AU2020103805A4 - A traditional chinese herbal ointment for promoting wound healing and reducing scar formation and preparation method thereof - Google Patents

A traditional chinese herbal ointment for promoting wound healing and reducing scar formation and preparation method thereof Download PDF

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AU2020103805A4
AU2020103805A4 AU2020103805A AU2020103805A AU2020103805A4 AU 2020103805 A4 AU2020103805 A4 AU 2020103805A4 AU 2020103805 A AU2020103805 A AU 2020103805A AU 2020103805 A AU2020103805 A AU 2020103805A AU 2020103805 A4 AU2020103805 A4 AU 2020103805A4
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traditional chinese
chinese herbal
salvia miltiorrhiza
wound healing
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Xianjun FU
Jinghong HU
Jia Li
Qingjun Li
Qian Liu
Gaobin Pu
Lingna Wang
Fang Zhang
Yongqing Zhang
Zhe Zhang
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Shandong University of Traditional Chinese Medicine
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537—Salvia (sage)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
    • A61K36/605—Morus (mulberry)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/634—Forsythia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/17—Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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Abstract

This invention discloses a traditional Chinese herbal ointment for promoting wound healing and reducing scar formation and preparation method thereof. it is made from the following weight parts of raw materials:2-4 parts of salvia miltiorrhiza, 1-2 parts of lonicera japonica, 2-4 parts of heracleum hemsleyanum diels, 2-4 parts of forsythia suspensa, 2-4 parts of morus alba L., 2-4 parts of achyranthes bidentata blume and 10-15 parts of mutton tallow.This invention adopts pure Chinese medicine compatibility.It is safe and has no toxic side effect and mild effect, and also has remarkable effect on promoting wound healing and reducing scar formation.The salvia miltiorrhiza was used as monarch drug in this invention; lonicera japonica, heracleum hemsleyanum diels, forsythia suspensa, morus alba L., achyranthes bidentata blume and mutton tallow were used as minister drug.Monarch and minister cooperate with each other to promote wound healing, reduce the formation of scars, and also reduce the pharmacological effects of inflammatory reaction. The ointment of the invention has the functions of promoting wound healing, bacteriostasis, anti-inflammation and reducing wound scar formation. Compared with traditional vaseline and other dressings, it has the characteristics of slow-release.

