AU2020397034B2 - Dosing of a Bruton's Tyrosine Kinase inhibitor - Google Patents

Dosing of a Bruton's Tyrosine Kinase inhibitor Download PDF

Info

Publication number
AU2020397034B2
AU2020397034B2 AU2020397034A AU2020397034A AU2020397034B2 AU 2020397034 B2 AU2020397034 B2 AU 2020397034B2 AU 2020397034 A AU2020397034 A AU 2020397034A AU 2020397034 A AU2020397034 A AU 2020397034A AU 2020397034 B2 AU2020397034 B2 AU 2020397034B2
Authority
AU
Australia
Prior art keywords
day
administered
cycle
days
btk
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2020397034A
Other languages
English (en)
Other versions
AU2020397034A1 (en
Inventor
Barbara Jean BRANDHUBER
Nora Chien Yee KU
Nisha NANDA
Steven August SMITH
Donald Tsai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Loxo Oncology Inc
Original Assignee
Loxo Oncology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Loxo Oncology Inc filed Critical Loxo Oncology Inc
Publication of AU2020397034A1 publication Critical patent/AU2020397034A1/en
Application granted granted Critical
Publication of AU2020397034B2 publication Critical patent/AU2020397034B2/en
Priority to AU2024201263A priority Critical patent/AU2024201263B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
AU2020397034A 2019-12-06 2020-12-03 Dosing of a Bruton's Tyrosine Kinase inhibitor Active AU2020397034B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2024201263A AU2024201263B2 (en) 2019-12-06 2024-02-26 Dosing of a Bruton's Tyrosine Kinase inhibitor

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201962944674P 2019-12-06 2019-12-06
US62/944,674 2019-12-06
US202063077996P 2020-09-14 2020-09-14
US63/077,996 2020-09-14
US202063109698P 2020-11-04 2020-11-04
US63/109,698 2020-11-04
PCT/US2020/063089 WO2021113497A1 (en) 2019-12-06 2020-12-03 Dosing of a bruton's tyrosine kinase inhibitor

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2024201263A Division AU2024201263B2 (en) 2019-12-06 2024-02-26 Dosing of a Bruton's Tyrosine Kinase inhibitor

Publications (2)

Publication Number Publication Date
AU2020397034A1 AU2020397034A1 (en) 2022-07-21
AU2020397034B2 true AU2020397034B2 (en) 2023-12-07

Family

ID=73854977

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2020397034A Active AU2020397034B2 (en) 2019-12-06 2020-12-03 Dosing of a Bruton's Tyrosine Kinase inhibitor
AU2024201263A Active AU2024201263B2 (en) 2019-12-06 2024-02-26 Dosing of a Bruton's Tyrosine Kinase inhibitor

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2024201263A Active AU2024201263B2 (en) 2019-12-06 2024-02-26 Dosing of a Bruton's Tyrosine Kinase inhibitor

Country Status (10)

Country Link
US (1) US12551463B2 (https=)
EP (1) EP4069219A1 (https=)
JP (3) JP7142173B2 (https=)
KR (2) KR20230127372A (https=)
CN (1) CN115175677A (https=)
AU (2) AU2020397034B2 (https=)
BR (1) BR112022009716A2 (https=)
IL (1) IL292882A (https=)
MX (1) MX2022006631A (https=)
WO (1) WO2021113497A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117285467A (zh) 2018-07-31 2023-12-26 罗索肿瘤学公司 喷雾干燥的分散体和制剂
JP7142173B2 (ja) * 2019-12-06 2022-09-26 ロクソ オンコロジー， インコーポレイテッド ブルトン型チロシンキナーゼ阻害剤の投薬

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017103611A1 (en) * 2015-12-16 2017-06-22 Redx Pharma Plc Compounds useful as kinase inhibitors
WO2020028258A1 (en) * 2018-07-31 2020-02-06 Loxo Oncology, Inc. Spray-dried dispersions and formulations of (s)-5-amino-3-(4-((5-fluoro-2-methoxybenzamido)methyl)phenyl)-1-(1,1,1-trifluoro propan-2-yl)-1h-pyrazole-4-carboxamide

