AU2020355240A1 - Extracellular vesicle compositions - Google Patents
Extracellular vesicle compositions Download PDFInfo
- Publication number
- AU2020355240A1 AU2020355240A1 AU2020355240A AU2020355240A AU2020355240A1 AU 2020355240 A1 AU2020355240 A1 AU 2020355240A1 AU 2020355240 A AU2020355240 A AU 2020355240A AU 2020355240 A AU2020355240 A AU 2020355240A AU 2020355240 A1 AU2020355240 A1 AU 2020355240A1
- Authority
- AU
- Australia
- Prior art keywords
- composition
- concentration
- aspects
- potassium phosphate
- sodium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 738
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 380
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 claims description 318
- 210000001808 exosome Anatomy 0.000 claims description 194
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- 239000005720 sucrose Substances 0.000 claims description 163
- 235000011009 potassium phosphates Nutrition 0.000 claims description 158
- 229910000160 potassium phosphate Inorganic materials 0.000 claims description 157
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- 235000019796 monopotassium phosphate Nutrition 0.000 claims description 152
- GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical group [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 claims description 149
- 239000001488 sodium phosphate Substances 0.000 claims description 148
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- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims description 148
- 229910000162 sodium phosphate Inorganic materials 0.000 claims description 147
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- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 69
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 69
- PYLIXCKOHOHGKQ-UHFFFAOYSA-L disodium;hydrogen phosphate;heptahydrate Chemical group O.O.O.O.O.O.O.[Na+].[Na+].OP([O-])([O-])=O PYLIXCKOHOHGKQ-UHFFFAOYSA-L 0.000 claims description 67
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- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 claims description 4
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| US11931458B2 (en) | 2021-01-11 | 2024-03-19 | Babak Ghalili | Exosome systems, products and methods |
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| US20250382613A1 (en) * | 2022-06-30 | 2025-12-18 | Lonza Sales Ag | Methods of using extracellular vesicle-aso targeting stat6 |
| CN115282065B (zh) * | 2022-08-11 | 2024-03-15 | 顾帅 | 一种含间充质干细胞外泌体的冻干粉及其制备方法和应用 |
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2020
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- 2020-09-25 AU AU2020355240A patent/AU2020355240A1/en not_active Abandoned
- 2020-09-25 BR BR112022005614A patent/BR112022005614A2/pt not_active Application Discontinuation
- 2020-09-25 KR KR1020227013488A patent/KR20220092654A/ko not_active Ceased
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- 2020-09-25 WO PCT/US2020/052935 patent/WO2021062317A1/en not_active Ceased
- 2020-09-25 EP EP20790126.5A patent/EP4034081A1/en active Pending
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| BR112022005614A2 (pt) | 2022-07-12 |
| CN114727947A (zh) | 2022-07-08 |
| KR20220092654A (ko) | 2022-07-01 |
| WO2021062317A1 (en) | 2021-04-01 |
| MX2022003570A (es) | 2022-07-11 |
| EP4034081A1 (en) | 2022-08-03 |
| JP2022549328A (ja) | 2022-11-24 |
| CA3152478A1 (en) | 2021-04-01 |
| US20240099973A1 (en) | 2024-03-28 |
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