Description

Description
A Traditional Chinese Herbal Ointment for Promoting Wound
Healing and Reducing Scar Formation and Preparation Method
Thereof
Technical Field The invention relates to the technical field of traditional Chinese herbal ointment, and in particular to a traditional Chinese herbal ointment for promoting wound healing and reducing scar formation and preparation method thereof
Background Art The obstinate scar after wound healing is a complex physiological reaction of the damaged skin, which includes four stages of hemostasis, inflammation, regeneration and remodeling.Skin wounds in burned, scalded or hyperglycemic patients usually heal slowly and leave scars after the wound heals.Obstinate scarring is caused by overproduction of blood vessels, overcontraction of granulation tissue, and overproliferation of fibroblasts. Chronic wound healing and scar residue after wound healing has always been an international medical problem, and no effective solution has been proposed at the stage of scar formation. At present, the main methods of removing scars are surgical excision, laser removal, silicone treatment and compression treatment, etc. . The main methods of promoting wound healing and reducing scars are hormone injection, surgical excision, etc. , the side effect is big and the effect is slow, causes the enormous spirit burden and the economic pressure to the patient. However, there are few treatments to prevent the formation of scar, and it is significant to reduce the formation of scar in the process of wound healing.
Summary of the Invention The invention is aimed at solving the above shortcomings in the prior art, and also providing a traditional Chinese herbal ointment for promoting wound healing and reducing scar formation and preparation method thereof The method uses traditional Chinese herbal ointment to smear on the wound surface of the patient, so as to promote wound healing and effectively prevent the formation of scars.
In order to achieve the above purposes, the invention adopts the following technical options: A traditional Chinese herbal ointment for promoting wound healing and reducing scar formation, it is made from the following weight parts of raw materials: 2-4 parts of salvia miltiorrhiza, 1-2 parts of lonicera japonica, 2-4 parts of heracleum hemsleyanum diels, 2-4 parts of forsythia suspensa, 2-4 parts of morus alba L., 2-4 parts of achyranthes bidentata blume and 10-15 parts of mutton tallow. Preferred, it is made from the following weight parts of raw materials: 4 parts of salvia miltiorrhiza, parts of lonicera japonica, 2 parts of heracleum hemsleyanum diels, 2 parts of forsythia suspensa, 2parts of morus alba L., 2 parts of achyranthes bidentata blume and parts of mutton tallow. Preferred, the salvia miltiorrhiza is fresh sliced salvia miltiorrhiza. Preferred, the mutton tallow is pure mutton tallow.
A preparation method of the traditional Chinese herbal ointment comprises the following steps:
(1)the raw materials of the medicinal materials were dried to a constant weight and sterilized with
the freshly mutton tallow;
(2) the dried medicinal materials were weighed according to the weight parts respectively, the
salvia miltiorrhiza, lonicera japonica, heracleum hemsleyanum diels, forsythia suspensa, morus
alba L., achyranthes bidentata blume were shattered respectively, and were passed from 80-OOM
screen, the water was added into salvia miltiorrhiza powder and then stirred well-distributed,
add water and moisten danshen powder and stir evenly, 4-5L of 95% ethanol was added into
lonicera japonica, heracleum hemsleyanum diels, forsythia suspensa, morus alba L. and
achyranthes bidentata blume, decocte until ethanol was evaporated;
(3) the dregs and the moistened and uniform powder of salvia miltiorrhiza were fried with mutton
tallow for 3-5 minutes, the dregs were filtered, and the traditional Chinese herbal ointment was
obtained after being cooled at room temperature.
The effect of the traditional Chinese herbal ointment adopted by the invention is as follows: Salvia miltiorrhiza: It has the effect of treating chest pain, abdominal pain, abdominal pain, syndrome accumulation of abdominal mass, pain, upset insomnia, irregular menstruation, dysmenorrhea, sore swelling and pain effect. Lonicera japonica: it has the effect of clearing away heat and detoxication, treating wind-heat or warm disease, heat stroke, dysentery, carbuncle, furuncle and Arthralgia. Heracleum hemsleyanum Diels: it has the effect of dispeling wind and removing dampness, relieving pain and Arthralgia.
Forsythia suspensa: it has the effect of clearing away heat, detoxifying, dispersing knot and reducing swelling. it can be used to treat the disease of febrile, erysipelas, macula, abscess swelling and toxicity, scrofula, urine gonorrhea. Morus alba L.:It can relieve asthma by relieving lung-fire, diuresis and detumescence, tonify deficiency,it also has the effect of promoting blood circulation and removing blood stasis, resolving phlegm and stopping cough, stopping bleeding, promoting body fluid and relieving thirst, purging and relieving constipation, expelling insects, dispelling food, expelling wind, removing lymph, relieving pain. Achyranthes bidentata blume: it has the effect of dissipating blood stasis and clearing channels, tonifying liver and kidney, stronging muscles and bones, diureticing tonglin, drawing blood down. The invention has the following advantages: This invention adopts pure Chinese medicine compatibility.It is safe and has no toxic side effect and mild effect, and also has remarkable effect on promoting wound healing and reducing scar formation. The salvia miltiorrhiza was used as monarch drug in this invention; lonicera japonica, heracleum hemsleyanum diels, forsythia suspensa, morus alba L., achyranthes bidentata blume and mutton tallow were used as minister drug.Monarch and minister cooperate with each other to promote wound healing, reduce the formation of scars, and also reduce the pharmacological effects of inflammatory reaction. It can inhibit the excessive proliferation of fibroblast, and at the same time, it can promote the secretion of growth factor EGF and VEGF-A, and promote the healing of the damaged part of the skin, reduces the obstinate scar caused by the overproliferation of fibroblast in the later period. In the experimental phase, we find that the traditional Chinese herbal ointment can reduce the secretion of VEGF-A growth factor early in wound healing to inhibit angiogenesis, in the inflammatory phase, by raising