AU2020221324A1 - Lym-1 and Lym-2 antibody compositions and improved CAR constructs - Google Patents

Lym-1 and Lym-2 antibody compositions and improved CAR constructs Download PDF

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Publication number
AU2020221324A1
AU2020221324A1 AU2020221324A AU2020221324A AU2020221324A1 AU 2020221324 A1 AU2020221324 A1 AU 2020221324A1 AU 2020221324 A AU2020221324 A AU 2020221324A AU 2020221324 A AU2020221324 A AU 2020221324A AU 2020221324 A1 AU2020221324 A1 AU 2020221324A1
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Australia
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cells
car
antibody
cell
domain
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AU2020221324A
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Alan L. Epstein
Peisheng Hu
Long Zheng
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University of Southern California USC
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University of Southern California USC
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • C12N15/62—DNA sequences coding for fusion proteins
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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
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    • C07K2319/00—Fusion polypeptide
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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AU2020221324A 2019-02-15 2020-02-14 Lym-1 and Lym-2 antibody compositions and improved CAR constructs Abandoned AU2020221324A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201962806632P 2019-02-15 2019-02-15
US62/806,632 2019-02-15
US201962815961P 2019-03-08 2019-03-08
US62/815,961 2019-03-08
US201962924151P 2019-10-21 2019-10-21
US62/924,151 2019-10-21
PCT/US2020/018441 WO2020168298A2 (en) 2019-02-15 2020-02-14 Lym-1 and lym-2 antibody compositions and improved car constructs

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AU2020221324A1 true AU2020221324A1 (en) 2021-09-02

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AU2020221324A Abandoned AU2020221324A1 (en) 2019-02-15 2020-02-14 Lym-1 and Lym-2 antibody compositions and improved CAR constructs

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US (2) US11667715B2 (https=)
EP (1) EP3924387A4 (https=)
JP (1) JP2022520106A (https=)
KR (1) KR20210118945A (https=)
CN (1) CN113710703A (https=)
AU (1) AU2020221324A1 (https=)
BR (1) BR112021015676A2 (https=)
CA (1) CA3129501A1 (https=)
IL (1) IL285463A (https=)
MX (1) MX2021009744A (https=)
SG (1) SG11202108655TA (https=)
WO (1) WO2020168298A2 (https=)

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GB201913697D0 (en) * 2019-09-23 2019-11-06 King S College London DAP10/DAP12 fusion polypeptides

