AU2020399030B2 - Calcium-sensing receptor agonist compound and application thereof - Google Patents

Calcium-sensing receptor agonist compound and application thereof

Info

Publication number
AU2020399030B2
AU2020399030B2 AU2020399030A AU2020399030A AU2020399030B2 AU 2020399030 B2 AU2020399030 B2 AU 2020399030B2 AU 2020399030 A AU2020399030 A AU 2020399030A AU 2020399030 A AU2020399030 A AU 2020399030A AU 2020399030 B2 AU2020399030 B2 AU 2020399030B2
Authority
AU
Australia
Prior art keywords
arg
compound
peptide
group
abu
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2020399030A
Other languages
English (en)
Other versions
AU2020399030A1 (en
Inventor
Fei Gao
Cheng LIAO
Lei Wang
Fangzhou WU
Ran WU
Jin Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beijing Tuo Jie Biopharmaceutical Co Ltd
Original Assignee
Beijing Tuo Jie Biopharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beijing Tuo Jie Biopharmaceutical Co Ltd filed Critical Beijing Tuo Jie Biopharmaceutical Co Ltd
Publication of AU2020399030A1 publication Critical patent/AU2020399030A1/en
Application granted granted Critical
Publication of AU2020399030B2 publication Critical patent/AU2020399030B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A61P5/20—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of PTH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Obesity (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AU2020399030A 2019-12-09 2020-12-08 Calcium-sensing receptor agonist compound and application thereof Active AU2020399030B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201911250088.1 2019-12-09
CN201911250088 2019-12-09
PCT/CN2020/134598 WO2021115272A1 (zh) 2019-12-09 2020-12-08 钙敏感受体激动剂化合物及其应用

Publications (2)

Publication Number Publication Date
AU2020399030A1 AU2020399030A1 (en) 2022-06-23
AU2020399030B2 true AU2020399030B2 (en) 2026-04-09

Family

ID=76328843

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2020399030A Active AU2020399030B2 (en) 2019-12-09 2020-12-08 Calcium-sensing receptor agonist compound and application thereof

Country Status (11)

Country Link
US (1) US20230041996A1 (https=)
EP (1) EP4091623A4 (https=)
JP (1) JP7796013B2 (https=)
KR (1) KR20220110789A (https=)
CN (2) CN114222578B (https=)
AU (1) AU2020399030B2 (https=)
BR (1) BR112022011127A2 (https=)
CA (1) CA3159744A1 (https=)
MX (1) MX2022006892A (https=)
TW (1) TW202122410A (https=)
WO (1) WO2021115272A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022257940A1 (zh) * 2021-06-08 2022-12-15 北京拓界生物医药科技有限公司 钙敏感受体激动剂化合物的盐酸盐及药物组合物和其应用
EP4353248A4 (en) * 2021-06-08 2024-10-23 Beijing Tuo Jie Biopharmaceutical Co. Ltd. CALCIUM-SENSITIVE RECEPTOR AGONIST COMPOSITION AND APPLICATION THEREOF

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011014707A2 (en) * 2009-07-29 2011-02-03 Kai Pharmaceuticals, Inc. Therapeutic agents for reducing parathyroid hormone levels

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0407097A (pt) * 2003-04-23 2006-01-24 Japan Tobacco Inc Antagonista do casr
EP2643292A1 (en) * 2010-11-26 2013-10-02 Leo Pharma A/S Calcium-sensing receptor-active compounds
JP2014508103A (ja) * 2010-11-26 2014-04-03 レオ ファーマ アクティーゼルスカブ カルシウム感知受容体活性化合物
HRP20161566T1 (hr) * 2011-06-08 2017-02-24 Kai Pharmaceuticals, Inc. Terapijski agensi za reguliranje serumskog fosfora
CN109985228A (zh) * 2011-11-10 2019-07-09 凯伊药品公司 拟钙剂及其使用方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011014707A2 (en) * 2009-07-29 2011-02-03 Kai Pharmaceuticals, Inc. Therapeutic agents for reducing parathyroid hormone levels

Also Published As

Publication number Publication date
CN114222578B (zh) 2024-06-25
KR20220110789A (ko) 2022-08-09
CN118496313A (zh) 2024-08-16
AU2020399030A1 (en) 2022-06-23
CN114222578A (zh) 2022-03-22
TW202122410A (zh) 2021-06-16
BR112022011127A2 (pt) 2022-08-23
JP2023504904A (ja) 2023-02-07
EP4091623A1 (en) 2022-11-23
WO2021115272A1 (zh) 2021-06-17
EP4091623A4 (en) 2024-01-03
JP7796013B2 (ja) 2026-01-08
CA3159744A1 (en) 2021-06-17
MX2022006892A (es) 2022-10-07
US20230041996A1 (en) 2023-02-09

Similar Documents

Publication Publication Date Title
EP3398957B1 (en) Method for synthesizing etelcalcetide
EP1165613A1 (en) Melanocortin receptor ligands
EP2720711A1 (en) Multi substituted insulins
WO2018128828A1 (en) Novel hepcidin mimetics and uses thereof
AU2020399030B2 (en) Calcium-sensing receptor agonist compound and application thereof
CN106164088A (zh) 长效肾上腺髓质素衍生物
KR940001711B1 (ko) 심방성 나트륨이뇨성 펩티드의 동족체
IE921572A1 (en) Endothelin antagonists
EP1997826A2 (en) Synthetic ligands for immunoglobulins and pharmaceutical compositions containing them
EP0101929B1 (en) Polypeptide-diesters, their production and use
RU2827834C1 (ru) Соединение, представляющее собой агонист кальций-чувствительного рецептора, и его применение
WO2022257940A1 (zh) 钙敏感受体激动剂化合物的盐酸盐及药物组合物和其应用
US20240269227A1 (en) Calcium-sensing receptor agonist composition and application thereof
JP2021080219A (ja) Ｍｍｐ２阻害作用を有する糖鎖付加ポリペプチド
EP0153865A2 (en) Diuretic peptide, and production and use thereof
CN116333092A (zh) 特立帕肽脂酰化衍生物
CN115057910A (zh) 补体活性调节剂，其制备方法及医药用途
HK40069562B (zh) 钙敏感受体激动剂化合物及其应用
HK40069562A (en) Calcium-sensing receptor agonist compound and application thereof
NZ247914A (en) Peptides having bradykinin antagonist activity, their preparation and compositions
KR20240117631A (ko) 아펠린성 거대고리 및 이의 용도
TW202608907A (zh) 肽類似物及使用其之方法
EP0386044A1 (en) HYPOGLYCEMIC PEPTIDES.
JPS6168499A (ja) 新規ペプチド
JPH0782298A (ja) モチリン様活性を有するポリペプチド誘導体及びその用途