the level of tumor necrosis factor, it promotes the aggregation of neutrophil and macrophages, which in turn reduces the duration of the inflammatory response and promotes the transfer of the wound from the inflammatory stage to the regenerative stage, and also to promote the role of wound healing;in the late wound healing, significantly promote Pro-epidermal growth factor, endothelial growth factor VEGF-A, and Transforming growth factor TGF-levels, reduce the level of Collagen fibers in the wound site, to reduce scarring.In the latter stages of wound healing, it significantly boosted levels of VEGF-A, Pro-epidermal growth factor, and transforming growth factor TGF-P, lowering collagen fiber levels at the site of the wound to reduce scar formation. The ointment of the invention has the functions of promoting wound healing, bacteriostasis, anti-inflammation and reducing wound scar formation. Compared with traditional vaseline and other dressings, it has the characteristics of slow-release.
Detailed Description of the Invention For better clarification of the objects, technical solutions and advantages of the invention, the technical solutions of the invention will be described clearly and completely below. Apparently, the examples described herein are some but not all of examples. All other examples obtained on the basis of the examples in the invention by a person of ordinary skill in the art without any creative efforts shall fall into the protection scope of the invention. Example 1 A traditional Chinese herbal ointment for promoting wound healing and reducing scar formation, it is made from the following weight parts of raw materials: 3 parts of salvia miltiorrhiza, 1 parts of lonicera japonica, 3 parts of heracleum hemsleyanum diels, 3 parts of forsythia suspensa, 3 parts of morus alba L., 3 parts of achyranthes bidentata blume and parts of mutton tallow.
A preparation method of the traditional Chinese herbal ointment comprises the following steps:
(1)the raw materials of the medicinal materials were dried to a constant weight and sterilized with
the freshly mutton tallow;
(2) the dried medicinal materials were weighed according to the weight parts respectively, the
salvia miltiorrhiza, lonicera japonica, heracleum hemsleyanum diels, forsythia suspensa, morus
alba L., achyranthes bidentata blume were shattered respectively, and were passed from 80M
screen, the water was added into salvia miltiorrhiza powder and then stirred well-distributed,
add water and moisten danshen powder and stir evenly, 4L of 95% ethanol was added into lonicera
japonica, heracleum hemsleyanum diels, forsythia suspensa, morus alba L. and achyranthes
bidentata blume, decocte until ethanol was evaporated;
(3) the dregs and the moistened and uniform powder of salvia miltiorrhiza were fried with mutton
tallow for 3 minutes, the dregs were filtered, and the traditional Chinese herbal ointment was
obtained after being cooled at room temperature.
Example 2 A traditional Chinese herbal ointment for promoting wound healing and reducing scar formation, it is made from the following weight parts of raw materials: 4 parts of salvia miltiorrhiza, 1 parts of lonicera japonica, 2 parts of heracleum hemsleyanum diels, 2 parts of forsythia suspensa, 2 parts of morus alba L., 2 parts of achyranthes bidentata blume and parts of mutton tallow.
A preparation method of the traditional Chinese herbal ointment comprises the following steps:
(1)the raw materials of the medicinal materials were dried to a constant weight and sterilized with
the freshly mutton tallow;
(2) the dried medicinal materials were weighed according to the weight parts respectively, the
salvia miltiorrhiza, lonicera japonica, heracleum hemsleyanum diels, forsythia suspensa, morus
alba L., achyranthes bidentata blume were shattered respectively, and were passed from OOM
screen, the water was added into salvia miltiorrhiza powder and then stirred well-distributed,add
water and moisten danshen powder and stir evenly, 5L of 95% ethanol was added into lonicera
japonica, heracleum hemsleyanum diels, forsythia suspensa, morus alba L. and achyranthes
bidentata blume, decocte until ethanol was evaporated;
(3) the dregs and the moistened and uniform powder of salvia miltiorrhiza were fried with mutton
tallow for 5 minutes, the dregs were filtered, and the traditional Chinese herbal ointment was
obtained after being cooled at room temperature.
Example 3 A traditional Chinese herbal ointment for promoting wound healing and reducing scar formation, it is made from the following weight parts of raw materials: 4 parts of salvia miltiorrhiza, 2parts of lonicera japonica, 4 parts of heracleum hemsleyanum diels, 4 parts of forsythia suspensa, 4 parts of morus alba L., 4 parts of achyranthes bidentata blume and parts of mutton tallow.
A preparation method of the traditional Chinese herbal ointment comprises the following steps:
(1)the raw materials of the medicinal materials were dried to a constant weight and sterilized with
the freshly mutton tallow;
(2) the dried medicinal materials were weighed according to the weight parts respectively, the
salvia miltiorrhiza, lonicera japonica, heracleum hemsleyanum diels, forsythia suspensa, morus
alba L., achyranthes bidentata blume were shattered respectively, and were passed from 80M
screen, the water was added into salvia miltiorrhiza powder and then stirred well-distributed,add
water and moisten danshen powder and stir evenly, 5L of 95% ethanol was added into lonicera
japonica, heracleum hemsleyanum diels, forsythia suspensa, morus alba L. and achyranthes
bidentata blume, decocte until ethanol was evaporated;
(3) the dregs and the moistened and uniform powder of salvia miltiorrhiza were fried with mutton
tallow for 4 minutes, the dregs were filtered, and the traditional Chinese herbal ointment was
obtained after being cooled at room temperature.
Finally, it is to be noted that the foregoing examples are merely for explaining the technical solutions of the invention, rather than limitations thereto. Although the invention has been detailed with reference to the foregoing examples, a person of ordinal skill in the art shall understand that modifications can still be made to the technical solutions documented in the foregoing examples, or equivalent substitutions can be made to some of the technical features therein. Such modifications or substitutions do not deviate the nature of the corresponding technical solutions from the spirit and scope of the technical solutions embodied in the examples of the invention.

