AU2020246221A1 - Cell analysis method, training method for deep learning algorithm, cell analysis device, training apparatus for deep learning algorithm, cell analysis program, and training program for deep learning algorithm - Google Patents

Cell analysis method, training method for deep learning algorithm, cell analysis device, training apparatus for deep learning algorithm, cell analysis program, and training program for deep learning algorithm Download PDF

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AU2020246221A1
AU2020246221A1 AU2020246221A AU2020246221A AU2020246221A1 AU 2020246221 A1 AU2020246221 A1 AU 2020246221A1 AU 2020246221 A AU2020246221 A AU 2020246221A AU 2020246221 A AU2020246221 A AU 2020246221A AU 2020246221 A1 AU2020246221 A1 AU 2020246221A1
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cell
signal
cells
deep learning
learning algorithm
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Shoichiro Asada
Konobu Kimura
Masamichi Tanaka
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Sysmex Corp
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Sysmex Corp
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483Physical analysis of biological material
    • G01N33/487Physical analysis of biological material of liquid biological material
    • G01N33/49Blood
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483Physical analysis of biological material
    • G01N33/487Physical analysis of biological material of liquid biological material
    • G01N33/48785Electrical and electronic details of measuring devices for physical analysis of liquid biological material not specific to a particular test method, e.g. user interface or power supply
    • G01N33/48792Data management, e.g. communication with processing unit
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02Investigating particle size or size distribution
    • G01N15/0205Investigating particle size or size distribution by optical means
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/1031Investigating individual particles by measuring electrical or magnetic effects
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • G01N15/1429Signal processing
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G01N15/1459Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06NCOMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00Computing arrangements based on biological models
    • G06N3/02Neural networks
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06NCOMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00Computing arrangements based on biological models
    • G06N3/02Neural networks
    • G06N3/04Architecture, e.g. interconnection topology
    • G06N3/045Combinations of networks
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06NCOMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00Computing arrangements based on biological models
    • G06N3/02Neural networks
    • G06N3/08Learning methods
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G01N2015/012Red blood cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G01N2015/016White blood cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G01N2015/018Platelets
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02Investigating particle size or size distribution
    • G01N2015/0294Particle shape
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N2015/1006Investigating individual particles for cytology
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • G01N15/1434Optical arrangements
    • G01N2015/144Imaging characterised by its optical setup
    • G01N2015/1443Auxiliary imaging
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1493Particle size
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1497Particle shape
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06NCOMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00Computing arrangements based on biological models
    • G06N3/02Neural networks
    • G06N3/04Architecture, e.g. interconnection topology
    • G06N3/048Activation functions

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  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Theoretical Computer Science (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Evolutionary Computation (AREA)
  • Hematology (AREA)
  • Mathematical Physics (AREA)
  • General Engineering & Computer Science (AREA)
  • Computing Systems (AREA)
  • Data Mining & Analysis (AREA)
  • Computational Linguistics (AREA)
  • Artificial Intelligence (AREA)
  • Software Systems (AREA)
  • Urology & Nephrology (AREA)
  • Signal Processing (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Databases & Information Systems (AREA)
  • Medical Informatics (AREA)
  • Optics & Photonics (AREA)
  • Human Computer Interaction (AREA)
  • Ecology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AU2020246221A 2019-03-22 2020-03-17 Cell analysis method, training method for deep learning algorithm, cell analysis device, training apparatus for deep learning algorithm, cell analysis program, and training program for deep learning algorithm Pending AU2020246221A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2019-055385 2019-03-22
JP2019055385A JP7352365B2 (ja) 2019-03-22 2019-03-22 細胞の分析方法、深層学習アルゴリズムの訓練方法、細胞分析装置、深層学習アルゴリズムの訓練装置、細胞の分析プログラム及び深層学習アルゴリズムの訓練プログラム
PCT/JP2020/011596 WO2020196074A1 (fr) 2019-03-22 2020-03-17 Procédé d'analyse de cellule, procédé d'apprentissage pour algorithme d'apprentissage profond, dispositif d'analyse de cellule, procédé d'apprentissage pour algorithme d'apprentissage profond, programme d'analyse de cellule et programme d'apprentissage pour algorithme d'apprentissage profond

