AU2020417804A1 - Anti-CD73 antibodies and uses thereof - Google Patents

Anti-CD73 antibodies and uses thereof Download PDF

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Publication number
AU2020417804A1
AU2020417804A1 AU2020417804A AU2020417804A AU2020417804A1 AU 2020417804 A1 AU2020417804 A1 AU 2020417804A1 AU 2020417804 A AU2020417804 A AU 2020417804A AU 2020417804 A AU2020417804 A AU 2020417804A AU 2020417804 A1 AU2020417804 A1 AU 2020417804A1
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AU
Australia
Prior art keywords
amino acid
seq
antibody
acid sequence
set forth
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Pending
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AU2020417804A
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English (en)
Inventor
Juan Carlos Almagro
Rebecca A. Buonpane
Horacio G. Nastri
Shaun M. STEWART
Jing Zhou
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Incyte Corp
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Incyte Corp
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Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of AU2020417804A1 publication Critical patent/AU2020417804A1/en
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Fats And Perfumes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU2020417804A 2020-01-03 2020-12-30 Anti-CD73 antibodies and uses thereof Pending AU2020417804A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062956847P 2020-01-03 2020-01-03
US62/956,847 2020-01-03
PCT/US2020/067533 WO2021138467A1 (en) 2020-01-03 2020-12-30 Anti-cd73 antibodies and uses thereof

Publications (1)

Publication Number Publication Date
AU2020417804A1 true AU2020417804A1 (en) 2022-07-21

Family

ID=74347717

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2020417804A Pending AU2020417804A1 (en) 2020-01-03 2020-12-30 Anti-CD73 antibodies and uses thereof

Country Status (19)

Country Link
US (2) US12018089B2 (https=)
EP (1) EP4084825A1 (https=)
JP (1) JP2023509448A (https=)
KR (1) KR20220121850A (https=)
CN (1) CN115135341A (https=)
AR (1) AR120936A1 (https=)
AU (1) AU2020417804A1 (https=)
BR (1) BR112022013236A2 (https=)
CA (1) CA3166533A1 (https=)
CL (2) CL2022001769A1 (https=)
CO (1) CO2022009248A2 (https=)
CR (1) CR20220317A (https=)
EC (1) ECSP22051701A (https=)
IL (1) IL294436A (https=)
MX (1) MX2022007575A (https=)
PE (1) PE20221409A1 (https=)
PH (1) PH12022551636A1 (https=)
TW (1) TWI873265B (https=)
WO (1) WO2021138467A1 (https=)

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Also Published As

Publication number Publication date
JP2023509448A (ja) 2023-03-08
CL2024002235A1 (es) 2024-12-27
TWI873265B (zh) 2025-02-21
BR112022013236A2 (pt) 2022-09-06
CA3166533A1 (en) 2021-07-08
US12018089B2 (en) 2024-06-25
CR20220317A (es) 2022-09-02
ECSP22051701A (es) 2022-08-31
TW202128768A (zh) 2021-08-01
WO2021138467A1 (en) 2021-07-08
PE20221409A1 (es) 2022-09-20
AR120936A1 (es) 2022-03-30
CN115135341A (zh) 2022-09-30
EP4084825A1 (en) 2022-11-09
MX2022007575A (es) 2022-09-23
KR20220121850A (ko) 2022-09-01
CL2022001769A1 (es) 2023-01-20
US20240352143A1 (en) 2024-10-24
IL294436A (en) 2022-09-01
US20210230293A1 (en) 2021-07-29
CO2022009248A2 (es) 2022-08-19
PH12022551636A1 (en) 2024-01-08

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