium caseinate,
0.38g polyglycerol fatty acid, 0.95g mono-and diglyceride fatty acis ester, 0.5g of
succinic acid monoglyceride, 0.45g of carrageenan, 0.57g of microcrystalline cellulose
and the balance is water.
The embodiment also provides a preparation method of the medical liquid enteral
nutrition composition, which comprises the following steps:
1) Preparation of fat emulsion
(1) Weighing concentrated milk protein, isolated soy protein, sodium caseinate and
polyglycerol fatty acid ester according to the proportion, adding into a vacuum mixing
tank containing pure water at 50°C, and stirring until completely dissolved to obtain a
water phase;
(2) Weighing low erucic acid rapeseed oil, corn oil, coconut oil, mono-diglyceride
fatty acid ester and succinic acid monoglyceride according to the proportion, adding into
a oil tank at 60°C, and stirring until completely mixed to obtain an oil phase.
(3) Adding the oil phase obtained in step (2) to the water phase obtained in step (1)
for shearing and stirring, and homogenizing the obtained liquid at a pressure of 30MPa
and a temperature of 65°C for one time to obtain fat emulsion.
2) Weighing glucose syrup, inulin, polydextrose, carrageenan and microcrystalline
cellulose according to the proportion, and adding into a mixing tank containing pure
water at 60°C, and stirring until completely dissolved to obtain liquid A.
3) Adding the liquid A into the fat emulsion, and uniformly mixing to obtain liquid
4) Weighing the mineral premix I according to the proportion, adding it to the
mixing tank containing pure water at 50°C, stirring to dissolve completely, then adding to
the liquid B, and mixing evenly to obtain the liquid C.
5) Weighing the mineral premix II according to the proportion, adding to the mixing
tank of pure water at 50°C, stiring to dissolve completely, then adding to the liquid C at a
flow rate of 12 L/min, and mixing evenly to obtain the liquid D.
6) Weighing the vitamin premix according to the proportion, adding to the mixing
tank containing pure water at 30°C, stiring to dissolve completely, then adding it to the
liquid D at a flow rate of 7 L/min, and mixing evenly to obtain liquid E.
7) Cooling the liquid E to below 30°C, and fixing the volume to obtain the liquid F.
8) Homogenizing the liquid F at a pressure of 25MPa and a temperature of 60°C for
two times.
9) Filtering the obtained feed liquid through a 200-mesh duplex filter.
10) Sterilizing the obtained liquid at 137°C for 10s, quickly cooled to 25°C, filling in
Tetra Pak bricks, then filling nitrogen and sealing.
Claims (10)
1. The method for preparing medical liquid enteral nutrition composition is
characterized in that it comprises the following steps:
1) Preparation of fat emulsion
(1) Weighing protein and water-soluble emulsifier according to the proportion,
adding into pure water at 40-60°C, and stirring until completely dissolved to obtain the
protein phase;
(2) Weighing fat and oil-soluble emulsifier according to the proportion, and stirring
at 40-80°C until being evenly mixed to obtain an oil phase;
(3) Adding the oil phase obtained in step (2) to the protein phase obtained in step
(1), shearing and stirring; Homogenizing the obtained feed liquid to obtain fat emulsion;
2) Weighing carbohydrate, dietary fiber and stabilize according to the proportion,
adding into pure water at 4060°C, and stirring until completely dissolved to obtain
liquid A;
3) Adding the liquid A into the fat emulsion, and uniformly mixing to obtain liquid
B;
4) Weighing mineral premix I according to the proportion, adding into pure water at
-60°C, stirring to completely dissolve, adding into the liquid B, and mixing evenly to
obtain liquid C; The mineral premix I contains copper, magnesium, iron and zinc;
5) Weighing mineral premix II according to the proportion, adding into pure water at
-60°C, stirring to completely dissolve, adding into the liquid C at a flow rate not higher than 23L/min, and mixing evenly to obtain liquid D; The mineral premix II contains sodium, potassium, manganese, calcium, phosphorus, chlorine and selenium.
6) Weighing the vitamin premix according to the proportion, adding into pure water
at 25-40°C, stirring to completely dissolved, adding into the liquid D at a flow rate not
higher than 12 L/min, and uniformly mixing to obtain liquid E;
7) Cooling the liquid E to below 30°C to obtain liquid F;
8) Homogenizing and filtering the liquid F; Or the solution further comprises the
steps of sterilizing and filling the filtered liquid.
2. The preparation method according to claim 1, characterized in that the
homogenization pressure in step 1) is 15-35 MPa and the temperature is 50-70°C; More
preferably, homogenizing for 1-2 times; And/or it further comprises the following steps:
The flow rate in step 5) is 12 L/min, 15 L/min, 20 L/min, 21 L/min or 23 L/min; or
12-21 L/min; and/or,
The flow rate in step 6) is 7 L/min, 8.5 L/min, 10 L/min or 12 L/min, or 7-8.5
L/min; And/or,
The homogenization pressure in step 8) is 15-35MPa, the temperature is 50-70°C;
homogenization for 1 -2 times.