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2526933T3 (en) 2006-09-22 2015-05-18 Pharmacyclics Inc Inhibitors of Bruton's tyrosine kinase
KR101668574B1 (ko) 2012-11-02 2016-10-24 화이자 인코포레이티드 브루톤 티로신 키나제 억제제
US9717745B2 (en) 2015-03-19 2017-08-01 Zhejiang DTRM Biopharma Co. Ltd. Pharmaceutical compositions and their use for treatment of cancer and autoimmune diseases
WO2017132474A1 (en) 2016-01-30 2017-08-03 Newave Pharmaceutical Inc. Bcl-2 inhibitors
US10829488B2 (en) 2016-08-05 2020-11-10 The Regents Of The University Of Michigan N-(phenylsulfonyl)benzamides and related compounds as bcl-2 inhibitors
EP3565815B1 (en) 2017-01-07 2024-03-13 Fochon Pharmaceuticals, Ltd. Compounds as bcl-2-selective apoptosis-inducing agents
EP3612531B1 (en) 2017-04-18 2022-08-24 Shanghai Fochon Pharmaceutical Co., Ltd. Apoptosis-inducing agents
JP2020528061A (ja) 2017-07-26 2020-09-17 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト ＢＥＴ阻害剤、Ｂｃｌ−２阻害剤及び抗ＣＤ２０抗体を用いた併用療法
KR20200108301A (ko) 2018-01-10 2020-09-17 리커리엄 아이피 홀딩스, 엘엘씨 벤즈아미드 화합물
SG11202009933WA (en) 2018-04-29 2020-11-27 Beigene Ltd Bcl-2 INHIBITORS
JP7142173B2 (ja) * 2019-12-06 2022-09-26 ロクソ オンコロジー， インコーポレイテッド ブルトン型チロシンキナーゼ阻害剤の投薬

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017103611A1 (en) * 2015-12-16 2017-06-22 Redx Pharma Plc Compounds useful as kinase inhibitors
WO2020028258A1 (en) * 2018-07-31 2020-02-06 Loxo Oncology, Inc. Spray-dried dispersions and formulations of (s)-5-amino-3-(4-((5-fluoro-2-methoxybenzamido)methyl)phenyl)-1-(1,1,1-trifluoro propan-2-yl)-1h-pyrazole-4-carboxamide

Also Published As

Publication number Publication date
AU2020397034A1 (en) 2022-07-21
AU2024201263A1 (en) 2024-03-14
BR112022009716A2 (pt) 2022-08-09
JP2022518974A (ja) 2022-03-17
IL292882A (en) 2022-07-01
WO2021113497A1 (en) 2021-06-10
JP7654604B2 (ja) 2025-04-01
KR20220100992A (ko) 2022-07-18
EP4069219A1 (en) 2022-10-12
JP2022177119A (ja) 2022-11-30
US12551463B2 (en) 2026-02-17
NZ788615A (en) 2024-10-25
JP7142173B2 (ja) 2022-09-26
JP2025098099A (ja) 2025-07-01
KR20230127372A (ko) 2023-08-31
MX2022006631A (es) 2022-09-07
CA3160417A1 (en) 2021-06-10
US20230041515A1 (en) 2023-02-09
AU2024201263B2 (en) 2025-05-01
CN115175677A (zh) 2022-10-11

Similar Documents

Publication Publication Date Title
EP3458091B1 (en) Combination therapy with notch and pd-1 or pd-l1 inhibitors
AU2024201263B2 (en) Dosing of a Bruton's Tyrosine Kinase inhibitor
AU2006247504B2 (en) Methods and compositions for the treatment of autoimmune and inflammatory diseases associated with Toll-like receptors
AU2021204687A1 (en) Combination therapies
US20170306050A1 (en) Compositions and methods for treating cancer, inflammatory diseases and autoimmune diseases
UA125216C2 (uk) Комбінована терапія
CA2914310A1 (en) Pharmaceutical combinations
JP7841838B2 (ja) ミオスタチンアンタゴニストの使用、それを含有する組合せ物およびその使用
CA3160417C (en) Dosing of a bruton's tyrosine kinase inhibitor
EA051944B1 (ru) Введение доз ингибитора тирозинкиназы брутона
AU2008335167B2 (en) Methods of treating hematologic cancers using PNP inhibitors such as forodesine in combination with alkylating agents or anti-CD20 agents
NZ788615A9 (en) Dosing of a bruton's tyrosine kinase inhibitor
EA046722B1 (ru) Введение доз ингибитора тирозинкиназы брутона
US20250134876A1 (en) Methods of treating a cancer overexpressing one or more bcl-2 family proteins
AU2013201347B2 (en) Methods of treating hematologic cancers
HK40004756B (en) Combination therapy with notch and pd-1 or pd-l1 inhibitors
HK40004756A (en) Combination therapy with notch and pd-1 or pd-l1 inhibitors
Radiosensitizer Azelnidipine Antihypertensive

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)