Publications (1)

Publication Number Publication Date
AU2020246221A1 true AU2020246221A1 (en) 2021-11-11

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AU2020246221A Pending AU2020246221A1 (en) 2019-03-22 2020-03-17 Cell analysis method, training method for deep learning algorithm, cell analysis device, training apparatus for deep learning algorithm, cell analysis program, and training program for deep learning algorithm

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US (1) US20220003745A1 (fr)
EP (1) EP3943933A4 (fr)
JP (2) JP7352365B2 (fr)
CN (1) CN113574380A (fr)
AU (1) AU2020246221A1 (fr)
WO (1) WO2020196074A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102533080B1 (ko) * 2020-09-25 2023-05-15 고려대학교 산학협력단 선 레이블을 이용한 세포 영상 분할 방법, 이를 수행하기 위한 기록 매체 및 장치
US20220230709A1 (en) * 2021-01-15 2022-07-21 Sanofi Sensing of biological cells in a sample for cell type identification
JP7374943B2 (ja) 2021-02-26 2023-11-07 シスメックス株式会社 表示方法および検体分析装置
EP4060319A1 (fr) * 2021-03-12 2022-09-21 Sysmex Corporation Procédé d'analyse et analyseur
JPWO2023282026A1 (fr) * 2021-07-09 2023-01-12
US20230338953A1 (en) * 2022-03-17 2023-10-26 Sysmex Corporation Specimen analyzer, specimen analysis method, and program

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63180836A (ja) 1987-01-21 1988-07-25 Japan Spectroscopic Co 粒子デ−タ解析装置
ES2278566T3 (es) 1994-10-20 2007-08-16 Sysmex Corporation Reactivo y metodo para analizar componentes solidos en la orina.
JP2001174456A (ja) 1999-12-20 2001-06-29 Toyobo Co Ltd 白血球細分類装置および白血球の細分類方法
JP3837006B2 (ja) 2000-03-22 2006-10-25 シスメックス株式会社 細菌の染色方法及び検出方法
US7309581B2 (en) 2000-11-01 2007-12-18 Sysmex Corporation Method of staining, detection and counting bacteria, and a diluent for bacterial stain
JP6001425B2 (ja) * 2012-11-26 2016-10-05 シスメックス株式会社 血球分析方法、血球分析装置およびプログラム
US20170052106A1 (en) 2014-04-28 2017-02-23 The Broad Institute, Inc. Method for label-free image cytometry
JP6661278B2 (ja) 2015-03-27 2020-03-11 シスメックス株式会社 血液分析装置および血液分析方法
WO2017053592A1 (fr) 2015-09-23 2017-03-30 The Regents Of The University Of California Apprentissage profond dans le domaine de la classification des cellules non labellisées et extraction de particules par vision par ordinateur
CN108351289B (zh) 2015-10-28 2021-11-26 国立大学法人东京大学 分析装置
JP2017219479A (ja) 2016-06-09 2017-12-14 住友電気工業株式会社 微小粒子計測装置及び分析方法
JP7104691B2 (ja) 2016-08-22 2022-07-21 アイリス インターナショナル, インコーポレイテッド 生体粒子の分類のシステム及び方法
WO2018203568A1 (fr) 2017-05-02 2018-11-08 シンクサイト株式会社 Système et procédé d'évaluation de cellules et programme d'évaluation de cellules

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US20220003745A1 (en) 2022-01-06
JP2023164555A (ja) 2023-11-10
JP2020153946A (ja) 2020-09-24
EP3943933A1 (fr) 2022-01-26
CN113574380A (zh) 2021-10-29
JP7352365B2 (ja) 2023-09-28
EP3943933A4 (fr) 2022-12-28
WO2020196074A1 (fr) 2020-10-01

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Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE INVENTION TITLE TO READ CELL ANALYSIS METHOD, TRAINING METHOD FOR DEEP LEARNING ALGORITHM, CELL ANALYSIS DEVICE, TRAINING APPARATUS FOR DEEP LEARNING ALGORITHM, CELL ANALYSIS PROGRAM, AND TRAINING PROGRAM FOR DEEP LEARNING ALGORITHM