3. The preparation method according to claim 1 or 2, wherein the protein is selected
from one or more of milk protein concentrate, isolated soy protein, casein, hydrolyzed
whey protein, soy peptides, whey protein concentrate, whey protein isolate, sodium caseinate, calcium caseinate, pea protein, collagen peptide; And/or, it is characterized in the following content:
The fat is selected from one or more of low erucic acid rapeseed oil, corn oil,
coconut oil, high oleic sunflower oil, medium chain triglyceride, soybean oil, peanut oil,
linseed oil, perilla seed oil, palm oil, DHA algae oil and fish oil;
The carbohydrate is selected from one or more of glucose syrup, dry glucose syrup
powder, maltodextrin, sucrose, glucose, and fructose;
The dietary fiber is selected from one or more of inulin, polydextrose,
galactooligosaccharide, fructooligosaccharide, polyfructose, raffinose, stachyose,
resistant dextrin, resistant starch, and soybean polysaccharide;
The vitamin premix contains any one or more of the following components: vitamin
A, vitamin D, vitamin E, vitamin Ki, vitamin Bi, vitamin B2, vitamin B6, vitamin B12,
nicotinamide, folic acid, pantothenic acid, vitamins C, Biotin and iodine; and/or,
The water-soluble emulsifier is selected from one or more of polyglycerol fatty acid
ester, sucrose fatty acid ester and diacetyl tartaric acid monoglyceride; The oil-soluble
emulsifier is selected from one or more of soybean phospholipid, monoglyceride and
succinic monoglyceride;
The stabilizer is selected from one or more of carrageenan, microcrystalline
cellulose, sodium carboxymethyl cellulose, xanthan gum, gellan gum, pectin,
hydroxypropyl starch, and locust bean gum.
4. The preparation method according to any one of claims 1-3, which is
characterized in that the components and contents of the mineral premix I are as follows:
Nutritional ingredient Content
Copper, pg/g 144.06-267.54
Magnesium, mg/g 56.595~105.105
Iron, mg/g 3.087-5.733
Zinc, mg/g 2.058-3.822
The mineral premix II comprises the following components and contents:
Nutritional ingredient Content
Sodium, mg/g 26.25-63.00
Potassium, mg/g 35.70-85.68
Manganese, pg/g 88.2~163.8
Calcium, mg/g 6.72~43.68
Phosphorus, mg/g 19.81-36.80
Chlorine, mg/g 22.75~42.25
Selenium, pg/g 1.47-2.73
5. The preparation method according to any one of claims 1-4, characterized in that
every IL of the enteral nutrition composition formula comprises the following
components: 36.25-83.05g of protein, 23.7-56.2g of fat, 103.5-245.7g of carbohydrate
(based on dry basis), 0~41.5g of dietary fiber, 0.36-0.87g of vitamin premix, 1.86~4.58g
of mineral premix I, 14.24-31.49g of mineral premix II, 0.72~4.19g of emulsifier and
0.68-2.75g of stabilizer; The solvent is water.
6. The medical liquid enteral nutrition composition prepared by any one of claims 1-
7. The medical liquid enteral nutrition composition according to claim 6,
characterized in that every IL of the enteral nutrition composition contains the following
components:
Component part Content
Protein, g 27.5-62.9
Fat, g 23.7-56.2
Linoleic acid, g 22.22
a -linolenic acid, g 20.556
Carbohydrates, g 93.1~212.9
Vitamin A, pg RE 469-2250
Vitamin D, pg 8.89-31.4
Vitamin E, mg a-TE 8.74 -466
Vitamin Ki, pg >46.9
Vitamin B1, mg 21.07
Vitamin B 2 , mg 21.05
Vitamin B6 , mg 1.03 -39.97
Vitamin B 1 2 , pg 1.4
Nicotinic acid (nicotinamide), mg 10~199.87
Folic acid, pg 234 -666
Pantothenic acid, mg >3.56
Vitamin C, mg 106.7 -133.2
Biotin, pg 21.3
Sodium, mg 889
Potassium, mg >1209
Copper, pg 497-5000
Magnesium, mg >195
Iron, mg 10.7-23
Zinc, mg 7.11-22
Manganese, pg 2133-6110
Calcium, mg 569~1332
Phosphorus, mg 427-803
Iodine, pg 71.1~133.9
Chlorine, mg 1066-2180
Selenium, pg 35.6-222
Dietary fiber, g <27
8. The medical liquid enteral nutrition composition according to claim 6, which is
characterized in that the particle size of the medical enteral nutrition composition is not
higher than 650nm; Preferably 230~420 nm.
9. The medical liquid enteral nutrition composition according to claim 6, which is
characterized in that the (- potential of the medical enteral nutrition composition is not
lower than-20 mV; Preferably-25 -- 35 mV.
10. Application of the medical enteral nutrition composition according to any one of
claims 6 to 8 in preparing enteral nutrition preparations.
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