AU2020304671A1 - Anti-CGRP receptor/anti-PAC1 receptor bispecific antigen binding proteins - Google Patents

Anti-CGRP receptor/anti-PAC1 receptor bispecific antigen binding proteins Download PDF

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Publication number
AU2020304671A1
AU2020304671A1 AU2020304671A AU2020304671A AU2020304671A1 AU 2020304671 A1 AU2020304671 A1 AU 2020304671A1 AU 2020304671 A AU2020304671 A AU 2020304671A AU 2020304671 A AU2020304671 A AU 2020304671A AU 2020304671 A1 AU2020304671 A1 AU 2020304671A1
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AU
Australia
Prior art keywords
seq
sequence
ips
nos
cdrh3
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
AU2020304671A
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English (en)
Inventor
Neeraj Jagdish Agrawal
Irwin Chen
Su CHONG
Bryna FUCHSLOCHER
Fernando Garces
Kevin Graham
Agnes Eva Hamburger
Mark Leo Michaels
Christopher MOHR
Derek E. Piper
Kenneth William Walker
Zhulun Wang
Cen XU
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Amgen Inc
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Amgen Inc
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Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of AU2020304671A1 publication Critical patent/AU2020304671A1/en
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2020304671A 2019-06-28 2020-06-26 Anti-CGRP receptor/anti-PAC1 receptor bispecific antigen binding proteins Pending AU2020304671A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962868557P 2019-06-28 2019-06-28
US62/868,557 2019-06-28
PCT/US2020/039940 WO2020264384A1 (en) 2019-06-28 2020-06-26 Anti-cgrp receptor/anti-pac1 receptor bispecific antigen binding proteins

Publications (1)

Publication Number Publication Date
AU2020304671A1 true AU2020304671A1 (en) 2022-01-20

Family

ID=71728920

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2020304671A Pending AU2020304671A1 (en) 2019-06-28 2020-06-26 Anti-CGRP receptor/anti-PAC1 receptor bispecific antigen binding proteins

Country Status (7)

Country Link
US (1) US20220363770A1 (enExample)
EP (1) EP3990493A1 (enExample)
JP (1) JP7756001B2 (enExample)
AU (1) AU2020304671A1 (enExample)
CA (1) CA3143524A1 (enExample)
MX (2) MX2021015791A (enExample)
WO (1) WO2020264384A1 (enExample)

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JP7339262B2 (ja) * 2018-01-12 2023-09-05 アムジェン インコーポレイテッド Ｐａｃ１抗体及びその使用
EP4200338A1 (en) * 2020-08-20 2023-06-28 Amgen Inc. Antigen binding proteins with non-canonical disulfide in fab region
US20240182600A1 (en) * 2021-04-20 2024-06-06 Amgen Inc. Balanced Charge Distribution in Electrostatic Steering of Chain Pairing in Multi-specific and Monovalent IgG Molecule Assembly
CN118556079A (zh) 2021-07-29 2024-08-27 瑟法隆有限责任公司 抗pacap抗体的组合物和方法
US20230109946A1 (en) * 2021-10-12 2023-04-13 Twill, Inc. Apparatus for computer generated dialogue and task-specific nested file architecture thereof
IL321300A (en) * 2022-12-29 2025-08-01 Biyopharma Co Ltd Fusion protein
CN118459595A (zh) * 2024-05-21 2024-08-09 杭州百懿生物药业有限公司 特异性结合cgrp受体的抗体分子及其用途

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Also Published As

Publication number Publication date
EP3990493A1 (en) 2022-05-04
US20220363770A1 (en) 2022-11-17
JP2022538232A (ja) 2022-09-01
JP7756001B2 (ja) 2025-10-17
MX2021015791A (es) 2022-04-01
WO2020264384A1 (en) 2020-12-30
CA3143524A1 (en) 2020-12-30
MX2026002776A (es) 2026-04-01

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