Claims (5)

  1. Claims 1. A traditional Chinese herbal ointment for promoting wound healing and reducing scar formation,characterized in that it is made from the following weight parts of raw materials: 2-4 parts of salvia miltiorrhiza, 1-2 parts of lonicera japonica, 2-4 parts of heracleum hemsleyanum diels, 2-4 parts of forsythia suspensa, 2-4 parts of morus alba L., 2-4 parts of achyranthes bidentata blume and 10-15 parts of mutton tallow.
  2. 2. The traditional Chinese herbal ointment according to claim 1, characterized in that it is made from the following weight parts of raw materials: 4 parts of salvia miltiorrhiza, parts of lonicera japonica, 2 parts of heracleum hemsleyanum diels, 2 parts of forsythia suspensa, 2parts of morus alba L., 2 parts of achyranthes bidentata blume and parts of mutton tallow.
  3. 3. The traditional Chinese herbal ointment according to claim 1, characterized in that the salvia miltiorrhiza is fresh sliced salvia miltiorrhiza.
  4. 4. The traditional Chinese herbal ointment according to claim 1, characterized in that the mutton
    tallow is pure mutton tallow.
  5. 5. A preparation method of the traditional Chinese herbal ointment according to either of claim
    1-4, characterized in that the preparation method comprises the following steps:
    (1)the raw materials of the medicinal materials were dried to a constant weight and sterilized with
    the freshly mutton tallow;
    (2) the dried medicinal materials were weighed according to the weight parts respectively, the
    salvia miltiorrhiza, lonicera japonica, heracleum hemsleyanum diels, forsythia suspensa, morus
    alba L., achyranthes bidentata blume were shattered respectively, and were passed from 80-OOM
    screen, the water was added into salvia miltiorrhiza powder and then stirred well-distributed,
    add water and moisten danshen powder and stir evenly, 4-5L of 95% ethanol was added into
    lonicera japonica, heracleum hemsleyanum diels, forsythia suspensa, morus alba L. and
    achyranthes bidentata blume, decocte until ethanol was evaporated;
    (3) the dregs and the moistened and uniform powder of salvia miltiorrhiza were fried with mutton
    tallow for 3-5 minutes, the dregs were filtered, and the traditional Chinese herbal ointment was
    obtained after being cooled at room temperature.
AU2020103805A 2020-11-30 2020-11-30 A traditional chinese herbal ointment for promoting wound healing and reducing scar formation and preparation method thereof Ceased AU2020103805A4 (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114832026A (en) * 2022-05-06 2022-08-02 南京大学 Preparation method of honeysuckle extract and application of honeysuckle extract in preparation of medicine for preventing or treating scars caused by burn or scald

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114832026A (en) * 2022-05-06 2022-08-02 南京大学 Preparation method of honeysuckle extract and application of honeysuckle extract in preparation of medicine for preventing or treating scars caused by burn or scald

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