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4724212A (en) 1985-05-24 1988-02-09 Northwestern University Murine hybridoma Lym-2 and diagnostic antibody produced thereby
US4724213A (en) 1985-05-24 1988-02-09 Northwestern University Murine hybridoma Lym-1 and diagnostic antibody produced thereby
ATE112172T1 (de) * 1987-10-30 1994-10-15 American Cyanamid Co Targetformer von antitumor-methyltrithioagenzien.
US7285268B2 (en) * 2002-11-26 2007-10-23 Pdl Biopharma, Inc. Chimeric and humanized antibodies to α5β1 integrin that modulate angiogenesis
CA2518552A1 (en) 2003-03-11 2004-09-23 Genentech, Inc. Novel compositions and methods for the treatment of immune related disease
NZ544924A (en) * 2003-06-27 2009-03-31 Biogen Idec Inc Modified binding molecules comprising connecting peptides
WO2005058251A2 (en) 2003-12-15 2005-06-30 Dendreon Corporation Hla-dr-specific antibodies, compositions and methods
EP1789087A4 (en) 2004-08-20 2009-10-21 Univ California GENETICALLY MODIFIED ANTIBODY FRAGMENT WHICH LINKS TO ANTIGEN IRREVERSIBLELY
CN1331887C (zh) 2004-08-20 2007-08-15 上海美恩生物技术有限公司 抗hla－dr10的淋巴瘤特异性嵌合单抗
ES2665422T3 (es) * 2005-03-03 2018-04-25 Immunomedics Inc. Anticuerpos L243 humanizados
WO2007058725A2 (en) 2005-10-12 2007-05-24 The Regents Of The University Of California Engineered antibody fragment that irreversibly binds an antigen
EP1957541A2 (en) * 2005-11-21 2008-08-20 Laboratoires Serono SA Compositions and methods of producing hybrid antigen binding molecules and uses thereof
GB0624500D0 (en) * 2006-12-07 2007-01-17 Istituto Superiore Di Sanito A novel passive vaccine for candida infections
EP2158318A2 (en) * 2007-05-14 2010-03-03 Biogen Idec MA, Inc. Single-chain fc (scfc) regions, binding polypeptides comprising same, and methods related thereto
CN101525385B (zh) * 2008-03-07 2013-09-11 苏州工业园区晨健抗体组药物开发有限公司 恶性淋巴瘤、自身免疫性疾病抗体药物的筛选及其制备方法和用途
CA2740900C (en) 2008-11-03 2019-09-24 Alethia Biotherapeutics Inc. Antibodies that specifically block the biological activity of a tumor antigen
PH12013501201A1 (en) 2010-12-09 2013-07-29 Univ Pennsylvania Use of chimeric antigen receptor-modified t cells to treat cancer
CA2861491C (en) 2012-02-13 2020-08-25 Seattle Children's Hospital D/B/A Seattle Children's Research Institute Bispecific chimeric antigen receptors and therapeutic uses thereof
EP2817330B1 (en) 2012-02-22 2020-07-08 The Trustees of the University of Pennsylvania Use of icos-based cars to enhance antitumor activity and car persistence
RU2766608C2 (ru) 2012-04-11 2022-03-15 Дзе Юнайтед Стейтс Оф Америка, Эз Репрезентед Бай Дзе Секретари, Департмент Оф Хелс Энд Хьюман Сёрвисез Химерные антигенные рецепторы, нацеленные на антиген созревания b-клеток
US9534044B2 (en) 2013-02-28 2017-01-03 United Arab Emirates University Alpha-synuclein antibodies and uses thereof
WO2014145252A2 (en) 2013-03-15 2014-09-18 Milone Michael C Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy
US20140348744A1 (en) 2013-05-24 2014-11-27 Jacek K. Pinski Compositions and methods for regulating cancer-related signaling pathways
CN105829349B (zh) 2013-10-15 2023-02-03 斯克利普斯研究所 肽嵌合抗原受体t细胞开关和其用途
KR101605421B1 (ko) 2014-03-05 2016-03-23 국립암센터 B 세포 림프종 세포를 특이적으로 인지하는 단일클론항체 및 이의 용도
JP2015057834A (ja) 2014-10-03 2015-03-26 株式会社村田製作所 積層セラミックコンデンサ
CA2874083C (en) * 2014-12-05 2024-01-02 Universite Laval Tdp-43-binding polypeptides useful for the treatment of neurodegenerative diseases
JP2018509148A (ja) 2015-03-11 2018-04-05 セレクティスＣｅｌｌｅｃｔｉｓ 患者における持続性および／または生着を増加させるために同種ｔ細胞を改変する方法
AU2016243128A1 (en) 2015-03-27 2017-11-02 University Of Southern California HLA-G as a novel target for CAR T-cell immunotherapy
WO2016160618A2 (en) 2015-03-27 2016-10-06 University Of Southern California Car t-cell therapy directed to lhr for the treatment of solid tumors
WO2016174652A1 (en) 2015-04-30 2016-11-03 Technion Research & Development Foundation Limited Chimeric antigen receptors and methods of their use
WO2016197064A1 (en) 2015-06-04 2016-12-08 Epstein Alan L Lym-1 and lym-2 targeted car cell immunotherapy
KR20230148844A (ko) 2016-03-29 2023-10-25 유니버시티 오브 써던 캘리포니아 암을 표적하는 키메라 항원 수용체
WO2018154386A1 (en) 2017-02-21 2018-08-30 Eutilex Co., Ltd. Hla-dr car-t compositions and methods of making and using the same

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